Aging Is Inevitable… Or is it?

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Aging is inevitable… Or is it?

We’ve talked before about how and why aging happens. We’ve also talked about the work to tackle aging as basically an engineering problem, with the premise that our bodies are biological machines, and machines can be repaired. We also recommended a great book about this, by the way. But that’s about interfering with the biological process of aging. What about if the damage is already done?

“When the damage is done, it’s done”

We can do a lot to try to protect ourselves from aging, and we might be able to slow down the clock, but we can’t stop it, and we certainly can’t reverse it… right?

Wrong! Or at least, so we currently understand, in some respects. Supplementation with phosphatidylserine, for example, has shown promise for not just preventing, but treating, neurodegeneration (such as that caused by Alzheimer’s disease). It’s not a magic bullet and so far the science is at “probably” and “this shows great promise for…” and “this appears to…”

Phosphatidylserene does help slow neurodegeneration

…because of its role in allowing your cells to know whether they have permission to die.

This may seem a flippant way of putting it, but it’s basically how cell death works. Cells do need to die (if they don’t, that’s called cancer) and be replaced with new copies, and those copies need to be made before too much damage is accumulated (otherwise the damage is compounded with each new iteration). So an early cell death-and-replacement is generally better for your overall health than a later one.

However, neurons are tricky to replace, so phosphatidylserine effectively says “not you, hold on” to keep the rate of neuronal cell death nearer to the (slow) rate at which they can be replaced.

One more myth to bust…

For the longest time we thought that adults, especially older adults, couldn’t make new brain cells at all, that we grew a certain number, then had to hang onto them until we died… suffering diminished cognitive ability with age, on account of losing brain cells along the way.

It’s partly true: it’s definitely easier to kill brain cells than to grow them… Mind you, that’s technically true of people, too, yet the population continues to boom!

Anyway, new research showing that adults do, in fact, grow new braincells was briefly challenged by a 2018 study that declared: Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults after all, never mind, go back to your business.

So was adult neurogenesis just a myth to be busted after all? Nope.

It turned out, the 2018 study had a methodological flaw!

To put it in lay terms: they had accidentally melted the evidence.

A 2019 study overcame this flaw by using a shorter fixation time for the cell samples they wanted to look at, and found that there were tens of thousands of “baby neurons” (again with the lay terms), newly-made brain cells, in samples from adults ranging from 43 to 87.

Now, there was still a difference: the samples from the youngest adult had 30% more newly-made braincells than the 87-year-old, but given that previous science thought brain cell generation stopped in childhood, the fact that an 87-year-old was generating new brain cells 30% less quickly than a 43-year-old is hardly much of a criticism!

As an aside: samples from patients with Alzheimer’s also had a 30% reduction in new braincell generation, compared to samples from patients of the same age without Alzheimer’s. But again… Even patients with Alzheimer’s were still growing some new brain cells.

Read it for yourself: Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

In a nutshell…

  • We can’t fully hit pause on aging just yet, but we can definitely genuinely slow it
  • We can also, in some very specific ways, reverse it
  • We can slow the loss of brain cells
  • We can grow new brain cells
  • We can reduce our risk of Alzheimer’s, and at least somewhat mitigate it if it appears
  • We know that phosphatidylserine supplementation may help with most (if not all) of the above
  • We don’t sell that (or anything else) but for your convenience, here it is on Amazon if you’re interested

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  • 14 Powerful Strategies To Prevent Dementia

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dementia risk starts climbing very steeply after the age of 65, but it’s not entirely predetermined. Dr. Brad Stanfield, a primary care physician, has insights:

    The strategies

    We’ll not keep them a mystery; they are:

    • Cognitive stimulation: which means genuinely challenging mental activities using a variety of mental faculties. This will usually mean that anything that is just “same old, same old” all the time will stop giving benefits after a short while once it becomes rote, and you’ll need something harder and/or different.
    • Hearing health: being unable to participate in conversations increases dementia risk; hearing aids can help.
    • Eyesight health: similar to the above; regular eye tests are good, and the use of glasses where appropriate.
    • Depression management: midlife depression is linked to later life dementia, likely in large part due to social isolation and a lack of stimulation, but either way, treating depression earlier reduces later dementia risk.
    • Exercising regularly: what’s good for the heart is good for the brain; the brain is a hungry organ and the blood is what feeds it (and removes things that shouldn’t be there)
    • Head injury avoidance: even mild head injuries can cause problems down the road. Protecting one’s head in sports, and even while casually cycling, is important.
    • Smoking cessation: just don’t smoke; if you smoke, make it a top priority to quit unless you are given direct strong medical advice to the contrary (there are cases, few and far between, whereby quitting smoking genuinely needs to be deferred until after something else is dealt with first, but they are a lot rarer than a lot of people who are simply afraid of quitting would like to believe)
    • Cholesterol management: again, healthy blood means a healthy brain, and that goes for triglycerides too.
    • Weight management: obesity, especially waist to hip ratio (indicating visceral abdominal fat specifically) is associated with many woes, including dementia.
    • Diabetes management: once again, healthy blood means a healthy brain, and that goes for blood sugar management too.
    • Blood pressure management: guess what, healthy blood still means a healthy brain, and that goes for blood pressure too.
    • Alcohol reduction/cessation: alcohol is bad for pretty much everything, and for most people who drink, quitting is probably the top thing to do after quitting smoking.
    • Social engagement: while we all may have our different preferences on a scale of introversion to extroversion, we are fundamentally a social species and thrive best with social contact, even if it’s just a few people.
    • Air pollution reduction: avoiding pollutants, and filtering the air we breathe where pollutants are otherwise unavoidable, makes a measurable difference to brain health outcomes.

    For more information on all of these (except the last two, which really he only mentions in passing), enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    How To Reduce Your Alzheimer’s Risk ← our own main feature on the topic

    Take care!

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  • Build Bone Without Jumping

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Lisa Moore shows us several ways:

    Understand the gravity of the situation

    Jumping is great to keep your bones healthy, strong, and dense!

    Jumping is not so great if you already have osteoporosis, as you are much more likely to break something.

    So, what to do?

    First, understand the mechanics and physiology of why jumping works: impact improves bone density by increasing ground reaction forces—when your body pushes into the ground and the ground pushes back, making it stronger, in accordance with Woolf’s Law (the bone of a healthy animal adapts to the loads placed on it).

    This is because bone is living tissue and when a bone experiences regular, appropriately applied loading—such as compression, tension, or shear—it responds by becoming denser and stronger in the areas where that stress occurs.

    Conversely, when loading is reduced or absent, bone tissue is gradually reabsorbed, and the bone becomes weaker.

    This is why weight-bearing, resistance, and impact-style forces are particularly effective for improving bone density, while non–weight-bearing activity has much less effect on skeletal strength.

    Note: you will need a certain baseline amount of strength to be able to do this. So if you don’t work up to it slowly first.

    Squats that will work:

    • Squats with speed: a slow bodyweight squat produces the force associated with about 1x bodyweight, while performing the same squat more explosively can raise ground reaction forces to 2–3x that of bodyweight, without jumping, as you accelerate due to gravity on the way down, and then you push downwards again, powerfully pushing the entire planet away, because that’s how strong you are.
      • It sounds silly like that, but as we know from Newton, these forces are equal and opposite!
    • Squats with speed and load: holding weight during strength or power exercises further increases ground reaction forces, providing more bone stimulus while remaining controlled, so that’s the progression to aim for here.

    Step-ups are great too; here are some considerations to get the most out of them:

    • Step height matters: step-ups create higher gravitational potential energy (and thus greater force when that energy is used on the way down) as the step gets higher, with lateral and forward step-ups offering different force levels while still being lower risk than jumping. On which note…
    • Lateral stepovers: lateral step-based movements combine power and speed to raise ground reaction forces in a way that often feels safer and more comfortable than traditional impact, and again, Woolf’s Law is quite specific about this—bones strengthen in the exact regions and directions that forces are applied. So if you only train in one direction, your bone will only be strong in one direction, which means it’ll break easily if a force is applied in a different direction (say, you slip and fall sideways).
    • Weighted step-ups: adding weight to step-ups also increases the force, of course.

    As for which to focus on increasing (safely, please) you probably remember from school that force = mass x acceleration, so increasing either the mass or the acceleration will give benefits.

    For more on all of this plus some notes about heel stomps vs heel drops, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Osteoporosis & Exercises: Which To Do (And Which To Avoid)

    Take care!

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  • Artichoke vs Pumpkin – Which is Healthier?

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    Our Verdict

    When comparing artichoke to pumpkin, we picked the artichoke.

    Why?

    It wasn’t close!

    In terms of macros, artichoke has 11x the fiber, slightly more carbs, and more than 3x the protein, winning easily in this category.

    In the category of vitamins, artichoke has more of vitamins B1, B3, B5, B6, B7, B9, C, and K, while pumpkin has more of vitamins A, B2, and E, giving artichoke an 8:3 victory here.

    Looking at minerals, artichoke has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and zinc, while pumpkin has more selenium, meaning an 8:1 victory for artichoke in this round.

    In other considerations, artichoke has more polyphenols by far, thus winning one more round.

    Adding up the sections makes for a clear overall win for artichoke, but by all means enjoy either or both, as diversity is good!

    Want to learn more?

    You might like:

    What Do The Different Kinds Of Fiber Do? 30 Foods That Rank Highest

    Enjoy!

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  • The World’s Shortest Weight Loss Course

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The third part of this is what most people are missing:

    As easy as 1-2-3?

    A lot of things that work very quickly are either not sustainable, or are optical illusions (e.g. loss of water weight) or both.

    That doesn’t mean you can or should wait forever for something to magically work, though. Instead, you want something that will offer you consistent measurable progress. Here’s a step-by-step guide to one such approach:

    First, the foundation:
    Eat in a small deficit: consume about 15% fewer calories than maintenance, with 18% from protein—any eating style that achieves this works.
    Move more: increase daily steps by 1,000 per month until reaching 6,000–10,000 a day; everyday movement burns more than workouts alone.
    Improve psychology: consistency matters more than fluctuations on the scale. Common blockers include emotional eating, unresolved beliefs about thinness, and lack of deeper motivation beyond appearance.

    Next, the optimization:
    Improve food quality: aim for 80% whole foods and 20% “anything goes”, reducing junk food gradually.
    Enjoy movement: pick fun, low-impact, medium-intensity activities (like hiking or dancing) to protect joints and build long-term habits.
    Prioritize sleep: add even just 15 minutes at a time, levelling up to another 15 minutes each month, until you reach 8–9 hours per night—vital for metabolic health, brain health, and health on the whole*.

    Finally, the continuation:
    Be prepared: expect progress to stall every few months; this is biological, not failure. These plateaus are inevitable (but not insurmountable, as you’ll see).
    Overcome plateaus: by adjusting one factor at a time—calories, carbs, protein, sensitivities, exercise type, or temporary maintenance eating.

    *Yes, even at your age, whatever age that may be. The idea that “older people need less sleep” is a myth, based on the observation of “older people get less sleep”.

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    How To Lose Weight (Healthily!) ← our own main feature on this, which is very compatible with the above method, while having more tips and some very useful resources

    Take care!

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  • How Acetaminophen (Paracetamol) Suppresses Endocannabinoids

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    …contrary to all expectations (and how this can lead to more effective acetaminophen-like pain relief, without the toxicity!

    It’s well known that acetaminophen (international name: paracetamol, most well-known brand name in the US: Tylenol) is a mild painkiller and anti-fever agent; what’s not well understood is how it actually works.

    Recently, a team of researchers (Dr. Michaela Dvorakova et al.) looked into this, and found something that was quite surprising, to understate it considerably.

    That sounds like a clickbait headline (“and what they discovered will shock you!”) but well, we don’t do clickbait and our own headline covers it: acetaminophen suppresses endocannabinoids, when generally for painkilling purposes we want more endocannabinoids, not less.

    Before we get into that, let’s take a moment to note some of the bad parts of acetaminophen’s safety profile, which is to say: it’s really not very safe.

    Rather than repeat ourselves though, we’ll link to where we did a whole main feature about that, here: Before You Reach For That Tylenol…

    Now, about acetaminophen and endocannabinoids

    In the lead researcher’s words:

    ❝There are hypotheses, but we still don’t know precisely how it works. Up until now we thought that elevated endocannabinoids in our body meant less pain, but our study shows that in the case of 2-AG, it might be the opposite. Actually, reduced levels of 2-AG leads to decreased pain.❞

    ~ Dr. Michaela Dvorakova

    You may be wondering: what’s 2-AG?

    And the answer is that it’s 2-arachidonoyl glycerol, which is a cannabinoid naturally made by the human body (thus, endogenous cannabinoid, or usually written: endocannabinoid).

    What the researchers found is that acetaminophen inhibits an enzyme that makes that endocannabinoid, namely, diacylglycerol lipase α (DAGLα) ← as in, this is the name of the enzyme that makes it.

    Thus, inhibiting the enzyme means inhibiting endocannabinoid production. So, what gives, and why does this work as a painkiller, when it looks like it’s doing the opposite?

    The researchers propose… Well, we’ll quote them:

    ❝This gives rise to the counterintuitive hypothesis that decreasing endocannabinoid production by DAGLα inhibition may be antinociceptive in certain settings.

    Supporting this hypothesis, we find that diacylglycerol lipase (DAGL) inhibition by RHC80267 is antinociceptive in wild-type but not CB1 knockout mice in the hot-plate test.

    We propose (1) that activation of DAGLα may exacerbate some forms of nociception and (2) a mechanism for the antinociceptive actions of acetaminophen, whereby acetaminophen inhibits a DAGLα/CB1-based circuit that plays a permissive role in at least one form of nociception.❞

    Translating from sciencese: by stopping the endocannabinoid production, the body is triggered to engage a different, more effective method of killing pain.

    You can read the paper in full here: Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception

    As for what the implications are? Per the researchers, it means that if we understand that inhibiting the enzyme DAGLα triggers a painkilling response, then new drugs can be designed to target DAGLα without the toxicity of acetaminophen.

    So, keep an eye out for that, and you heard it hear first!

    Want to learn more?

    We’ve written quite a bit about pain management, including:

    Take care!

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  • The Secret Behind Losing Inches, Not Weight

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    “Ignore the numbers on the scale” turns out to be good advice:

    What matters more for the health

    Taken at face value, the numbers on the scale represent nothing more nor less than your relationship with gravity.

    On a more complex level, weight reflects muscle, fat, water, hormonal fluctuations, food*, stress, and sleep, so the number can stay the same while your body shrinks.

    *Literally, the food itself, not the consequences. Let’s put it this way: if you eat an entire cabbage, then you’re not going to “put on weight” from it, but nevertheless, the mass of the cabbage is inside you right now and the scale will reflect that.

    As you probably know, muscle weighs more than fat, so if you gain the former and lose the latter, you can look leaner at the same weight. In other words, losing inches without losing weight means body recomposition is happening and your body is probably doing well, all else being equal. This also means that you can see progress sooner than the scale would tell you, by taking measurements and noting how your clothes fit.

    A common mistake that many people make when trying to “lose weight” is cutting calories and adding cardio, but that usually breaks down muscle and slows long-term fat loss, rather than hastening it.

    A three-step process that’s better:

    • Set your intentions by replacing restricting and overtraining with fueling well, training with purpose, and recovering intentionally too
    • Add protein, nutrient diversity, water, and energizing whole foods that contain plenty of fiber
    • Strengthen by focusing on strength training and progressive overload, which outperforms cardio for long-term fat burning

    Some myths to not fall for:

    • The muscle and fat myth: muscle does not turn into fat; losing muscle lowers daily burn and increases fat storage
    • The menopause myth: you can build muscle during menopause by adjusting training, protein intake, and recovery
    • The cardio myth: cardio burns energy briefly, but muscle burns energy all day and thus has a bigger long-term impact

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Can You Gain Muscle & Lose Fat At The Same Time?

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

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