Too much vitamin B6 can be toxic. 3 symptoms to watch outĀ for

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Side effects from taking too much vitamin B6 – including nerve damage – may be more widespread than we think, Australia’s medicines regulator says.

In an ABC report earlier this week, a spokesperson for the Therapeutic Goods Administration (TGA) says it may have underestimated the extent of the side effects from vitamin B6 supplements.

However, there are proposals to limit sales of high-dose versions due to safety concerns.

A pathologist who runs a clinic that tests vitamin B6 in blood samples from across Australia also appeared on the program. He told the ABC that data from May suggests 4.5% of samples tested had returned results ā€œvery likelyā€ indicating nerve damage.

Selena3726/Shutterstock

What is vitamin B6?

Vitamin B6, also known as pyridoxine, plays an important role in keeping the body healthy. It is involved in the metabolism of proteins, carbohydrates and fats in food. It is also important for the production of neurotransmitters – chemical messengers in the brain that maintain its function and regulate your mood.

Vitamin B6 also supports the immune system by helping to make antibodies, which fight off infections. And it is needed to produce haemoglobin, the protein in red blood cells that carries oxygen around the body.

Some women take a vitamin B6 supplement when pregnant. It is thought this helps reduce the nausea associated with the early stages of pregnancy. Some women also take it to help with premenstrual syndrome.

However, most people don’t need, and won’t benefit from, a vitamin B6 supplement. That’s because you get enough vitamin B6 from your diet through meat, breakfast cereal, fruit and vegetables.

You don’t need much. A dose of 1.3–1.7 milligrams a day is enough for most adults.

Currently, vitamin B6 supplements with a daily dose of 5–200mg can be sold over the counter at health food stores, supermarkets and pharmacies.

Because of safety concerns, the TGA is proposing limiting their sale to pharmacies, and only after consultation with a pharmacist.

Daily doses higher than 200mg already need a doctor’s prescription. So under the proposal that would stay the same.

What happens if you take too much?

If you take too much vitamin B6, in most cases the excess will be excreted in your urine and most people won’t experience side effects. But there is a growing concern about long-time, high-dose use.

A side effect the medical community is worried about is peripheral neuropathy – where there is damage to the nerves outside the brain and spinal cord. This results in pain, numbness or weakness, usually in your hands and feet. We don’t yet know exactly how this happens.

In most reported cases, these symptoms disappear once you stop taking the supplement. But for some people it may take three months to two years before they feel completely better.

There is growing, but sometimes contradictory, evidence that high doses (more than 50mg a day) for extended periods can result in serious side effects.

A study from the 1990s followed 70 patients for five years who took a dose of 100 to 150mg a day. There were no reported cases of neuropathy.

But more recent studies show high rates of side effects.

A 2023 case report provides details of a man who was taking multiple supplements. This resulted in a daily combined 95mg dose of vitamin B6, and he experienced neuropathy.

Another report describes seven cases of neuropathy linked to drinking energy drinks containing vitamin B6.

Reports to the TGA’s database of adverse events notifications (a record of reported side effects) shows 174 cases of neuropathy linked with vitamin B6 use since 2023.

What should I do if I take vitamin B6?

The current advice is that someone who takes a dose of 50mg a day or more, for more than six months, should be monitored by a health-care professional. So if you regularly take vitamin B6 supplements you should discuss continued use with your doctor or pharmacist.

There are three side effects to watch out for, the first two related to neuropathy:

  1. numbness or pain in the feet and hands
  2. difficulty with balance and coordination as a result of muscle weakness
  3. heartburn and nausea.

If you have worrying side effects after taking vitamin B6 supplements, contact your state’s poison information centre on 13 11 26 for advice.

Nial Wheate, Professor, School of Natural Sciences, Macquarie University and Slade Matthews, Senior Lecturer, Toxicology, University of Sydney

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Olive oil is healthy. Turns out olive leaf extract may be good for usĀ too

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    Olive oil is synonymous with the Mediterranean diet, and the health benefits of both are well documented.

    Olive oil reduces the risk of heart disease, cancer, diabetes and premature death. Olives also contain numerous healthy nutrients.

    Now evidence is mounting about the health benefits of olive leaves, including from studies in a recent review.

    Here’s what’s in olive leaves and who might benefit from taking olive leaf extract.

    mtphoto19/Shutterstock

    What’s in olive leaves?

    Olive leaves have traditionally been brewed as a tea in the Mediterranean and drunk to treat fever and malaria.

    The leaves contain high levels of a type of antioxidant called oleuropein. Olives and olive oil contain this too, but at lower levels.

    Generally, the greener the leaf (the less yellowish) the more oleuropein it contains. Leaves picked in spring also have higher levels compared to ones picked in autumn, indicating levels of oleuropein reduce as the leaves get older.

    Olive leaves also contain other antioxidants such as hydroxytyrosol, luteolin, apigenin and verbascoside.

    Antioxidants work by reducing the oxidative stress in the body. Oxidative stress causes damage to our DNA, cell membranes and tissues, which can lead to chronic diseases such as cancer and heart disease.

    Are olive leaves healthy?

    One review and analysis combined data from 12 experimental studies with 819 participants in total. Overall, olive leaf extract improved risk factors for heart disease. This included healthier blood lipids (fats) and lowering blood pressure.

    The effect was greater for people who already had high blood pressure.

    Most studies in this review gave olive leaf extract as a capsule, with daily doses of 500 milligrams to 5 grams for six to 48 weeks.

    Another review and analysis published late last year looked at data from 12 experimental studies, with a total of 703 people. Some of these studies involved people with high blood lipids, people with high blood pressure, people who were overweight or obese, and some involved healthy people.

    Daily doses were 250-1,000mg taken as tablets or baked into bread.

    Individual studies in the review showed significant benefits in improving blood glucose (sugar) control, blood lipid levels and reducing blood pressure. But when all the data was combined, there were no significant health effects. We’ll explain why this may be the case shortly.

    Olive leaf tea in glass cup on counter, olive leaves in front of cup
    Olive leaves can be brewed into tea. Picture Partners/Shutterstock

    Another review looked at people who took oleuropein and hydroxytyrosol (the antioxidants in olive leaves). This found significant improvement in body weight, blood lipid profiles, glucose metabolism and improvements in bones, joints and cognitive function.

    The individual studies included tested either the two antioxidants or olive leaf incorporated into foods such as bread and cooking oils (but not olive oil). The doses were 6-500mg per day of olive leaf extract.

    So what can we make of these studies overall? They show olive leaf extract may help reduce blood pressure, improve blood lipids and help our bodies handle glucose.

    But these studies show inconsistent results. This is likely due to differences in the way people took olive leaf extract, how much they took and how long for. This type of inconsistency normally tells us we need some more research to clarify the health effects of olive leaves.

    Can you eat olive leaves?

    Olive leaves can be brewed into a tea, or the leaves added to salads. Others report grinding olive leaves into smoothies.

    However the leaves are bitter, because of the antioxidants, which can make them hard to eat, or the tea unpalatable.

    Olive leaf extract has also been added to bread and other baked goods. Researchers find this improves the level of antioxidants in these products and people say the foods tasted better.

    Sprig of olive leaves
    Olive leaves can taste bitter, which can put people off. But you can bake the extract into bread. Repina Valeriya/Shutterstock

    Is olive leaf extract toxic?

    No, there seem to be no reported toxic effects of eating or drinking olive leaf extract.

    It appears safe up to 1g a day, according to studies that have used olive leaf extract. However, there are no official guidelines about how much is safe to consume.

    There have been reports of potential toxicity if taken over 85mg/kg of body weight per day. For an 80kg adult, this would mean 6.8g a day, well above the dose used in the studies mentioned in this article.

    Pregnant and breastfeeding women are recommended not to consume it as we don’t know if it’s safe for them.

    What should I do?

    If you have high blood pressure, diabetes or raised blood lipids you may see some benefit from taking olive leaf extract. But it is important you discuss this with your doctor first and not change any medications or start taking olive leaf extract until you have spoken to them.

    But there are plenty of antioxidants in all plant foods, and you should try to eat a wide variety of different coloured plant foods. This will allow you to get a range of nutrients and antioxidants.

    Olive leaf and its extract is not going to be a panacea for your health if you’re not eating a healthy diet and following other health advice.

    Evangeline Mantzioris, Program Director of Nutrition and Food Sciences, Accredited Practising Dietitian, University of South Australia

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Genital herpes is on the rise. Here’s what to know about this commonĀ infection

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    The World Health Organization (WHO) recently released new estimates suggesting around 846 million people aged between 15 and 49 live with a genital herpes infection.

    That’s equivalent to one in every five people from that age group.

    At least one person each second (42 million people annually) contracts a new genital herpes infection.

    So what is genital herpes, and are cases on the rise? Here’s what to know about this common infection.

    Peakstock/Shutterstock

    First, what causes genital herpes?

    Genital herpes is a sexually transmitted infection (STI) caused by the herpes simplex virus, which also causes cold sores.

    There are two types of herpes simplex virus, HSV-1 and HSV-2 (and it’s possible to be infected by both at the same time).

    HSV-1 most commonly spreads through oral contact such as kissing or sharing infected objects such as lip balm, cups or utensils, and presents as cold sores (or oral herpes) around the mouth. But it can also be sexually transmitted to cause a genital herpes infection.

    An estimated 3.8 billion people under the age of 50 (64%) globally have HSV-1.

    HSV-2 is less prevalent, but almost always causes a genital herpes infection. Some 520 million people aged 15–49 (13%) worldwide are believed to have HSV-2.

    The initial episode of genital herpes can be quite painful, with blisters, ulcers and peeling skin around the genitals over 7–10 days.

    Not all people have severe (or any) initial symptoms. This means a person might not know they have been infected with a herpes virus.

    Herpes is a lifelong infection, which means once you contract the virus, you have it forever. After an initial episode, subsequent episodes can occur, but are usually less painful or even symptom free.

    Both oral and genital herpes are particularly easy to spread when you have active lesions (cold sores or genital ulcers). But even with no symptoms, herpes can still be spread to a partner.

    And although relatively rare, oral herpes can be transmitted to the genital area, and genital herpes can be transmitted to the mouth through oral sex.

    If an expectant mother exhibits a genital herpes infection close to childbirth, there are risks to the baby. A herpes infection can be very serious in a baby, and the younger the infant, the more vulnerable they are. This is also one reason why you should avoid kissing a baby on the mouth.

    Changing trends

    WHO’s recent figures brought together data from around the world to estimate the prevalence of genital herpes in 2020, compared with previous estimates in 2012 and 2016.

    This data shows no significant difference in the prevalence of genital herpes caused by HSV-2 since 2016, but does highlight increases in genital herpes infections caused by HSV-1.

    The estimated number of genital HSV-1 infections globally was nearly twice as high in 2020 compared with 2016 (376 million compared with 192 million).

    A 2022 study looking at Australia, New Zealand and Canada found more than 60% of genital herpes infections are still caused by HSV-2. But this is declining by about 2% each year while new genital infections that result from HSV-1 are rising.

    A woman holding her crotch area.
    Genital herpes can be quite painful, presenting as sores and lesions that in severe cases, may take up to a month to fully heal. Christian Moro

    There’s no simple fix, but safe sex is important

    Genital herpes causes a substantial disease burden and economic cost to health-care services.

    With such a large proportion of the world’s population infected with HSV-1, evidence this virus is increasingly causing genital herpes is concerning.

    There’s no cure for genital herpes, but some medications, such as antivirals, can help reduce the amount of virus present in the system. While this won’t kill it completely, it helps to prevent symptomatic genital herpes recurrences, improve quality of life, and minimise the risk of transmission.

    To prevent the spread of genital herpes and other STIs, practise safe sex, particularly if you’re not sure of your partner’s sexual health. You need to use a barrier method such as condoms to protect against STIs (a contraceptive such as the pill won’t work). This includes during oral sex.

    As herpes is now so common, testing is not usually included as part of a regular sexual health check-up, except for in specific circumstances such as during pregnancy or severe episodes.

    So it’s wise not to let your guard down, even if your partner insists they have received the all-clear from a recent check-up.

    If there are herpes lesions present around the genitals, avoid sex entirely. Even condoms are not fully effective at these times, as exposed areas can still transmit the infection.

    A woman happily embracing a man.
    Practising safe sex can help prevent the spread of herpes. cottonbro studio/Pexels

    Immune health

    If you are infected with HSV-1 or HSV-2 it’s more likely symptoms will appear when you’re stressed, tired or overwhelmed. During these times, our immune system may not be as functional, and dormant viruses such as herpes can start to develop quickly in our bodies.

    To reduce the risk of recurrent herpes infections, try to eat healthily, get at least seven hours of sleep each night if possible, and look out for when your body may be telling you to take a step back and relax. This self-care can go a long way towards keeping latent viruses at bay.

    While the prevalence has increased significantly in recent years, we have not lost the war on genital herpes just yet. Safe sexual practices, education and awareness can help reduce its spread, and the stigma around it.

    If you have personal concerns, you should discuss them with a medical professional.

    Christian Moro, Associate Professor of Science & Medicine, Bond University and Charlotte Phelps, Senior Teaching Fellow in Medicine, Bond University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Retirement Can Be A Time Of Great Health! If…

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    Will Harlow, the over-50s specialist physio, observes and advises:

    Move with care, but do move

    Avoid these three common mistakes:

    Mistake 1: Stopping strength-building movements. Many retirees become less active, losing daily movement that used to maintain strength without them thinking about it. This naturally leads to muscle loss (the body will generally not maintain what’s not being used), reduced mobility, increased fall risk, chronic pain (often with arthritis, which in turn came with the reduced mobility), and the like. So instead, do 2–3 short strength-training sessions each week.

    Mistake 2: Ignoring small aches and pains. It’s common to dismiss pain as “just age,” but it’s better to take things seriously and deal with them as they arise, and/or best yet, proactively. Many aches can improve with targeted mobility exercises, done gently and consistently.

    Mistake 3: Not pushing yourself enough. Being overly cautious, on the other hand, can lead to deterioration. Safe doesn’t necessarily mean easy—a little discomfort or fatigue during exercise is often necessary for results. A good way of pushing yourself without overexerting yourself is to use “reps in reserve” to gauge intensity: stop with 2–3 reps left “in the tank”. For cardio, aim to be slightly breathless but not overly strained.

    For more on each of these plus some recommended exercises, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Beyond Stretching: Four Habits That Drastically Improve Mobility

    Take care!

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  • Acorns vs Chestnuts – Which is Healthier?

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    Our Verdict

    When comparing acorns to chestnuts, we picked the acorns.

    Why?

    In terms of macros, chestnuts are mostly water, so it’s not surprising that acorns have a lot more carbs, fat, protein, and fiber. Thus, unless you have personal reasons for any of those to be a problem, acorns are the better choice, offering a lot more nutritional value.

    In the category of vitamins, acorns lead with a lot more of vitamins A, B2, B3, B5, B6, and B9, while chestnuts have more of vitamins B1 and C. However, that vitamin C is useless to us, because it is destroyed in the cooking process (by boiling or roasting), and both of these nuts can be harmful if consumed raw, so that cooking does need to be done. That leaves acorns with a 6:1 lead.

    When it comes to minerals, things are more even; acorns have more copper, magnesium, manganese, and zinc, while chestnuts have more calcium, iron, phosphorus, and potassium. Thus, a 4:4 tie (and yes, the margins of difference are approximately equal too).

    We mentioned “both of these nuts can be harmful if consumed raw”, so a note on that: it’s because, while both contain an assortment of beneficial phytochemicals, they also both contain tannins that, if consumed raw, chelate with iron, essentially taking it out of our diet and potentially creating an iron deficiency. Cooking tannins stops this from being an issue, and the same cooking process renders the tannins actively beneficial to the health, for their antioxidant powers.

    You may have heard that acorns are poisonous; that’s not strictly speaking true, except insofar as anything could be deemed poisonous in excess (including such things as water, and oxygen). Rather, it’s simply the above-described matter of the uncooked tannins and iron chelation. Even then, you’re unlikely to suffer ill effects unless you consume them raw in a fair quantity. While acorns have fallen from popular favor sufficient that one doesn’t see them in supermarkets, the fact is they’ve been enjoyed as an important traditional part of the diet by various indigenous peoples of N. America for centuries*, and provided they are cooked first, they are a good healthy food for most people.

    *(going so far as to cultivate natural oak savannah areas, by burning out young oaks to leave the old ones to flourish without competition, to maximize acorn production, and then store dried acorns in bulk sufficient to cover the next year or so in case of a bad harvest later—so these was not just an incidental food, but very important “our life may depend on this” food. Much like grain in many places—and yes, acorns can be ground into flour and used to make bread etc too)

    Do note: they are both still tree nuts though, so if you have a tree nut allergy, these ones aren’t for you.

    Otherwise, enjoy both; just cook them first!

    Want to learn more?

    You might like to read:

    Why You Should Diversify Your Nuts

    Take care!

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  • Calcium + Vitamin D: ā€œLittle To No Useā€ vs Fractures?

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    We’ve written before about supplementation of calcium and vitamin D, for example:

    Vit D + Calcium: Too Much Of A Good Thing? ← this also talks about safe and effective doses, and what goes wrong if you take too much

    And even if you get the dosage right, there are still more ways to mess it up! See: How Taking Vitamin D Supplements Can Sabotage Your Vitamin D Levels

    Which latter is mostly because of people making mistakes in the category of: Vitamin D2 vs Vitamin D3: What You Would Benefit From Knowing

    But we still should supplement to keep our bones healthy, right?

    Per the title of this one (the main title, at the top, with the words “little to not use” in it), no, it’s probably not that helpful, really. To be clear, getting plenty of these things one way or another is important; diet is the best means of doing it (more on this later in the “learn more” section), and if anything, it’s possible those who supplement in order to “be on the safe side” and “cover all bases” may:

    1. fall into the sabotage trap we talked about up top
    2. fall into complacency by not including enough dietary sources “because the supplements will cover it”

    Recently, researchers (Dr. Katherine Desforges et al.) did a very large (n=153,902 over the course of 69 randomized controlled trials) systematic review and meta-analysis and found that calcium supplements, vitamin D supplements, or the combination of both provided little to no clinically meaningful reduction in fractures for most adults studied, and even the absolute reduction in fracture risk was too small to be considered clinically meaningful.

    That’s absolute risk reduction for fractures in general; calcium, vitamin D, and/or combined supplementation also showed little to no benefit for:

    • Total number of falls
    • Hip fractures
    • Vertebral fractures
    • Non-vertebral fractures
    • Risk of falling*

    *This may seem like an odd one to include, but it is relevant too, for example: The Common Meds That Make You More Likely To Die From A fall

    You may be wondering how applicable these numbers are to you, and who the sample population was. Most participants were:

    • Not considered at high risk for fractures or falls (73%)
    • Living independently in the community (87%)

    The findings therefore apply mainly to typical independently-living adults, especially older adults without severe osteoporosis or other major bone disorders. Evidence was more limited for:

    • Individuals with specific metabolic bone diseases
    • People at very high fracture risk
    • Residents of nursing homes or long-term care facilities
    • People already receiving osteoporosis medications

    For the longest time, calcium and vitamin D supplementation has been routinely recommended for bone health. This review shakes that all up, and strongly suggests that for the average adult, these supplements are unlikely to meaningfully prevent fractures or falls.

    You can read the paper itself, here: Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis

    As for what to do instead, you might consider checking out:

    Want to learn more?

    There is also a common issue that a lot of people get enough calcium and vitamin D, but then a lot of that calcium doesn’t make it past the arteries.

    Thus, the calcium paradox: we want to get (usually: more) calcium, but we want it building our bones, not lining our arteries. How, then, to resolve this problem, and simultaneously fight the dual threats of calcium deficiency (osteoporosis) and calcium excess (atherosclerosis)?

    The answer lies in vitamin K2, which assists the calcium in getting to where you need it, rather than having it accumulating where you don’t.

    Learn more: Vitamin K2 And The Calcium Paradox

    And as for why you might want to favor getting it from food if you can, then while the title says ā€œvitaminsā€, this book discusses an assortment of vitamins, minerals, and other nutrients; the ā€œother nutrientsā€ category including amino acids (branched chain and essential), prebiotics and probiotics, and triglycerides of various kinds:

    Eat Your Vitamins – by Mascha Davis, RDN ← see our review, here

    Take care!

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  • 5 Tips For Muscle Growth As A Woman

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    Building muscle improves your body composition, as you’ll be leaner even at a higher weight. It supports insulin sensitivity, boosts metabolic health, and helps break through weight loss plateaus while improving overall performance and hormone balance. In short, it’s a very healthful thing to do.

    But there are ways people can err, so here’s how to do it best:

    Mistakes to avoid

    There are five key things to bear in mind:

    1. Don’t obsess over the scale: your overall bodyweight will probably increase; don’t worry about that; it doesn’t mean you have necessarily put on fat. Indeed, muscle weighs more than fat in any case.
    2. Don’t worry about eating too much: unless you really go out of your way to overeat, eating larger amounts according to your hunger will not result in overeating. Simply, your body needs more fuel in order to build muscle, and that’s fine and is to be expected.
    3. Don’t overdo cardio: it’s easy to think “I must stay trim while putting on muscle” and look to cardio to facilitate that, but the reality is that strength training will boost your metabolism anyway, whereas cardio can sap your energy that was needed for muscle-building (and, famously, can result in a metabolic slump)
    4. Don’t go too easy… or too hard! Lest that seem like a difficult directive to follow, this means: train hard yes, but make sure to get adequate rest also! Both are critical for muscle growth—without hard training, your muscle will have no reason to grow, and without rest, your body will be unable to do more than maintenance at most. So: train hard, rest well.
    5. Don’t eat junk just to hit calorie/macro goals. Quality still matters, even if the numbers are higher than you’d normally be taking.

    For more details on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    How To Build Muscle (Healthily!)

    Take care!

    Don’t Forget…

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