How Exercise Rewires Your Brain for Better Mental Wellbeing

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Dr. Tracey Marks, psychiatrist, explains what happens immediately, and what happens over the long term:

For now and for later

First of all, a single workout can already alter brain chemistry and protect against stress. In the longer term, exercise promotes neurogenesis, primarily in the hippocampus, improving memory and reversing brain aging. It also strengthens the prefrontal cortex, which is critical for decision-making, focus, and emotional regulation.

In more general terms, exercise boosts brain-derived neurotrophic factor (BDNF) levels, which in turn boost neuron growth and connectivity.

Exercise also promotes angiogenesis (blood vessel construction), improving oxygen and nutrient delivery to the brain.

Timeline of benefits:

  • Immediate: increased blood flow and temporary BDNF spike.
  • Weeks: new neurons, connections, and blood vessel growth.
  • Months: visible brain volume changes and better brain connectivity.

Dr. Marks’ Timing Tips

  • Morning: boosts energy and helps regulate the circadian rhythm.
  • Midday: resets stress levels (specifically: to low)
  • Evening: helps process emotions (but it’s still recommended to avoid high-intensity exercise close to bedtime)

For more on all of this, enjoy:

Click Here If The Embedded Video Doesn’t Load Automatically!

Wondering what kind of exercise is best?

You might also like to read:

The Neuroscientist In The Gym: Dr. Wendy Suzuki Explains The Exercise That Protects Your Brain

Take care!

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  • Three Critical Kitchen Prescriptions

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    Three Critical Kitchen Prescriptions

    This is Dr. Saliha Mahmood-Ahmed. She’s a medical doctor—specifically, a gastroenterologist. She’s also a chef, and winner of the BBC’s MasterChef competition. So, from her gastroenterology day-job and her culinary calling, she has some expert insights to share on eating well!

    ❝Food and medicine are inextricably linked to one another, and it is an honour to be a doctor who specialises in digestive health and can both cook, and teach others to cook❞

    ~ Dr. Saliha Mahmood-Ahmed, after winning MasterChef and being asked if she’d quit medicine to be a full-time chef

    Dr. Mahmood-Ahmed’s 3 “Kitchen Prescriptions”

    They are:

    1. Cook, cook, cook
    2. Feed your gut bugs
    3. Do not diet

    Let’s take a look at each of those…

    Cook, cook, cook

    We’re the only species on Earth that cooks food. An easy knee-jerk response might be to think maybe we shouldn’t, then, but… We’ve been doing it for at least 30,000 years, which is about 1,500 generations, while a mere 100 generations is generally sufficient for small evolutionary changes. So, we’ve evolved this way now.

    More importantly in this context: we, ourselves, should cook our own food, at least per household.

    Not ready meals; we haven’t evolved for those (yet! Give it another few hundred generations maybe)

    Feed your gut bugs

    The friendly ones. Enjoy prebiotics, probiotics, and plenty of fiber—and then be mindful of what else you do or don’t eat. Feeding the friendly bacteria while starving the unfriendly ones may seem like a tricky task, but it actually can be quite easily understood and implemented. We did a main feature about this a few weeks ago:

    Making Friends With Your Gut (You Can Thank Us Later)

    Do not diet

    Dr. Mahmood-Ahmed is a strong critic of calorie-counting as a weight-loss strategy:

    Rather than focusing on the number of calories consumed, try focusing on introducing enough variety of food into your daily diet, and on fostering good microbial diversity within your gut.

    It’s a conceptual shift from restrictive weight loss, to prescriptive adding of things to one’s diet, with fostering diversity of microbiota as a top priority.

    This, too, she recommends be undertaken gently, though—making small, piecemeal, but sustainable improvements. Nobody can reasonably incorporate, say, 30 new fruits and vegetables into one’s diet in a week; it’s unrealistic, and more importantly, it’s unsustainable.

    Instead, consider just adding one new fruit or vegetable per shopping trip!

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  • Yes, you still need to use sunscreen, despite what you’ve heard on TikTok

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    Summer is nearly here. But rather than getting out the sunscreen, some TikTokers are urging followers to chuck it out and go sunscreen-free.

    They claim it’s healthier to forgo sunscreen to get the full benefits of sunshine.

    Here’s the science really says.

    Karolina Grabowska/Pexels

    How does sunscreen work?

    Because of Australia’s extreme UV environment, most people with pale to olive skin or other risk factors for skin cancer need to protect themselves. Applying sunscreen is a key method of protecting areas not easily covered by clothes.

    Sunscreen works by absorbing or scattering UV rays before they can enter your skin and damage DNA or supportive structures such as collagen.

    When UV particles hit DNA, the excess energy can damage our DNA. This damage can be repaired, but if the cell divides before the mistake is fixed, it causes a mutation that can lead to skin cancers.

    The energy from a particle of UV (a photon) causes DNA strands to break apart and reconnect incorrectly. This causes a bump in the DNA strand that makes it difficult to copy accurately and can introduce mutations. NASA/David Herring

    The most common skin cancers are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Melanoma is less common, but is the most likely to spread around the body; this process is called metastasis.

    Two in three Australians will have at least one skin cancer in their lifetime, and they make up 80% of all cancers in Australia.

    Around 99% of skin cancers in Australia are caused by excessive exposure to UV radiation.

    Excessive exposure to UV radiation also affects the appearance of your skin. UVA rays are able to penetrate deep into the skin, where they break down supportive structures such as elastin and collagen.

    This causes signs of premature ageing, such as deep wrinkling, brown or white blotches, and broken capillaries.

    Sunscreen can help prevent skin cancers

    Used consistently, sunscreen reduces your risk of skin cancer and slows skin ageing.

    In a Queensland study, participants either used sunscreen daily for almost five years, or continued their usual use.

    At the end of five years, the daily-use group had reduced their risk of squamous cell carcinoma by 40% compared to the other group.

    Ten years later, the daily use group had reduced their risk of invasive melanoma by 73%

    Does sunscreen block the health-promoting properties of sunlight?

    The answer is a bit more complicated, and involves personalised risk versus benefit trade-offs.

    First, the good news: there are many health benefits of spending time in the sun that don’t rely on exposure to UV radiation and aren’t affected by sunscreen use.

    Woman applies sunscreen
    Sunscreen only filters UV rays, not all light. Ron Lach/Pexels

    Sunscreen only filters UV rays, not visible light or infrared light (which we feel as heat). And importantly, some of the benefits of sunlight are obtained via the eyes.

    Visible light improves mood and regulates circadian rhythm (which influences your sleep-wake cycle), and probably reduces myopia (short-sightedness) in children.

    Infrared light is being investigated as a treatment for several skin, neurological, psychiatric and autoimmune disorders.

    So what is the benefit of exposing skin to UV radiation?

    Exposing the skin to the sun produces vitamin D, which is critical for healthy bones and muscles.

    Vitamin D deficiency is surprisingly common among Australians, peaking in Victoria at 49% in winter and being lowest in Queensland at 6% in summer.

    Luckily, people who are careful about sun protection can avoid vitamin D deficiency by taking a supplement.

    Exposing the skin to UV radiation might have benefits independent of vitamin D production, but these are not proven. It might reduce the risk of autoimmune diseases such as multiple sclerosis or cause release of a chemical that could reduce blood pressure. However, there is not enough detail about these benefits to know whether sunscreen would be a problem.

    What does this mean for you?

    There are some benefits of exposing the skin to UV radiation that might be blunted by sunscreen. Whether it’s worth foregoing those benefits to avoid skin cancer depends on how susceptible you are to skin cancer.

    If you have pale skin or other factors that increase you risk of skin cancer, you should aim to apply sunscreen daily on all days when the UV index is forecast to reach 3.

    If you have darker skin that rarely or never burns, you can go without daily sunscreen – although you will still need protection during extended times outdoors.

    For now, the balance of evidence suggests it’s better for people who are susceptible to skin cancer to continue with sun protection practices, with vitamin D supplementation if needed.

    Katie Lee, PhD Candidate, Dermatology Research Centre, The University of Queensland and Rachel Neale, Principal research fellow, QIMR Berghofer Medical Research Institute

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • The Link Between Introversion & Sensory Processing

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    We’ve talked before about how to beat loneliness and isolation, and how that’s important for all of us, including those of us on the less social end of the scale.

    However, while we all need at least the option of social contact in order to be at our best, there’s a large portion of the population who also need to be able to retreat to somewhere quiet to recover from too much social goings-on.

    Clinically speaking, this sometimes gets called introversion, or at least a negative score for extroversion on the “Big Five Inventory”, the only personality-typing system that actually gets used in science. Today we’re going to be focusing on a term that typically gets applied to those generally considered introverts:

    The “highly sensitive person”

    This makes it sound like a very rare snowflake condition, when in fact the diagnostic criteria yield a population bell curve of 30:40:30, whereupon 30% are in the band of “high sensitivity”, 40% “normal sensitivity” and the remaining 30% “low sensitivity”.

    You may note that “high” and “low” together outnumber “normal”, but statistics is like that. It is interesting to note, though, that this statistical spread renders it not a disorder, so much as simply a description.

    You can read more about it here:

    Sensory-processing sensitivity and its relation to introversion and emotionality

    What it means in practical terms

    Such a person will generally seek solitude more frequently during the day than others will, and it’s not because of misanthropy (at least, statistically speaking it’s not; can’t speak for individuals!), but rather, it’s about needing downtime after what has felt like too much sensory processing resulting:

    The Effects of Multifaceted Introversion and Sensory Processing Sensitivity on Solitude-Seeking Behavior

    If this need for solitude is not met (sometimes it’s simply not practicable), then it can lead to overwhelm.

    Sidenote about overwhelm: pick your battles! No, pick fewer than that. Put some back. That’s still too many 😜

    Back to seriousness: if you’re the sort of person to walk into a room and immediately do the Sherlock Holmes thing of noticing everything about everyone, who is doing what, what has changed about the room since last time you were there, etc… Then that’s great; it’s a sign of a sharp mind, but it’s also a lot of information to process and you’re probably going to need a little decompression afterwards:

    Experiences of Adults High in the Personality Trait Sensory Processing Sensitivity: A Qualitative Study

    This is the biological equivalent of needing to let an overworked computer or phone cool down after excessive high-intensity use of its CPU.

    The same goes if you’re the sort of person who goes into “performance mode” when in company, is “the life and soul of the party” etc, and/or perhaps “the elegant hostess”, but needs to then collapse afterwards because it’s more of a role you play than your natural inclination.

    Take care of your battery

    To continue the technological metaphor from earlier, if you repeatedly overuse a device without allowing it cooldown periods, it will break down (and if it’s a certain generation of iPhone, it might explode).

    Similarly, if you repeatedly overuse your own highly sensitive senses (such as being often in social environment where there’s a lot going on) without allowing yourself adequate cooldown periods, you will break down (or indeed, explode: not literally, but some people are prone to emotional outbursts after bottling things up).

    None of this is good for the health, not in the short term and not in the long term, either:

    Sensory processing sensitivity as a predictor of health-related quality of life outcomes via stress and sleep quality

    With that in mind, take care to take care of yourself, meeting your actual needs instead of just those that get socially assumed.

    Want to take the test?

    Here’s a two-minute test (results available immediately right there on-screen; no need to give your email or anything) 😎

    Want to know more?

    We reviewed this book about playing to one’s strengths in the context of sensitivity, a while back, and highly recommend it:

    Sensitive – by Jenn Granneman and Andre Sólo

    Enjoy!

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  • Osteoarthritis Of The Knee

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    ❝Very informative thank you. And made me think. I am a 72 yr old whitewoman, have never used ( or even been offered) HRT since menopause ~15 yrs ago. Now I’m wondering if it would have delayed the onset of osteoarthritis ( knee) and give me more energy in general. And is it wise to start taking hrt after being without those hormones for so long?❞

    (this was in response to our article about menopausal HRT)

    Thanks for writing! To answer your first question, obviously we can never know for sure now, but it certainly is possible, per for example a large-ish (n=1003) study of women aged 45–64, in which:

    • Those with HRT were significantly less likely to have knee arthritis than those without
    • However, to enjoy this benefit depended on continued use (those who used it for a bit and then stopped did not enjoy the same results)
    • While it made a big difference to knee arthritis, it made only a small (but still beneficial) difference to wrist/hand arthritis.

    We could hypothesize that this is because the mechanism of action is more about strengthening the bones (proofing against osteoporosis is one of the main reasons many people take HRT) and cartilage than it is against inflammation directly.

    Since the knee is load-bearing and the hand/wrist joints usually are not, this would mean the HRT strengthening the bones makes a big difference to the “wear and tear” aspect of potential osteoarthritis of the knee, but not the same level of benefit for the hand/wrist, which is less about wear and tear and more about inflammatory factors. But that latter, about it being load-bearing, is just this writer’s hypothesis as to why the big difference.

    The researchers do mention:

    ❝In OA the mechanisms by which HRT might act are highly speculative, but could entail changes in cartilage repair or bone turnover, perhaps with cytokines such as interleukin 6, for example.❞

    ~ Dr. Spector et al.

    What is clear though, is that it does indeed appear to have a protective effect against osteoarthritis of the knee.

    With regard to the timing, the researchers do note:

    ❝Why as little as three years of HRT should have a demonstrable effect is unclear. Given the difficulty in ascertaining when the disease starts, it is hard to be sure of the importance of the timing of HRT, and whether early or subclinical disease was present.

    These results taken together suggest that HRT has a metabolic action that is only effective if given continuously, perhaps by preventing disease initiation; once HRT is stopped there might be a ‘rebound’ effect, explaining the rapid return to normal risk❞

    ~ Ibid.

    You can read the study here:

    Is hormone replacement therapy protective for hand and knee osteoarthritis in women?: The Chingford Study

    On whether it is worth it now…

    Again, do speak with an endocrinologist because your situation may vary, but:

    • hormones are simply messengers, and your body categorically will respond to those messages regardless of age, or time elapsed without having received such a message. Whether it will repair all damage done is another matter entirely, but it would take a biological miracle for it to have no effect at all.
    • anecdotally, many women do enjoy life-changing benefits upon starting HRT at your age and older!

    (We don’t like to rely on “anecdotally”, but we couldn’t find studies isolating according to “length of time since menopause”—we’ll keep an eye out and if we find something in the future, we’ll mention it!)

    Meanwhile, take care!

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  • How To En-Joy Life (With Long-Term Benefits)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    New Year’s Dissolutions?

    We have talked previously about:

    The Science Of New Year’s Pre-Resolutions

    …and here we are now at the end of the first week of January; how’s it going?

    Hopefully, based on that article, it’s been going just great since December! For most people, statistically speaking, it hasn’t.

    Around now is typically when many people enter the “bargaining” stage of New Year’s Resolutions, which at this point are often in serious danger of becoming New Year’s Dissolutions.

    What’s important, really?

    When trying to juggle potentially too many new items, it’s important to be able to decide where to focus one’s efforts in the case of needing to drop a ball or two.

    First, the laziest way…

    The path of least resistance

    This is perhaps most people’s go-to. It, without too much thought, drops whatever feels most onerous, and continues with what seems easiest.

    This is not a terrible approach, because what we enjoy, we will be more likely to continue. But it can be improved upon, while still getting that benefit.

    Marie Kondo your resolutions values

    Instead of throwing out the new habits that “don’t spark joy”, ask yourself:

    “What brings me joy?”

    …because often, the answer is something that’s a result of a thing that didn’t “spark joy” directly. Many things in life involve delayed gratification.

    Let’s separate the [unwanted action] from the [wanted result] for a moment.

    Rather than struggling on with something unpleasant for the hope of joy at the end of the rainbow, though, give yourself permission to improve the middle bit.

    For example, if the idea of having lots of energy and good cardiovascular fitness is what prompted you to commit to those 6am runs each morning (but they’re not actually joyous in your experience), what would be more fun and still give you the same benefit?

    Now that you know “having lots of energy and good CV fitness” is what sparks joy, not “getting up to run at 6am”, you can change lanes without pulling off the highway entirely.

    Maybe a dance class will be more your speed, for example.

    The key here is: you’ll have changed your resolution, without breaking it in any way that mattered

    Want more ways to keep on track without burning out?

    Who doesn’t? So, check out:

    How To Keep On Keeping On… Long Term!

    Enjoy!

    Don’t Forget…

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    Learn to Age Gracefully

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  • Make Your Coffee Heart-Healthier!

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    Health-Hack Your Coffee

    We have previously written about the general health considerations (benefits and potential problems) of coffee:

    The Bitter Truth About Coffee (or is it?)

    Today, we will broadly assume that you are drinking coffee (in general, not necessarily right now, though if you are, same!) and would like to continue to do so. We also assume you’d like to do so as healthily as possible.

    Not all coffees are created equal

    If you order a coffee in France or Italy without specifying what kind, the coffee you receive will be short, dark, and handsome and without sugar. Healthwise, this is not a bad starting point. However…

    • It will usually be espresso
    • Or it may be what in N. America is called a French press (in Europe it’s just called a cafetière)

    Both of these kinds of coffee mean that cafestol, a compound found in the oily part of coffee and which is known to raise LDL (“bad” cholesterol”), stays in the drink.

    Read: Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties

    Also: Cafestol extraction yield from different coffee brew mechanisms

    If you’re reading that second one and wondering what a mocha pot or a Turkish coffee is, they are these things:

    So, wonderful as they are for those of us who love strong coffee, they also produce the highest in-drink levels of cafestol. If you’d like to cut the cafestol (for example, if you are keeping an eye on your LDL), we recommend…

    The humble filter coffee

    Whether by your favorite filter coffee machine or a pour-over low-tech coffee setup of the kind you could use even without an electricity supply, the filter keeps more than just the coffee grinds out; it keeps the cafestol out too; most of it, anyway, depending on what kind of filter you use, and the grind of the coffee:

    Physical characteristics of the paper filter and low cafestol content filter coffee brews

    What about instant coffee?

    It has very little cafestol in it. It’s up to you whether that’s sufficient reason to choose it over any other form of coffee (this coffee-lover could never)

    Want to make any coffee healthier?

    This one isn’t about the cafestol, but…

    If you take l-theanine (see here for our previous main feature about l-theanine), the l-theanine acts as a moderator and modulator of the caffeine, amongst other benefits:

    The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review

    As to where to get that, we don’t sell it, but here’s an example product on Amazon

    Enjoy!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails: