Winter Wellness & The Pills That Increase Your Alzheimer’s Risk

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This week in health news…

Do not go gentle into that good night

As wildfires rage in California, snow is falling from Texas to Georgia, meaning that a lot of people are facing weather they’re not accustomed to, in houses that were not built for it. And that’s the lucky ones; there are many thousands of people who are homeless, of whom many will die.

Hopefully all our readers are safe, but it pays to watch out for the signs of hypothermia as it is a condition that really sneaks up on people and, in the process, takes away their ability to notice the hypothermia. You and your loved ones are not immune to this, so it’s good to keep an eye on each other, looking out for:

  • Shivering, first ← when this stops, assuming it’s not because the temperature has risen, it is often a sign of hypothermia entering a later stage, in which the body is no longer responding appropriately to the cold
  • Slurred speech or mumbling
  • Slow, shallow breathing
  • A weak pulse
  • Clumsiness or lack of coordination
  • Drowsiness or very low energy
  • Confusion or memory loss
  • Loss of consciousness
  • In infants, bright red, cold skin

How cold is too cold? It doesn’t even have to be sub-zero. According to the CDC, temperatures of 4℃ (40℉) can be low enough to cause hypothermia.

Read in full: The warning signs to notice if someone has hypothermia

Related: Cold Weather Health Risks

Lethal lottery of pathogens

In Minnesota, hospital emergency room waiting times have skyrocketed since yesterday (at time of writing), with 40% of Minnesota’s 1,763 flu-related hospitalizations this fall and winter occurring in the same week, according to yesterday’s report. To put it further into perspective, 17 out of 20 of this season’s flu outbreaks have occurred in the past two weeks.

And that’s just the flu, without considering COVID, RSV, and Norovirus, which are also all running rampant in MN right now.

The advice presently is:

❝Go to the ER if you are super-sick. If you are not super-sick, go to urgent care, go to your clinic, schedule a virtual appointment.❞

And if you’re not in Minneapolis? These stats won’t apply, but definitely consider, before going to the hospital, whether you might leave sicker than you arrived, and plan accordingly, making use of telehealth where reasonably possible.

Read in full: Minnesota ERs stressed by “quad-demic” of COVID, flu, RSV, norovirus

Related: Move over, COVID and Flu! We Have “Hybrid Viruses” To Contend With Now

Sleep, but at what cost?

This was a study looking at the effects of sleeping pills on the brain, specifically zolpidem (most well-known by its brand name of Ambien).

What they found is that while it does indeed effectively induce sleep, part of how it does that is suppressing norepinephrine oscillations (which might otherwise potentially wake you up, though in healthy people these oscillations and the micro-arousals that they cause shouldn’t disrupt sleep at all, and are just considered part of our normal sleep cycles), which oscillations are necessary to generate the pumping action required to move cerebrospinal fluid through the glymphatic system while asleep.

This is a big problem, because the glymphatic system is almost entirely responsible for keeping the brain free from waste products such as beta-amyloids (whose build-up is associated with Alzheimer’s disease and is considered to be a significant part of Alzheimer’s pathogensesis) and alpha-synuclein (same but for Parkinson’s disease), amongst others:

Read in full: Common sleeping pill may pave way for disorders like Alzheimer’s

Related: How To Clean Your Brain (Glymphatic Health Primer)

Take care!

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  • How long does back pain last? And how can learning about pain increase the chance of recovery?

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    Back pain is common. One in thirteen people have it right now and worldwide a staggering 619 million people will have it this year.

    Chronic pain, of which back pain is the most common, is the world’s most disabling health problem. Its economic impact dwarfs other health conditions.

    If you get back pain, how long will it take to go away? We scoured the scientific literature to find out. We found data on almost 20,000 people, from 95 different studies and split them into three groups:

    • acute – those with back pain that started less than six weeks ago
    • subacute – where it started between six and 12 weeks ago
    • chronic – where it started between three months and one year ago.

    We found 70%–95% of people with acute back pain were likely to recover within six months. This dropped to 40%–70% for subacute back pain and to 12%–16% for chronic back pain.

    Clinical guidelines point to graded return to activity and pain education under the guidance of a health professional as the best ways to promote recovery. Yet these effective interventions are underfunded and hard to access.

    More pain doesn’t mean a more serious injury

    Most acute back pain episodes are not caused by serious injury or disease.

    There are rare exceptions, which is why it’s wise to see your doctor or physio, who can check for signs and symptoms that warrant further investigation. But unless you have been in a significant accident or sustained a large blow, you are unlikely to have caused much damage to your spine.

    Factory worker deep-breathes with a sore back
    Your doctor or physio can rule out serious damage.
    DG fotostock/Shutterstock

    Even very minor back injuries can be brutally painful. This is, in part, because of how we are made. If you think of your spinal cord as a very precious asset (which it is), worthy of great protection (which it is), a bit like the crown jewels, then what would be the best way to keep it safe? Lots of protection and a highly sensitive alarm system.

    The spinal cord is protected by strong bones, thick ligaments, powerful muscles and a highly effective alarm system (your nervous system). This alarm system can trigger pain that is so unpleasant that you cannot possibly think of, let alone do, anything other than seek care or avoid movement.

    The messy truth is that when pain persists, the pain system becomes more sensitive, so a widening array of things contribute to pain. This pain system hypersensitivity is a result of neuroplasticity – your nervous system is becoming better at making pain.

    Reduce your chance of lasting pain

    Whether or not your pain resolves is not determined by the extent of injury to your back. We don’t know all the factors involved, but we do know there are things that you can do to reduce chronic back pain:

    • understand how pain really works. This will involve intentionally learning about modern pain science and care. It will be difficult but rewarding. It will help you work out what you can do to change your pain
    • reduce your pain system sensitivity. With guidance, patience and persistence, you can learn how to gradually retrain your pain system back towards normal.

    How to reduce your pain sensitivity and learn about pain

    Learning about “how pain works” provides the most sustainable improvements in chronic back pain. Programs that combine pain education with graded brain and body exercises (gradual increases in movement) can reduce pain system sensitivity and help you return to the life you want.

    Physio helps patient use an exercise strap
    Some programs combine education with gradual increases in movement.
    Halfpoint/Shutterstock

    These programs have been in development for years, but high-quality clinical trials are now emerging and it’s good news: they show most people with chronic back pain improve and many completely recover.

    But most clinicians aren’t equipped to deliver these effective programs – good pain education is not taught in most medical and health training degrees. Many patients still receive ineffective and often risky and expensive treatments, or keep seeking temporary pain relief, hoping for a cure.

    When health professionals don’t have adequate pain education training, they can deliver bad pain education, which leaves patients feeling like they’ve just been told it’s all in their head.

    Community-driven not-for-profit organisations such as Pain Revolution are training health professionals to be good pain educators and raising awareness among the general public about the modern science of pain and the best treatments. Pain Revolution has partnered with dozens of health services and community agencies to train more than 80 local pain educators and supported them to bring greater understanding and improved care to their colleagues and community.

    But a broader system-wide approach, with government, industry and philanthropic support, is needed to expand these programs and fund good pain education. To solve the massive problem of chronic back pain, effective interventions need to be part of standard care, not as a last resort after years of increasing pain, suffering and disability.The Conversation

    Sarah Wallwork, Post-doctoral Researcher, University of South Australia and Lorimer Moseley, Professor of Clinical Neurosciences and Foundation Chair in Physiotherapy, University of South Australia

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • How Regularity Of Sleep Can Be Even More Important Than Duration

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    A recent, large (n=72,269) 8-year prospective* observational study of adults aged 40-79 has found an association between irregular sleep and major cardiovascular events.

    *this means they started the study at a given point, and measured what happened for the next eight years—as opposed to a retrospective study, which would look at what had happened during the previous 8 years.

    As to what qualifies as major cardiovascular events, they counted:

    • Heart attack
    • Cardiac arrest
    • Stroke
    • Cardiovascular death (any)

    Irregular sleep, meanwhile, was defined per a bell curve of participants. Based on a sleep regularity index (SRI) score, those with a score of 87 or more were on the “regular” side of the curve, and those with a score of 72 or lower were on the “irregular” side of the curve.

    What they found is that irregular sleep is associated with major cardiovascular events, regardless of the actual amount of sleep that people got. So in other words, you could be sleeping 9 hours per day, but if it’s a different 9 hours each day, your cardiovascular risk will still be higher.

    How much higher?

    • For those in the middle of the curve (so, moderate irregularity), it was 8% higher than those on the “regular” side.
    • For those on the “irregular” side of the curve, it was 26% higher than those on the “regular” side.

    All of the above is after taking into account confounding variables such as age, physical activity levels, discretionary screen time, fruit, vegetable, and coffee intake, alcohol consumption, smoking, mental health issues, medication use, and shift work. Which is quite something, given that shift work is a very common reason for irregular sleep schedules in a lot of people.

    Limitations

    While, as noted above, they did their best to account for a lot of things, this was an observational study, not an interventional study or a randomized controlled trial, and as such, it cannot truly establish cause and effect.

    For example, an observational study in the 90s found that the sport most strongly associated with longevity was polo. For any unfamiliar, it’s a game played on horseback with mallets and balls. Why was this game so much better than, say, swimming? And the answer is most likely that polo is played almost entirely by very rich people. It wasn’t the sport that enhanced longevity—it was the wealth.

    So similarly here, it could be for example that people who are predisposed to heart conditions, are prone to having irregular schedules. We won’t know for sure until we have interventional studies (and we probably can’t get RCTs for this, for practical reasons).

    Still, it seems likely that the association is indeed causal, in which case, having a regular sleep schedule if at all possible seems like a very good way to look after one’s health.

    You can read more about the study here:

    Irregular sleep may elevate risk of major cardiovascular events

    Practical take-away

    This study strongly suggests that sleep regularity is even more important than sleep duration.

    This means that there is extra reason to not sleep in past one’s normal getting-up time, even if one had a less restful night.

    That’s the end of sleep that’s the most important in practical terms, too, because we can control our getting-up time, whereas we can’t really control our going-to-sleep time, because it’s perfectly possible to just lie there awake.

    So, controlling the getting-up time is really the key to the whole thing. See also:

    Calculate (And Enjoy) The Perfect Night’s Sleep

    And for scope, you might enjoy reading:

    Morning Larks vs Night Owls: How Much Can We Control Our Sleep Schedule?

    Enjoy!

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  • News of a ‘giant’ baby boy is all over TikTok. Here’s what women really need to know

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    Baby boy Cassian is an internet sensation. He was born earlier this year in the United States weighing 5.8 kilograms. But after his mum and the hospital shared the news recently, it wasn’t long before headlines about the “giant” baby spread around the world. These included:

    ‘Are you OK’?: Woman breaks record with giant newborn baby

    Record-breaking baby tips the scales at almost double the average size of a newborn

    While baby Cassian was born heavier than average, he’s not unique. There have been other examples in the news of babies born heavier. That includes a baby boy born in Brazil in 2023 who weighed 7.3kg.

    These stories might make women all over the world cross their legs. But how common are big babies, and does their birth always lead to complications?

    What are big babies?

    Macrosomia describes babies born over 4kg or 4.5kg, depending on the definition.

    A big baby can also be defined as having a birth weight over the 90th percentile at a particular gestational age. In other words, more than 90% of babies have a lower birth weight at this particular stage of the pregnancy. The term “large for gestational age” is probably a more accurate term as the weeks of gestation is used alongside the weight.

    There has been little change overall in the percentage of large babies in the past decade in Australia. While stories of such births hit the media, their proportion hovers around 9–10% of births.

    What are the problems for big babies and their mums?

    We don’t know the specific circumstances of Cassian’s birth, his health or that of his mother. And we don’t know whether common reasons for larger babies are relevant in this situation.

    But, generally speaking, birth complications can be higher for mothers and babies when the baby is big, especially if more than 4.5kg. This is certainly not always the case, however.

    There is an increased need for interventions during the birth, such as forceps or vacuum delivery, or a caesarean section the bigger the baby is. Having these interventions can impact a women’s recovery after the birth, and options for the next birth.

    For the baby there are higher risks of the shoulders getting stuck in the birth canal during the birth (known as shoulder dystocia).

    Midwives and obstetricians also may need to make extra manoeuvres for the baby to be safely delivered. For instance, they may need to try and bring down one shoulder if it’s stuck behind the mother’s pubic bone.

    These manoeuvres can damage the baby or lead to oxygen restrictions, with the baby needing to be resuscitated. However, these complications are rare and can occur when a big baby was not expected.

    What leads to a big baby?

    Big babies are most often healthy babies, and there are a number of reasons for them.

    Genetic factors mean babies are always big in some families.

    Babies that go over their due dates tend to be a bit bigger as they have more time to grow inside their mothers.

    Having diabetes, especially if this is poorly controlled, can lead to larger babies. This is because the mother’s higher blood sugar leads to the baby receiving more energy than it needs, so it stores this extra energy as fat.

    Babies of mothers with diabetes diagnosed for the first time in pregnancy (gestational diabetes) are at increased risk of being obese and developing diabetes in the future.

    Mothers who are larger before pregnancy, or when pregnant, may also be more likely to have big babies. This is mostly due to the increased likelihood of developing diabetes in pregnancy, and perhaps poorer nutrition choices.

    Can you predict a big baby?

    Estimations of babies’ weights before they are born are imprecise. That’s why so many women are told they are going to have a big baby and don’t, and others are surprised by a big baby when it arrives.

    Midwives and obstetricians routinely feel a woman’s growing uterus when they provide antenatal check-ups. They are looking at the position the baby is lying in the uterus as well as where the top of the uterus is compared to the woman’s belly button. This gives an idea of whether the baby is growing as you would expect at that time.

    They also measure from the top of a woman’s belly to the top of her pubic bone with a tape measure. The weeks of pregnancy usually correspond to the measurement within a couple of centimetres.

    For example, at 36 weeks of pregnancy the tape measurement would be somewhere between 34cm and 38cm. If there is more or less than a 3cm difference between the measurement and the numbers of weeks of pregnancy then an ultrasound would be offered to look at how the baby’s growing and to estimate the size.

    But ultrasounds are poor predictors of actual birth weight. The Big Baby Trial was published earlier this year. It randomised nearly 3,000 women in the United Kingdom to being induced at 39 weeks if suspected to be having a big baby (according to an ultrasound) or waiting for labour to start.

    There was little difference in birth weight or poor outcomes, such as shoulder dystocia for the baby, leading to the trial being stopped early. Around 60% of babies screened as being big babies were not actually big at birth, showing the inaccuracy of ultrasounds in predicting birth weight.

    What can women do?

    The best health advice for women is to try to be a healthy weight (under a BMI of 30) before getting pregnant.

    Eat a balanced diet and limit your intake of foods and drinks high in saturated fats and sugar. Try not to put too much weight on during pregnancy and exercise regularly. Talk to your midwife or obstetrician for advice and support about this.

    If you have diabetes, or if this has been diagnosed during the pregnancy, close monitoring of your blood sugar and baby’s growth is important.

    Hannah Dahlen, Professor of Midwifery, Associate Dean Research and HDR, Midwifery Discipline Leader, Western Sydney University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • How To Stop Ingrown Hair & Razor Bumps From Waxing & Shaving

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    Dr. Simi Adedeji shares her expertise:

    Staying smooth

    Ingrown hairs (pseudofolliculitis) are inflamed hair follicles caused by hairs growing back into the skin—common in coarse, curly hair areas such as the underarms, pubic region, legs, and face.

    It can be caused by shaving, waxing, plucking, tweezing, and more—in fact, almost anything aside from “trim it or leave it be”. This is because most methods cause irritation by cutting or pulling hair in ways that make it more likely to re-enter the skin.

    Normally, it’s just a case of rash or itchy red bumps appearing a few days after hair removal. However, it can also get more pronounced, in cases of bacterial infection (true folliculitis), hyperpigmentation, or scarring (keloid or hypertrophic).

    There are two main kinds of ingrown hair to be aware of:

    1. extra-follicular penetration: occurs after shaving—sharply cut hairs re-enter the skin beside the follicle, causing inflammation.
    2. trans-follicular penetration: occurs after plucking, waxing, or tweezing—trapped hair grows through the follicle wall into the skin, creating lumps.

    Treatment options include:

    • Hydrocortisone: reduces inflammation and redness.
    • Benzoyl peroxide: antibacterial effect for inflamed areas.
    • Chemical exfoliants: help stop hair from getting trapped

    How to stop it from happening in the future:

    • First, reset things and let it all calm down—stop shaving, waxing, or plucking for about a month—when hairs grow 10 mm or more, irritation usually resolves.
    • Next, consider alternatives, such as depilatory creams, which dissolve hair, leaving a blunt or feathered tip that can still ingrow, but is less likely to than the other methods we talked about above. However, this comes with the tradeoff that the cream itself may irritate the skin.
    • Then, consider long-term hair removal methods, such as laser or IPL, if you have dark hair on light skin—this is because laser/IPL superheats melanin in the hair to destroy the follicle, which means it won’t work on light hair (no melanin to superheat), and can harm dark skin (superheats the wrong melanin)—or electrolysis otherwise, which doesn’t depend on pigment. Removing the hair permanently means stopping ingrown hairs permanently, because a hair can’t ingrow if it’s not growing back at all.

    If you are going to shave or wax, though, then:

    • Shaving tips: shave after a warm bath or shower (or pre-soak the area with a warm towel); use shaving cream or a gentle cleanser for slip; avoid stretching your skin; use a bland, fragrance-free moisturizer afterwards; wait 3–4 days before applying glycolic acid.
    • Waxing tips: wax before showering and avoid moisturizers beforehand; taking acetaminophen and antihistamines 30–45 minutes before can reduce pain and inflammation, respectively. Ibuprofen will also reduce both things (pain and inflammation).

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Skin Care Down There (Incl. Butt Acne, Hyperpigmentation, & More)

    Take care!

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  • How To Stay Alive (When You Really Don’t Want To)

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    How To Stay Alive (When You Really Don’t Want To)

    A subscriber recently requested:

    ❝Request: more people need to be aware of suicidal tendencies and what they can do to ward them off❞

    …and we said we’d do that one of these Psychology Sundays, so here we are, doing it!

    First of all, we’ll mention that we did previously do a main feature on managing depression (in oneself or a loved one); here it is:

    The Mental Health First Aid That You’ll Hopefully Never Need

    Now, not all depression leads to suicidality, and not all suicide is pre-empted by depression, but there’s a large enough crossover that it seems sensible to put that article here, for anyone who might find it of use, or even just of interest.

    Now, onwards, to the specific, and very important, topic of suicide.

    This should go without saying, but some of today’s content may be a little heavy.

    We invite you to read it anyway if you’re able, because it’s important stuff that we all should know, and not talking about it is part of what allows it to kill people.

    So, let’s take a deep breath, and read on…

    The risk factors

    Top risk factors for suicide include:

    • Not talking about it
    • Having access to a firearm
    • Having a plan of specifically how to commit suicide
    • A lack of social support
    • Being over 40

    Now, some of these are interesting sociologically, but aren’t very useful practically; what a convenient world it’d be if we could all simply choose to be under 40, for instance.

    Some serve as alarm bells, such as “having a plan of specifically how to commit suicide”.

    If someone has a plan, that plan’s never going to disappear entirely, even if it’s set aside!

    (this writer is deeply aware of the specifics of how she has wanted to end things before, and has used the advice she gives in this article herself numerous times. So far so good, still alive to write about it!)

    Specific advices, therefore, include:

    Talk about it / Listen

    Depending on whether it’s you or someone else at risk:

    • Talk about it, if it’s you
    • Listen attentively, if it’s someone else

    There are two main objections that you might have at this point, so let’s look at those:

    “I have nobody to talk to”—it can certainly feel that way, sometimes, but you may be surprised who would listen if you gave them the chance. If you really can’t trust anyone around you, there are of course suicide hotlines (usually per area, so we’ll not try to list them here; a quick Internet search will get you what you need).

    If you’re worried it’ll result in bad legal/social consequences, check their confidentiality policy first:

    • Some hotlines can and will call the police, for instance.
    • Others deliberately have a set-up whereby they couldn’t even trace the call if they wanted to.
      • On the one hand, that means they can’t intervene
      • On the other hand, that means they’re a resource for anyone who will only trust a listener who can’t intervene.

    “But it is just a cry for help”—then that person deserves help. What some may call “attention-seeking” is, in effect, care-seeking. Listen, without judgement.

    Remove access to firearms, if applicable and possible

    Ideally, get rid of them (safely and responsibly, please).

    If you can’t bring yourself to do that, make them as inconvenient to get at as possible. Stored securely at your local gun club is better than at home, for example.

    If your/their plan isn’t firearm-related, but the thing in question can be similarly removed, remove it. You/they do not need that stockpile of pills, for instance.

    And of course you/they could get more, but the point is to make it less frictionless. The more necessary stopping points between thinking “I should just kill myself” and being able to actually do it, the better.

    Have/give social support

    What do the following people have in common?

    • A bullied teenager
    • A divorced 40-something who just lost a job
    • A lonely 70-something with no surviving family, and friends that are hard to visit

    Often, at least, the answer is: the absence of a good social support network

    So, it’s good to get one, and be part of some sort of community that’s meaningful to us. That could look different to a lot of people, for example:

    • A church, or other religious community, if we be religious
    • The LGBT+ community, or even just a part of it, if that fits for us
    • Any mutual-support oriented, we-have-this-shared-experience community, could be anything from AA to the VA.

    Some bonus ideas…

    If you can’t live for love, living for spite might suffice. Outlive your enemies; don’t give them the satisfaction.

    If you’re going to do it anyway, you might as well take the time to do some “bucket list” items first. After all, what do you have to lose? Feel free to add further bucket list items as they occur to you, of course. Because, why not? Before you know it, you’ve postponed your way into a rich and fulfilling life.

    Finally, some gems from Matt Haig’s “The Comfort Book”:
    • “The hardest question I have been asked is: “How do I stay alive for other people if I have no one?” The answer is that you stay alive for other versions of you. For the people you will meet, yes, but also the people you will be.”
    • “Stay for the person you will become”
    • “You are more than a bad day, or week, or month, or year, or even decade”
    • “It is better to let people down than to blow yourself up”
    • “Nothing is stronger than a small hope that doesn’t give up”
    • “You are here. And that is enough.”

    You can find Matt Haig’s excellent “The Comfort Book” on Amazon, as well as his more well-known book more specifically on the topic we’ve covered today, “Reasons To Stay Alive“.

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  • How Does Anesthesia Work?

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    What do we know, and what mysteries remain?

    Lights-out

    Anesthesia doesn’t simply make you “sleep”—it creates a controlled state combining unconsciousness, immobility, memory loss, and pain prevention so surgery can happen without psychological trauma, or more physical trauma than necessary.

    • Local anesthesia: local (or “regional”) anesthetics block pain from a specific body area by preventing electrical impulses in nerves from reaching your brain, usually by locking ion channels in neuron membranes; cocaine was one of the first discovered examples, though safer (albeit often related!) drugs are now more common.
    • General anesthesia: major surgery usually merits whole-body anesthesia, often (but not always) using inhaled agents like ether, nitrous oxide, or modern sevoflurane, often (but not always) combined with intravenous drugs such as propofol for unconsciousness and (for example) fentanyl for pain relief*.

    Yes, pain relief is important even when you’re not conscious and can’t feel it, because the nerves themselves are still active, and thus without simultaneous pain relief, even if you are unconscious and thus not suffering in the slightest, your body will internally respond as though you are, meaning for example that your heartrate will skyrocket, and you’ll be dumping adrenaline and cortisol like there’s no tomorrow (because so far as your body has reason to believe, there will indeed be no tomorrow unless we wake up and deal with whatever vicious animal is tearing us apart).

    How anesthetics work: many anesthetics disrupt communication between different brain regions (we mostly don’t know how), reducing the chaotic connectivity associated with wakefulness (again, we mostly don’t know how), and/but with at least part of it being how they act on receptors like GABA-A to increase inhibitory signals and suppress neural activity—which, to be clear, we are almost certain plays an important role; it’s just not sufficient to explain the full effect by itself.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Calm For Surgery – by Dr Chris Bonney

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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