Herbs for Evidence-Based Health & Healing 

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Herbs for Evidence-Based Health & Healing

Herbs have been used since prehistoric times to treat injuries and illnesses, but which ones actually work, as opposed to being “old wives’ tales”?

Even today, in pharmacies herbals products may come with a disclaimer “based on traditional use only”, which, in scientific terms, means it likely performs no better than placebo.

This is a “Saturday Life Hacks” edition, not a “Research Review Monday”, so we won’t be doing any deep-dives today, and will instead keep things short and snappy. We’ll also spotlight one main benefit, rather than trying to cover all bases, as we often have room to do on a Monday!

Basil

Helps boost immunity:

Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers

Chamomile

Significantly reduces symptoms of osteoarthritis:

Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomized controlled clinical trial

(This one challenged your writer’s resolve as it does so many things, it was hard to pick just one. So, she went with one that’s less known that “settling the stomach” and “relieving PMS” and “relaxation” and so forth)

Echinacea

Significantly reduces the risk of catching a cold (but won’t help once you’ve caught it):

Echinacea for preventing and treating the common cold

Elderberry

Significantly hastens recovery from upper respiratory viral infections:

Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials

Evening Primrose

Fights neuropathy, along with many other benefits:

An updated review on pharmacological activities and phytochemical constituents of evening primrose

Fennel

Antinflammatory, along with many other benefits:

Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology

Ginkgo biloba

Antioxidant effects provide anti-aging benefits:

Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases

Ginseng

Combats fatigue:

Ginseng as a Treatment for Fatigue: A Systematic Review

Lavender

Enjoyed for its sedative effects, which is really does have:

Evidence for Sedative Effects of the Essential Oil of Lavender after Inhalation

Sage

Helps fight HIV type 1 and Herpes simplex type 2 (and probably other viruses, but that’s what we have the science for right now):

Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity

Valerian

Inconclusive data; “traditional use only” for restful sleep.

Can’t have everything!

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  • The Green Roasting Tin – by Rukmini Iyer

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    You may be wondering: “do I really need a book to tell me to put some vegetables in a roasting tin and roast them?” and maybe not, but the book offers a lot more than that.

    Indeed, the author notes “this book was slightly in danger of becoming the gratin and tart book, because I love both”, but don’t worry, most of the recipes are—as you might expect—very healthy.

    As for formatting: the 75 recipes are divided first into vegan or vegetarian, and then into quick/medium/slow, in terms of how long they take.

    However, even the “slow” recipes don’t actually take more effort, just, more time in the oven.

    One of the greatest strengths of this book is that not only does it offer a wide selection of wholesome mains, but also, if you’re putting on a big spread, these can easily double up as high-class low-effort sides.

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    Click here to check out The Green Roasting Tin, and level-up yours!

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  • Which Comes First, Cardio or Weights? – by Alex Hutchinson

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    This is a book of questions and answers, myths and busts, and in short, all things exercise.

    It’s laid out as many micro-chapters with questions as headers. The explanations are clear and easy to understand, with several citations (of studies and other academic papers) per question.

    While it’s quite comprehensive (weighing in at a hefty 300+ pages), it’s not the kind of book where one could just look up any given piece of information that one wants.

    Its strength, rather, lies in pre-emptively arming the reader with knowledge, and correcting many commonly-believed myths. It can be read cover-to-cover, or just dipped into per what interests you (the table of contents lists all questions, so it’s easy to flip through).

    Bottom line: if you’ve found the world of exercise a little confusing and would like it demystifying, this book will result in a lot of “Oooooh” moments.

    Click here to check out Which Comes First, Cardio or Weights?, and know your stuff!

    PS: the short answer to the titular question is “mix it up and keep it varied”

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  • The Immunostimulant Superfood

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Eat These Greens!

    Chlorella vulgaris, henceforth “chlorella”, is a simple green algae that has a lot of health benefits.

    Note: most of the studies here are for Chlorella vulgaris specifically. However, some are for other species of the Chlorella genus, of which Chlorella vulgaris is by far the most common, hence the name (vulgaris = common). The relevant phytochemical properties appear to be the same regardless.

    Superfood

    While people generally take it as a supplement rather than a food item in any kind of bulk, it is more than 50% protein and contains all 9 essential amino acids.

    As you might expect of a green superfood, it’s also full of many antioxidants, most of them carotenoids, and these pack a punch, for example against cancer:

    Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells

    It also has a lot of vitamins and minerals, and even omega-3.

    Which latter also means it helps improve lipids and is thus particularly…

    Heart healthy

    ❝Daily consumption of Chlorella supplements provided the potential of health benefits reducing serum lipid risk factors, mainly triglycerides and total cholesterol❞

    ~ Dr. Na Hee Ryu et al.

    Read more: Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: a double-blinded, randomized, placebo-controlled study

    Its heart-healthy benefits don’t stop at lipids though, and include blood pressure management, as in this study that found…

    ❝GABA-rich Chlorella significantly decreased high-normal blood pressure and borderline hypertension, and is a beneficial dietary supplement for prevention of the development of hypertension. ❞

    ~ Dr. Morio Shimada et al.

    Read more: Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study

    About that GABA, if you’re curious about that, check out:

    GABA Against Stress, Anxiety, & More

    May remove heavy metals

    We’re going with “may” for this one as we could only find animal studies so far (probably because most humans don’t have megadoses of heavy metals in them, which makes testing harder).

    Here’s an example animal study, though:

    Enhanced elimination of tissue methyl mercury in [Chlorella]-fed mice

    Immunostimulant

    This one’s clearer, for example in this 8-week study (with humans) that found…

    ❝Serum concentrations of interferon-γ (p<0.05) and interleukin-1β (p<0.001) significantly increased and that of interleukin-12 (p<0.1) tended to increase in the Chlorella group.

    The increments of these cytokines after the intervention were significantly bigger in the Chlorella group than those in the placebo group. In addition, NK cell activities (%) were significantly increased in Chlorella group, but not in Placebo group.

    The increments of NK cell activities (%) were also significantly bigger in the Chlorella group than the placebo group.

    Additionally, changed levels of NK cell activity were positively correlated with those of serum interleukin-1β (r=0.280, p=0.047) and interferon-γ (r=0.271, p<0.005).❞

    ~ Dr. Jung Hyun Kwak et al.

    tl;dr = it boosts numerous different kinds of immune cells

    Read more: Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial)

    PS, if you click though to the study, you may be momentarily alarmed by the first paragraph of the abstract that says “However, there were no direct evidences for the effect of Chlorella supplementation on immune/inflammation response in healthy humans“

    this is from the “Background” section of the abstract, so what they are saying is “before we did this study, nobody had done this yet”.

    So, be assured that the results are worthwhile and compelling.

    Is it safe?

    Based on the studies, it has a good safety profile. However, as it boosts the immune system, you may want to check with your doctor if you have an autoimmune disorder, and/or you are on immunosuppressants.

    And in general, of course always check with your doctor/pharmacist if unsure about any potential drug interactions.

    Want some?

    We don’t sell it, but here for your convenience is an example product on Amazon

    Enjoy!

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    Since this reviewer got her copy, the subtitle and marketing of the book have changed, but the content has not. It’s now being marketed as “achieve more by thinking differently” like a pop-psychology business book. But it’s not that. What, then, is it?

    It’s 20 chapters of exercises for different kinds of thinking. And yes, the exercises will help those hungry 25–35-year-old MBAs too, but it’s more of a complete how-to-think overhaul.

    Its exercises cover psychology and philosophy, creativity and communication, logic and relaxation, cognition and motivation, and lots more.

    The style of the book is that of a workbook, and as such, it’s very clearly laid-out; one can go through them methodically, or get an overview and then dive in to whatever one wants/needs most at the moment.

    Bottom line: if you’d like a book that’s a one-stop shop for honing many different kinds of thinking, this is the book for you.

    Click here to check out The Mindgym, and get training yours!

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  • Superfood Energy Balls

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    They are healthy, they are tasty, they are convenient! Make some of these and when you need an energizing treat at silly o’clock when you don’t have time to prepare something, here they are, full of antioxidants, vitamins and minerals, good for blood sugars too, and ready to go:

    You will need

    • 1 cup pitted dates
    • 1 cup raw mixed nuts
    • ¼ cup goji berries
    • 1 tbsp cocoa powder
    • 1 tsp chili flakes

    Naturally, you can adjust the spice level if you like! But this is a good starter recipe.

    Method

    (we suggest you read everything at least once before doing anything)

    1) Blend all the ingredients in a good processor to make a dough

    2) Roll the dough into 1″ balls; you should have enough dough for about 16 balls. If you want them to be pretty, you can roll them in some spare dry ingredients (e.g. chopped nuts, goji berries, chili flakes, seeds of some kind, whatever you have in your kitchen that fits the bill).

    3) Refrigerate for at least 1–2 hours, and serve! They can also be kept in the fridge for at least a good while—couldn’t tell you how long for sure though, because honestly, they’ve never stayed that long in the fridge without being eaten.

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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  • Drug Metabolism (When You’re Not Average!)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    When Your Medications Run Out… Of You

    Everybody knows that alcohol can affect medications’ effects, but what of smoking, and what of obesity? And how does the alcohol thing work anyway?

    It’s all about the enzymes

    Medicines that are processed by the liver (which is: most medicines) are metabolized there by specialist enzymes, and the things we do can increase or decrease the quantity of those enzymes—and/or how active they are.

    Dr. Kata Wolff Pederson and her team of researchers at Aarhus University in Denmark examined the livers of recently deceased donors in ways that can’t (ethically) be done with live patients, and were able to find the associations between various lifestyle factors and different levels of enzymes responsible for drug metabolism.

    And it’s not always how you might think!

    Some key things they found:

    • Smokers have twice as high levels of enzyme CYP1A2 than non-smokers, which results in the faster metabolism of a lot of drugs.
    • Drinkers have 30% higher levels of enzyme CYP2E1, which also results in a faster metabolism of a lot of drugs.
    • Patients with obesity have 50% lower levels of enzyme CYP3A4, resulting in slower metabolism of many drugs

    This gets particularly relevant when we take into account the next fact:

    • Of the individuals in the study, 40% died from poisoning from a mixture of drugs (usually: prescription and otherwise)

    Read in full: Sex- and Lifestyle-Related Factors are Associated with Altered Hepatic CYP Protein Levels

    Read a pop-sci article about it: Your lifestyle can determine how well your medicine will work

    How much does the metabolism speed matter?

    It can matter a lot! If you’re taking drugs and carefully abiding by the dosage instructions, those instructions were assuming they know your speed of metabolism, and this is based on an average.

    • If your metabolism is faster, you can get too much of a drug too quickly, and it can harm you
    • If your metabolism is faster, it also means that while yes it’ll start working sooner, it’ll also stop working sooner
      • If it’s a painkiller, that’s inconvenient. If it’s a drug that keeps you alive, then well, that’s especially unfortunate.
    • If your metabolism is slower, it can mean your body is still processing the previous dose(s) when you take the next one, and you can overdose (and potentially die)

    We touched on this previously when we talked about obesity in health care settings, and how people can end up getting worse care:

    Let’s Shed Some Obesity Myths

    As for alcohol and drugs? Obviously we do not recommend, but here’s some of the science of it with many examples:

    Why it’s a bad idea to mix alcohol with some medications

    Take care!

    Don’t Forget…

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