Undoing Creatine’s Puffiness Side Effect
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In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small 😎
❝Creatine is known to increase “puffiness”, especially in my face. Are there any supplements that do the opposite?!❞
So first, let’s examine why this happens: creatine is most often taken to boost muscle size and performance. Your muscles are, of course, mostly water by mass, and so building your muscles requires extra water, which triggers systemic water retention.
In other words: you take creatine, exercise, and as the muscles start growing, the body goes “oh heck, we are running out of water, better save as much as possible in order to keep hydrating the muscles without running out” and starts putting it anywhere it can that’s not your bladder, so this will largely be the soft tissues of your body.
So, this results in classic water retentions symptoms including bloating and, yes, facial puffiness.
How much this happens, and how long the effects last, depend on three main things:
- What daily dose of creatine you are taking
- What kind of exercise you are doing
- What your hydration is like
The dose is relevant as it’s most common to get this puffiness during the “loading” phase, i.e. if you’re taking an increased dose to start with.
The exercise is relevant as it affects how much your body is actually using the water to build muscles.
The hydration is relevant because the less water you are taking, the more the body will try to retain whatever you do have.
This means, of course, that the supplement you are looking for to undo the facial puffiness is, in fact, water (even, nay, especially, if you feel bloated too):
Water For Everything? Water’s Counterintuitive Properties
Additionally, you could scale back the dose of creatine you’re taking, if you’re not currently doing heavy muscle-building exercise.
That said, the recommended dose for cognitive benefits is 5g/day, which is a very standard main-phase (i.e., post-loading) bodybuilding dose, so do with that information what you will.
See also: Creatine’s Brain Benefits Increase With Age
On which note: whether or not you want to take creatine for brain benefits, however, may depend on your age:
Creatine: Very Different For Young & Old People
Most research on creatine’s effects on humans has usually been either collegiate athletes or seniors, which leaves quite a research gap in the middle—so it’s unclear at what age the muscle-building effects begin to taper off, and at what age the cognitive benefits begin to take off.
Want a quicker fix?
If you want to reduce your facial puffiness acutely (e.g., you have a date in an hour and would like to not have a puffy face), then there are two things you can do that will help immediately, and/but only have short-term effects, meaning you’d have to do them daily to enjoy the results every day:
The first is an ice bath; simply fill a large bowl with water and ice cubes, give it a couple of minutes to get down to temperature, hold your breath and plunge your face in for as long as you can comfortably hold your breath. Repeat a few times, and towel off.
This helps by waking up the vasculature in your face, helping it to reduce puffiness naturally.
The second is facial yoga or guā shā, which is the practice of physically manipulating the soft tissues of your face to put them where you want them, rather than where you don’t want them. This will work against water retention puffiness, as well as cortisol puffiness, lymphatic puffiness, and more:
7-Minute Face Fitness For Lymphatic Drainage & Youthful Jawline
Enjoy!
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Lycopene’s Benefits For The Gut, Heart, Brain, & More
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What Doesn’t Lycopene Do?
Lycopene is an antioxidant carotenoid famously found in tomatoes; it actually appears in even higher levels in watermelon, though. If you are going to get it from tomato, know that cooking improves the lycopene content rather than removing it (watermelon, on the other hand, can be enjoyed as-is and already has the higher lycopene content).
Antioxidant properties
Let’s reiterate the obvious first, for the sake of being methodical and adding a source. Lycopene is a potent antioxidant with multiple health benefits:
Lycopene: A Potent Antioxidant with Multiple Health Benefits
…and as such, it does all the things you might reasonably expect and antioxidant to do. For example…
Anti-inflammatory properties
In particular, it regulates macrophage activity, reducing inflammation while improving immune response:
Lycopene Regulates Macrophage Immune Response through the Autophagy Pathway Mediated by RIPK1
As can be expected of most antioxidants and anti-inflammatory agents, it also has…
Anticancer properties
Scientific papers tend to be “per cancer type”, so we’re just going to give one example, but there’s pretty much evidence for its utility against most if not all types of cancer. We’re picking prostate cancer though, as it’s one that’s been studied the most in the context of lycopene intake—in this study, for example, it was found that men who enjoyed at least two servings of lycopene-rich tomato sauce per week were 30% less likely to develop prostate cancer than those who didn’t:
Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression
If you’d like to see something more general, however, then check out:
Potential Use of Tomato Peel, a Rich Source of Lycopene, for Cancer Treatment
It also fights Candida albicans
Ok, this is not (usually) so life-and-death as cancer, but reducing our C. albicans content (specifically: in our gut) has a lot of knock-on effects for other aspects of our health, so this isn’t one to overlook:
The title does not make this clear, but yes: this does mean it has an antifungal effect. We mention this because often cellular apoptosis is good for an overall organism, but in this case, it simply kills the Candida.
It’s good for the heart
A lot of studies focus just on triglyceride markers (which lycopene improves), but more tellingly, here’s a 10-year observational study in which diets rich in lycopene were associated to a 17–26% lower risk of heart disease:
Relationship of lycopene intake and consumption of tomato products to incident CVD
…and a 39% overall reduced mortality in, well, we’ll let the study title tell it:
…which means also:
It’s good for the brain
As a general rule of thumb, what’s good for the heart is good for the brain (because the brain needs healthy blood flow to stay healthy, and is especially vulnerable when it doesn’t get that), and in this case that rule of thumb is also borne out by the post hoc evidence, specifically yielding a 31% decreased incidence of stroke:
Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies
Is it safe?
As a common food product, it is considered very safe.
If you drink nothing but tomato juice all day for a long time, your skin will take on a reddish hue, which will go away if you stop getting all your daily water intake in tomato juice.
In all likelihood, even if you went to extremes, you would get sick from the excess of vitamin A (generally present in the same foods) sooner than you’d get sick from the excess of lycopene.
Want to try some?
We don’t sell it, and also we recommend simply enjoying tomatoes, watermelons, etc, but if you do want a supplement, here’s an example product on Amazon
Enjoy!
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Hold Me Tight – by Dr. Sue Johnson
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A lot of relationship books are quite wishy-washy. This one isn’t.
This one is evidenced-based (and heavily referenced!), and yet at the same time as being deeply rooted in science, it doesn’t lose the human touch.
Dr. Johnson has spent her career as a clinical psychologist and researcher; she’s the primary developer of Emotionally Focused Therapy (EFT), which has demonstrated its effectiveness in over 35 years of peer-reviewed clinical research. In other words, it works.
EFT—and thus also this book—finds roots in Attachment Theory. As such, topics this book covers include:
- Recognizing and recovering from attachment injury
- How fights in a relationship come up, and how they can be avoided
- How lot of times relationships end, it’s not because of fights, but a loss of emotional connection
- Building a lifetime of love instead, falling in love again each day
This book lays the groundwork for ensuring a strong, secure, ongoing emotional bond, of the kind that makes/keeps a relationship joyful and fulfilling.
Dr. Johnson has been recognized in her field with a Lifetime Achievement Award, and the Order of Canada.
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Real Self-Care – by Pooja Lakshmin MD
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As the subtitle says, “crystals, cleanses, and bubble baths not included”. So, if it’s not about that sort of self-care, what is it about?
Dr. Lakshmin starts by acknowledging something that many self-help books don’t:
We can do everything correctly and still lose. Not only that, but for many of us, that is the probable outcome. Not because of any fault or weakness of ours, but simply because one way or another the game is rigged against us from the start.
So, should we throw in the towel, throw our hands in the air, and throw the book out of the window?
Nope! Dr. Lakshmin has actually helpful advice, that pertains to:
- creating healthy boundaries and challenging guilt
- treating oneself with compassion
- identifying and aligning oneself with one’s personal values
- asserting one’s personal power to fight for one’s own self-interest
If you’re reading this and thinking “that seems very selfish”, then let’s remember the “challenging guilt” part of that. We’ve all-too-often been conditioned to neglect our own needs and self-sacrifice for others.
And, while selfless service really does have its place, needlessly self-destructive martyrdom does not!
Bottom line: this book delivers a lot of “real talk” on a subject that otherwise often gets removed from reality rather. In short, it’s a great primer for finding the right place to draw the line between being a good-hearted person and being a doormat.
Click here to check out Real Self-Care and “put your own oxygen mask on first”!
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How Intermittent Fasting Reduces Heart Attack Risk (Directly, Not Via Weight Control!)
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We’ve written before about the benefits of intermittent fasting, such as:
- Intermittent Fasting: What’s The Truth?
- 16/8 Intermittent Fasting For Beginners
- Before You Eat Breakfast: 3 Surprising Facts About Intermittent Fasting
Intermittent fasting is mostly enjoyed for its metabolic benefits, such as How To Prevent And Reverse Type 2 Diabetes.
We also covered a very related topic, with intermittent fasting once again being on the suggestions list:
Improve Your Insulin Sensitivity! ← this is actually more important even that blood sugar control itself, important as that latter is!
So, how does it work to reduce heart attack risk?
While intermittent fasting can be used as a weight loss tool (it also doesn’t have to be—it depends on what you eat and what you’re doing in terms of exercise, amongst other factors), this isn’t about that.
Although it is also worth mentioning that intermittent fasting does reduce the risks associated with diabetes, hypercholesterolemia, cancer, Alzheimer’s, and more, as well as generally improving cardiovascular health by reducing blood pressure, cholesterol, and insulin resistance, amongst other metrics.
However, this is about platelet aggregation. Or in whole: platelet activation, aggregation, and thrombosis.
A team of scientists, Dr. Shimo Dai et al., investigated the effects of alternate-day intermittent fasting on platelets and thrombosis, in two quite different, but both important, demographics:
- Humans with coronary artery disease
- Mice with the ApoE gene (the Alzheimer’s risk gene)
Why the mice? Because they wanted to check the level of cerebral ischemia-reperfusion injury (the damage that occurs after a stroke), and no ethics board will let scientists slice up human participants brains at will.
In both cases, the intermittent fasting group enjoyed protective effects that the control group (ad libitum eating) did not.
Specifically, reduced platelet activation, as well as reduced platelet aggregation. Just to be clear:
- Platelet activation = platelets getting deployed
- Platelet aggregation = platelets sticking together
Both are required for thrombosis, which occurs when the platelets, having been activated and aggregated (which is their job, for example to stop bleeding in the case of an injury), block one or more blood vessels.
A healthy level of platelet activation and aggregation rests in the sweet spot wherefrom it can stop bleeding, without stopping blood circulation.
This was found to be associated with increased levels of indole-3-propionic acid (IPA), which is created by certain gut bacteria (C. sporogenes), who proliferate enthusiastically during intermittent fasting.
In few words:
- intermittent fasting triggers the C. sporogenes to proliferate,
- which increases IPA levels,
- which reduces platelet activation and aggregation,
- which reduces the risk of thrombosis,
- and thus reduces the risk of heart attack.
We may hypothesize that this may be a reason to not do intermittent fasting if you have a bleeding disorder, and consult your doctor if you’re on blood thinners.
For everyone else, this is one more thing that makes intermittent fasting a very healthful practice!
You can find the paper itself here:
And here’s a pop-science article that gets more technical than we have, if you’d like a middle-ground in terms of complexity:
Intermittent fasting cuts heart attack risk by preventing dangerous blood clots
Want to try intermittent fasting, but it sounds hard?
Check out this:
Enjoy!
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How Your Brain Chooses What To Remember
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During the day, your brain is simply too busy to encode memories without interfering with normal processing. At night, however…
The filing system
The brain decides which memories to keep based on significance, using sharp brain wave ripples as an internal bookmarking system. Everyday memories fade, while important events are tagged in this manner for consolidation during sleep.
How does it do this? It starts in the hippocampus, which records experiences during wakefulness and replays them repeatedly at high speed during sleep, preparing them for transfer to the neocortex.
How do we know? Uniform Manifold Approximation & Projection (UMAP) for dimension reduction is a tool that condenses 400-dimensional neural activity data into 3D for visualization. Mice navigating a maze showed hippocampal activity encoding location and learning progression; it also showed neural patterns reflecting maze layout and task mastery.
What this means in practical terms: you need to get good sleep if you don’t want to lose your memories!
For more on all of this, enjoy:
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Want to learn more?
You might also like to read:
How To Boost Your Memory Immediately (Without Supplements)
Take care!
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The Autoimmune Cure – by Dr. Sara Gottfried
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We’ve featured Dr. Gottfried before, as well as another of her books (“Younger”), and this one’s a little different, and on the one hand very specific, while on the other hand affecting a lot of people.
You may be thinking, upon reading the subtitle, “this sounds like Dr. Gabor Maté’s ideas” (per: “When The Body Says No”), and 1) you’d be right, and 2) Dr. Gottfried does credit him in the introduction and refers back to his work periodically later.
What she adds to this, and what makes this book a worthwhile read in addition to Dr. Maté’s, is looking clinically at the interactions of the immune system and nervous system, but also the endocrine system (Dr. Gottfried’s specialty) and the gut.
Another thing she adds is more of a focus on what she writes about as “little-t trauma”, which is the kind of smaller, yet often cumulative, traumas that often eventually add up over time to present as C-PTSD.
While “stress increases inflammation” is not a novel idea, Dr. Gottfried takes it further, and looks at a wealth of clinical evidence to demonstrate the series of events that, if oversimplified, seem unbelievable, such as “you had a bad relationship and now you have lupus”—showing evidence for each step in the snowballing process.
The style is a bit more clinical than most pop-science, but still written to be accessible to laypersons. This means that for most of us, it might not be the quickest read, but it will be an informative and enlightening one.
In terms of practical use (and living up to its subtitle promise of “cure”), this book does also cover all sorts of potential remedial approaches, from the obvious (diet, sleep, supplements, meditation, etc) to the less obvious (ketamine, psilocybin, MDMA, etc), covering the evidence so far as well as the pros and cons.
Bottom line: if you have or suspect you may have an autoimmune problem, and/or would just like to nip the risk of such in the bud (especially bearing in mind that the same things cause neuroinflammation and thus, putatively, depression and dementia too), then this is one for you.
Click here to check out the Autoimmune Cure, and take care of your body and mind!
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