Drug Metabolism (When You’re Not Average!)
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When Your Medications Run Out… Of You
Everybody knows that alcohol can affect medications’ effects, but what of smoking, and what of obesity? And how does the alcohol thing work anyway?
It’s all about the enzymes
Medicines that are processed by the liver (which is: most medicines) are metabolized there by specialist enzymes, and the things we do can increase or decrease the quantity of those enzymes—and/or how active they are.
Dr. Kata Wolff Pederson and her team of researchers at Aarhus University in Denmark examined the livers of recently deceased donors in ways that can’t (ethically) be done with live patients, and were able to find the associations between various lifestyle factors and different levels of enzymes responsible for drug metabolism.
And it’s not always how you might think!
Some key things they found:
- Smokers have twice as high levels of enzyme CYP1A2 than non-smokers, which results in the faster metabolism of a lot of drugs.
- Drinkers have 30% higher levels of enzyme CYP2E1, which also results in a faster metabolism of a lot of drugs.
- Patients with obesity have 50% lower levels of enzyme CYP3A4, resulting in slower metabolism of many drugs
This gets particularly relevant when we take into account the next fact:
- Of the individuals in the study, 40% died from poisoning from a mixture of drugs (usually: prescription and otherwise)
Read in full: Sex- and Lifestyle-Related Factors are Associated with Altered Hepatic CYP Protein Levels
Read a pop-sci article about it: Your lifestyle can determine how well your medicine will work
How much does the metabolism speed matter?
It can matter a lot! If you’re taking drugs and carefully abiding by the dosage instructions, those instructions were assuming they know your speed of metabolism, and this is based on an average.
- If your metabolism is faster, you can get too much of a drug too quickly, and it can harm you
- If your metabolism is faster, it also means that while yes it’ll start working sooner, it’ll also stop working sooner
- If it’s a painkiller, that’s inconvenient. If it’s a drug that keeps you alive, then well, that’s especially unfortunate.
- If your metabolism is slower, it can mean your body is still processing the previous dose(s) when you take the next one, and you can overdose (and potentially die)
We touched on this previously when we talked about obesity in health care settings, and how people can end up getting worse care:
As for alcohol and drugs? Obviously we do not recommend, but here’s some of the science of it with many examples:
Why it’s a bad idea to mix alcohol with some medications
Take care!
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Thriving Beyond Fifty – by Will Harlow
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We’ve featured this author sometimes in our video section; he’s an over-50s specialist physiotherapist with a lot of very functional advice to offer.
In this book, Harlow focusses heavily on three things: mobility, strength, endurance.
You may not want to be a gymnast, powerlifter, or marathon-runner, but these things are important for us all to maintain to at least a fair degree:
- Mobility can be the difference between tweaking one’s shoulder getting something from a high shelf, or not
- Strength can be the difference between being able to get back up, or not
- Endurance can be the difference between coming back from a long day on your feet and thinking “that was a good day; I’m looking forward to tomorrow now”, or not
One of the greatest strengths of this book is its comprehensive troubleshooting aspect; if you have a weak spot, chances are this book has the remedy.
As for the style, it’s quite casual/conversational in tone, but without skimping on science and detail. It’s clear, explanatory, and helpful throughout.
Bottom line: if you’d like to maintain/improve mobility, strength, and endurance, then this book is a very recommendable resource.
Click here to check out Thriving Beyond Fifty, and keep thriving at every age!
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Eating For Energy (In Ways That Actually Work)
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Snacks & Hacks: The Real Energy Boosters
Declining energy levels are a common complaint of people getting older, and this specific kind of “getting older” is starting earlier and earlier (even Gen-Z are already getting in line for this one). For people of all ages, however, diet is often a large part of the issue.
The problem:
It can sometimes seem, when it comes to food and energy levels, that we have a choice:
- Don’t eat (energy levels decline)
- Eat quick-release energy snacks (energy spikes and crashes)
- Eat slow-release energy meals (oh hi, post-dinner slump)
But, this minefield can be avoided! Advice follows…
Skip the quasi-injectables
Anything the supermarket recommends for rapid energy can be immediately thrown out (e.g. sugary energy drinks, glucose tablets, and the like).
Same goes for candy of most sorts (if the first ingredient is sugar, it’s not good for your energy levels).
Unless you are diabetic and need an emergency option to keep with you in case of a hypo, the above things have no place on a healthy shopping list.
Aside from that, if you have been leaning on these heavily, you might want to check out yesterday’s main feature:
The Not-So-Sweet Science Of Sugar Addiction
…and if your knee-jerk response is “I’m not addicted; I just enjoy…” then ok, test that! Skip it for this month.
- If you succeed, you’ll be in better health.
- If you don’t, you’ll be aware of something that might benefit from more attention.
Fruit and nuts are your best friends
Unless you are allergic, in which case, obviously skip your allergen(s).
But for most of us, we were born to eat fruit and nuts. Literally, those two things are amongst the oldest and most well-established parts of human diet, which means that our bodies have had a very long time to evolve the perfect fruit-and-nut-enjoying abilities, and reap the nutritional benefits.
Nuts are high in fat (healthy fats) and that fat is a great source of energy’s easy for the body to get from the food, and/but doesn’t result in blood sugar spikes (and thus crashes) because, well, it’s not a sugar.
See also: Why You Should Diversify Your Nuts
Fruit is high in sugars, and/but high in fiber that slows the absorption into a nice gentle curve, and also contains highly bioavailable vitamins to perk you up and polyphenols to take care of your long-term health too.
Be warned though: fruit juice does not work the same as actual fruit; because the fiber has been stripped and it’s a liquid, those sugars are zipping straight in exactly the same as a sugary energy drink.
See also: Which Sugars Are Healthier, And Which Are Just The Same?
Slow release carbs yes, but…
Eating a bowl of wholegrain pasta is great if you don’t have to do anything much immediately afterwards, but it won’t brighten your immediately available energy much—on the contrary, energy will be being used for digestion for a while.
So if you want to eat slow-release carbs, make it a smaller portion of something more-nutrient dense, like oats or lentils. This way, the metabolic load will be smaller (because the portion was smaller) but the higher protein content will prompt satiety sooner (so you addressed your hunger with a smaller portion) and the iron and B vitamins will be good for your energy too.
See also: Should You Go Light Or Heavy On Carbs?
Animal, vegetable, or mineral?
At the mention of iron and B vitamins, you might be thinking about various animal products that might work too.
If you are vegetarian or vegan: stick to that; it’s what your gut microbiome is used to now, and putting an animal product in will likely make you feel ill.
If you have them in your diet already, here’s a quick rundown of how broad categories of animal product work (or not) for energy:
- Meat: nope. Well, the fat, if applicable, will give you some energy, but less than you need just to digest the meat. This, by the way, is a likely part of why the paleo diet is good for short term weight loss. But it’s not very healthy.
- Fish: healthier than the above, but for energy purposes, just the same.
- Dairy: high-fat dairy, such as cream and butter, are good sources of quick energy. Be aware if they contain lactose though, that this is a sugar and can be back to spiking blood sugars.
- As an aside for diabetics: this is why milk can be quite good for correcting a hypo: the lactose provides immediate sugar, and the fat keeps it more balanced afterwards
- Eggs: again the fat is a good source of quick energy, and the protein is easier to digest than that of meat (after all, egg protein is literally made to be consumed by an embryo, while meat protein is made to be a functional muscle of an animal), so the metabolic load isn’t too strenuous. Assuming you’re doing a moderate consumption (under 3 eggs per day) and not Sylvester Stallone-style 12-egg smoothies, you’re good to go.
See also: Do We Need Animal Products To Be Healthy?
…and while you’re at it, check out:
Eggs: Nutritional Powerhouse
or Heart-Health Timebomb?(spoiler: it’s the former; the title was because it was a mythbusting edition)
Hydration considerations
Lastly, food that is hydrating will be more energizing than food that is not, so how does your snack/meal rank on a scale of watermelon to saltines?
You may be thinking: “But you said to eat nuts! They’re not hydrating at all!”, in which case, indeed, drink water with them, or better yet, enjoy them alongside fruit (hydration from food is better than hydration from drinking water).
And as for those saltines? Salt is not your friend (unless you are low on sodium, because then that can sap your energy)
How to tell if you are low on sodium: put a little bit (e.g. ¼ tsp) of salt into a teaspoon and taste it; does it taste unpleasantly salty? If not, you were low on sodium. Have a little more at five minute intervals, until it tastes unpleasantly salty. Alternatively have a healthy snack that nonetheless contains a little salt.
If you otherwise eat salty food as an energy-giving snack, you risk becoming dehydrated and bloated, neither of which are energizing conditions.
Dehydrated and bloated at once? Yes, the two often come together, even though it usually doesn’t feel like it. Basically, if we consume too much salty food, our homeostatic system goes into overdrive to try to fix it, borrows a portion of our body’s water reserves to save us from the salt, and leaves us dehydrated, bloated, and sluggish.
For more on salt in general, check out:
How Too Much Salt Can Lead To Organ Failure: Lesser-Known Salt Health Risks
Take care!
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Ozempic vs Five Natural Supplements
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Semaglutide (GLP-1 agonist) drugs Ozempic and Wegovy really do work for losing weight, provided one then remains on these expensive drugs for life. Dr. Jin Sung recommends a supplements-based approach, instead.
Natural Alternatives
Dr. Sung recommends:
- Berberine, which increases production and secretion of GLP-1.
- Probiotics, which increase GLP-1 secretion. In particular he recommends Akkermansia municiphila which secretes P9, and this protein stimulates GLP-1 production and secretion.
- Psyllium, a soluble dietary fiber which will increase short-chain fatty acids which then help with increasing GLP-1.
- Curcumin, which enhances L-cell numbers, in turn promoting and increasing GLP-1 secretion. Also, curcumin may prolong gastric emptying, and increase insulin sensitivity.
- Ginseng, of which the bioactive compound stimulates secretion of GLP-1, and also has anti-diabetic effects.
Dr. Sung explains more about each of these in his video:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to know more?
You might enjoy our previous main feature looking at some of the pros and cons:
Take care!
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The Mediterranean Diet Cookbook for Beginners – by Jessica Aledo
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There are a lot of Mediterranean Diet books on the market, and not all of them actually stick to the Mediterranean Diet. There’s a common mistake of thinking “Well, this dish is from the Mediterranean region, so…”, but that doesn’t make, for example, bacon-laden carbonara part of the Mediterranean Diet!
Jessica Aledo does better, and sticks unwaveringly to the Mediterranean Diet principles.
First, she gives a broad introduction, covering:
- The Mediterranean Diet pyramid
- Foods to eat on the Mediterranean Diet
- Foods to avoid on the Mediterranean Diet
- Benefits of the Mediterranean Diet
Then, it’s straight into the recipes, of which there are 201 (as with many recipe books, the title is a little misleading about this).
They’re divided into sections, thus:
- Breakfasts
- Lunches
- Snacks
- Dinners
- Desserts
The recipes are clear and simple, one per double-page, with high quality color illustrations. They give ingredients/directions/nutrients. There’s no padding!
Helpfully, she does include a shopping list as an appendix, which is really useful!
Bottom line: if you’re looking to build your Mediterranean Diet repertoire, this book is an excellent choice.
Get your copy of The Mediterranean Diet Cookbook for Beginners from Amazon today!
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Fall Asleep In 2 Minutes (Doctor Explains)
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Beyond “sleep hygiene”, Dr. Siobhan Deshauer has insights to share:
Rest for your body and mind
First, do still do the basics. That means dimming/filtering lights for an hour before bed, lowering the room temperature a little, ensuring you have nice fresh sheets, not having alcohol or caffeine before bed, and getting out of bed if you’re not asleep within half an hour, to avoid associating being in bed with wakefulness.
Next, the extra tips:
- Progressive relaxation: tense and relax each muscle group from toes to head
- Box breathing: inhale, hold, exhale, and hold for 4 seconds each; helps calm the nervous system (it’s called “box breathing” because of the 4:4:4:4 setup)
- Diaphragmatic breathing: focus on belly breathing, with longer exhalation to activate the parasympathetic nervous system (note that this can, and even ideally should, be done at the same time as the previous)
- Cognitive shuffling: think of words starting with each letter of a chosen word while visualizing them (this is like “counting sheep”, but does the job better—the job in question being preventing your brain from moving to anything more strenuous or stressful)
For more on all of these plus some extra side-along advice, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Non-Sleep Deep Rest: A Neurobiologist’s Take ← a way to get many of the benefits of sleep, while awake
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Asparagus vs Edamame – Which is Healthier?
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Our Verdict
When comparing asparagus to edamame, we picked the edamame.
Why?
Perhaps it’s a little unfair comparing a legume to a vegetable that’s not leguminous (given legumes’ high protein content), but these two vegetables often serve a similar culinary role, and there is more to nutrition than protein. That said…
In terms of macros, edamame has a lot more protein and fiber; it also has more carbs, but the ratio is such that edamame still has the lower glycemic index. Thus, the macros category is a win for edamame in all relevant aspects.
When it comes to vitamins, things are a little closer; asparagus has more of vitamins A, B3, and C, while edamame has more of vitamins B1, B2, B5, B6, and B9. All in all, a moderate win for edamame, unless we want to consider the much higher vitamin C content of asparagus as particularly more relevant.
In the category of minerals, asparagus boasts only more selenium (and more sodium, not that that’s a good thing for most people in industrialized countries), while edamame has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and zinc. An easy win for edamame.
In short, enjoy both (unless you have a soy allergy, because edamame is young soy beans), but edamame is the more nutritionally dense by far.
Want to learn more?
You might like to read:
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