How Exercise Rewires Your Brain for Better Mental Wellbeing

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Dr. Tracey Marks, psychiatrist, explains what happens immediately, and what happens over the long term:

For now and for later

First of all, a single workout can already alter brain chemistry and protect against stress. In the longer term, exercise promotes neurogenesis, primarily in the hippocampus, improving memory and reversing brain aging. It also strengthens the prefrontal cortex, which is critical for decision-making, focus, and emotional regulation.

In more general terms, exercise boosts brain-derived neurotrophic factor (BDNF) levels, which in turn boost neuron growth and connectivity.

Exercise also promotes angiogenesis (blood vessel construction), improving oxygen and nutrient delivery to the brain.

Timeline of benefits:

  • Immediate: increased blood flow and temporary BDNF spike.
  • Weeks: new neurons, connections, and blood vessel growth.
  • Months: visible brain volume changes and better brain connectivity.

Dr. Marks’ Timing Tips

  • Morning: boosts energy and helps regulate the circadian rhythm.
  • Midday: resets stress levels (specifically: to low)
  • Evening: helps process emotions (but it’s still recommended to avoid high-intensity exercise close to bedtime)

For more on all of this, enjoy:

Click Here If The Embedded Video Doesn’t Load Automatically!

Wondering what kind of exercise is best?

You might also like to read:

The Neuroscientist In The Gym: Dr. Wendy Suzuki Explains The Exercise That Protects Your Brain

Take care!

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  • “The Longevity Vitamin” (That’s Not A Vitamin)

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    The Magic of Mushrooms

    “The Longevity Vitamin that’s not a vitamin” is a great tagline for what’s actually an antioxidant amino acid nutraceutical, but in this case, we’re not the ones spearheading its PR, but rather, the Journal of Nutritional Science:

    Is ergothioneine a “longevity vitamin” limited in the American diet?

    It can be found in all foods, to some extent, but usually in much tinier amounts than would be useful. The reason for this is that it’s synthesized by a variety of microbes (mostly fungi and actinobacteria), and enters the food chain via vegetables that are grown in soil that contain such (which is basically all soil, unless you were to go out of your way to sterilize it, or something really unusually happened).

    About those fungi? That includes common popular edible fungi, where it is found quite generously. An 85g (3oz) portion of (most) mushrooms contains about 5mg of ergothioneine, the consumption of which is associated with a 16% reduced all-cause mortality:

    Association of mushroom consumption with all-cause and cause-specific mortality among American adults: prospective cohort study findings from NHANES III

    However… Most Americans don’t eat that many mushrooms, and those polled averaged 1.1mg/day ergothioneine (in contrast with, for example, Italians’ 4.6mg/day average).

    Antioxidant properties

    While its antioxidant properties aren’t the most exciting quality, they are worth a mention, on account of their potency:

    The biology of ergothioneine, an antioxidant nutraceutical

    This is also part of its potential bid to get classified as a vitamin, because…

    ❝Decreased blood and/or plasma levels of ergothioneine have been observed in some diseases, suggesting that a deficiency could be relevant to the disease onset or progression❞

    ~ Dr. Barry Halliwell et al.

    Source: Ergothioneine: a diet-derived antioxidant with therapeutic potential

    Healthy aging

    Building on from the above, ergothioneine has been specifically identified as being associated with healthy aging and the prevention of cardiometabolic diseases:

    ❝An increasing body of evidence suggests ergothioneine may be an important dietary nutrient for the prevention of a variety of inflammatory and cardiometabolic diseases and ergothioneine has alternately been suggested as a vitamin, “longevity vitamin”, and nutraceutical❞

    ~ Dr. Bernadette Moore et al., citing more references every few words there

    Source: Ergothioneine: an underrecognised dietary micronutrient required for healthy ageing?

    Good for the heart = good for the brain

    As a general rule of thumb, “what’s good for the heart is good for the brain” is almost always true, and it appears to be so in this case, too:

    ❝Ergothioneine crosses the blood–brain barrier and has been reported to have beneficial effects in the brain. In this study, we discuss the cytoprotective and neuroprotective properties of ergotheioneine, which may be harnessed for combating neurodegeneration and decline during aging.❞

    ~ Dr. Bindu Paul

    Source: Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?

    Want to get some?

    You can just eat a portion of mushrooms per day! But if you don’t fancy that, it is available as a supplement in convenient 1/day capsule form too.

    We don’t sell it, but for your convenience, here is an example product on Amazon

    Enjoy!

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  • Three Daily Servings of Beans?

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    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    ❝Not crazy about the Dr.s food advice. Beans 3X a day?❞

    For reference, this is in response to our recent article on the topic of 12 things to aim to get a certain amount of each day:

    Dr. Greger’s Daily Dozen

    So, there are a couple of things to look at here:

    Firstly, don’t worry, it’s a guideline and an aim. If you don’t hit it on a given day, there is always tomorrow. It’s just good to know what one is aiming for, because without knowing that, achieving it will be a lot less likely!

    Secondly, the beans/legumes/pulses category says three servings, but the example serving sizes are quite small, e.g. ½ cup cooked beans, or ¼ cup hummus. And also as you notice, dips/pastes/sauces made from beans count too. So given the portion sizes, you could easily get two servings in by breakfast (and two servings of whole grains, too) if you enjoy frijoles refritos, for example. Many of the recipes we share on this site have “stealth” beans/legumes/pulses in this fashion

    Take care!

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  • Chai-Spiced Rice Pudding

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    Sweet enough for dessert, and healthy enough for breakfast! Yes, “chai tea” is “tea tea”, just as “naan bread” is “bread bread”. But today, we’re going to be using the “tea tea” spices to make this already delicious and healthy dish more delicious and more healthy:

    You will need

    • 1 cup wholegrain rice (a medium-length grain is best for the optimal amount of starch to make this creamy but not sticky)
    • 1½ cups milk (we recommend almond milk, but any milk will work)
    • 1 cup full fat coconut milk
    • 1 cup water
    • 4 Medjool dates, soaked in hot water for 5 minutes, drained, and chopped
    • 2 tbsp almond butter
    • 1 tbsp maple syrup (omit if you prefer less sweetness)
    • 1 tbsp chia seeds
    • 2 tsp ground sweet cinnamon
    • 1 tsp ground ginger
    • 1 tsp vanilla extract
    • ½ tsp ground cardamom
    • ½ tsp ground nutmeg
    • ½ ground cloves
    • Optional garnish: berries (your preference what kind)

    Method

    (we suggest you read everything at least once before doing anything)

    1) Add all of the ingredients except the berries into the cooking vessel* you’re going to use, and stir thoroughly.

    *There are several options here and they will take different durations:

    • Pressure cooker: 10 minutes at high pressure (we recommend, if available)
    • Rice cooker: 25 minutes or thereabouts (we recommend only if the above or below aren’t viable options for you)
    • Slow cooker: 3 hours or thereabouts, but you can leave it for 4 if you’re busy (we recommend if you want to “set it and forget it” and have the time; it’s very hard to mess this one up unless you go to extremes)

    Options that we don’t recommend:

    • Saucepan: highly variable and you’re going to have to watch and stir it (we don’t recommend this unless the other options aren’t available)
    • Oven: highly variable and you’re going to have to check it frequently (we don’t recommend this unless the other options aren’t available)

    2) Cook, using the method you selected from the list.

    3) Get ready to serve. Depending on the method, they may be some extra liquid at the top; this can just be stirred into the rest and it will take on the same consistency.

    4) Serve in bowls, with a berry garnish if desired:

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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  • Melatonin: A Safe, Natural Sleep Aid?

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    Melatonin: A safe sleep supplement?

    Melatonin is a hormone normally made in our pineal gland. It helps regulate our circadian rhythm, by making us sleepy.

    It has other roles too—it has a part to play in regulating immune function, something that also waxes and wanes as a typical day goes by.

    Additionally, since melatonin and cortisol are antagonistic to each other, a sudden increase in either will decrease the other. Our brain takes advantage of this, by giving us a cortisol spike in the morning to help us wake up.

    As a supplement, it’s generally enjoyed with the intention of inducing healthy, natural, restorative sleep.

    Does it really induce healthy, natural, restorative, sleep?

    Yes! Well, “natural” is a little subject and relative, if you’re taking it as a supplement, but it’s something your body produces naturally anyway.

    Contrast with, for example, benzodiazepines (that whole family of medications with names ending in -azopan or -alozam), or other tranquilizing drugs that do not so much induce healthy sleep, but rather reduce your brain function and hopefully knock you out, and/but often have unwanted side effects, and a tendency to create dependency.

    Melatonin, unlike most of those drugs, does not create dependency, and furthermore, we don’t develop tolerance to it. In other words, the same dose will continue working (we won’t need more and more).

    In terms of benefits, melatonin not only reduces the time to fall asleep and increases total sleep time, but also (quite a bonus) improves sleep quality, too:

    Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders

    Because it is a natural hormone rather than a drug with many side effects and interactions, it’s also beneficial for those who need good sleep and/but don’t want tranquilizing:

    The Efficacy of Oral Melatonin in Improving Sleep in Cancer Patients with Insomnia: A Randomized Double-Blind Placebo-Controlled Study

    Any other benefits?

    Yes! It can also help guard against Seasonal Affective Disorder, also called seasonal depression. Because SAD is not just about “not enough light = not enough serotonin”, but also partly about circadian rhythm and (the body is not so sure what time of day it is when there are long hours of darkness, or even, in the other hemisphere / other time of year, long hours of daylight), melatonin can help, by giving your brain something to “anchor” onto, provided you take it at the same time each day. See:

    As a small bonus, melatonin also promotes HGH production (important for maintaining bone and muscle mass, especially in later life):

    Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone

    Anything we should worry about?

    Assuming taking a recommended dose only (0.5mg–10mg per day), toxicity is highly unlikely, especially given that it has a half-life of only 40–60 minutes, so it’ll be eliminated quite quickly.

    However! It does indeed induce sleepiness, so for example, don’t take melatonin and then try to drive or operate heavy machinery—or, ideally, do anything other than go to bed.

    It can interfere with some medications. We mentioned that melatonin helps regulate immune function, so for example that’s something to bear in mind if you’re on immunosuppressants or otherwise have an autoimmune disorder. It can also interfere with blood pressure medications and blood thinners, and may make epilepsy meds less effective.

    As ever, if in doubt, please speak with your doctor and/or pharmacist.

    Where to get it?

    As ever, we don’t sell it (or anything else), but for your convenience, here is an example product on Amazon.

    Enjoy!

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  • We looked at 700 plant-based foods to see how healthy they really are. Here’s what we found

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    If you’re thinking about buying plant-based foods, a trip to the supermarket can leave you bewildered.

    There are plant-based burgers, sausages and mince. The fridges are loaded with non-dairy milk, cheese and yoghurt. Then there are the tins of beans and packets of tofu.

    But how much is actually healthy?

    Our nutritional audit of more than 700 plant-based foods for sale in Australian supermarkets has just been published. We found some products are so high in salt or saturated fat, we’d struggle to call them “healthy”.

    We took (several) trips to the supermarket

    In 2022, we visited two of each of four major supermarket retailers across Melbourne to collect information on the available range of plant-based alternatives to meat and dairy products.

    We took pictures of the products and their nutrition labels.

    We then analysed the nutrition information on the packaging of more than 700 of these products. This included 236 meat substitutes, 169 legumes and pulses, 50 baked beans, 157 dairy milk substitutes, 52 cheese substitutes and 40 non-dairy yoghurts.

    Plant-based meats were surprisingly salty

    We found a wide range of plant-based meats for sale. So, it’s not surprising we found large variations in their nutrition content.

    Sodium, found in added salt and which contributes to high blood pressure, was our greatest concern.

    The sodium content varied from 1 milligram per 100 grams in products such as tofu, to 2,000mg per 100g in items such as plant-based mince products.

    This means we could eat our entire daily recommended sodium intake in just one bowl of plant-based mince.

    An audit of 66 plant-based meat products in Australian supermarkets conducted in 2014 found sodium ranged from 316mg in legume-based products to 640mg in tofu products, per 100g. In a 2019 audit of 137 products, the range was up to 1,200mg per 100g.

    In other words, the results of our audit seems to show a consistent trend of plant-based meats getting saltier.

    Plant-based meat on supermarket shelves
    Looking for plant-based meat? Check the label for the sodium content.
    Michael Vi/Shutterstock

    What about plant-based milks?

    Some 70% of the plant-based milks we audited were fortified with calcium, a nutrient important for bone health.

    This is good news as a 2019-2020 audit of 115 plant-based milks from Melbourne and Sydney found only 43% of plant-based milks were fortified with calcium.

    Of the fortified milks in our audit, almost three-quarters (73%) contained the recommended amount of calcium – at least 100mg per 100mL.

    We also looked at the saturated fat content of plant-based milks.

    Coconut-based milks had on average up to six times higher saturated fat content than almond, oat or soy milks.

    Previous audits also found coconut-based milks were much higher in saturated fat than all other categories of milks.

    Supermarket shelves of plant-based milks
    Some plant-based milks were healthier than others.
    TY Lim/Shutterstock

    A first look at cheese and yoghurt alternatives

    Our audit is the first study to identify the range of cheese and yoghurt alternatives available in Australian supermarkets.

    Calcium was only labelled on a third of plant-based yoghurts, and only 20% of supermarket options met the recommended 100mg of calcium per 100g.

    For plant-based cheeses, most (92%) were not fortified with calcium. Their sodium content varied from 390mg to 1,400mg per 100g, and saturated fat ranged from 0g to 28g per 100g.

    So, what should we consider when shopping?

    As a general principle, try to choose whole plant foods, such as unprocessed legumes, beans or tofu. These foods are packed with vitamins and minerals. They’re also high in dietary fibre, which is good for your gut health and keeps you fuller for longer.

    If opting for a processed plant-based food, here are five tips for choosing a healthier option.

    1. Watch the sodium

    Plant-based meat alternatives can be high in sodium, so look for products that have around 150-250mg sodium per 100g.

    2. Pick canned beans and legumes

    Canned chickpeas, lentils and beans can be healthy and low-cost additions to many meals. Where you can, choose canned varieties with no added salt, especially when buying baked beans.

    3. Add herbs and spices to your tofu

    Tofu can be a great alternative to meat. Check the label and pick the option with the highest calcium content. We found flavoured tofu was higher in salt and sugar content than minimally processed tofu. So it’s best to pick an unflavoured option and add your own flavours with spices and herbs.

    4. Check the calcium

    When choosing a non-dairy alternative to milk, such as those made from soy, oat, or rice, check it is fortified with calcium. A good alternative to traditional dairy will have at least 100mg of calcium per 100g.

    5. Watch for saturated fat

    If looking for a lower saturated fat option, almond, soy, rice and oat varieties of milk and yoghurt alternatives have much lower saturated fat content than coconut options. Pick those with less than 3g per 100g.The Conversation

    Laura Marchese, PhD Student at the Institute for Physical Activity and Nutrition, Deakin University and Katherine Livingstone, NHMRC Emerging Leadership Fellow and Senior Research Fellow at the Institute for Physical Activity and Nutrition, Deakin University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • When Age Is A Flexible Number

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    Aging, Counterclockwise!

    In the late 1970s, Dr. Ellen Langer hypothesized that physical markers of aging could be affected by psychosomatic means.

    Note: psychosomatic does not mean “it’s all in your head”.

    Psychosomatic means “your body does what your brain tells it to do, for better or for worse”

    She set about testing that, in what has been referred to since as…

    The Counterclockwise Study

    A small (n=16) sample of men in their late 70s and early 80s were recruited in what they were told was a study about reminiscing.

    Back in the 1970s, it was still standard practice in the field of psychology to outright lie to participants (who in those days were called “subjects”), so this slight obfuscation was a much smaller ethical aberration than in some famous studies of the same era and earlier (cough cough Zimbardo cough Milgram cough).

    Anyway, the participants were treated to a week in a 1950s-themed retreat, specifically 1959, a date twenty years prior to the experiment’s date in 1979. The environment was decorated and furnished authentically to the date, down to the food and the available magazines and TV/radio shows; period-typical clothing was also provided, and so forth.

    • The control group were told to spend the time reminiscing about 1959
    • The experimental group were told to pretend (and maintain the pretense, for the duration) that it really was 1959

    The results? On many measures of aging, the experimental group participants became quantifiably younger:

    ❝The experimental group showed greater improvement in joint flexibility, finger length (their arthritis diminished and they were able to straighten their fingers more), and manual dexterity.

    On intelligence tests, 63 percent of the experimental group improved their scores, compared with only 44 percent of the control group. There were also improvements in height, weight, gait, and posture.

    Finally, we asked people unaware of the study’s purpose to compare photos taken of the participants at the end of the week with those submitted at the beginning of the study. These objective observers judged that all of the experimental participants looked noticeably younger at the end of the study.❞

    ~ Dr. Ellen Langer

    Remember, this was after one week.

    Her famous study was completed in 1979, and/but not published until eleven years later in 1990, with the innocuous title:

    Higher stages of human development: Perspectives on adult growth

    You can read about it much more accessibly, and in much more detail, in her book:

    Counterclockwise: A Proven Way to Think Yourself Younger and Healthier – by Dr. Ellen Langer

    We haven’t reviewed that particular book yet, so here’s Linda Graham’s review, that noted:

    ❝Langer cites other research that has made similar findings.

    In one study, for instance, 650 people were surveyed about their attitudes on aging. Twenty years later, those with a positive attitude with regard to aging had lived seven years longer on average than those with a negative attitude to aging.

    (By comparison, researchers estimate that we extend our lives by four years if we lower our blood pressure and reduce our cholesterol.)

    In another study, participants read a list of negative words about aging; within 15 minutes, they were walking more slowly than they had before.❞

    ~ Linda Graham

    Read the review in full:

    Aging in Reverse: A Review of Counterclockwise

    The Counterclockwise study has been repeated since, and/but we are still waiting for the latest (exciting, much larger sample, 90 participants this time) study to be published. The research proposal describes the method in great detail, and you can read that with one click over on PubMed:

    PubMed | Ageing as a mindset: a study protocol to rejuvenate older adults with a counterclockwise psychological intervention

    It was approved, and has now been completed (as of 2020), but the results have not been published yet; you can see the timeline of how that’s progressing over on ClinicalTrials.gov:

    Clinical Trials | Ageing as a Mindset: A Counterclockwise Experiment to Rejuvenate Older Adults

    Hopefully it’ll take less time than the eleven years it took for the original study, but in the meantime, there seems to be nothing to lose in doing a little “Citizen Science” for ourselves.

    Maybe a week in a 20 years-ago themed resort (writer’s note: wow, that would only be 2004; that doesn’t feel right; it should surely be at least the 90s!) isn’t a viable option for you, but we’re willing to bet it’s possible to “microdose” on this method. Given that the original study lasted only a week, even just a themed date-night on a regular recurring basis seems like a great option to explore (if you’re not partnered then well, indulge yourself how best you see fit, in accord with the same premise; a date-night can be with yourself too!).

    Just remember the most important take-away though:

    Don’t accidentally put yourself in your own control group!

    In other words, it’s critically important that for the duration of the exercise, you act and even think as though it is the appropriate date.

    If you instead spend your time thinking “wow, I miss the [decade that does it for you]”, you will dodge the benefits, and potentially even make yourself feel (and thus, potentially, if the inverse hypothesis holds true, become) older.

    This latter is not just our hypothesis by the way, there is an established potential for nocebo effect.

    For example, the following study looked at how instructions given in clinical tests can be worded in a way that make people feel differently about their age, and impact the results of the mental and/or physical tests then administered:

    ❝Our results seem to suggest how manipulations by instructions appeared to be more largely used and capable of producing more clear performance variations on cognitive, memory, and physical tasks.

    Age-related stereotypes showed potentially stronger effects when they are negative, implicit, and temporally closer to the test of performance. ❞

    ~ Dr. Francesco Pagnini

    Read more: Age-based stereotype threat: a scoping review of stereotype priming techniques and their effects on the aging process

    (and yes, that’s the same Dr. Francesco Pagnini whose name you saw atop the other study we cited above, with the 90 participants recreating the Counterclockwise study)

    Want to know more about [the hard science of] psychosomatic health?

    Check out Dr. Langer’s other book, which we reviewed recently:

    The Mindful Body: Thinking Our Way to Chronic Health – by Dr. Ellen Langer

    Enjoy!

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