Bromelain vs Inflammation & Much More
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Let’s Get Fruity
Bromelain is an enzyme* found in pineapple (and only in pineapple), that has many very healthful properties, some of them unique to bromelain.
*actually a combination of enzymes, but most often referred to collectively in the singular. But when you do see it referred to as “they”, that’s what that means.
What does it do?
It does a lot of things, for starters:
❝Various in vivo and in vitro studies have shown that they are anti-edematous, anti-inflammatory, anti-cancerous, anti-thrombotic, fibrinolytic, and facilitate the death of apoptotic cells. The pharmacological properties of bromelain are, in part, related to its arachidonate cascade modulation, inhibition of platelet aggregation, such as interference with malignant cell growth; anti-inflammatory action; fibrinolytic activity; skin debridement properties, and reduction of the severe effects of SARS-Cov-2❞
Some quick notes:
- “facilitate the death of apoptotic cells” may sound alarming, but it’s actually good; those cells need to be killed quickly; see for example: Fisetin: The Anti-Aging Assassin
- If you’re wondering what arachidonate cascade modulation means, that’s the modulation of the cascade reaction of arachidonic acid, which plays a part in providing energy for body functions, and has a role in cell structure formation, and is the precursor of assorted inflammatory mediators and cell-signalling chemicals.
- Its skin debridement properties (getting rid of dead skin) are most clearly seen when using bromelain topically (one can literally just make a pineapple poultice), but do occur from ingestion also (because of what it can do from the inside).
- As for being anti-thrombotic and fibrinolytic, let’s touch on that before we get to the main item, its anti-inflammatory properties.
If you want to read more of the above before moving on, though, here’s the full text:
Anti-thrombotic and fibrinolytic
While it does have anti-thrombotic effects, largely by its fibrinolytic action (i.e., it dissolves the fibrin mesh holding clots together), it can have a paradoxically beneficial effect on wound healing, too:
For more specifically on its wound-healing benefits:
In Vitro Effect of Bromelain on the Regenerative Properties of Mesenchymal Stem Cells
Anti-inflammatory
Bromelain is perhaps most well-known for its anti-inflammatory powers, which are so diverse that it can be a challenge to pin them all down, as it has many mechanisms of action, and there’s a large heterogeneity of studies because it’s often studied in the context of specific diseases. But, for example:
❝Bromelain reduced IL-1β, IL-6 and TNF-α secretion when immune cells were already stimulated in an overproduction condition by proinflammatory cytokines, generating a modulation in the inflammatory response through prostaglandins reduction and activation of cascade reactions that trigger neutrophils and macrophages, in addition to accelerating the healing process❞
~ Dr. Taline Alves Nobre et al.
Read in full:
Bromelain as a natural anti-inflammatory drug: a systematic review
Or if you want a more specific example, here’s how it stacks up against arthritis:
❝The results demonstrated the chondroprotective effects of bromelain on cartilage degradation and the downregulation of inflammatory cytokine (tumor necrosis factor (TNF)-α, IL-1β, IL-6, IL-8) expression in TNF-α–induced synovial fibroblasts by suppressing NF-κB and MAPK signaling❞
~ Dr. Perephan Pothacharoen et al.
Read in full:
More?
Yes more! You’ll remember from the first paper we quoted today, that it has a long laundry list of benefits. However, there’s only so much we can cover in one edition, so that’s it for today
Is it safe?
It is generally recognized as safe. However, its blood-thinning effect means it should be avoided if you’re already on blood-thinners, have some sort of bleeding disorder, or are about to have a surgery.
Additionally, if you have a pineapple allergy, this one may not be for you.
Aside from that, anything can have drug interactions, so do check with your doctor/pharmacist to be sure (with the pharmacist usually being the more knowledgeable of the two, when it comes to drug interactions).
Want to try some?
You can just eat pineapples, but if you don’t enjoy that and/or wouldn’t want it every day, bromelain is available in supplement form too.
We don’t sell it, but here for your convenience is an example product on Amazon
Enjoy!
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Top 10 Causes Of High Blood Pressure
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As Dr. Frita Fisher explains, these are actually the top 10 known causes of high blood pressure. Number zero on the list would be “primary hypertension”, which means high blood pressure with no clear underlying cause.
Superficially, this feels a little like the sometime practice of writing the catch-all “heart failure” as the cause of death on a death certificate, because yes, that heart sure did stop beating. But in reality, primary hypertension is most likely often caused by such things as unmanaged chronic stress—something that doesn’t show up on most health screenings.
Dr. Fisher’s Top 10
- Thyroid disease: both hyperthyroidism and hypothyroidism can cause high blood pressure.
- Obstructive sleep apnea: characterized by snoring, daytime sleepiness, and headaches, this condition can lead to hypertension.
- Chronic kidney disease: diseases ranging from diabetic nephropathy to renal vascular disease can cause high blood pressure.
- Elevated cortisol levels: conditions like Cushing’s syndrome or disease, which involve high cortisol levels, can lead to hypertension—as can a lifestyle with a lot of chronic stress, but that’s less readily diagnosed as such than something one can tell from a blood test.
- Elevated aldosterone levels: excess aldosterone from the adrenal glands causes the body to retain salt and water, increasing blood pressure, because more stuff = more pressure.
- Brain tumor: tumors that increase intracranial pressure can cause a rise in blood pressure to ensure adequate brain perfusion. In these cases, the hypertension is keeping you alive—unless it kills you first. If this seems like a strange bodily response, remember that our bodily response to an infection is often fever, to kill off the infection which can’t survive at such high temperatures (but neither can we, so it becomes a game of chicken with our life on the line), so sometimes our body does kill us with one thing while trying to save us from another.
- Coarctation of the aorta: this congenital heart defect results in narrowing of the aorta, leading to hypertension, especially in the upper body.
- Pregnancy: pregnancy can either induce or worsen existing hypertension.
- Obesity: excess weight increases blood flow and pressure on arteries, raising the risk of hypertension and associated conditions, e.g. diabetes etc.
- Drugs: certain medications and recreational drugs (including, counterintuitively, alcohol!) can elevate blood pressure.
For more information on each of these, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Hypertension: Factors Far More Relevant Than Salt
Take care!
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Health Shots − by Toby Amidor
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First a quick note on qualifications: while not a doctor, she’s a RD, CDN, FAND, and as such, this is a very nutrition-focused book.
As a general rule of thumb, juices are unhealthy because of being largely liquid sugar and no fiber, but in this case:
- even the juice-based tonics are very small portions, so even if some have a high glycemic index, they’ll still have a low glycemic load, which means that having one is unlikely to spike blood glucose and thus insulin
- many of the tonics have fiber in any case, due to how they are made.
The tonics are divided into sections per what one wants to focus on, e.g. anti-inflammatory, brain health, sleep, gut health, skin/nails/hair, etc.
That said, some of the recipes are a little optimistic about how much effect the dosage present will have. For example, we calculate an an average of 0.03mg of resveratrol in her grape-based shot boasting resveratrol benefits. For contrast, resveratrol supplements range from 500mg to 200mg. So, to get the equivalent of the least generous supplement, you’d need to drink 16,667 shots.
Bottom line: some of the the health claims in this book are overstated, but by and large, it’s hard to go wrong consuming more plants, and these “health shots” are not a bad way to get a good dose of phytonutrients without hitting glycemic problems.
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Mimosa For Healing Your Body & Mind
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Today we’re looking at mimosa (no relation to the cocktail!), which is a name given to several related plant species that belong to the same genus or general clade, look similar, and have similar properties and behavior.
As a point of interest that’s not useful: mimosa is one of those plants whereby if you touch it, it’ll retract its leaves and shrink away from you. The leaves also droop at nighttime (perfectly healthily; they’re not wilting or anything; this too is just plant movement), and spring back up in the daytime.
So that’s what we mean when we say “and behavior” 😉
Antidepressant & anxiolytic
Mimosa bark and leaves have long been used in Traditional Chinese Medicine, as well as (albeit different species) in the North-East of Brazil, and (again, sometimes different species) in Mexico.
Animal studies, in vivo studies, and clinical practice in humans, have found this to be effective, for example:
❝[Mimosa pudica extract] has anti-anxiety, anti-depressant and memory enhancing activities that are mediated through multiple mechanisms❞
Source: Effects of Mimosa pudica L. leaves extract on anxiety, depression and memory
Research is ongoing with regard to how, exactly, mimosa does what it does. Here’s a paper about another species mimosa:
(notwithstanding the genus name, it’s still part of the mimosa clade)
Anti-inflammatory & analgesic
In this case, mimosa has traditionally been used as a topical tincture (for skin damage of many kinds, ranging from cuts and abrasions to burns to autoimmune conditions and more), so what does the science say about that?
❝In summary, the present study provided evidence that the [mimosa extract], its fractions and the isolated compound sakuranetin showed significant anti-inflammatory and antinociceptive activities❞
Wound healing
About those various skin damages, here’s another application, and a study showing that it doesn’t just make it feel better, it actually helps it to heal, too:
❝Therapeutic effectiveness occurred in all patients of the extract group; after the 8th treatment week, ulcer size was reduced by 92% as mean value in this group, whereas therapeutic effectiveness was observed only in one patient of the control group (chi(2), p=0.0001). No side effects were observed in any patient in either group.❞
Very compelling stats!
Read more: Therapeutic effectiveness of a Mimosa tenuiflora cortex extract in venous leg ulceration treatment
Is it safe?
Yes, for most people, with some caveats:
- this one comes with a clear “don’t take if pregnant or breastfeeding” warning, as for unknown reasons it has caused a high incidence of fetal abnormalities or fetal death in animal studies.
- while the stem bark (the kind used in most mimosa supplements and most readily found online) has negligible psychoactivity, as do many species of mimosa in general, the root of M. tenuiflora has psychedelic effects similar to ayahuasca if taken orally, for example as a decoction, if in the presence of a monoamine oxidase inhibitor (MAOI), as otherwise MAO would metabolize the psychoactive component in the gut before it can enter the bloodstream.
That’s several “ifs”, meaning that the chances of unwanted psychedelic effects are slim if you’re paying attention, but as ever, do check with your doctor/pharmacist to be sure.
Want to try some?
We don’t sell it, but here for your convenience is an example product on Amazon 😎
Enjoy!
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Rethinking Diabetes – by Gary Taubes
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We’ve previously reviewed this author’s “The Case Against Sugar” and “Why We Get Fat And What To Do About It“. There’s an obvious theme, and this book caps it off nicely:
By looking at the history of diabetes treatment (types 1 and 2) in the past hundred years, and analysing the patterns over time, we can see how:
- diabetics have been misled a lot over time by healthcare providers
- we can learn from those mistakes going forwards
Happily, he does this without crystal-balling the future or expecting diet to fix, for example, a pancreas that can’t produce insulin. But what he does do is focus on the “can” items rather than the “can’t” items.
In the category of criticism, one of the strategies he argues for is basically the keto diet, which is indeed just fine for diabetes but often not great for the heart in the long-term (it depends on various factors, including genes). However, even if you choose not to implement that, there is plenty more to try out in this book.
Bottom line: whether you have diabetes, love someone who does, or just plain like to be on top of your glycemic health, this book is full of important insights and opportunities to improve things progressively along the way.
Click here to check out Rethinking Diabetes, and rethink diabetes!
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How To Stay Alive (When You Really Don’t Want To)
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How To Stay Alive (When You Really Don’t Want To)
A subscriber recently requested:
❝Request: more people need to be aware of suicidal tendencies and what they can do to ward them off❞
…and we said we’d do that one of these Psychology Sundays, so here we are, doing it!
First of all, we’ll mention that we did previously do a main feature on managing depression (in oneself or a loved one); here it is:
The Mental Health First Aid That You’ll Hopefully Never Need
Now, not all depression leads to suicidality, and not all suicide is pre-empted by depression, but there’s a large enough crossover that it seems sensible to put that article here, for anyone who might find it of use, or even just of interest.
Now, onwards, to the specific, and very important, topic of suicide.
This should go without saying, but some of today’s content may be a little heavy.
We invite you to read it anyway if you’re able, because it’s important stuff that we all should know, and not talking about it is part of what allows it to kill people.
So, let’s take a deep breath, and read on…
The risk factors
Top risk factors for suicide include:
- Not talking about it
- Having access to a firearm
- Having a plan of specifically how to commit suicide
- A lack of social support
- Being male
- Being over 40
Now, some of these are interesting sociologically, but aren’t very useful practically; what a convenient world it’d be if we could all simply choose to be under 40, for instance.
Some serve as alarm bells, such as “having a plan of specifically how to commit suicide”.
If someone has a plan, that plan’s never going to disappear entirely, even if it’s set aside!
(this writer is deeply aware of the specifics of how she has wanted to end things before, and has used the advice she gives in this article herself numerous times. So far so good, still alive to write about it!)
Specific advices, therefore, include:
Talk about it / Listen
Depending on whether it’s you or someone else at risk:
- Talk about it, if it’s you
- Listen attentively, if it’s someone else
There are two main objections that you might have at this point, so let’s look at those:
“I have nobody to talk to”—it can certainly feel that way, sometimes, but you may be surprised who would listen if you gave them the chance. If you really can’t trust anyone around you, there are of course suicide hotlines (usually per area, so we’ll not try to list them here; a quick Internet search will get you what you need).
If you’re worried it’ll result in bad legal/social consequences, check their confidentiality policy first:
- Some hotlines can and will call the police, for instance.
- Others deliberately have a set-up whereby they couldn’t even trace the call if they wanted to.
- On the one hand, that means they can’t intervene
- On the other hand, that means they’re a resource for anyone who will only trust a listener who can’t intervene.
“But it is just a cry for help”—then that person deserves help. What some may call “attention-seeking” is, in effect, care-seeking. Listen, without judgement.
Remove access to firearms, if applicable and possible
Ideally, get rid of them (safely and responsibly, please).
If you can’t bring yourself to do that, make them as inconvenient to get at as possible. Stored securely at your local gun club is better than at home, for example.
If your/their plan isn’t firearm-related, but the thing in question can be similarly removed, remove it. You/they do not need that stockpile of pills, for instance.
And of course you/they could get more, but the point is to make it less frictionless. The more necessary stopping points between thinking “I should just kill myself” and being able to actually do it, the better.
Have/give social support
What do the following people have in common?
- A bullied teenager
- A divorced 40-something who just lost a job
- A lonely 70-something with no surviving family, and friends that are hard to visit
Often, at least, the answer is: the absence of a good social support network
So, it’s good to get one, and be part of some sort of community that’s meaningful to us. That could look different to a lot of people, for example:
- A church, or other religious community, if we be religious
- The LGBT+ community, or even just a part of it, if that fits for us
- Any mutual-support oriented, we-have-this-shared-experience community, could be anything from AA to the VA.
Some bonus ideas…
If you can’t live for love, living for spite might suffice. Outlive your enemies; don’t give them the satisfaction.
If you’re going to do it anyway, you might as well take the time to do some “bucket list” items first. After all, what do you have to lose? Feel free to add further bucket list items as they occur to you, of course. Because, why not? Before you know it, you’ve postponed your way into a rich and fulfilling life.
Finally, some gems from Matt Haig’s “The Comfort Book”:
- “The hardest question I have been asked is: “How do I stay alive for other people if I have no one?” The answer is that you stay alive for other versions of you. For the people you will meet, yes, but also the people you will be.”
- “Stay for the person you will become”
- “You are more than a bad day, or week, or month, or year, or even decade”
- “It is better to let people down than to blow yourself up”
- “Nothing is stronger than a small hope that doesn’t give up”
- “You are here. And that is enough.”
You can find Matt Haig’s excellent “The Comfort Book” on Amazon, as well as his more well-known book more specifically on the topic we’ve covered today, “Reasons To Stay Alive“.
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Heal Your Nervous System – by Dr. Linnea Passaler
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This book focuses on the oft-overlooked connection between nervous system dysregulation (i.e. sympathetic nervous system dominance, keeping the brain in “may have to fight for my life at any moment” mode) and the many symptoms—mental and physical—that can arise as a result.
While there is a lot of theory explained in here, there’s practicality too, providing the reader with tools to assess our own levels of nervous system dysregulation and what factors affect that.
In particular in that category, a lot of value is delivered in terms of practical guidance on avoiding common pitfalls in the healing journey. Dr. Passaler discusses the four biggest mistakes people make when attempting to heal, and gives clear strategies to sidestep each of them, with exercises to do and habits to implement.
Another thing that sets this book apart from many of its genre is her emphasis on the importance of sequencing healing practices in the right order. By offering a structured approach, the book helps us implement healing practices without getting overwhelmed or hitting the proverbial brick wall and getting frustrated, which makes a big difference.
The style is easy-to-understand pop-science, albeit with a reassuring 20 pages of references at the back.
Bottom line: if you feel like “peace of mind” is something that’s always just out of reach, this book can help you to get where you need to be, physically as well as mentally.
Click here to check out Heal Your Nervous System, and get things into much better order!
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