Aging Backwards – by Miranda Esmonde-White

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In this book, there’s an upside and a downside to the author’s professional background:

  • Upside: Miranda Esmonde-White is a ballet-dancer-turned-physical-trainer, and it shows
  • Downside: Miranda Esmonde-White is not a scientist, and it shows

She cites a lot of science, but she either does not understand it or else intentionally misrepresents it. We will assume the former. But as one example, she claims:

“for every minute you exercise, you lengthen your life by 7 minutes”

…which cheat code to immortality is absolutely not backed-up by the paper she cites for it. The paper, like most papers, was much more measured in its proclamations; “there was an association” and “with these conditions”, etc.

Nevertheless, while she misunderstands lots of science along the way, her actual advice is good and sound. Her workout programs really will help people to become younger by various (important, life-changing!) metrics of biological age, mostly pertaining to mobility.

And yes, this is a workout-based approach; we won’t read much about diet and other lifestyle factors here.

Bottom line: it has its flaws, but nevertheless delivers on its premise of helping the reader to become biologically younger through exercises, mostly mobility drills.

Click here to check out Aging Backwards, and age backwards!

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  • Top 5 Anti-Aging Exercises

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    There are some exercises that get called such things as “The King of Exercises!”, but how well-earned is that title and could it be that actually a mix of the top few is best?

    The Exercises

    While you don’t have to do all 5, your body will thank you if you are able to:

    • Plank: strengthens most of the body, and can reduce back pain while improving posture.
    • Squats: another core-strengthening exercise, this time with an emphasis on the lower body, which makes for strong foundations (including strong ankles, knees, and hips). Improves circulation also, and what’s good for circulation is good for the organs, including the brain!
    • Push-ups: promotes very functional strength and fitness; great for alternating with planks, as despite their similar appearance, they work the abs and back more, respectively.
    • Lunges: these are great for lower body strength and stability, and doing these greatly reduces the risk of falling.
    • Glute Bridges: this nicely rounds off one’s core strength, increasing stability and improving posture, as well as reducing lower back pain too.

    If the benefits of these seem to overlap a little, it’s because they do! But each does some things that the others don’t, so put together, they make for a very well-balanced workout.

    For advice on how to do each of them, plus more about the muscles being used and the benefits, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Take care!

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  • The Mental Health First-Aid That You’ll Hopefully Never Need

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Take Your Mental Health As Seriously As General Health!

    Sometimes, health and productivity means excelling—sometimes, it means avoiding illness and unproductivity. Both are essential, and today we’re going to tackle some ground-up stuff. If you don’t need it right now, great; we suggest to read it for when and if you do. But how likely is it that you will?

    • One in four of us are affected by serious mental health issues in any given year.
    • One in five of us have suicidal thoughts at some point in our lifetime.
    • One in six of us are affected to at least some extent by the most commonly-reported mental health issues, anxiety and depression, in any given week.

    …and that’s just what’s reported, of course. These stats are from a UK-based source but can be considered indicative generally. Jokes aside, the UK is not a special case and is not measurably worse for people’s mental health than, say, the US or Canada.

    While this is not an inherently cheery topic, we think it’s an important one.

    Depression, which we’re going to focus on today, is very very much a killer to both health and productivity, after all.

    One of the most commonly-used measures of depression is known by the snappy name of “PHQ9”. It stands for “Patient Health Questionnaire Nine”, and you can take it anonymously online for free (without signing up for anything; it’s right there on the page already):

    Take The PHQ9 Test Here! (under 2 minutes, immediate results)

    There’s a chance you took that test and your score was, well, depressing. There’s also a chance you’re doing just peachy, or maybe somewhere in between. PHQ9 scores can fluctuate over time (because they focus on the past two weeks, and also rely on self-reports in the moment), so you might want to bookmark it to test again periodically. It can be interesting to track over time.

    In the event that you’re struggling (or: in case one day you find yourself struggling, or want to be able to support a loved one who is struggling), some top tips that are useful:

    Accept that it’s a medical condition like any other

    Which means some important things:

    • You/they are not lazy or otherwise being a bad person by being depressed
    • You/they will probably get better at some point, especially if help is available
    • You/they cannot, however, “just snap out of it”; illness doesn’t work that way
    • Medication might help (it also might not)

    Do what you can, how you can, when you can

    Everyone knows the advice to exercise as a remedy for depression, and indeed, exercise helps many. Unfortunately, it’s not always that easy.

    Did you ever see the 80s kids’ movie “The Neverending Story”? There’s a scene in which the young hero Atreyu must traverse the “Swamp of Sadness”, and while he has a magical talisman that protects him, his beloved horse Artax is not so lucky; he slows down, and eventually stops still, sinking slowly into the swamp. Atreyu pulls at him and begs him to keep going, but—despite being many times bigger and stronger than Atreyu, the horse just sinks into the swamp, literally drowning in despair.

    See the scene: The Neverending Story movie clip – Artax and the Swamp of Sadness (1984)

    Wow, they really don’t make kids’ movies like they used to, do they?

    But, depression is very much like that, and advice “exercise to feel less depressed!” falls short of actually being helpful, when one is too depressed to do it.

    If you’re in the position of supporting someone who’s depressed, the best tool in your toolbox will be not “here’s why you should do this” (they don’t care; not because they’re an uncaring person by nature, but because they are physiologically impeded from caring about themself at this time), but rather:

    “please do this with me”

    The reason this has a better chance of working is because the depressed person will in all likelihood be unable to care enough to raise and/or maintain an objection, and while they can’t remember why they should care about themself, they’re more likely to remember that they should care about you, and so will go with your want/need more easily than with their own. It’s not a magic bullet, but it’s worth a shot.

    What if I’m the depressed person, though?

    Honestly, the same, if there’s someone around you that you do care about; do what you can to look after you, for them, if that means you can find some extra motivation.

    But I’m all alone… what now?

    Firstly, you don’t have to be alone. There are free services that you can access, for example:

    …which varyingly offer advice, free phone services, webchats, and the like.

    But also, there are ways you can look after yourself a little bit; do the things you’d advise someone else to do, even if you’re sure they won’t work:

    • Take a little walk around the block
    • Put the lights on when you’re not sleeping
    • For that matter, get out of bed when you’re not sleeping. Literally lie on the floor if necessary, but change your location.
    • Change your bedding, or at least your clothes
    • If changing the bedding is too much, change just the pillowcase
    • If changing your clothes is too much, change just one item of clothing
    • Drink some water; it won’t magically cure you, but you’ll be in slightly better order
    • On the topic of water, splash some on your face, if showering/bathing is too much right now
    • Do something creative (that’s not self-harm). You may scoff at the notion of “art therapy” helping, but this is a way to get at least some of the lights on in areas of your brain that are a little dark right now. Worst case scenario is it’ll be a distraction from your problems, so give it a try.
    • Find a connection to community—whatever that means to you—even if you don’t feel you can join it right now. Discover that there are people out there who would welcome you if you were able to go join them. Maybe one day you will!
    • Hiding from the world? That’s probably not healthy, but while you’re hiding, take the time to read those books (write those books, if you’re so inclined), learn that new language, take up chess, take up baking, whatever. If you can find something that means anything to you, go with that for now, ride that wave. Motivation’s hard to come by during depression and you might let many things slide; you might as well get something out of this period if you can.

    If you’re not depressed right now but you know you’re predisposed to such / can slip that way?

    Write yourself instructions now. Copy the above list if you like.

    Most of all: have a “things to do when I don’t feel like doing anything” list.

    If you only take one piece of advice from today’s newsletter, let that one be it!

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  • An Accessible New Development Against Alzheimer’s

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    Dopamine vs Alzheimer’s

    One of the key hallmarks of Alzheimer’s disease is the formation of hardened beta-amyloid plaques around neurons. The beta-amyloid peptides themselves are supposed to be in the brain, but the hardened pieces of them that form the plaques are not.

    While the full nature of the relationship between those plaques and Alzheimer’s disease is not known for sure (there are likely other factors involved, and “the amyloid hypothesis” is at this stage nominally just that, a hypothesis), one thing that has been observed is that increasing or reducing the plaques increases or reduces (respectively) Alzheimer’s symptoms such as memory loss.

    Neprilysin

    There is an enzyme, neprilysin, that can break down those plaques.

    Neprilysin is made naturally in the brain, and/but we cannot take it as a supplement or medication, because it’s too big to pass through the blood-brain barrier.

    A team of researchers led by Dr. Takaomi Saido genetically manipulated mice to produce more neprilysin, and those mice resultantly experienced fewer beta-amyloid plaques and better memory in their old age.

    However wonderful for the mice (and a great proof of principle) the above approach is not useful as a treatment for humans whose genomes weren’t modified at our conception in a lab.

    Since (as mentioned before) we also can’t take it as a medication/supplement, that leaves one remaining option: find a way to make our already-existing brains produce more of it.

    The team’s previous research allowed them to narrow this down to “there is probably a hormone made in the hypothalamus that modulates this”, so they began experimenting with making the mice produce more hormones there.

    The DREADD switch

    DREADDs, or Designer Receptors Exclusively Activated by Designer Drugs, were the next tool in the toolbox. The scientists attached these designer receptors to dopamine-producing neurons in the mice, so that they could be activated by the appropriate designer drugs—basically, allowing for a “make more dopamine” button, without having to literally wire up the brains with electrodes. The “button” gets triggered instead by a chemical trigger, the designer drug. You can read more about them here:

    DREADDs for Neuroscientists: A Primer

    The result was positive; when the mice made more dopamine, the result was that they also made more neprilysin. So far, the hypothesis is that the presence of dopamine upregulates the production of neprilysin. In other words, the increased neprilysin levels were caused by the increased dopamine levels (the alternatives would have been: they were both caused by the same thing—in this case that’d be the DREADD activation—or the increase was caused by something else entirely that hadn’t been controlled for).

    As to how the causal relationship was determined…

    “But I don’t have (or want) a DREADD switch in my head”

    Happily for us (and probably happily for the mice too, because dopamine causes feelings of happiness), the experiments continued.

    This time, instead of using the DREADD system, they tried simply supplementing the mouse food with l-dopa, a dopamine precursor. L-dopa is often used in the treatment of Parkinson’s disease, because the molecules are small enough to pass through the blood-brain barrier, and can be converted to full dopamine inside the brain itself. So, taking l-dopa normally raises dopamine levels.

    The results? The mice who were given l-dopa enjoyed:

    • higher dopamine levels
    • higher neprilysin levels
    • lower beta-amyloid plaque levels
    • better memory in tests

    The next step for the researchers is to investigate how exactly dopamine regulates neprilysin in the brain, but for now, the relationship between l-dopa consumption and the reduction of Alzheimer’s symptoms seems clear.

    You can read about the study here:

    The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

    Is there a catch?

    L-dopa has common side effects that are not pleasant; the list begins with nausea and vomiting, and continues with things that one might expect from having “too much of a good thing” when it comes to dopamine, such as dyskinesia (extra movements) and hallucinations.

    You can read about it more here at the Parkinson’s Foundation:

    Parkinson’s Foundation | Levodopa

    However! All is not lost. Rather than reaching for the heavy guns by taking l-dopa unnecessarily, there are other dopamine precursors that don’t have those side effects (and are consequently less restricted, to the point they can be purchased as supplements, or indeed, enjoyed where they occur naturally in some foods).

    Top of the list of such safe* and readily-available dopamine precursors is…

    N-Acetyl L-Tyrosine (NALT): The Dopamine Precursor & More

    If you’d like to try that, here’s an example product on Amazon… Or you could eat fish, white beans, tofu, natto, or pumpkin seeds 😉

    *Quick note on safety: “safe” is a relative term and may vary from person to person. Please speak with your own doctor to be sure, check with your pharmacist in case of any meds interactions, and be especially careful taking anything that increases dopamine levels if you have bipolar disorder or are otherwise prone to psychosis of any kind. For most people, this shouldn’t be an issue as our brains have a built-in mechanism for scrubbing excess dopamine and ensuring we don’t end up with too much, but for some people whose dopamine regulation is not so good in that regard, it can cause problems. So again, speak with your doctor to be sure, because we are not doctors, let alone your doctor.

    Lastly…

    If you’d like an entirely drug-free approach, that’s skipping even the “nutraceuticals”, you might enjoy:

    Short On Dopamine? Science Has The Answer

    Take care!

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Related Posts

  • Tech Bliss – by Clo S., MSc.
  • In the Realm of Hungry Ghosts – by Dr. Gabor Maté

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve reviewed books by Dr. Maté before, and this one’s about addiction. We’ve reviewed books about addiction before too, so what makes this one different?

    Wow, is this one so different. Most books about addiction are about “beating” it. Stop drinking, quit sugar, etc. And, that’s all well and good. It is definitely good to do those things. But this one’s about understanding it, deeply. Because, as Dr. Maté makes very clear, “there, but for the grace of epigenetics and environmental factors, go we”.

    Indeed, most of us will have addictions; they’re (happily) just not too problematic for most of us, being either substances that are not too harmful (e.g. coffee), or behavioral addictions that aren’t terribly impacting our lives (e.g. Dr. Maté’s compulsion to keep buying more classical music, which he then tries to hide from his wife).

    The book does also cover a lot of much more serious addictions, the kind that have ruined lives, and the kind that definitely didn’t need to, if people had been given the right kind of help—instead of, all too often, they got the opposite.

    Perhaps the greatest value of this book is that; understanding what creates addiction in the first place, what maintains it, and what help people actually need.

    Bottom line: if you’d like more insight into the human aspect of addiction without getting remotely wishy-washy, this book is probably the best one out there.

    Click here to check out In the Realm of Hungry Ghosts, and learn about this much-misunderstood health condition!

    Don’t Forget…

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    Learn to Age Gracefully

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  • Creamy Zucchini, Edamame, & Asparagus Linguine

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Protein, fiber, and polyphenols are the dish of the day here:

    You will need

    • 1½ cups milk (your choice what kind; we recommend soy for its neutral taste, though hazelnut’s nutty flavor would also work in this recipe)
    • 6 oz wholegrain linguine (or your pasta of choice)
    • 2 zucchini, thinly sliced
    • 5 oz edamame beans (frozen is fine)
    • 5 oz asparagus tips, cut into 2″ lengths
    • ½ bulb garlic, crushed
    • 1 tbsp chia seeds
    • 1 small handful arugula
    • 1 small handful parsley, chopped
    • A few mint leaves, chopped
    • Juice of ½ lemon
    • 2 tsp black pepper, coarse ground
    • ½ tsp MSG or 1 tsp low-sodium salt
    • Extra virgin olive oil

    Method

    (we suggest you read everything at least once before doing anything)

    1) Heat some oil in a sauté pan or similar, over a low to medium heat. Add the zucchini and cook for 5 minutes until they start to soften.

    2) Add the garlic and continue cooking for 1 minute, stirring gently.

    3) Add the milk, bring to the boil, and add the past, chia seeds (the resistant starch from the pasta will help thicken the sauce, as will the chia seeds), and MSG or salt.

    4) Reduce the heat, cover, and simmer for 8 minutes.

    5) Add the edamame beans and asparagus, and cook for a further 2 minutes, or until the pasta is cooked but still firm to the bite. The sauce should be quite thick now.

    6) Stir in the remaining ingredients and serve, adding a garnish if you wish.

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

    Don’t Forget…

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  • Brave – by Dr. Margie Warrell

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    Whether it’s the courage to jump out of a plane or the courage to have a difficult conversation, bravery is an important quality that we often don’t go far out of our way to grow. At least, not as adults.

    Rather than viewing bravery as a static attribute—you either have it or you don’t—psychologist Dr. Margie Warrell makes the case for its potential for lifelong development.

    The book is divided into five sections:

    1. Live purposefully
    2. Speak bravely
    3. Work passionately
    4. Dig deep
    5. Dare boldly

    …and each has approximately 10 chapters, each a few pages long, the kind that can easily make this a “chapter-a-day” daily reader.

    As a quick clarification: that “speak bravely” section isn’t about public speaking, but is rather about speaking up when it counts. Life is too short for regrets, and our interactions with others tend to be what matters most in the long-run. It makes a huge difference to our life!

    Dr. Warrell gives us tools to reframe our challenges and tackle them. Rather than just saying “Feel the fear and do it anyway”, she also delivers the how, in all aspects. This is one of the main values the book brings, as well as a sometimes-needed reminder of how and why being brave is something to which we should always aspire… and hold.

    Bottom line: if you’d like to be more brave—in any context—this book can help. We only get one life; might as well live it.

    Click here to check out Brave and give your life a boost!

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