How To Rebuild Your Neurons’ Myelin Sheaths

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PS: We Love You

Phosphatidylserine, or “PS” for short, is a phospholipid found in the brain. In other words, a kind of fatty compound that is such stuff as our brains are made of.

In particular, it’s required for healthy nerve cell membranes and myelin (the protective sheath that neurons live in—basically, myelin sheaths do for neurons what telomere caps do for DNA).

For an overview that’s more comprehensive than we have room for here, check out:

Phosphatidylserine and the human brain

Many people take it as a supplement.

Does taking it as a supplement work?

This is a valid question, as a lot of supplements can’t be absorbed well, and/or can’t pass the blood-brain barrier. But, as the above-linked study notes:

❝Exogenous PS (300-800 mg/d) is absorbed efficiently in humans, crosses the blood-brain barrier, and safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells. It supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate. It also supports locomotor functions, especially rapid reactions and reflexes.❞

~ Glade & Smith.

(“Exogenous” means “coming from outside of the body”, as opposed to “endogenous”, meaning “made inside the body”. Effectively, in this context “exogenous” means “taken as a supplement”.)

Why do people take it?

The health claims for phosphatidylserine fall into two main categories:

  1. Neuroprotection (helping your brain to avoid age-related decline in the long term)
  2. Cognitive enhancement (helping your brain work better in the short term)

What does the science say?

There’s a lot of science that’s been done on the neuroprotective properties of PS, and there are thousands of studies we could draw from here. The upshot is that regular phosphatidylserine supplementation (most often 300mg/day, but studies are also found for 100–500mg/day) is strongly associated with a reduction in cognitive decline over the course of 12 weeks (a common study duration). Here are a some spotlight studies showing this:

Note: PS can be derived from various sources, with the two most common forms being bovine (i.e., from cow brains) or soy-derived.

There is no established difference in the efficacy of these.

There have been some concerns raised about the risk of CJD (the human form of BSE, as in “mad cow disease”) from consuming brain matter from cows, but studies have not found any evidence of this actually happening.

There is also some evidence that phosphatidyserine significantly boosts cognitive performance, even in young people with no extant cognitive decline, for example:

The effects of [phosphatidylserine supplementation] on cognitive function, mood and endocrine response before and following acute exercise

(as the title suggests, they did also test for its effect on mood and endocrine response, but found it made no difference to those, just the cognitive function—which enjoyed a boost before exercise, as well as after it, meaning that the boost wasn’t dependent on the exercise)

PS for cognitive enhancement in the young and healthy is not nearly so well-explored as its use as a later-life guard against age-related cognitive decline. However, just because the studies in younger people are dwarfed in number by the studies in older people, doesn’t detract from the validity of the studies in younger people.

Basically: its use in older people has been studied the most, but all available evidence points to it being beneficial to brain health at all ages.

Where can we get it?

We don’t sell it (or anything else), but for your convenience, here’s an example product on Amazon.

Enjoy!

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  • Yoga that Helps You on the Loo

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    How This Video Helps You Poo

    When you’re feeling a bit bloated, Yoga With Bird’s 10-minute yoga routine promises to help you release…your gas. And, perhaps, more.

    From a tabletop flow to soothing twists, each pose allows you to sync your breath with movement, helping to promote organic relief.

    With options to modify with pillows for extra support, this video (below) caters to everyone needing a digestive reset.

    Other Toilet Tricks

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    Namaste and goodbye to bloat!

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  • Top 10 Early Warning Signs Of Dementia

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    What’s a harmless momentary mind-blank, and what’s a potential warning sign of dementia? Dementia Careblazers, a dementia care organization, has input:

    The signs

    With the caveat that this is a list of potential warning signs, not a diagnostic tool, the 10 signs are:

    • Memory loss: e.g. forgetting important or well-learned information, such as one’s home address
    • Challenges in planning or solving problems: e.g. difficulty with tasks such as paying bills (for organizational rather than financial reasons), following recipes, or managing medications
    • Difficulty completing familiar tasks: e.g. trouble remembering rules of a familiar game, or directions to a familiar place
    • Confusion with place or time: e.g. forgetting where one is, or making mistakes with the date, season, or other time-related details. Note that anyone can be momentarily unsure of today’s date, but if someone thinks it’s 1995, probably something wrong is not quite right. Similarly, being wrong about who is the current national leader is often used as a test, too—assuming countries with enough political stability to not have five different national leaders in the past four years, including one who did not outlast a lettuce *side-eyeing the UK*
    • Trouble understanding visual images and spatial relationships: e.g. increased clumsiness, difficulty parking, or bumping into objects
    • New problems with speaking or writing: e.g. losing track in conversations, or struggling to find the right words
    • Misplacing things: e.g. losing items and being unable to retrace one’s steps to find them
    • Decreased or poor judgment: e.g. falling for scams, giving out too much information or money without investigating appropriately first
    • Withdrawal from social activities or hobbies: e.g. losing interest in activities one used to enjoy or avoiding social interactions
    • Changes in mood and personality: e.g. increased irritability, anxiety, or other noticeable changes in behavior and personality

    For more information on each of these, enjoy:

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    Want to learn more?

    You might also like to read:

    Dementia: Spot The Signs (Because None Of Us Are Immune)

    Take care!

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  • An apple cider vinegar drink a day? New study shows it might help weight loss

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Made from fermented apples and naturally high in acetic acid, apple cider vinegar has been popular in recent years for its purported health benefits – from antibacterial properties to antioxidant effects and potential for helping manage blood sugars.

    Its origins as a health tonic stretch much further back. Hippocrates used it to treat wounds, fever and skin sores.

    An experimental study, released today, looks into whether apple cider vinegar could be effective for weight loss, reduce blood glucose levels and reduce blood lipids (cholesterol and triglycerides).

    The results suggest it could reduce all three – but it might not be as simple as downing an apple cider vinegar drink a day.

    What did they do?

    A group of scientists in Lebanon did a double-blinded, randomised, clinical trial in a group of overweight and obese young people aged from 12–25 years.

    Researchers randomly placed 30 participants in one of four groups. The participants were instructed to consume either 5, 10 or 15ml of apple cider vinegar diluted into 250ml of water each morning before they ate anything for 12 weeks. A control group consumed an inactive drink (a placebo) made (from lactic acid added to water) to look and taste the same.

    Typically this sort of study provides high quality evidence as it can show cause and effect – that is the intervention (apple cider vinegar in this case) leads to a certain outcome. The study was also double-blinded, which means neither the participants or the scientists involved with collecting the data knew who was in which group.

    So, what did they find?

    After a period of three months apple cider vinegar consumption was linked with significant falls in body weight and body mass index (BMI). On average, those who drank apple cider vinegar during that period lost 6–8kg in weight and reduced their BMI by 2.7–3 points, depending on the dose. They also showed significant decreases in the waist and hip circumference.

    The authors also report significant decreases in levels of blood glucose, triglycerides, and cholesterol in the apple cider groups. This finding echoes previous studies. The placebo group, who were given water with lactic acid, had much smaller decreases in weight and BMI. There were also no significant decreases in blood glucose and blood lipids.

    From animal studies, it is thought the acetic acid in apple cider vinegar may affect the expression of genes involved in burning fats for energy. The new study did not explore whether this mechanism was involved in any weight loss.

    Is this good news?

    While the study appears promising, there are also reasons for caution.

    Firstly, study participants were aged from 12 to 25, so we can’t say whether the results could apply to everyone.

    The statistical methods used in the study don’t allow us to confidently say the same amount of weight loss would occur again if the study was done again.

    And while the researchers kept records of the participants’ diet and exercise during the study, these were not published in the paper. This makes it difficult to determine if diet or exercise may have had an impact. We don’t know whether participants changed the amount they ate or the types of food they ate, or whether they changed their exercise levels.

    The study used a placebo which they tried to make identical in appearance and taste to the active treatment. But people may still be able to determine differences. Researchers may ask participants at the end of a study to guess which group they were in to test the integrity of the placebo. Unfortunately this was not done in this study, so we can’t be certain if the participants knew or not.

    Finally, the authors do not report whether anyone dropped out of the study. This could be important and influence results if people who did not lose weight quit due to lack of motivation.

    open glass of liquid with cloudy substance at bottom, surrounded by apples
    Is that you mother? The enzymes in apple cider vinegar might be health-giving.
    Shutterstock

    Any other concerns?

    Apple cider vinegar is acidic and there are concerns it may erode tooth enamel. This can be a problem with any acidic beverages, including fizzy drinks, lemon water and orange juice.

    To minimise the risk of acid erosion some dentists recommend the following after drinking acidic drinks:

    • rinsing out your mouth with tap water afterwards
    • chewing sugar-free gum afterwards to stimulate saliva production
    • avoiding brushing your teeth immediately after drinking because it might damage the teeth’s softened top layer
    • drink with a straw to minimise contact with the teeth.
    woman holds glass of water and has full cheeks
    Rinsing with water could prevent acid damaging your teeth.
    Shutterstock

    Down the hatch?

    This study provides us with some evidence of a link between apple cider vinegar and weight loss. But before health professionals can recommend this as a weight loss strategy we need bigger and better conducted studies across a wider age range.

    Such research would need to be done alongside a controlled background diet and exercise across all the participants. This would provide more robust evidence that apple cider vinegar could be a useful aid for weight loss.

    Still, if you don’t mind the taste of apple cider vinegar then you could try drinking some for weight loss, alongside a healthy balanced and varied dietary intake. This study does not suggest people can eat whatever they like and drink apple cider vinegar as a way to control weight. The Conversation

    Evangeline Mantzioris, Program Director of Nutrition and Food Sciences, Accredited Practising Dietitian, University of South Australia

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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    A no-nonsense guide to (more than!) public speaking that isn’t just “tell jokes in your speech and imagine the audience naked”.

    Because this isn’t just about speech-writing or speech delivery, so much as giving you important life skills. The kind that weren’t taught in school, but that nevertheless make a huge impact on success… whether you’re giving a presentation or hosting a party or negotiating a deal or just attending a social event. Or making a phonecall, even.

    Whereas a lot of books of this kind treat “the audience” as a nebulous and purely responsive passive crowd of extras, Goyder does better. People are individuals, even if they’re all facing the same way for a moment. She works with that! She also teaches how to deal with not just hecklers, but also simply those people who sap your confidence and find fault with you and anything you do or say.b

    Bottom line is: if you for whatever reason communicate with people, and would like them to think better of you, this is the book for you.

    Order your copy of Gravitas from Amazon today!

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  • Nasal Hair; How Far To Go?

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    t’s Q&A Day at 10almonds!

    Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

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    ❝As a man in his sixties I find I need to trim my nasal hair quite frequently, otherwise it sticks out in an unsightly manner. But I’m never sure how severely I should cut the hairs back, or even how best to do it. Please advise.❞

    As you might know, those hairs are really important for our health, so let’s start by mentioning that yes, trimming is the way, not plucking!

    In an ideal world, we’d not trim them further back than the entrance to our nostrils, but given the constant nature of hair-growing, that could become a Sisyphean task.

    A good compromise, if you’re not up for trimming when you get up and having visible hairs by evening, is to put the scissors away (if you haven’t already) and use a nasal hair trimmer; these are good at a) trimming nasal hairs b) abstaining from trimming them too far back.

    By all means shop around, but here’s an example product on Amazon, for your convenience!

    Enjoy!

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  • The Circadian Code – by Dr. Satchin Panda

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    • Our body needs to know what time it is, for those processes to work correctly
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