Why You Can’t Skimp On Amino Acids
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Our body requires 20 amino acids (the building blocks of protein), 9 of which it can’t synthesize (thus called: “essential”) and absolutely must get from food. Normally, we get these amino acids from protein in our diet, and we can also supplement them by taking amino acid supplements if we wish.
Specifically, we require (per kg of bodyweight) a daily average of:
- Histidine: 10 mg
- Isoleucine: 20 mg
- Leucine: 39 mg
- Lysine: 30 mg
- Methionine: 10.4 mg
- Phenylalanine*: 25 mg
- Threonine: 15 mg
- Tryptophan: 4 mg
- Valine: 26 mg
*combined with the non-essential amino acid tyrosine
Source: Protein and Amino Acid Requirements In Human Nutrition: WHO Technical Report
Why this matters
A lot of attention is given to protein, and making sure we get enough of it, especially as we get older, because the risk of sarcopenia (muscle mass loss) increases with age:
However, not every protein comes with a complete set of essential amino acids, and/or have only trace amounts of of some amino acids, meaning that a dietary deficiency can arrive if one’s diet is too restrictive.
And, if we become deficient in even just one amino acid, then bad things start to happen quite soon. We only have so much space, so we’re going to oversimplify here, but:
- Histidine: is needed to produce histamine (vital for immune responses, amongst other things), and is also important for maintaining the myelin sheaths on nerve cells.
- Isoleucine: is very involved in muscle metabolism and makes up the bulk of muscle tissue.
- Leucine: is critical for muscle synthesis and repair, as well as wound healing in general, and blood sugar regulation.
- Lysine: is also critical in muscle synthesis, as well as calcium absorption and hormone production, as well as making collagen.
- Methionine: is very important for energy metabolism, zinc absorption, and detoxification.
- Phenylalanine: is a necessary building block of a lot of neurotransmitters, as well as being a building block of some amino acids not listed here (i.e., the ones your body synthesizes, but can’t without phenylalanine).
- Threonine: is mostly about collagen and elastin production, and is also very important for your joints, as well as fat metabolism.
- Tryptophan: is the body’s primary precursor to serotonin, so good luck making the latter without the former.
- Valine: is mostly about muscle growth and regeneration.
So there you see, the ill effects of deficiency can range from “muscle atrophy” to “brain stops working” and “bones fall apart” and more. In short, any essential amino acid deficiency not remedied will ultimately result in death; we literally become non-viable as organisms without these 9 things.
What to do about it (the “life hack” part)
Firstly, if you eat a lot of animal products, those are “complete” proteins, meaning that they contain all 9 essential amino acids in sensible quantities. The reason that all animal products have these, is because they are just as essential for the other animals as they are for us, so they, just like us, must consume (and thus contain) them.
However, a lot of animal products come with other health risks:
Do We Need Animal Products To Be Healthy? ← this covers which animal products are definitely very health-risky, and which are probably fine according to current best science
…so many people may prefer to get more (or possibly all) dietary protein from plants.
However, plants, unlike us, do not need to consume all 9 essential amino acids, and this may or may not contain them all.
Soy is famously a “complete” protein insofar as it has all the amino acids we need.
But what if you’re allergic to soy?
Good news! Peas are also a “complete” protein and will do the job just fine. They’re also usually cheaper.
Final note
An oft-forgotten thing is that some other amino acids are “conditionally essential”, meaning that while we can technically synthesize them, sometimes we can’t synthesize enough and must get them from our diet.
The conditions that trigger this “conditionally essential” status are usually such things as fighting a serious illness, recovering from a serious injury, or pregnancy—basically, things where your body has to work at 110% efficiency if it wants to get through it in one piece, and that extra 10% has to come from somewhere outside the body.
Examples of commonly conditionally essential amino acids are arginine and glycine.
Arginine is critical for a lot of cell-signalling processes as well as mitochondrial function, as well as being a precursor to other amino acids, including creatine.
As for glycine?
Check out: The Sweet Truth About Glycine
Enjoy!
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Chickpeas vs Pinto Beans – Which is Healthier?
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Our Verdict
When comparing chickpeas to pinto beans, we picked the pinto beans.
Why?
Both are great! And an argument could be made for either…
In terms of macros, pinto beans have slightly more fiber and slightly more protein, while chickpeas have slightly more carbs, and thus predictably higher net carbs. In the category of those proteins, they both have a comparable spread of amino acods, with pinto beans having very slightly more of each amino acid. All this adds up to a clear, but moderate, win for pinto beans.
When it comes to vitamins, technically chickpeas have more of vitamins A, B3, B5, C, K, and choline, but the margins are so small as to be almost meaningless. Meanwhile, pinto beans have more of vitamins B1, B6, and E, and/but the only one where the margin is enough to really care about is vitamin E (a little over 2x what chickpeas have). So, an argument could be made either way, but we’re going to call this category a tie.
The story with minerals is similar; chickpeas have more copper, iron, manganese, phosphorus, and zinc, all with small margins, while pinto beans have more potassium and selenium, and/but also less sodium. We’d call this either a tie, or a very slight win for chickpeas.
Adding up the sections gives for a very modest win for pinto beans, but as we say, an argument could be made for either.
Certainly, enjoy both!
Want to learn more?
You might like to read:
- Chickpeas vs Black Beans – Which is Healthier?
- Kidney Beans vs Fava Beans – Which is Healthier?
- What Matters Most For Your Heart? Eat More (Of This) For Lower Blood Pressure
Take care!
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Shrimp vs Caviar – Which is Healthier?
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Our Verdict
When comparing shrimp to caviar, we picked the caviar.
Why?
Both of these seafoods share a common history (also shared with lobster, by the way) of “nutrient-dense peasant-food that got gentrified and now it’s more expensive despite being easier to source”. But, cost and social quirks aside, what are their strengths and weaknesses?
In terms of macros, both are high in protein, but caviar is much higher in fat. You may be wondering: are the fats healthy? And the answer is that it’s a fairly even mix between monounsaturated (healthy), polyunsaturated (healthy), and saturated (unhealthy). The fact that caviar is generally enjoyed in very small portions is its saving grace here, but quantity for quantity, shrimp is the natural winner on macros.
…unless we take into account the omega-3 and omega-6 balance, in which case, it’s worthy of note that caviar has more omega-3 (which most people could do with consuming more of) while shrimp has more omega-6 (which most people could do with consuming less of).
When it comes to vitamins, caviar has more of vitamins A, B1, B2, B5, B6, B9, B12, D, K, and choline; nor are the margins small in most cases, being multiples (or sometimes, tens of multiples) higher. Shrimp, meanwhile, boasts only more vitamin B3.
In the category of minerals, caviar leads with more calcium, iron, magnesium, manganese, phosphorus, potassium, and selenium, while shrimp has more copper and zinc.
All in all, while shrimp has its benefits for being lower in fat (and thus also, for those whom that may interest, lower in calories), caviar wins the day by virtue of its overwhelming nutritional density.
Want to learn more?
You might like to read:
What Omega-3 Fatty Acids Really Do For Us
Take care!
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Ayurveda’s Contributions To Science
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Ayurveda’s Contributions To Science (Without Being Itself Rooted in Scientific Method)
Yesterday, we asked you for your opinions on ayurveda, and got the above-depicted, below-described, set of responses. Of those who responded…
- A little over 41% said “I don’t know what ayurveda is without looking it up”
- A little over 37% said “It is a fine branch of health science with millennia of evidence”
- A little over 16% said “It gets some things right, but not by actual science”
- A little over 4% said “It is a potentially dangerous pseudoscience”
So, what does the science say?
Ayurveda is scientific: True or False?
False, simply. Let’s just rip the band-aid off in this case. That doesn’t mean it’s necessarily without merit, though!
Let’s put it this way:
- If you drink coffee to feel more awake because scientific method has discerned that caffeine has vasoconstrictive and adenosine-blocking effects while also promoting dopaminergic activity, then your consumption of coffee is evidence-based and scientific. Great!
- If you drink coffee to feel more awake because somebody told you that that somebody told them that it energizes you by balancing the elements fire (the heat of the coffee), air (the little bubbles on top), earth (the coffee grinds), water (the water), and ether (steam), then that is neither evidence-based nor scientific, but it will still work exactly the same.
Ayurveda is a little like that. It’s an ancient traditional Indian medicine, based on a combination of anecdotal evidence and supposition.
- The anecdotal evidence from ayurveda has often resulted in herbal remedies that, in modern scientific trials, have been found to have merit.
- Ayurvedic meditative practices also have a large overlap with modern mindfulness practices, and have also been found to have merit
- Ayurveda also promotes the practice of yoga, which is indeed a very healthful activity
- The supposition from ayurveda is based largely in those five elements we mentioned above, as well as a “balancing of humors” comparable to medieval European medicine, and from a scientific perspective, is simply a hypothesis with no evidence to support it.
Note: while ayurveda is commonly described as a science by its practitioners in the modern age, it did not originally claim to be scientific, but rather, wisdom handed down directly by the god Dhanvantari.
Ayurveda gets some things right: True or False?
True! Indeed, we covered some before in 10almonds; you may remember:
Bacopa Monnieri: A Well-Evidenced Cognitive Enhancer
(Bacopa monnieri is also known by its name in ayurveda, brahmi)
There are many other herbs that have made their way from ayurveda into modern science, but the above is a stand-out example. Others include:
- Ashwagandha: The Root of All Even-Mindedness?
- Boswellia serrata (Frankincense) Against Pain and Depression/Anxiety
Yoga and meditation are also great, and not only that, but great by science, for example:
- NCCIH | Yoga for Health: Clinical Guidelines, Scientific Literature, Info for Patients
- The Neuroscience of Mindfulness: How Mindfulness Alters the Brain and Facilitates Emotion Regulation
Ayurveda is a potentially dangerous pseudoscience: True or False?
Also True! We covered why it’s a pseudoscience above, but that doesn’t make it potentially dangerous, per se (you’ll remember our coffee example).
What does, however, make it potentially dangerous (dose-dependent) is its use of heavy metals such as lead, mercury, and arsenic:
Heavy Metal Content of Ayurvedic Herbal Medicine Products
Some final thoughts…
Want to learn more about the sometimes beneficial, sometimes uneasy relationship between ayurveda and modern science?
A lot of scholarly articles trying to bridge (or further separate) the two were very biased one way or the other.
Instead, here’s one that’s reasonably optimistic with regard to ayurveda’s potential for good, while being realistic about how it currently stands:
Development of Ayurveda—Tradition to trend
Take care!
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Overdone It? How To Speed Up Recovery After Exercise
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How To Speed Up Recovery After A Workout (According To Actual Science)
Has your enthusiasm ever been greater than your ability, when it comes to exercise?
Perhaps you leapt excitedly into a new kind of exercise, or maybe you made a reprise of something you used to do, and found out the hard way you’re not in the same condition you used to be?
If you’ve ever done an exercise session and then spent the next three days recovering, this one’s for you. And if you’ve never done that? Well, prevention is better than cure!
Post-exercise stretching probably won’t do much to help
If you like to stretch after a workout, great, don’t let us stop you. Stretching is, generally speaking, good.
But: don’t rely on it to hasten recovery. Here’s what scientists Afonso et al. had to say recently, after doing a big review of a lot of available data:
❝There wasn’t sufficient statistical evidence to reject the null hypothesis that stretching and passive recovery have equivalent influence on recovery.
Data is scarce, heterogeneous, and confidence in cumulative evidence is very low. Future research should address the limitations highlighted in our review, to allow for more informed recommendations.
For now, evidence-based recommendations on whether post-exercise stretching should be applied for the purposes of recovery should be avoided, as the (insufficient) data that is available does not support related claims.❞
…and breath! What a title.
Hot and Cold
Contrast bath therapy (alternating hot and cold, which notwithstanding the name, can also be done in a shower) can help reduce muscle soreness after workout, because of how the change in temperature stimulates vasodilation and vasoconstriction, reducing inflammation while speeding up healing:
Contrast Water Therapy and Exercise Induced Muscle Damage: A Systematic Review and Meta-Analysis
If doing this in the shower isn’t practical for you, and you (like most people) have only one bathtub, then cold is the way to go for the most evidence-based benefits:
Whole-Body Cryotherapy in Athletes: From Therapy to Stimulation. An Updated Review of the Literature
Eat protein whenever, carbs after
Eating protein before a workout can boost muscle protein synthesis. Be aware that even if you’re not bodybuilding, your body will still need to do cell replacement and repair, including in any muscle tissue that got damaged* during the workout
If you don’t like eating before a workout, eating protein after is fine too:
Pre- versus post-exercise protein intake has similar effects on muscular adaptations
*Note: muscle tissue is supposed to get damaged (slightly!) during many kinds of workout.
From lactic acid (that “burn” you feel when exercising) to microtears, the body’s post-workout job is to make the muscle stronger than before, and to do that, it needs you to have found the weak spots for it.
That’s what exercise-to-exhaustion does.
Eating carbs after a workout helps replace lost muscle glycogen.
For a lot more details on optimal nutrition timing in the context of exercise (carbs, proteins, micronutrients, different kinds of exercise, etc), check out this very clear guide:
International society of sports nutrition position stand: nutrient timing
Alcohol is not the post-workout carb you want
Shocking, right? But of course, it’s very common for casual sportspeople to hit the bar for a social drink after their activity of choice.
However, consuming alcohol after exercise doesn’t merely fail to help, it actively inhibits glycogen replacement and protein synthesis:
Also, if you’re tempted to take alcohol “to relax”, please be aware that alcohol only feels relaxing because of what it does to the brain; to the rest of the body, it is anything but, and also raises blood pressure and cortisol levels.
As to what to drink instead…
Hydrate, and consider creatine and tart cherry supplementation
Hydration is a no-brainer, but when you’re dehydrated, it’s easy to forget!
Creatine is a very well-studied supplement, that helps recovery from intense exercise:
Tart cherry juice has been found to reduce muscle damage, soreness, and inflammation after exercise:
Wondering where you can get tart cherry powder? We don’t sell it (or anything else), but here’s an example product on Amazon.
And of course, actually rest
That includes good sleep, please. Otherwise…
Effects of Sleep Deprivation on Acute Skeletal Muscle Recovery after Exercise
Rest well!
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Strawberries vs Blackberries – Which is Healthier?
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Our Verdict
When comparing strawberries to blackberries, we picked the blackberries.
Why?
Shocking nobody, both are very healthy options. However, blackberries do come out on top:
In terms of macros, the main thing that sets them apart is that blackberries have more than 2x the fiber. Other differences in macros are also in blackberries’ favor, but only very marginally, so we’ll not distract with those here. The fiber difference is distinctly significant, though.
In the category of vitamins, blackberries lead with more of vitamins A, B2, B3, B5, B9, E, and K, as well as more choline. Meanwhile, strawberries boast more of vitamins B1, B6, and C. So, a 8:2 advantage for blackberries (and some of the margins are very large, such as 9x more choline, 4x more vitamin E, and nearly 18x more vitamin A).
When it comes to minerals, things are not less clear: blackberries have considerably more calcium, copper, iron, magnesium, manganese, and zinc. The two fruits are equal in other minerals that they both contain, and strawberries don’t contain any mineral in greater amounts than blackberries do.
A discussion of these berries’ health benefits would be incomplete without at least mentioning polyphenols, but both of them are equally good sources of such, so there’s no distinction to set one above the other in this category.
As ever, enjoy both, though! Diversity is good.
Want to learn more?
You might like to read:
- Strawberries vs Cherries – Which is Healthier?
- Blackberries vs Blueberries – Which is Healthier?
- Strawberries vs Raspberries – Which is Healthier?
Take care!
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Improve Your Insulin Sensitivity!
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We’ve written before about blood sugar management, for example:
10 Ways To Balance Blood Sugars ← this one really is the most solid foundation possible; if you do nothing else, do these 10 things!
And as for why we care:
Good (Or Bad) Health Starts With Your Blood
…because the same things that cause type 2 diabetes, go on to cause many other woes, with particularly strong comorbidities in the case of Alzheimer’s disease and other dementias, as well as heart disease of various kinds, and a long long laundry list of immune dysfunctions / inflammatory disorders in general.
In short, if you can’t keep your blood sugars even, the rest of your health will fall like so many dominoes.
Getting a baseline
Are you counting steps? Counting calories? Monitoring your sleep? Heart rate zones? These all have their merits:
- Steps: One More Resource Against Osteoporosis!
- Calories: Is Cutting Calories The Key To Healthy Long Life?
- Sleep: A Head-To-Head Of Google and Apple’s Top Apps For Getting Your Head Down
- Heart Rate Zones: Heart Rate Zones, Oxalates, & More
But something far fewer people do unless they have diabetes or are very enthusiastic about personal health, is to track blood sugars:
Here’s how: Track Your Blood Sugars For Better Personalized Health
And for understanding some things to watch out for when using a continuous glucose monitor:
Continuous Glucose Monitors Without Diabetes: Pros & Cons
Writer’s anecdote: I decided to give one a try for a few months, and so far it has been informative, albeit unexciting. It seems that with my diet (mostly whole-foods plant based, though I do have a wholegrain wheat product about twice per week (usually: flatbread once, pasta once) which is… Well, we could argue it’s whole-food plant based, but let’s be honest, it’s a little processed), my blood sugars don’t really have spikes at all; the graph looks more like gently rolling low hills (which is good). However! Even so, by experimenting with it, I can see for myself what differences different foods/interventions make to my blood sugars, which is helpful, and it also improves my motivation for intermittent fasting. It also means that if I think “hmm, my energy levels are feeling low; I need a snack” I can touch my phone to my arm and find out if that is really the reason (so far, it hasn’t been). I expect that as I monitor my blood sugars continuously and look at the data frequently, I’ll start to get a much more intuitive feel for my own blood sugars, in much the same way I can generally intuit my hormone levels correctly after years of taking-and-testing.
So much for blood sugars. Now, what about insulin?
Step Zero
If taking care of blood sugars is step one, then taking care of insulin is step zero.
Often’s it’s viewed the other way around: we try to keep our blood sugars balanced, to reduce the need for our bodies to produce so much insulin that it gets worn out. And that’s good and fine, but…
To quote what we wrote when reviewing “Why We Get Sick” last month:
❝Dr. Bikman makes the case that while indeed hyper- or hypoglycemia bring their problems, mostly these are symptoms rather than causes, and the real culprit is insulin resistance, and this is important for two main reasons:
- Insulin resistance occurs well before the other symptoms set in (which means: it is the thing that truly needs to be nipped in the bud; if your fasting blood sugars are rising, then you missed “nipping it in the bud” likely by a decade or more)
- Insulin resistance causes more problems than “mere” hyperglycemia (the most commonly-known result of insulin resistance) does, so again, it really needs to be considered separately from blood sugar management.
This latter, Dr. Bikman goes into in great detail, linking insulin resistance (even if blood sugar levels are normal) to all manner of diseases (hence the title).
You may be wondering: how can blood sugar levels be normal, if we have insulin resistance?
And the answer is that for as long as it is still able, your pancreas will just faithfully crank out more and more insulin to deal with the blood sugar levels that would otherwise be steadily rising. Since people measure blood sugar levels much more regularly than anyone checks for actual insulin levels, this means that one can be insulin resistant for years without knowing it, until finally the pancreas is no longer able to keep up with the demand—then that’s when people finally notice.❞
You can read the full book review here:
Now, testing for insulin is not so quick, easy, or accessible as testing for glucose, but it can be worthwhile to order such a test—because, as discussed, your insulin levels could be high even while your blood sugars are still normal, and it won’t be until the pancreas finally reaches breaking point that your blood sugars show it.
So, knowing your insulin levels can help you intervene before your pancreas reaches that breaking point.
We can’t advise on local services available for ordering blood tests (because they will vary depending on location), but a simple Google search should suffice to show what’s available in your region.
Once you know your insulin levels (or even if you don’t, but simply take the principled position that improving insulin sensitivity will be good regardless), you can set about managing them.
Insulin sensitivity is important, because the better it is (higher insulin sensitivity), the less insulin the pancreas has to make to tidy up the same amount of glucose into places that are good for it to go—which is good. In contrast, the worse it is (higher insulin resistance), the more insulin the pancreas has to make to do the same blood sugar management. Which is bad.
What to do about it
We imagine you will already be eating in a way that is conducive to avoiding or reversing type 2 diabetes, but for anyone who wants a refresher,
See: How To Prevent And Reverse Type 2 Diabetes
…which yes, as well as meaning eating/avoiding certain foods, does recommend intermittent fasting. For anyone who wants a primer on that,
See: Intermittent Fasting: Methods & Benefits
There are also drugs you may want to consider:
Metformin Without Diabetes, For Weight-Loss & More
And “nutraceuticals” that sound like drugs, for example:
Glutathione’s Benefits: The Usual And The Unique ← the good news is, it’s found in several common foods
You may have heard the hype about “nature’s Ozempic”, and berberine isn’t exactly that (works in mostly different ways), but its benefits do include improving insulin sensitivity:
Berberine For Metabolic Health
Lastly, while eating for blood sugar management is all well and good, do be aware that some things affect insulin levels without increased blood sugar levels. So even if you’re using a CGM, you may go blissfully unaware of an insulin spike, because there was no glucose spike on the graph—and in contrast, there could even be a dip in blood sugar levels, if you consumed something that increased insulin levels without providing glucose at the same time, making you think “I should have some carbs”, which visually on the graph would even out your blood sugars, but invisibly, would worsen the already-extant insulin spike.
Read more about this: Strange Things Happening In The Islets Of Langerhans: When Carbs, Proteins, & Fats Switch Metabolic Roles
Now, since you probably can’t test your insulin at a moment’s notice, the way to watch out for this is “hmm, I ate some protein/fats (delete as applicable) without carbs and my blood sugars dipped; I know what’s going on here”.
Want to know more?
We heartily recommend the “Why We Get Sick” book we linked above, as this focuses on insulin resistance/sensitivity itself!
However, a very good general primer on blood sugar management (and thus, by extension, at least moderately good insulin management), is:
Glucose Revolution: The Life-Changing Power of Balancing Your Blood Sugar – by Jessie Inchauspé
Enjoy!
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