What Are Nootropics, Really?

10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

What are nootropics, really?

A nootropic is anything that functions as a cognitive enhancerin other words, improves our brainpower.

These can be sensationalized as “smart drugs”, misrepresented excitingly in science fiction, meme-ified in the mundane (“but first, coffee”), and reframed entirely, (“exercise is the best nootropic”).

So, clearly, “nootropics” can mean a lot of different things. Let’s look at some of the main categories…

The neurochemical modulators

These are what often get called “smart drugs”. They are literally drugs (have a chemical effect on the body that isn’t found in our diet), and they affect the levels of certain neurotransmitters in the brain, such as by:

  • Adding more of that neurotransmitter (simple enough)
  • Decreasing the rate at which we lose that neurotransmitter (re-uptake inhibitors)
  • Antagonizing an unhelpful neurotransmitter (doing the opposite thing to it)
  • Blocking an unhelpful neurotransmitter (stopping the receptors from receiving it)

“Unhelpful” here is relative and subjective, of course. We need all the neurotransmitters that are in our brain, after all, we just don’t need all of them all the time.

Examples: modafinil, a dopamine re-uptake inhibitor (mostly prescribed for sleep disorders), reduces the rate at which our brains scrub dopamine, resulting in a gradual build-up of dopamine that we naturally produced, so we get to enjoy that dopamine for longer. This will tend to promote wakefulness, and may also help with problem-solving and language faculties—as well as giving a mood boost. In other words, all things that dopamine is used for. Mirtazaрine, an adrenoreceptor agonist (mostly prescribed as an antidepressant), increases noradrenergic neurotransmission, thus giving many other brain functions a boost.

Why it works: our brains need healthy levels of neurotransmitters, in order to function well. Those levels are normally self-regulating, but can become depleted in times of stress or fatigue, for example.

The metabolic brain boosters

These are the kind of things that get included in nootropic stacks (stack = a collection of supplements and/or drugs that complement each other and are taken together—for example, a multivitamin tablet could be described as a vitamin stack) even though they have nothing specifically relating them to brain function. Why are they included?

The brain needs so much fuel. Metabolically speaking, it’s a gas-guzzler. It’s the single most resource-intensive organ of our body, by far. So, metabolic brain boosters tend to:

  • Increase blood flow
  • Increase blood oxygenation
  • Increase blood general health
  • Improve blood pressure (this is relative and subjective, since very obviously there’s a sweet spot)

Examples: B-vitamins. Yep, it can be that simple. A less obvious example might be Co-enzyme Q10, which supports energy production on a cellular level, and good cardiovascular health.

Why it works: you can’t have a healthy brain without a healthy heart!

We are such stuff as brains are made of

Our brains are made of mostly fat, water, and protein. But, not just any old fat and protein—we’re at least a little bit special! So, brain-food foods tend to:

  • Give the brain the fats and proteins it’s made of
  • Give the brain the stuff to make the fats and proteins it’s made of (simpler fats, and amino acids)
  • Give the brain hydration! Just having water, and electrolytes as appropriate, does this

Examples: healthy fats from nuts, seeds, and seafood; also, a lot of phytonutrients from greens and certain fruits. Long-time subscribers may remember our article “Brain Food: The Eyes Have It!” on the importance of dietary lutein in reducing Alzheimer’s risk, for example

Why it works: this is matter of structural upkeep and maintenance—our brains don’t work fabulously if deprived of the very stuff they’re made of! Especially hydration is seriously underrated as a nootropic factor, by the way. Most people are dehydrated most of the time, and the brain dehydrates quickly. Fortunately, it rehydrates quickly as well when we take hydrating liquids.

Weird things that sound like ingredients in a witch’s potion

These are too numerous and too varied in how they work to cover here, but they do appear a lot in nootropic stacks and in popular literature on the subject.

Often they work by one of the mechanisms described above; sometimes we’re not entirely sure how they work, and have only measured their effects sufficiently to know that, somehow, they do work.

Examples: panax ginseng is one of the best-studied examples that still remains quite mysterious in many aspects of its mechanism. Lion’s Mane (the mushroom, not the jellyfish or the big cat hairstyle), meanwhile, is known to contain specific compounds that stimulate healthy brain cell growth.

Why it works: as we say, it varies so much from on ingredient to another in this category, so… Watch out for our Research Review Monday features, as we’ll be covering some of these in the coming weeks!

(PS, if there’s any you’d like us to focus on, let us know! We always love to hear from you. You can hit reply to any of our emails, or use the handy feedback widget at the bottom)

Don’t Forget…

Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

  • Hair-Loss Remedies, By Science
    Combat hair loss with finasteride, spironolactone, and minoxidil. Effective remedies for both men and women. Consult your doctor for more information.

Learn to Age Gracefully

Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:

  • Cashews vs Walnuts – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing cashews to walnuts, we picked the walnuts.

    Why?

    Both are great! But a winner did emerge:

    In terms of macros, cashews have slightly more protein, while walnuts have about 2x the fiber. As for fats, walnuts have more fat. Looking further into it: cashews’ fats are mostly monounsaturated, while walnuts’ fats are mostly polyunsaturated, both of which are considered healthy. All in all, we consider this a win for walnuts on account of the noteworthy fiber difference, but both are great.

    It’s worth mentioning that notwithstanding being both high in calories, neither nut is associated with weight gain—largely because of their low glycemic indices (of which, walnuts have the slightly lower GI, but both are low-GI foods).

    In the category of vitamins, cashews have more of vitamins B1, B5, E, and K, while walnuts have more of vitamins A, B2, B3 B6, B9, and C, giving walnuts the victory here.

    Looking at minerals, cashews get their day, as cashews have more copper, iron, magnesium, phosphorus, potassium, selenium, and zinc, while walnuts have more calcium and manganese, meaning that cashews score a point finally.

    In other considerations, walnuts are much higher in polyphenols, of which, especially flavonoids, of which especially flavonols, of which especially epicatechins. So, this round gives an extra point for walnuts.

    Adding up the sections makes for a clear overall win for walnuts, but (unless you have a nut allergy, of course) do enjoy either or both, as diversity is best!

    Want to learn more?

    You might like:

    Enjoy!

    Share This Post

  • Why You Don’t Need 8 Glasses Of Water Per Day

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The idea that you need to drink eight glasses of water daily is a myth. For most people most of the time, this practice will not make your skin brighter, improve mental clarity, or boost energy levels. All that will happen as a result of drinking beyond your thirst, is that you’ll pee more.

    A self-regulating system

    Our kidneys regulate hydration by monitoring blood volume and salt levels. When blood becomes slightly saltier or its volume drops, such as through sweating, the kidneys absorb more water into the bloodstream. If needed, the body triggers thirst signals to encourage fluid intake.

    In most cases, you can rely on your body’s natural thirst cues to manage hydration. Thirst is a reliable indicator of when you need to drink water, making constant monitoring of water intake unnecessary for most people.

    There are some exceptions, though! Some people, such as those with kidney stones, especially older adults, or those with specific medical considerations and resultant advice from your doctor, may need to pay closer attention to their water intake.

    Nor does hydration have to be a matter of “drinking water”: many foods and drinks, such as fruit, coffee, soups, etc, contribute to your daily water intake and (because the body processes it more slowly) are often more hydrating than plain water (which can just pass straight through if you take more than a certain amount at once). If you listen to your body’s thirst signals, there’s no need to rigidly count eight glasses of water each day.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Hydration Mythbusting ← this also covers why urine color is not as good a guide as your thirst

    Take care!

    Share This Post

  • Mindfulness: An Eight-Week Plan – by Dr. Mark Williams & Dr. Danny Penman

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The authors, with their PhDs in psychology and biochemistry, respectively, bring the science that you might expect (and some that you might not!) to this book about mindfulness meditation and mindfulness in everyday life.

    The book’s realism comes not just from studies, though, but also from a realistic perspective on modern life, in which many of us have sufficient responsibilities to afford us only limited downtime, and we certainly cannot all take time off for a mountaintop retreat.

    What we can do, however, is enjoy this eight-week program for finding peace in a frantic world, while still going about our necessary business in that frantic world on a daily basis.

    The eight weeks go as follows:

    1. Waking up to the autopilot
    2. Keeping the body in mind
    3. The mouse in the maze
    4. Moving beyond the rumor mill
    5. Turning toward difficulties
    6. Trapped in the past or living in the present?
    7. When did you stop dancing?
    8. Your wild and precious life

    …with meditations, as well as reframes and other tools, for each.

    The style is very easy-reading, with neither scientific jargon nor spiritual arcana, just clear explanations, instructions, and guidance.

    Bottom line: if you’re the sort of person who tries to take each day as it comes, but sometimes several days gang up on you at once, then this book can help get things into order.

    Click here to check out Mindfulness: An Eight-Week Plan for Finding Peace in a Frantic World, and indeed find peace in a frantic world!

    Share This Post

  • Blueberry & Banana Collagen Baked Oats

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Good news for vegans/vegetarians! While we include an optional tablespoon of collagen powder in this recipe, the whole recipe is already geared around collagen synthesis, so it’s very collagen-boosting even with just the plants, providing collagen’s building blocks of protein, zinc, and vitamins C and D (your miraculous body will use these to assemble the collagen inside you).

    You will need

    • 2 cups oats, whence the protein and zinc
    • 1 cup milk (your preference what kind; we recommend almond for flavor; whether you choose plant or animal though, it should be fortified with vitamin D)
    • 2 bananas, peeled and mashed
    • 4 oz blueberries, whence the vitamin C (frozen is fine) (chopped dried apricots are also a fine substitute if that’s more convenient)
    • 1 oz flaked almonds, whence the protein and zinc
    • 1 tbsp pumpkin seeds, whence the protein and zinc
    • 1 tbsp flax seeds, whence the protein and zinc
    • Optional: 1 tbsp maple syrup
    • Optional: 1 tbsp collagen powder, dissolved in 1 oz hot water

    Method

    (we suggest you read everything at least once before doing anything)

    1) Preheat the oven to 350℉ / 180℃.

    2) Mix the oats with 2 cups boiling water; allow to stand for 10–15 minutes, and then drain any excess water.

    3) Mix the mashed bananas with the remaining ingredients except the milk and blueberries, stirring thoroughly.

    4) Add the softened oats, and stir those in thoroughly too.

    5) Add the milk and blueberries, in that order, stirring gently if using fresh blueberries, lest they get crushed.

    6) Pour the mixture into an 8″ square cake tin that you have lined with baking paper, and smooth the top.

    7) Bake for about 40 minutes or until firm and golden brown. Allow to cool; it will firm up more while it does.

    8) Cut into squares or bars, and serve or store for later.

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    We Are Such Stuff As Fish Are Made Of ← our main feature about collagen

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:

  • How a Michigan community center supports young people’s mental health

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Even before the COVID-19 pandemic made mental health problems worse for people of all ages, young people already struggled with a lack of support and treatment for issues like depression, anxiety, and ADHD. 

    Like many states, Michigan doesn’t have enough health care providers, and youth mental health professionals are in high demand. 

    Some local groups step in to support kids when they aren’t getting the help they need or experience long wait times for services.

    To learn more about how one community-based organization tackles these challenges, Public Good News spoke with Avion Williams, Youth Coordinator at Community Family Life Center.

    Here’s what she said.

    [Editor’s note: The contents of this interview have been edited for length and clarity.]

    Public Good News: Can you tell us more about your organization and where you’re located?

    A.W.: Community Family Life Center is a community outreach center. We offer a multitude of after-school programs and services to Ypsilanti-Ann Arbor and even the Belleville community. 

    Ypsilanti is a small community. It was originally a farmer’s town. You will still see a lot of older families here. 

    A lot of our restaurants are like mom-and-pop shops. We have our downtown area, which is now being modernized a little bit, but again, a lot of shops are family-owned businesses that have been around for decades. 

    We have a lot of colleges. We have Eastern Michigan, which is the college I actually attend, and that’s in Ypsilanti. But we also have colleges right next door that are 10 minutes away, like University of Michigan and Concordia. 

    So it’s a college town, very family-oriented, but also a very small town with not too many resources.

    PGN: Can you share some of your experiences as a youth coordinator trying to help young people access your organization’s services and programs?

    A.W.: So we offer a ton of different programs, but our main focus is for kids to have something to do. There’s definitely a lot of young people in Ypsilanti. 

    I’m 25, and when I was in high school, a lot of people in my grade were having children. And they weren’t just having one baby, they were having multiple babies. You know, maybe one in tenth grade, another when we graduated our senior year, another right after. So a lot of people my age have a lot of children. And now I work with a lot of their children. 

    Many of those children come to after-school programs, and they’re in need of not just school things like math and reading, but they’re in need of, you know, love and care. Maybe mom can’t do everything because she has to work two or three jobs, or she doesn’t have the best financial help, and so she doesn’t know what to do. 

    And these young children get stuck with teachers that may not necessarily know how to give the best support, because maybe they’re stressed. 

    We have after-school programs and community centers like ours, where we get all of that. 

    Not only do we have to deal with mental health, we have to deal with these babies being hungry. We have to teach what mental health is. 

    PGN: What about therapy? How does that fit into the picture?

    A.W.: Sometimes in society, people just throw therapy out there, like, ‘Go to therapy, go to therapy, go to therapy,’ but they don’t talk about the process of what it’s like getting a therapist. 

    I love the idea of therapy. Don’t get me wrong. Having somebody to talk to is very real. Having the right person to talk to is very real, right? 

    But I think sometimes we don’t talk about how everybody is not able to get therapy. 

    And a lot of times when people are ready for therapy, it’s after everything has happened. 

    You know, ‘Mom is gone, dad is gone. I’m doing terribly in school now. I’m acting out. Now I’m lashing out. I’m super hungry. I don’t have money for this. I don’t have money for that. I don’t know what to do about this…’ and then it’s like, ‘okay, I think I need therapy.’ 

    Instead of us approaching it as, ‘Hey, this person’s mom is a young mom, maybe we should see if we can get therapy for both of them.’ Or when that child is being born, or when we see this young mom at the hospital and we see that she’s pregnant. Let’s offer some help before things start to hit the fan, right? 

    And maybe this mom doesn’t even have the proper health care to receive therapy, or let alone, doesn’t have the money to pay for it. 

    PGN: How does your organization respond to this need?

    A.W.: We have a lot of ways to access our therapists. We started maybe two years ago, and at first a lot of people weren’t going. And now there’s so many people going that yes, we have this wait list.

    So we also all do daily check-ins with our kids. We really do get to know our kids and their families and have consistent conversations with parents. 

    I always tell my kids this is a safe space to talk. I’m open to hear anything my students have to say.

    This article first appeared on Public Good News and is republished here under a Creative Commons license.

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:

  • Parents find Health Star Ratings confusing and unhelpful. We need a better food labelling system

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Food labels are intended to support healthy choices. But not all labelling schemes are equal.

    Australia currently uses a voluntary Health Star Rating system. Food manufacturers can choose to add a star label to their packaging to indicate how it compares to other similar products. Or they can choose not to show a star rating on a product at all.

    The Australian government is now considering making it mandatory.

    But our new research on parenting and food in Australia found the Health Star Ratings are often confusing, misunderstood and have little credibility among shoppers.

    If Health Stars are mandated, the system will also need a major overhaul to be trusted and useful for shoppers.

    Gustavo Fring/Pexels

    How do Health Star Ratings work?

    The government set up the front-of-pack Health Star Rating system in 2014 in collaboration with the food industry, public health and consumer groups.

    Product ratings range from (bad) ½ to (good) 5 stars.

    Calories, saturated fat, sugars and sodium decrease the rating. Fibre, protein, and the content of fruit, vegetables, nuts and legumes increase it.

    The good and bad offset each other. This means companies can strategically formulate products to boost the rating and mask unhealthy ingredients.

    Processing and additives – such as sweeteners, colouring, emulsifiers, preservatives and artificial flavourings – are not part of the calculation.

    Previous research has found the ratings can incentivise ultra-processed foods over minimally and unprocessed foods, and misrepresent healthfulness. Some researchers have also suggested practical ways to modify the rating algorithm to account for processing.

    The Health Star Rating’s own consumer research found 74% of consumers do not understand that the rating cannot be used to compare dissimilar products.

    What parents told us

    In our interviews with 34 parents in Australia, participants often described the Health Star Ratings as “misleading”, “not helpful” and “on the wrong product”. One participant called it the “fake health star rating”.

    They gave many examples:

    Like you might buy 100% orange juice or fruit juice and it might have only half a star health star rating, but then you can buy like a box of processed muesli bars and it will have five stars. – Mother of three high school aged children, urban WA

    Coco Pops or Nutrigrain have three and a half star rating, and what exactly does that mean? – Mother of one primary school aged child, urban WA

    Participants wondered if the Health Stars were something companies paid for, a “marketing thing”.

    Positivity bias

    Part of the problem with the Health Stars is the positivity bias of the symbol. As one participant put it, “All stars are good. Right?”

    Another noted their children comment on the stars, saying “but look Mum, it’s five stars.”

    However, parents were not convinced:

    A lot of packaged stuff is rated as five stars. I’m like yeah, well, don’t know about that. It’s still packaged. – Mother of two primary school aged children, urban NSW

    Participants thought discretionary foods should not have any stars. As one participant said:

    The other day, we saw a mud cake and it has a two out of five star health rating. How can that be a two out of five star?… Like there should not even be a star available for this. – Mother of pre-school aged child, urban NSW

    Burden on parents

    Parents often disregarded the rating. For example:

    This particular thing, you know, had all sorts of additives, had actually had a much higher rating than something that actually didn’t have any additives… what I ended up buying was rated slightly lower. – Mother of two primary school aged children, rural Victoria

    Instead participants used ingredients lists, apps such as Yuka, and “hours of internet research” to guide healthier choices.

    But there was a sense of frustration that the burden was on them. Participants said:

    I feel like food labels are extremely deceptive and by producers, purposely confusing. – Mother of one primary school aged child, urban SA

    It has to be government driven because companies won’t change unless they’re forced to by the government. – Father of two primary school aged children, urban Tasmania

    We need a food labelling system that works

    Still, the parents we spoke to think a front-of-pack system is valuable. As one participant explained:

    I do think if I had a better system for that, that would get a lot of use. – Mother of two primary school aged children, urban NSW

    Parents repeatedly stated a desire for transparency over food, for information they can trust and food policies that prioritise consumer health.

    As one mother put it, the “multi-billion dollar” food industry will not do this on their own, and “that’s where the government needs to step in.”

    If Health Stars are mandatory, how could labelling be overhauled?

    Chile, Mexico, Brazil and other countries, including Canada from 2026, are now using “stop-sign” warnings to steer consumers away from the least healthy products. Large Black Octagons alert consumers to high sugar, sodium and saturated fats, and ultra-processing.

    New Canadian food labelling system
    Starting in 2026, a new front-of-package symbol will be required on many Canadian foods and drinks that are high in saturated fat, sugars or salt. Canada.ca/en/health

    Evidence shows these warning labels have improved nutrition and public health in other countries and could be an option for Australia.

    We need to mandate a fit-for-purpose food labelling system that supports healthy eating. Governments should centre the voices of consumers in these and other national food policies to ensure they work as intended.

    Juliet Bennett, Postdoctoral Research Fellow, University of Sydney; Alex Broom, Professor of Sociology & Director, Sydney Centre for Healthy Societies, University of Sydney, and David Raubenheimer, Leonard P. Ullman Chair in Nutritional Ecology, Nutrition Theme Leader Charles Perkins Centre, Chair Sydney Food and Nutrition Network, University of Sydney

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails: