The Dangers Of Fires, Floods, & Having Your Hair Washed
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It’s a dangerous business, going out of your door… And this week’s news round-up looks at 5 reasons why that might be:
Superspreading like wildfire
Environmental health risks are a big topic these days, with our changing climate. As for wildfires? Some of the risks are obvious: burning to death or choking to death in the smoke—but even upon surviving the seemingly worst, more threats remain that themselves can still kill.
Those threats include that both burns and smoke inhalation can cause acute and chronic changes in the immune system. Specifically: changes for the worse. The mechanisms by which this happens depend on the nature of any burns received, and in the case of smoke, what exactly was in the smoke. Now, there is no kind of smoke that is healthy to inhale, but definitely some kinds are a lot worse than others, and let’s just say, people’s homes contain a lot of plastic.
Additionally, if you think someone coughing near you spreads germs, imagine how far germs can be spread by miles-high, miles-wide billowing hot air.
In short, there’s a lot going on and none of it is good, and we’ve barely had room to summarise here, so…
Read in full: Wildfires ignite infection risks by weakening the body’s immune defenses and spreading bugs in smoke
Related: What’s Lurking In Your Household Air?
A flood of diseases
*record scratch*
Environmental health risks are a big topic these days, with our changing climate. As for floods? Some of the risks are obvious: drowning to death or having your house washed away—but even upon surviving the seemingly worst, more threats remain that themselves can still kill.
Those threats include increases in deaths from infectious and parasitic diseases, and respiratory diseases in general. Simply, a place that has been waterlogged, even if it seems “safe” now, is not a healthy place to be, due to bacteria, viruses, fungi, and more. In fact, it even increases all-cause mortality, because being healthy in such a place is simply harder:
Read in full: Linked to higher mortality rates, large floods emerge as an urgent public health concern
Related: Dodging Dengue In The US
Don’t lose your head
Visiting the hairdresser is not something that most people consider a potential brush with death—your hairdresser is probably not Sweeney Todd, after all. However…
There is an issue specifically with getting your hair washed there. Backwash basins—the sink things into which one rests one’s head at a backwards tilt—create an awkward angle for the cervical vertebrae and a sudden reduction in blood flow to the brain can cause a stroke, with the risk being sufficiently notable as to have its own name in scientific literature: beauty parlor stroke syndrome (BPSS).
❝While research suggests BPSS is most likely to occur in women over 50—and previous history of narrowing or thinning of blood vessels and arthritis of the spinal column in the neck are particular risk factors—it could happen to anyone regardless of age or medical history.❞
Read in full: The hidden health risk of having your hair washed
Related: Your Stroke Survival Plan
The smartwatch wristbands that give you cancer
It’s about the PFAS content. The article doesn’t discuss cancer in detail, just mentioning the increased risk, but you can read about the link between the two in our article below.
Basically, if your smartwatch wristband is a) not silicone and b) waterproof anyway, especially if it’s stain-resistant (as most are designed to be, what with wearing it next to one’s skin all the time while exercising, and not being the sort of thing one throws in the wash), then chances are it has PFAS levels much higher than normally found in consumer goods or clothing.
You can read more about how to identify the risks, here:
Read in full: Smartwatch bands can contain high levels of toxic PFAS, study finds
Related: PFAS Exposure & Cancer: The Numbers Are High
The cows giving milk with a little extra
Bird flu (HPAI) is now not the only flu epidemic amongst cattle in the US, and not only that, but rather than “merely” colonizing the lungs and upper respiratory tracts, in this case the virus (IAV) is thriving in the mammary glands, meaning that yes, it gets dispensed into the milk, and so far scientists are simply scrambling to find better ways to vaccinate the cattle, in the hopes that the milk will not be so risky because yes, it is currently a “reservoir and transmission vector” for the virus.
There are, however, barriers to creating those vaccines:
Read in full: Unexpected viral reservoir: influenza A thrives in cattle mammary glands
Related: Cows’ Milk, Bird Flu, & You
Take care!
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The Sucralose News: Scaremongering Or Serious?
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What’s the news on sucralose?
These past days the press has been abuzz with frightening tales:
- This Common Artificial Sweetener Can Break Down DNA, Scientists Warn
- Sucralose Damages DNA, Linked to Leaky Gut
- Chemical found in common sweetener damages DNA
- Chemical found in widely used sweetener breaks up DNA
- Chemical from Splenda breaks up DNA
How true and/or serious is this?
Firstly, let’s manage expectations. Pineapple juice also breaks down DNA, but is not generally considered a health risk. So let’s keep that in mind, while we look into the science.
Is sucralose as scary as pineapple juice, or is it something actually dangerous?
The new study (that sparked off these headlines)
The much-referenced study is publicly available to read in full—here it is:
You may notice that this doesn’t have quite the snappy punchiness of some of the headlines, but let’s break this down, if you’ll pardon the turn of phrase:
- Toxicological: pertaining to whether or not it has toxic qualities
- Pharmacokinetic: the science of asking, of chemicals in bodies, “where did it come from; where did it go; what could it do there; what can we know?”
- Sucralose-6-acetate: an impurity that can be found in sucralose. For perspective, the study found that the sucralose in Splenda contained “up to” 0.67% sucralose-6-acetate.
- Sucralose: a modified form of sucrose, that makes it hundreds of times sweeter, and non-caloric because the body cannot break it down so it’s treated as a dietary fiber and just passes through
- In vitro: things are happening in petri dishes, not in animals (human or otherwise), which would be called “in vivo”
- Screening assays: “we set up a very closed-parameters chemical test, to see what happens when we add this to this” ⇽ oversimplification, but this is the basic format of a screening assay
Great, now we understand the title, but what about the study?
Researchers looked primarily at the effects of sucralose-6-acetate and sucralose (together and separately) on epithelial cells (these are very simple cells that are easy to study; conveniently, they are also most of what makes up our intestinal walls). For this, they used a fancy way of replicating human intestinal walls, that’s actually quite fascinating but beyond the scope of today’s newsletter. Suffice it to say: it’s quite good, and/but has its limitations too. They also looked at some in vivo rat studies.
What they found was…
Based on samples from the rat feces (somehow this didn’t make it into the headlines), it appears that sucralose may be acetylated in the intestines. What that means is that we, if we are like the rats (definitely not a given, but a reasonable hypothesis), might convert up to 10% of sucralose into sucralose-6-acetate inside us. Iff we do, the next part of the findings become more serious.
Based on the in vitro simulations, both sucralose and sucralose-6-acetate reduced intestinal barrier integrity at least a little, but sucralose-6-acetate was the kicker when it came to most of the effects—at least, so we (reasonably!) suppose.
Basically, there’s a lot of supposition going on here but the suppositions are reasonable. That’s how science works; there’s usually little we can know for sure from a single study; it’s when more studies roll in that we start to get a more complete picture.
What was sucralose-6-acetate found to do? It increased the expression of genes associated with inflammation, oxidative stress, and cancer (granted those three things generally go together). So that’s a “this probably has this end result” supposition.
More concretely, and which most of the headlines latched onto, it was found (in vitro) to induce cytogenic damage, specifically, of the clastogenic variety (produces DNA strand breaks—so this is different than pineapple’s bromelain and DNA-helicase’s relatively harmless unzipping of genes).
The dose makes the poison
So, how much is too much and is that 0.67% something to worry about?
- Remembering the rat study, it may be more like 10% once our intestines have done their thing. Iff we’re like rats.
- But, even if it’s only 0.67%, this will still be above the “threshold of toxicological concern for genotoxicity”, of 0.15µg/person/day.
- On the other hand, the fact that these were in vitro studies is a serious limitation.
- Sometimes something is very dangerous in vitro, because it’s being put directly onto cells, whereas in vivo we may have mechanisms for dealing with that.
We won’t know for sure until we get in vivo studies in human subjects, and that may not happen any time soon, if ever, depending on the technical limitations and ethical considerations that sometimes preclude doing certain studies in humans.
Bottom line:
- The headlines are written to be scary, but aren’t wrong; their claims are fundamentally true
- What that means for us as actual humans may not be the same, however; we don’t know yet
- For now, it is probably reasonable to avoid sucralose just in case
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Progesterone Menopausal HRT: When, Why, And How To Benefit
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Progesterone doesn’t get talked about as much as other sex hormones, so what’s its deal? Dr. Heather Hirsch explains:
Menopausal progesterone
Dr. Hirsch considers progesterone essential for menopausal women who are taking estrogen and have an intact uterus, to keep conditions at bay such as endometriosis or even uterine cancer.
However, she advises it is not critical in those without a uterus, unless there was a previous case of one of the above conditions.
10almonds addition: on the other hand, progesterone can still be beneficial from a metabolic and body composition standpoint, so do speak with your endocrinologist about it.
As an extra bonus: while not soporific (it won’t make you sleepy), taking progesterone at night will improve the quality of your sleep once you do sleep, so that’s a worthwhile thing for many!
Dr. Hirsch also discusses the merits of continuous vs cyclic use; continuous maintains the above sleep benefits, for example, while cyclic use can help stabilize menstrual patterns in late perimenopause and early menopause.
For more on these things, plus discussion of different types of progesterone, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
- What Does “Balance Your Hormones” Even Mean?
- What You Should Have Been Told About The Menopause Beforehand
- HRT: Bioidentical vs Animal – A Tale Of Two Approaches
Take care!
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To Medicate or Not? That is the Question! – by Dr. Asha Bohannon
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Medications are, of course, a necessity of life (literally!) for many, especially as we get older. Nevertheless, overmedication is also a big problem that can cause a lot of harm too, and guess what, it comes with the exact same “especially as we get older” tag too.
So, what does Dr. Bohannon (a doctor of pharmacy, diabetes educator, and personal trainer too) recommend?
Simply put: she recommends starting with a comprehensive health history assessment and analysing one’s medication/supplement profile, before getting lab work done, tweaking all the things that can be tweaked along the way, and—of course—not neglecting lifestyle medicine either.
The book is prefaced and ended with pep talks that probably a person who has already bought the book does not need, but they don’t detract from the practical content either. Nevertheless, it feels a little odd that it takes until chapter 4 to reach “step 1” of her 7-step method!
The style throughout is conversational and energetic, but not overly padded with hype; it’s just a very casual style. Nevertheless, she brings to bear her professional knowledge and understanding as a doctor of pharmacy, to include her insights into the industry that one might not observe from outside of it.
Bottom line: if you’d like to do your own personal meds review and want to “know enough to ask the right questions” before bringing it up with your doctor, this book is a fine choice for that.
Click here to check out To Medicate Or Not, and make informed choices!
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Which gut drugs might end up in a lawsuit? Are there really links with cancer and kidney disease? Should I stop taking them?
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Common medicines used to treat conditions including heartburn, reflux, indigestion and stomach ulcers may be the subject of a class action lawsuit in Australia.
Lawyers are exploring whether long-term use of these over-the-counter and prescription drugs are linked to stomach cancer or kidney disease.
The potential class action follows the settlement of a related multi-million dollar lawsuit in the United States. Last year, international pharmaceutical company AstraZeneca settled for US$425 million (A$637 million) after patients made the case that two of its drugs caused significant and potentially life-threatening side effects.
Specifically, patients claimed the company’s drugs Nexium (esomeprazole) and Prilosec (omeprazole) increased the risk of kidney damage.
Doucefleur/Shutterstock Which drugs are involved in Australia?
The class of drugs we’re talking about are “proton pump inhibitors” (sometimes called PPIs). In the case of the Australian potential class action, lawyers are investigating:
- Nexium (esomeprazole)
- Losec, Asimax (omeprazole)
- Somac (pantoprazole)
- Pariet (rabeprazole)
- Zoton (lansoprazole).
Depending on their strength and quantity, these medicines are available over-the-counter in pharmacies or by prescription.
They have been available in Australia for more than 20 years and are in the top ten medicines dispensed through the Pharmaceutical Benefits Scheme.
They are used to treat conditions exacerbated by stomach acid. These include heartburn, gastric reflux and indigestion. They work by blocking the protein responsible for pumping acid into the stomach.
These drugs are also prescribed with antibiotics to treat the bacterium Helicobacter pylori, which causes stomach ulcers and stomach cancer.
This class of drugs is also used with antibiotics to treat Helicobacter pylori infections. nobeastsofierce/Shutterstock What do we know about the risks?
Appropriate use of proton pump inhibitors plays an important role in treating several serious digestive problems. Like all medicines, there are risks associated with their use depending on how much and how long they are used.
When proton pump inhibitors are used appropriately for the short-term treatment of stomach problems, they are generally well tolerated, safe and effective.
Their risks are mostly associated with long-term use (using them for more than a year) due to the negative effects from having reduced levels of stomach acid. In elderly people, these include an increased risk of gut and respiratory tract infections, nutrient deficiencies and fractures. Long-term use of these drugs in elderly people has also been associated with an increased risk of dementia.
In children, there is an increased risk of serious infection associated with using these drugs, regardless of how long they are used.
How about the cancer and kidney risk?
Currently, the Australian consumer medicine information sheets that come with the medicines, like this one for esomeprazole, do not list stomach cancer or kidney injury as a risk associated with using proton pump inhibitors.
So what does the evidence say about the risk?
Over the past few years, there have been large studies based on observing people in the general population who have used proton pump inhibitors. These studies have found people who take them are almost two times more likely to develop stomach cancer and 1.7 times more likely to develop chronic kidney disease when compared with people who are not taking them.
In particular, these studies report that users of the drugs lansoprazole and pantoprazole have about a three to four times higher risk than non-users of developing chronic kidney disease.
While these observational studies show a link between using the drugs and these outcomes, we cannot say from this evidence that one causes the other.
Researchers have not yet shown these drugs cause kidney disease. crystal light/Shutterstock What can I do if I’m worried?
Several digestive conditions, especially reflux and heartburn, may benefit from simple dietary and lifestyle changes. But the overall evidence for these is not strong and how well they work varies between individuals.
But it may help to avoid large meals within two to three hours before bed, and reduce your intake of fatty food, alcohol and coffee. Eating slowly and getting your weight down if you are overweight may also help your symptoms.
There are also medications other than proton pump inhibitors that can be used for heartburn, reflux and stomach ulcers.
These include over-the-counter antacids (such as Gaviscon and Mylanta), which work by neutralising the acidic environment of the stomach.
Alternatives for prescription drugs include nizatidine and famotidine. These work by blocking histamine receptors in the stomach, which decreases stomach acid production.
If you are concerned about your use of proton pump inhibitors it is important to speak with your doctor or pharmacist before you stop using them. That’s because when you have been using them for a while, stopping them may result in increased or “rebound” acid production.
Nial Wheate, Professor and Director – Academic Excellence, Macquarie University; Joanna Harnett, Senior Lecturer – Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, and Wai-Jo Jocelin Chan, Pharmacist and Associate Lecturer, University of Sydney
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Antihistamines for Runny Nose?
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small 😎
❝Do you have any articles about using Anti-Histamines? My nose seems to be running a lot. I don’t have a cold or any allergies that I know of. I tried a Nasal spray Astepro, but it doesn’t do much.?❞
Just for you, we wrote such an article yesterday in response to this question!
The Astepro that you tried, by the way, is a brand name of the azelastine we mentioned near the end, before we got to talking about systemic corticosteroids such as beclometasone dipropionate—this latter might help you if antihistamines haven’t, and if your doctor advises there’s no contraindication (for most people it is safe for there are exceptions, such as if you are immunocompromised and/or currently fighting some infection).
You can find more details on all this in yesterday’s article, which in case you missed it, can be found at:
Antihistamines’ Generation Gap: Are You Ready For Allergy Season?
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12 Foods That Fight Depression & Anxiety
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Food impacts mental health, and while it won’t magically cure mental illness, dietary changes can do a lot to improve mood. Here’s how:
Nutraceuticals
We’ll not keep the 12 nutraceutical foods a mystery; here’s what they are and a few words on how they work (in many cases, we could write whole articles about them; in some cases, we already have! You can find many of them by using the search function in the top-right of each page).
- Walnuts are rich in omega-3s for brain health; arguably the best nut for depression relief.
- Fermented foods because probiotics in foods like yogurt and sauerkraut support the gut-brain connection as well as serotonin production there, enhancing mood.
- Cherry tomatoes are rich in lycopene, which helps combat both depression and mood swings.
- Leafy greens reduce brain inflammation linked to depression.
- Apples and other fruit are high in fiber and antioxidants that stabilize blood sugar and mood, reducing brain inflammation.
- Beans are high in B vitamins, crucial for neurotransmitter production and mood regulation (without also being high in brain-harmful things, as red meat is).
- Berries are super-high antioxidants and cortisol-lowering anthocyanidins, promoting calmness and reducing stress.
- Oats contain the healthiest kind of fiber, β-glucan, and additionally help stabilize blood sugar and mood; they’re also rich in selenium, which boosts mood.
- Mushrooms help regulate blood sugar and act as prebiotics, supporting serotonin production in the gut.
- Avocados are famously rich in healthy fats, including omega-3s and oleic acid, which support brain health and combat depression.
- Dark chocolate contains antioxidants, magnesium, and gut-healthy prebiotics that indirectly reduce mental stress and improve brain function. Also a famous comfort food for many, of course, and that factor’s not to be overlooked either.
- Pumpkin seeds are rich in tryptophan, which boosts serotonin production. As a bonus, they also help some kinds of antidepressant to work better—check with your doctor or pharmacist to be sure in your case, though.
For more on all of these, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
The 6 Pillars Of Nutritional Psychiatry
Take care!
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