What does it mean to be immunocompromised?

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Our immune systems help us fight off disease, but certain health conditions and medications can weaken our immune systems. People whose immune systems don’t work as well as they should are considered immunocompromised.

Read on to learn more about how the immune system works, what causes people to be immunocompromised, and how we can protect ourselves and the immunocompromised people around us from illness.

What is the immune system?

The immune system is a network of cells, organs, and chemicals that helps our bodies fight off infections caused by invaders, such as bacteria, viruses, fungi, and parasites.

Some important parts of the immune system include: 

  • White blood cells, which attack and kill germs that don’t belong inside our bodies. 
  • Lymph nodes, which help our bodies filter out germs. 
  • Antibodies, which help our bodies recognize invaders.
  • Cytokines, which tell our immune cells what to do.

What causes people to be immunocompromised?

Some health conditions and medications can prevent our immune systems from functioning optimally, which makes us more vulnerable to infection. Health conditions that compromise the immune system fall into two categories: primary immunodeficiency and secondary immunodeficiency.

Primary immunodeficiency

People with primary immunodeficiency are born with genetic mutations that prevent their immune systems from functioning as they should. There are hundreds of types of primary immunodeficiencies. Since these mutations affect the immune system to varying degrees, some people may experience symptoms and get diagnosed early in life, while others may not know they’re immunocompromised until adulthood.

Secondary immunodeficiency

Secondary immunodeficiency happens later in life due to an infection like HIV, which weakens the immune system over time, or certain types of cancer, which prevent the body from producing enough white blood cells to adequately fight off infection. Studies have also shown that getting infected with COVID-19 may cause immunodeficiency by reducing our production of “killer T-cells,” which help fight off infections.

Sometimes necessary treatments for certain medical conditions can also cause secondary immunodeficiency. For example, people with autoimmune disorders—which cause the immune system to become overactive and attack healthy cells—may need to take immunosuppressant drugs to manage their symptoms. However, the drugs can make them more vulnerable to infection. 

People who receive organ transplants may also need to take immunosuppressant medications for life to prevent their body from rejecting the new organ. (Given the risk of infection, scientists continue to research alternative ways for the immune system to tolerate transplantation.)

Chemotherapy for cancer patients can also cause secondary immunodeficiency because it kills the immune system’s white blood cells as it’s trying to kill cancer cells.

What are the symptoms of a compromised immune system?

People who are immunocompromised may become sick more frequently than others or may experience more severe or longer-term symptoms than others who contract the same disease.

Other symptoms of a compromised immune system may include fatigue; digestive problems like cramping, nausea, and diarrhea; and slow wound healing.

How can I find out if I’m immunocompromised?

If you think you may be immunocompromised, talk to your health care provider about your medical history, your symptoms, and any medications you take. Blood tests can determine whether your immune system is producing adequate proteins and cells to fight off infection.

I’m immunocompromised—how can I protect myself from infection?

If you’re immunocompromised, take precautions to protect yourself from illness.

Wash your hands regularly, wear a well-fitting mask around others to protect against respiratory viruses, and ensure that you’re up to date on recommended vaccines.

Immunocompromised people may need more doses of vaccines than people who are not immunocompromised—including COVID-19 vaccines. Talk to your health care provider about which vaccines you need.

How can I protect the immunocompromised people around me?

You never know who may be immunocompromised. The best way to protect immunocompromised people around you is to avoid spreading illnesses. 

If you know you’re sick, isolate whenever possible. Wear a well-fitting mask around others—especially if you know that you’re sick or that you’ve been exposed to germs. Make sure you’re up to date on recommended vaccines, and practice regular hand-washing.

If you’re planning to spend time with someone who is immunocompromised, ask them what steps you can take to keep them safe.

For more information, talk to your health care provider.

This article first appeared on Public Good News and is republished here under a Creative Commons license.

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  • The Optimal Morning Routine, Per Neuroscience

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    Dr. Andrew Huberman, neuroscientist and professor of neurobiology, has insights:

    The foundations of a good day

    Here are some key things to consider:

    • The role of light: get sunlight exposure within an hour of waking to anchor your body’s cortisol pulse, set your circadian rhythm, and boost mood-regulating dopamine. Light exposure on the skin also boost hormone levels like testosterone and estrogen, contributing to energy, motivation, and overall wellbeing.
    • The role of caffeine: delay caffeine intake for 60–90 minutes after waking to allow adenosine to clear naturally, preventing afternoon energy crashes. Otherwise, caffeine will block the adenosine for 4–8 hours, causing the wave of adenosine-induced sleepiness to resurge later.
    • The role of exercise: morning exercise helps clear adenosine, raise core body temperature, and improve wakefulness
    • The role of cold: cold showers or ice baths trigger adrenaline and dopamine surges, enhancing mood and drive for hours.

    For more on each of these, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Morning Routines That Just Flow

    Take care!

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  • Why Going Gluten-Free Could Be A Bad Idea

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Is A Gluten-Free Diet Right For You?

    This is Rachel Begun, MS, RD. She’s a nutritionist who, since her own diagnosis with Celiac disease, has shifted her career into a position of educating the public (and correcting misconceptions) about gluten sensitivity, wheat allergy, and Celiac disease. In short, the whole “gluten-free” field.

    First, a quick recap

    We’ve written on this topic ourselves before; here’s what we had to say:

    Gluten: What’s The Truth?

    On “Everyone should go gluten-free”

    Some people who have gone gluten-free are very evangelical about the lifestyle change, and will advise everyone that it will make them lose weight, have clearer skin, more energy, and sing well, too. Ok, maybe not the last one, but you get the idea—a dietary change gets seen as a cure-all.

    And for some people, it can indeed make a huge difference!

    Begun urges us to have a dose of level-headedness in our approach, though.

    Specifically, she advises:

    • Don’t ignore symptoms, and/but…
    • Don’t self-diagnose
    • Don’t just quit gluten

    One problem with self-diagnosis is that we can easily be wrong:

    Suspected Nonceliac Gluten Sensitivity Confirmed in Few Patients After Gluten Challenge in Double-Blind, Placebo-Controlled Trials

    But why is that a problem? Surely there’s not a health risk in skipping the gluten just to be on the safe side? As it turns out, there actually is:

    If we self-diagnose incorrectly, Begun points out, we can miss the actual cause of the symptoms, and by cheerfully proclaiming “I’m allergic to gluten” or such, a case of endometriosis, or Hashimoto’s, or something else entirely, might go undiagnosed and thus untreated.

    “Oh, I feel terrible today, there must have been some cross-contamination in my food” when in fact, it’s an undiagnosed lupus flare-up, that kind of thing.

    Similarly, just quitting gluten “to be on the safe side” can mask a different problem, if wheat consumption (for example) contributed to, but did not cause, some ailment.

    In other words: it could reduce your undesired symptoms, but in so doing, leave a more serious problem unknown.

    Instead…

    If you suspect you might have a gluten sensitivity, a wheat allergy, or even Celiac disease, get yourself tested, and take professional advice on proceeding from there.

    How? Your physician should be able to order the tests for you.

    You can also check out resources available here:

    Celiac Disease Foundation | How do I get tested?

    Or for at-home gluten intolerance tests, here are some options weighed against each other:

    MNT | 5 gluten intolerance tests and considerations

    Want to learn more?

    Begun has a blog:

    Rachel Begun | More than just recipes

    (it is, in fact, just recipes—but they are very simple ones!)

    You also might enjoy this interview, in which she talks about gluten sensitivity, celiac disease, and bio-individuality:

    !

    Want to watch it, but not right now? Bookmark it for later

    Take care!

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  • What Length Of Walk Is Best?

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    It is not shocking news that walking is good for the health.

    See for example: Top 8 Habits Of The Top 1% Healthiest Over-50s ← walking is #3 on the list!

    And a lot of research has been done into how many steps per day are important. Of which, the general consensus is:

    • Under 5,000 steps = bad; one needs to walk more than this if possible
    • 5,000 to 8,000 steps = good, with more being better than fewer
    • Over 8,000 steps = also good, but with diminishing marginal returns

    Some research has even been done with regard to when it is best to get these steps in!

    See: The Japanese Health Initiative That Lowers Blood Sugars

    But today we’ll look at the question: is it better to get many short walks, or a few long ones?

    The road goes ever on and on

    The above heading is a nod to a line from Tolkien, and while it’s not necessary to walk all the way to Mordor for good for health (in fact, we recommend against walking to Mordor specifically; famously risky for the health), as it turns out, one long walk may be better than many short ones.

    Researchers (Dr. Borja del Pozo Cruz et al.) examined whether step accumulation patterns—not just total steps—affect long-term health in low-activity adults (defined as walking fewer than 8,000 steps per day).

    How these were sorted: 33,560 adults averaging 5,165 steps daily were followed for 9.5 years, grouped by typical walking bout length from under 5 minutes to 15 minutes or longer.

    What they found, in few words: people who bundled steps into longer, uninterrupted walks had substantially lower risks of all-cause mortality and cardiovascular disease than those whose steps came in short, scattered bursts.

    There was a clear dose-dependent gradient to this; all-cause mortality risk fell steadily as walking bouts lengthened, from 4.36% in bouts under 5 minutes to about 0.8% in bouts lasting 15 minutes or longer. In other words, more than a 5x difference in mortality!

    Not only that, but cardiovascular disease risk (not just mortality, but any CVD incidence) showed a steep decline too, dropping from 13.03% with under-5-minute bouts to 4.39% with walks of 15 minutes or longer.

    If you’re on the low end of activity, there’s good news: the benefits were most pronounced among people taking fewer than 5,000 steps per day, suggesting longer walks matter most when overall activity is low.

    Note: this isn’t an argument for “walk less to get greater benefits”; that’d be the opposite of the correct interpretation of these statistics. The take-away here is “longer walks matter even more when overall activity is low“.

    There is an important cited limitation, namely:

    ❝Observational design with potential residual confounding and reverse causation❞

    In other words, the results could also be at least partly explained by the alternative hypothesis “people who are healthier and have healthier hearts, walk for longer because of their good health, whereas people who are less health and have weaker hearts, walk for shorter durations only”.

    However, even if this may be true, it is clear which group one should aim to be in.

    You can find the paper itself here: Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults

    Want to learn more?

    You might like this very good book we reviewed a while back:

    In Praise Of Walking – by Dr. Shane O’Mara

    …and, for that matter:

    52 Ways To Walk – by Annabel Streets

    Enjoy!

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  • Mental illness, psychiatric disorder or psychological problem. What should we call mental distress?

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    We talk about mental health more than ever, but the language we should use remains a vexed issue.

    Should we call people who seek help patients, clients or consumers? Should we use “person-first” expressions such as person with autism or “identity-first” expressions like autistic person? Should we apply or avoid diagnostic labels?

    These questions often stir up strong feelings. Some people feel that patient implies being passive and subordinate. Others think consumer is too transactional, as if seeking help is like buying a new refrigerator.

    Advocates of person-first language argue people shouldn’t be defined by their conditions. Proponents of identity-first language counter that these conditions can be sources of meaning and belonging.

    Avid users of diagnostic terms see them as useful descriptors. Critics worry that diagnostic labels can box people in and misrepresent their problems as pathologies.

    Underlying many of these disagreements are concerns about stigma and the medicalisation of suffering. Ideally the language we use should not cast people who experience distress as defective or shameful, or frame everyday problems of living in psychiatric terms.

    Our new research, published in the journal PLOS Mental Health, examines how the language of distress has evolved over nearly 80 years. Here’s what we found.

    Engin Akyurt/Pexels

    Generic terms for the class of conditions

    Generic terms – such as mental illness, psychiatric disorder or psychological problem – have largely escaped attention in debates about the language of mental ill health. These terms refer to mental health conditions as a class.

    Many terms are currently in circulation, each an adjective followed by a noun. Popular adjectives include mental, mental health, psychiatric and psychological, and common nouns include condition, disease, disorder, disturbance, illness, and problem. Readers can encounter every combination.

    These terms and their components differ in their connotations. Disease and illness sound the most medical, whereas condition, disturbance and problem need not relate to health. Mental implies a direct contrast with physical, whereas psychiatric implicates a medical specialty.

    Mental health problem, a recently emerging term, is arguably the least pathologising. It implies that something is to be solved rather than treated, makes no direct reference to medicine, and carries the positive connotations of health rather than the negative connotation of illness or disease.

    Therapist talks to young man
    Is ‘mental health problem’ actually less pathologising? Monkey Business Images/Shutterstock

    Arguably, this development points to what cognitive scientist Steven Pinker calls the “euphemism treadmill”, the tendency for language to evolve new terms to escape (at least temporarily) the offensive connotations of those they replace.

    English linguist Hazel Price argues that mental health has increasingly come to replace mental illness to avoid the stigma associated with that term.

    How has usage changed over time?

    In the PLOS Mental Health paper, we examine historical changes in the popularity of 24 generic terms: every combination of the nouns and adjectives listed above.

    We explore the frequency with which each term appears from 1940 to 2019 in two massive text data sets representing books in English and diverse American English sources, respectively. The findings are very similar in both data sets.

    The figure presents the relative popularity of the top ten terms in the larger data set (Google Books). The 14 least popular terms are combined into the remainder.

    Relative popularity of alternative generic terms in the Google Books corpus. Haslam et al., 2024, PLOS Mental Health.

    Several trends appear. Mental has consistently been the most popular adjective component of the generic terms. Mental health has become more popular in recent years but is still rarely used.

    Among nouns, disease has become less widely used while illness has become dominant. Although disorder is the official term in psychiatric classifications, it has not been broadly adopted in public discourse.

    Since 1940, mental illness has clearly become the preferred generic term. Although an assortment of alternatives have emerged, it has steadily risen in popularity.

    Does it matter?

    Our study documents striking shifts in the popularity of generic terms, but do these changes matter? The answer may be: not much.

    One study found people think mental disorder, mental illness and mental health problem refer to essentially identical phenomena.

    Other studies indicate that labelling a person as having a mental disease, mental disorder, mental health problem, mental illness or psychological disorder makes no difference to people’s attitudes toward them.

    We don’t yet know if there are other implications of using different generic terms, but the evidence to date suggests they are minimal.

    Dark field
    The labels we use may not have a big impact on levels of stigma. Pixabay/Pexels

    Is ‘distress’ any better?

    Recently, some writers have promoted distress as an alternative to traditional generic terms. It lacks medical connotations and emphasises the person’s subjective experience rather than whether they fit an official diagnosis.

    Distress appears 65 times in the 2022 Victorian Mental Health and Wellbeing Act, usually in the expression “mental illness or psychological distress”. By implication, distress is a broad concept akin to but not synonymous with mental ill health.

    But is distress destigmatising, as it was intended to be? Apparently not. According to one study, it was more stigmatising than its alternatives. The term may turn us away from other people’s suffering by amplifying it.

    So what should we call it?

    Mental illness is easily the most popular generic term and its popularity has been rising. Research indicates different terms have little or no effect on stigma and some terms intended to destigmatise may backfire.

    We suggest that mental illness should be embraced and the proliferation of alternative terms such as mental health problem, which breed confusion, should end.

    Critics might argue mental illness imposes a medical frame. Philosopher Zsuzsanna Chappell disagrees. Illness, she argues, refers to subjective first-person experience, not to an objective, third-person pathology, like disease.

    Properly understood, the concept of illness centres the individual and their connections. “When I identify my suffering as illness-like,” Chappell writes, “I wish to lay claim to a caring interpersonal relationship.”

    As generic terms go, mental illness is a healthy option.

    Nick Haslam, Professor of Psychology, The University of Melbourne and Naomi Baes, Researcher – Social Psychology/ Natural Language Processing, The University of Melbourne

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • When BMI Doesn’t Measure Up

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    When BMI Doesn’t Quite Measure Up

    Last month, we did a “Friday Mythbusters” edition of 10almonds, tackling many of the misconceptions surrounding obesity. Amongst them, we took a brief look at the usefulness (or lack thereof) of the Body Mass Index (BMI) scale of weight-related health for individuals. By popular subscriber request, we’re now going to dive a little deeper into that today!

    The wrong tool for the job

    BMI was developed as a tool to look at large-scale demographic trends, stemming from a population study of white European men, who were for the purpose of the study (the widescale health of the working class in that geographic area in that era), considered a reasonable default demographic.

    In other words: as a system, it’s now being used in a way it was never made for, and the results of that misappropriation of an epidemiological tool for individual health are predictably unhelpful.

    If you want to know yours…

    Here’s the magic formula for calculating your BMI:

    • Metric: divide your weight in kilograms by your height in square meters
    • Imperial: divide your weight in pounds by your height in square inches and then multiply by 703

    “What if my height doesn’t come in square meters or square inches, because it’s a height, not an area?”

    We know. Take your height and square it anyway. If this seems convoluted and arbitrary, yes, it is.

    But!

    While on the one hand it’s convoluted and arbitrary… On the other hand, it’s also a gross oversimplification. So, yay for the worst of both worlds?

    If you don’t want to grab a calculator, here’s a quick online tool to calculate it for you.

    So, how did you score?

    According to the CDC, a BMI score…

    • Under 18.5 is underweight
    • 18.5 to 24.9 is normal
    • 25 to 29.9 is overweight
    • 30 and over is obese

    And, if we’re looking at a representative sample of the population, where the representation is average white European men of working age, that’s not a bad general rule of thumb.

    For the rest of us, not so representative

    BMI is a great and accurate tool as a rule of thumb, except for…

    Women

    An easily forgotten demographic, due to being a mere 51% of the world’s population, women generally have a higher percentage of body fat than men, and this throws out BMI’s usefulness.

    If pregnant or nursing

    A much higher body weight and body fat percentage—note that these are two things, not one. Some of the extra weight will be fat to nourish the baby; some will be water weight, and if pregnant, some will be the baby (or babies!). BMI neither knows nor cares about any of these things. And, this is a big deal, because BMI gets used by healthcare providers to judge health risks and guide medical advice.

    People under the age of 16 or over the age of 65

    Not only do people below and above those ages (respectively) tend to be shorter—which throws out the calculations and mean health risks may increase before the BMI qualifies as overweight—but also:

    • BMI under 23 in people over the age of 65 is associated with a higher health risk
    • A meta-analysis showed that a BMI of 27 was the best in terms of decreased mortality risk for the over-65 age group

    This obviously flies in the face of conventional standards regards BMI—as you’ll recall from the BMI brackets we listed above.

    Read the science: BMI and all-cause mortality in older adults: a meta-analysis

    Athletic people

    A demographic often described in scientific literature as “athletes”, but that can be misleading. When we say “athletes”, what comes to mind? Probably Olympians, or other professional sportspeople.

    But also athletic, when it comes to body composition, are such people as fitness enthusiasts and manual laborers. Which makes for a lot more people affected by this!

    Athletic people tend to have more lean muscle mass (muscle weighs more than fat), and heavier bones (can’t build strong muscles on weak bones, so the bones get stronger too, which means denser)… But that lean muscle mass can actually increase metabolism and help ward off many of the very same things that BMI is used as a risk indicator for (e.g. heart disease, and diabetes). So people in this category will actually be at lower risk, while (by BMI) getting told they are at higher risk.

    If not white

    Physical characteristics of race can vary by more than skin color, relevant considerations in this case include, for example:

    • Black people, on average, not only have more lean muscle mass and less fat than white people, but also, have completely different risk factors for diseases such as diabetes.
    • Asian people, on average, are shorter than white people, and as such may see increased health risks before BMI qualifies as overweight.
    • Hispanic people, on average, again have different physical characteristics that throw out the results, in a manner that would need lower cutoffs to be even as “useful” as it is for white people.

    Further reading on this: BMI and the BIPOC Community

    In summary:

    If you’re an average white European working-age man, BMI can sometimes be a useful general guide. If however you fall into one or more of the above categories, it is likely to be inaccurate at best, if not outright telling the opposite of the truth.

    What’s more useful, then?

    For heart disease risk and diabetes risk both, waist circumference is a much more universally reliable indicator. And since those two things tend to affect a lot of other health risks, it becomes an excellent starting point for being aware of many aspects of health.

    Pregnancy will still throw off waist circumference a little (measure below the bump, not around it!), but it will nevertheless be more helpful than BMI even then, as it becomes necessary to just increase the numbers a little, according to gestational month and any confounding factors e.g. twins, triplets, etc. Ask your obstetrician about this, as it’s beyond the scope of today’s newsletter!

    As to what’s considered a risk:
    • Waist circumference of more than 35 inches for women
    • Waist circumference of more than 40 inches for men

    These numbers are considered applicable across demographics of age, sex, ethnicity, and lifestyle.

    Source: Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity

    There are more options than just waist circumference though; we delve into them in detail here:

    Better Than BMI

    Take care!

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  • Soybeans vs White Beans – Which is Healthier?

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    Our Verdict

    When comparing soybeans to white beans, we picked the soy.

    Why?

    Both are great! But…

    In terms of macros, soy has 2x the protein while white beans have 3x the carbs, and they’re equal on fiber. We’ll prioritize the protein over the carbs, and call this round a win for soybeans.

    In the category of vitamins, soy has more of vitamins B1, B2, B3, B6, C, K, and choline, while white beans have more of vitamins B5, B7, B9, and E, adding up to a 7:4 win for soy.

    Looking at minerals, soybeans have more calcium, copper, iron, magnesium, manganese, phosphorus, and selenium, while white beans have more potassium and zinc; thus, a 7:2 win for soy.

    Adding up the sections makes for a clear overall win for soy, but by all means enjoy either or both, as diversity is good (unless you have a soy allergy, in which case, don’t do that)!

    Want to learn more?

    You might like:

    Why You Can’t Skimp On Amino Acids

    Enjoy!

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