GABA Against Stress/Anxiety

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A Neurotransmitter Less Talked-About

GABA is taken by many people as a supplement, mostly as a mood modifier, though its health claims go beyond the recreational—and also, we’re of the opinion that mental health is also just health, and if it works, it works. We’ll explore some of the claims and science behind them today…

What is GABA?

GABA stands for gamma-aminobutyric acid, and it’s a neurotransmitter. It’s a lot less talked-about than for example dopamine or serotonin, but it’s very important nonetheless.

We make it ourselves inside our body, and we can also get it from our food, or supplement it, and some drugs will also have an effect on its presence and/or activity in our body.

What foods is it found in?

  • Animals, obviously (just like in human brains*)
  • Fermented foods (many kinds)
  • Yeast
  • Tea
  • Tomatoes
  • Mulberries

For more details, see:

γ-Aminobutyric acid found in fermented foods and beverages: current trends

*However, we do not recommend eating human brains, due to the risk of CJD and prion diseases in general.

What claims are made about it and are they true?

For brevity, we’ll give a little spoiler up-front: all the popular claims for it appear to be valid, though there’s definitely room for a lot more human trials (we skipped over a lot of rodent studies today!).

So we’ll just drop some of its main benefits, and human studies to back those.

Reduction of stress and anxiety

GABA decreases task-related stress and anxiety within 30 minutes of being taken, both in subjective measures (i.e., self-reports) and in objective clinical physiological measures:

Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks

Cognitive enhancement

It’s not a does-everything nootropic like some, but it does have clear benefits to episodic memory:

❝GABA intake might help to distribute limited attentional resources more efficiently, and can specifically improve the identification and ordering of visual events that occur in close temporal succession

One of the things that makes this one important is that it also deals with the often-asked question of “does GABA pass the blood-brain barrier”:

❝The present findings do give further credence to the idea that oral ingestion does allow GABA to reach the brain and exert direct effects on cognition, which in the present case were specific to temporal attention.❞

Read more:

Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention

Potential for more

We take care to give good quality sources, so the following study comes with a big caveat that it has since been retracted. Why was it retracted, you wonder?

It’s about the sample; they cite “30 healthy adults”, but neglected tp mention that this figure was initially 46. What happened to the other 16 participants is unclear, but given that this was challenged and the challenge not answered, it was sufficient for the journal (Nature) to pull the study, in case of deliberate sample bias.

However! Running the numbers in their results section, a probability of 0.03 is very compelling unless the disappearance of 16 subjects was outright fraudulent (which we regrettably cannot know either way).

Here’s the study (so take it with a pinch of salt, considering the above), and taken at face value, it shows how GABA supplementation improves accurate reactions to fast-moving visual and auditory stimuli:

RETRACTED ARTICLE: γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial

…so, hopefully this experiment will be repeated, without disappearing participants!

The sweet spot

You may be wondering how something that slows a person down (having a relaxing effect) can also speed a person up. This has to do with what it is and isn’t affecting; think of it like a “focus mode” on your computer or other device that greys-out everything else a bit so that you can focus on what you’re doing.

It’s in some ways (by different neurochemical pathways, though) a similar effect to the “relaxed alertness” created by l-theanine supplementation.

There’s also a sweet spot whereby GABA is toning some things down just the right amount, without adversely affecting performance in areas we don’t want slowed down. For the science of this, see:

Too Little and Too Much: Hypoactivation and Disinhibition (Reduced GABAergic Inhibition) of Medial Prefrontal Cortex Cause Attentional Deficits

Is it safe?

GABA is “Generally Recognized As Safe”. However:

  • you should speak with your pharmacist if you are taking any medications for blood pressure or epilepsy, as GABA supplementation may cause them to work too well.
  • you should absolutely not take GABA with alcohol or opioids as (dose-dependent for all the substances involved, and also depending on your metabolic base rate and other factors) its acute depression of the CNS can mean you relax and slow down too much, and you may find yourself not breathing often enough to sustain life.

Aside from that, it is considered safe up to at least 1g/kg/day*. Given that popular doses are 120–750mg, and most people weigh more than 750g, this is very safe for most people:

United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)

Where can I get it?

We don’t sell it, but for your convenience, here’s an example product on Amazon

Enjoy!

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  • Why ’10almonds’? Newsletter Name Explained

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day!

    Each Thursday, we respond to subscriber questions and requests! If it’s something small, we’ll answer it directly; if it’s something bigger, we’ll do a main feature in a follow-up day instead!

    So, no question/request to big or small; they’ll just get sorted accordingly

    Remember, you can always hit reply to any of our emails, or use the handy feedback widget at the bottom. We always look forward to hearing from you!

    Q: Why is your newsletter called 10almonds? Maybe I missed it in the intro email, but my curiosity wants to know the significance. Thanks!”

    It’s a reference to a viral Facebook hoax! There was a post going around that claimed:

    ❝HEADACHE REMEDY. Eat 10–12 almonds, the equivalent of two aspirins, next time you have a headache❞ ← not true!

    It made us think about how much health-related disinformation there was online… So, calling ourselves 10almonds was a bit of a tongue-in-cheek reference to that story… but also a reminder to ourselves:

    We must always publish information with good scientific evidence behind it!

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  • Paris in spring, Bali in winter. How ‘bucket lists’ help cancer patients handle life and death

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    In the 2007 film The Bucket List Jack Nicholson and Morgan Freeman play two main characters who respond to their terminal cancer diagnoses by rejecting experimental treatment. Instead, they go on a range of energetic, overseas escapades.

    Since then, the term “bucket list” – a list of experiences or achievements to complete before you “kick the bucket” or die – has become common.

    You can read articles listing the seven cities you must visit before you die or the 100 Australian bucket-list travel experiences. https://www.youtube.com/embed/UvdTpywTmQg?wmode=transparent&start=0

    But there is a more serious side to the idea behind bucket lists. One of the key forms of suffering at the end of life is regret for things left unsaid or undone. So bucket lists can serve as a form of insurance against this potential regret.

    The bucket-list search for adventure, memories and meaning takes on a life of its own with a diagnosis of life-limiting illness.

    In a study published this week, we spoke to 54 people living with cancer, and 28 of their friends and family. For many, a key bucket list item was travel.

    Why is travel so important?

    There are lots of reasons why travel plays such a central role in our ideas about a “life well-lived”. Travel is often linked to important life transitions: the youthful gap year, the journey to self-discovery in the 2010 film Eat Pray Love, or the popular figure of the “grey nomad”.

    The significance of travel is not merely in the destination, nor even in the journey. For many people, planning the travel is just as important. A cancer diagnosis affects people’s sense of control over their future, throwing into question their ability to write their own life story or plan their travel dreams.

    Mark, the recently retired husband of a woman with cancer, told us about their stalled travel plans:

    We’re just in that part of our lives where we were going to jump in the caravan and do the big trip and all this sort of thing, and now [our plans are] on blocks in the shed.

    For others, a cancer diagnosis brought an urgent need to “tick things off” their bucket list. Asha, a woman living with breast cancer, told us she’d always been driven to “get things done” but the cancer diagnosis made this worse:

    So, I had to do all the travel, I had to empty my bucket list now, which has kind of driven my partner round the bend.

    People’s travel dreams ranged from whale watching in Queensland to seeing polar bears in the Arctic, and from driving a caravan across the Nullarbor Plain to skiing in Switzerland.

    Humpback whale breaching off the coast
    Whale watching in Queensland was on one person’s bucket list. Uwe Bergwitz/Shutterstock

    Nadia, who was 38 years old when we spoke to her, said travelling with her family had made important memories and given her a sense of vitality, despite her health struggles. She told us how being diagnosed with cancer had given her the chance to live her life at a younger age, rather than waiting for retirement:

    In the last three years, I think I’ve lived more than a lot of 80-year-olds.

    But travel is expensive

    Of course, travel is expensive. It’s not by chance Nicholson’s character in The Bucket List is a billionaire.

    Some people we spoke to had emptied their savings, assuming they would no longer need to provide for aged care or retirement. Others had used insurance payouts or charity to make their bucket-list dreams come true.

    But not everyone can do this. Jim, a 60-year-old whose wife had been diagnosed with cancer, told us:

    We’ve actually bought a new car and [been] talking about getting a new caravan […] But I’ve got to work. It’d be nice if there was a little money tree out the back but never mind.

    Not everyone’s bucket list items were expensive. Some chose to spend more time with loved ones, take up a new hobby or get a pet.

    Our study showed making plans to tick items off a list can give people a sense of self-determination and hope for the future. It was a way of exerting control in the face of an illness that can leave people feeling powerless. Asha said:

    This disease is not going to control me. I am not going to sit still and do nothing. I want to go travel.

    Something we ‘ought’ to do?

    Bucket lists are also a symptom of a broader culture that emphasises conspicuous consumption and productivity, even into the end of life.

    Indeed, people told us travelling could be exhausting, expensive and stressful, especially when they’re also living with the symptoms and side effects of treatment. Nevertheless, they felt travel was something they “ought” to do.

    Travel can be deeply meaningful, as our study found. But a life well-lived need not be extravagant or adventurous. Finding what is meaningful is a deeply personal journey.

    Names of study participants mentioned in this article are pseudonyms.

    Leah Williams Veazey, ARC DECRA Research Fellow, University of Sydney; Alex Broom, Professor of Sociology & Director, Sydney Centre for Healthy Societies, University of Sydney, and Katherine Kenny, ARC DECRA Senior Research Fellow, University of Sydney

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Vodka vs Beer – Which is Healthier?

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    Our Verdict

    When comparing vodka to beer, we picked the vodka.

    Why?

    As you might have guessed, neither are exactly healthy. But one of them is relatively, and we stress relatively, less bad than the other.

    In the category of nutrients, vodka is devoid of nutrients, and beer has small amounts of some vitamins and minerals—but the amounts are so small, that you would need to drink yourself to death before benefiting from them meaningfully. And while beer gets touted as “liquid bread”, it really isn’t. A thousand years ago it will have been a lot less alcoholic and more carby, but even then, it wasn’t a health product aside from that it provided a way of making potentially contaminated water safer to drink.

    In the category of carbohydrates, vodka nominally has none, due to the distillation process, and beer has some. Glycemic index websites often advise that the GI of beers, wines, and spirits can’t be measured as their carb content is not sufficient to get a meaningful sample, but diabetes research tells a more useful story:

    Any alcoholic drink will generally cause a brief drop in blood sugars, followed by a spike. This happens because the liver prioritises metabolizing alcohol over producing glycogen, so it hits pause on the sugar metabolism and then has a backlog to catch up on. In the case of alcoholic drinks that have alcohol and carbs, this will be more pronounced—so this means that the functional glycemic load of beer is higher.

    That’s a point in favor of vodka.

    Additionally, in terms of the alcohol content, correctly-distilled vodka’s alcohol is pure ethanol, while beer will contain an amount of methanol that will vary per beer, but an illustrative nominal figure could be about 16mg/L. Methanol is more harmful than ethanol.

    So that’s another point in favor of vodka.

    Once again, neither drink is healthy; both are distinctly unhealthy. But unit for unit, beer is the least healthy of the two, making vodka the lesser of two evils.

    Want to learn more?

    You might like to read:

    Take care!

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  • What Do The Different Kinds Of Fiber Do? 30 Foods That Rank Highest

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve talked before about how important fiber is:

    Why You’re Probably Not Getting Enough Fiber (And How To Fix It)

    And even how it’s arguably the most important dietary factor when it comes to avoiding heart disease:

    What Matters Most For Your Heart? Eat More (Of This) For Lower Blood Pressure ← Spoiler: it’s fiber

    And yes, that’s even when considered alongside other (also laudable) dietary interventions such as lowering intake of sodium, various kinds of saturated fat, and red meat.

    So, what should we know about fiber, aside from “aim to get nearer 40g/day instead of the US average 16g/day”?

    Soluble vs Insoluble

    The first main way that dietary fibers can be categorized is soluble vs insoluble. Part of the difference is obvious, but bear with us, because there’s more to know about each:

    • Soluble fiber dissolves (what a surprise) in water and, which part is important, forms a gel. This slows down things going through your intestines, which is important for proper digestion and absorption of nutrients (as well as avoiding diarrhea). Yes, you heard right: getting enough of the right kind of fiber helps you avoid diarrhea.
    • Insoluble fiber does not dissolve (how shocking) in water and thus mostly passes through undigested by us (some will actually be digested by gut microbes who subsist on this, and in return for us feeding them daily, they make useful chemicals for us). This kind of fiber is also critical for healthy bowel movements, because without it, constipation can ensue.

    Both kinds of fiber improve just about every metric related to blood, including improving triglycerides and improving insulin sensitivity and blood glucose levels. Thus, they help guard against various kinds of cardiovascular disease, diabetes, and metabolic disease in general. Do note that because whatever’s good for your heart/blood is good for your brain (which requires a healthy heart and bloodstream to nourish it and take away waste), likely this also has a knock-on effect against cognitive decline, but we don’t have hard science for that claim so we’re going to leave that last item as a “likely”.

    However, one thing’s for sure: if you want a healthy gut, heart, and brain, you need a good balance of soluble and insoluble fibers.

    10 of the best for soluble fiber

    FoodSoluble Fiber Type(s)Soluble Fiber (g per serving)Insoluble Fiber Type(s)Insoluble Fiber (g per serving)Total Fiber (g per serving)
    Kidney beans (1 cup cooked)Pectin, Resistant Starch1.5–2Hemicellulose, Cellulose68
    Lentils (1 cup cooked)Pectin, Resistant Starch1.5–2Cellulose67.5
    Barley (1 cup cooked)Beta-glucan3–4Hemicellulose26
    Brussels sprouts (1 cup cooked)Pectin1–1.5Cellulose, Hemicellulose23.5
    Oats (1 cup cooked)Beta-glucan2–3Cellulose13
    Apples (1 medium)Pectin1–2Cellulose, Hemicellulose23
    Carrots (1 cup raw)Pectin1–1.5Cellulose, Hemicellulose23
    Citrus fruits (orange, 1 medium)Pectin1–1.5Cellulose12.5
    Flaxseeds (2 tbsp)Mucilage, Lignin1–1.5Cellulose12.5
    Psyllium husk (1 tbsp)Mucilage3–4Trace amounts03–4

    10 of the best for insoluble fiber

    FoodSoluble Fiber Type(s)Soluble Fiber (g per serving)Insoluble Fiber Type(s)Insoluble Fiber (g per serving)Total Fiber (g per serving)
    Wheat bran (1 cup)Trace amounts0Cellulose, Lignin6–86–8
    Black beans (1 cup cooked)Pectin, Resistant Starch1.5Cellulose67.5
    Brown rice (1 cup cooked)Trace amounts0.5Hemicellulose, Lignin2–32.5–3.5
    Popcorn (3 cups popped)Trace amounts0.5Hemicellulose33.5
    Broccoli (1 cup cooked)Pectin1Cellulose, Hemicellulose45
    Green beans (1 cup cooked)Trace amounts0.5Cellulose, Hemicellulose33.5
    Sweet potatoes (1 cup cooked)Pectin1–1.5Cellulose34.5
    Whole wheat bread (1 slice)Trace amounts0.5Cellulose, Hemicellulose11.5
    Pears (1 medium)Pectin1Cellulose, Hemicellulose45
    Almonds (1 oz)Trace amounts0.5Cellulose, Hemicellulose22.5

    10 of the best for a balance of both

    FoodSoluble Fiber Type(s)Soluble Fiber (g per serving)Insoluble Fiber Type(s)Insoluble Fiber (g per serving)Total Fiber (g per serving)
    Raspberries (1 cup)Pectin1Cellulose56
    Edamame (1 cup cooked)Pectin1Cellulose56
    Chia seeds (2 tbsp)Mucilage, Pectin2–3Lignin, Cellulose35.5
    Artichokes (1 medium)Inulin1Cellulose, Hemicellulose56
    Avocado (1 medium)Pectin~2Cellulose46
    Black beans (1 cup cooked)Pectin, Resistant Starch1.5Cellulose67.5
    Quinoa (1 cup cooked)Pectin, Saponins1Cellulose, Hemicellulose34
    Spinach (1 cup cooked)Pectin0.5Cellulose, Lignin33.5
    Prunes (1/2 cup)Pectin, Sorbitol2Cellulose46
    Figs (3 medium)Pectin1Cellulose23

    You’ll notice that the above “balance” is not equal; that’s ok; we need greater quantities of insoluble than soluble anyway, so it is as well that nature provides such.

    This is the same kind of balance when we talk about “balanced hormones” (does not mean all hormones are in equal amounts; means they are in the right proportions) or “balanced microbiome” (does not mean that pathogens and friendly bacteria are in equal numbers), etc.

    Some notes on the above:

    About those fiber types, some of the most important soluble ones to aim for are:

    • Beta-glucan: found in oats and barley, it supports heart health.
    • Pectin: found in fruits like apples, citrus, and pears, it helps with cholesterol control.
    • Inulin: a type of prebiotic fiber found in artichokes.
    • Lignin: found in seeds and wheat bran, it has antioxidant properties.
    • Resistant starch: found in beans and lentils, it acts as a prebiotic for gut health.

    See also: When Is A Fiber Not A Fiber? The Food Additive You Do Want

    One fiber to rule them all

    Well, not entirely (we still need the others) but there is a best all-rounder:

    The Best Kind Of Fiber For Overall Health?

    Enjoy!

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  • The Glucose Goddess Method – by Jessie Inchausspé

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve previously reviewed Inchausspé’s excellent book “Glucose Revolution”. So what does this book add?

    This book is for those who found that book a little dense. While this one still gives the same ten “hacks”, she focuses on the four that have the biggest effect, and walks the reader by the hand through a four-week programme of implementing them.

    The claim of 100+ recipes is a little bold, as some of the recipes are things like vinegar, vinegar+water, vinegar+water but now we’re it’s in a restaurant, lemon+water, lemon+water but now it’s in a bottle, etc. However, there are legitimately a lot of actual recipes too.

    Where this book’s greatest strength lies is in making everything super easy, and motivating. It’s a fine choice for being up-and-running quickly and easily without wading through the 300-odd pages of science in her previous book.

    Bottom line: if you’ve already happily and sustainably implemented everything from her previous book, you can probably skip this one. However, if you’d like an easier method to implement the changes that have the biggest effect, then this is the book for you.

    Click here to check out The Glucose Goddess Method, and build it into your life the easy way!

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  • An unbroken night’s sleep is a myth. Here’s what good sleep looks like

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    What do you imagine a good night’s sleep to be?

    Often when people come into our sleep clinic seeking treatment, they share ideas about healthy sleep.

    Many think when their head hits the pillow, they should fall into a deep and restorative sleep, and emerge after about eight hours feeling refreshed. They’re in good company – many Australians hold the same belief.

    In reality, healthy sleep is cyclic across the night, as you move in and out of the different stages of sleep, often waking up several times. Some people remember one or more of these awakenings, others do not. Let’s consider what a healthy night’s sleep looks like.

    Bricolage/Shutterstock

    Sleep cycles are a roller-coaster

    As an adult, our sleep moves through different cycles and brief awakenings during the night. Sleep cycles last roughly 90 minutes each.

    We typically start the night with lighter sleep, before moving into deeper sleep stages, and rising again into rapid eye movement (REM) sleep – the stage of sleep often linked to vivid dreaming.

    If sleeping well, we get most of our deep sleep in the first half of the night, with REM sleep more common in the second half of the night.

    An older man sleeps peacefully in bed.
    Deepest sleep usually happens during the first half of the night. Verin/Shutterstock

    Adults usually move through five or six sleep cycles in a night, and it is entirely normal to wake up briefly at the end of each one. That means we might be waking up five times during the night. This can increase with older age and still be healthy. If you’re not remembering these awakenings that’s OK – they can be quite brief.

    What does getting a ‘good’ sleep actually mean?

    You’ll often hear that adults need between seven and nine hours of sleep per night. But good sleep is about more than the number of hours – it’s also about the quality.

    For most people, sleeping well means being able to fall asleep soon after getting into bed (within around 30 minutes), sleeping without waking up for long periods, and waking feeling rested and ready for the day.

    You shouldn’t be feeling excessively sleepy during the day, especially if you’re regularly getting at least seven hours of refreshing sleep a night (this is a rough rule of thumb).

    But are you noticing you’re feeling physically tired, needing to nap regularly and still not feeling refreshed? It may be worthwhile touching base with your general practitioner, as there a range of possible reasons.

    Common issues

    Sleep disorders are common. Up to 25% of adults have insomnia, a sleep disorder where it may be hard to fall or stay asleep, or you may wake earlier in the morning than you’d like.

    Rates of common sleep disorders such as insomnia and sleep apnoea – where your breathing can partially or completely stop many times during the night – also increase with age, affecting 20% of early adults and 40% of people in middle age. There are effective treatments, so asking for help is important.

    Beyond sleep disorders, our sleep can also be disrupted by chronic health conditions – such as pain – and by certain medications.

    There can also be other reasons we’re not sleeping well. Some of us are woken by children, pets or traffic noise during the night. These “forced awakenings” mean we may find it harder to get up in the morning, take longer to leave bed and feel less satisfied with our sleep. For some people, night awakenings may have no clear cause.

    A good way to tell if these awakenings are a problem for you is by thinking about how they affect you. When they cause feelings of frustration or worry, or are impacting how we feel and function during the day, it might be a sign to seek some help.

    Weary woman leans against a pole in an empty train carriage.
    If waking up in the night is interfering with your normal day-to-day activities, it may indicate a problem. BearFotos/Shutterstock

    We also may struggle to get up in the morning. This could be for a range of reasons, including not sleeping long enough, going to bed or waking up at irregular times – or even your own internal clock, which can influence the time your body prefers to sleep.

    If you’re regularly struggling to get up for work or family needs, it can be an indication you may need to seek help. Some of these factors can be explored with a sleep psychologist if they are causing concern.

    Can my smart watch help?

    It is important to remember sleep-tracking devices can vary in accuracy for looking at the different sleep stages. While they can give a rough estimate, they are not a perfect measure.

    In-laboratory polysomnography, or PSG, is the best standard measure to examine your sleep stages. A PSG examines breathing, oxygen saturation, brain waves and heart rate during sleep.

    Rather than closely examining nightly data (including sleep stages) from a sleep tracker, it may be more helpful to look at the patterns of your sleep (bed and wake times) over time.

    Understanding your sleep patterns may help identify and adjust behaviours that negatively impact your sleep, such as your bedtime routine and sleeping environment.

    And if you find viewing your sleep data is making you feel worried about your sleep, this may not be useful for you. Most importantly, if you are concerned it is important to discuss it with your GP who can refer you to the appropriate specialist sleep health provider.

    Amy Reynolds, Associate Professor in Clinical Sleep Health, Flinders University; Claire Dunbar, Research Associate, Sleep Health, Flinders University; Gorica Micic, Postdoctoral Research Fellow, Clinical Psychologist, Flinders University; Hannah Scott, Research Fellow in Sleep Health, Flinders University, and Nicole Lovato, Associate Professor, Adelaide Institute for Sleep Health, Flinders University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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