
How Exercise Reverses Muscle Aging
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First things first, let’s quickly cover that biological age is not one thing but quite a lot of things, each of which can age at different rates, for example:
- Visual markers of aging (e.g. wrinkles, graying hair)
- Performative markers of aging (e.g. mobility tests)
- Internal functional markers of aging (e.g. tests for cognitive decline, eyesight, hearing, etc)
- Cellular markers or aging (e.g. telomere length)
- …and more, but we only have so much room here and we do want to get on to the topic of muscle aging
For what we can do about each of those other ones we mentioned, see: Age & Aging: What Can (And Can’t) We Do About It?
So, what’s this about exercise vs muscle aging?
You can rebuild you; you have the (bio)technology
Your body is constantly rebuilding itself, in fact. Every single cell gets regularly replaced—some kinds more quickly than others, but yes, all of them (yes, even brain cells, per: Building Your Brain At Every Age).
Even the inorganic minerals of your bones, teeth, etc are constantly being added and removed by active processes (see: Which Osteoporosis Medication, If Any, Is Right For You?, for an explainer on that, since it has to do with acting on your body’s specialized cells that, respectively, destroy and rebuild bone for you).
Your muscles are also very much part of the constant destroy-and-rebuild processes of your body, as the mTORC1 growth pathway helps maintain muscle by regulating protein production, but healthy muscles must also remove damaged proteins to remain functional.
In aging muscles, mTORC1 becomes overactive, shifting the balance towards producing new proteins while reducing the removal of damaged ones. You would think that would result in bigger muscles, but no: allowing defective proteins to accumulate actively makes the muscles weaker, and biologically older.
The new discovery we want to talk about is the role of DEAF1 (that’s a gene)*. Researchers (Dr. Weiyi Jiang et al.) found that DEAF1 levels rise with age, driving excessive mTORC1 activity and worsening the imbalance between protein production and protein clearance, accelerating muscle deterioration.
*Specifically, a genetic transcription factor, and nothing to do with deafness (although certain mutations of DEAF1 can cause speech impairments, but that’s a separate matter). The name comes from “Deformed Epidermal Autoregulatory Factor 1”.
To explain in few words why this matters:
- Why DEAF1 increases: under normal conditions, FOXO proteins keep DEAF1 under control, but FOXO activity naturally declines with age, allowing DEAF1 levels to increase.
- How exercise helps: exercise activates proteins that lower DEAF1 levels, restoring a healthier balance in mTORC1 activity so muscles can remove damaged proteins more effectively, repair themselves, and remain stronger and more resilient. Yay!
There are some limitations still: when DEAF1 levels become extremely high, or FOXO activity falls too far, exercise alone might not fully restore muscle repair, potentially explaining why some older adults benefit more from exercise than others, but research is still ongoing in this regard.
Meanwhile, if you’d like to read the paper in full, here it is: Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging
Want to learn more?
For more practical pointers than just “exercise more”, see:
Age & Strength Loss: What Happens When, & How Much Is Unavoidable?
Take care!
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This Bad Habit Is Silently Wrecking Your Joints After 50
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Many people over age 50 unknowingly harm their joints daily through increasingly limited movement habits (if you always stop at 90% of your range of motion, that range of motion will gradually decrease due to disuse, and then you’ll be doing 90% of your new, reduced range of motion, and so on). However, it’s easy to avoid this happening, with some daily habits:
Use it or lose it
Most daily activities involve a very small range of motion, causing joints to gradually stiffen and lose mobility. The body adapts to this by tightening ligaments and reducing the available range of motion—“use it or lose it.” This joint stiffness develops gradually and can lead to hip, knee, and shoulder pain over time.
So, how to avoid it: regularly move your joints through their full range of motion.
Here are three key exercises that he recommends focusing on:
- Knee flexion: lie on your back and work one leg at a time. Start by pressing your leg flat into the surface, holding for a couple of seconds, then bend your knee as far as possible. The key is to push gently into the last few millimeters of motion where stiffness begins, as that’s where actual progress happens. Alternate between full extension and maximum flexion for 10–15 repetitions on each leg.
- Hip rotation: this exercise targets hip rotation and is especially useful if you struggle with activities like putting on shoes or getting in and out of a car. Sit tall on a chair or kitchen countertop—ideally with your feet off the ground—and rotate one leg outward and then inward, keeping your thigh in contact with the seat. Your shin moves in and out while your femur rotates in the hip socket. Spend a few minutes per leg, holding each position for two to three seconds.
- Shoulder flexion: sit upright on a chair with your back away from the backrest. Drop one arm by your side and slowly lift it upward, leading with your thumb, until you reach a point of stiffness—then hold briefly before lowering it again in a controlled motion. This movement takes your shoulder through its full range and helps raise the point of restriction over time. Aim for 5–10 repetitions per arm, done twice daily.
For more on each of these plus visual demonstrations, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
If Life Is A Marathon, Here’s How To Train Mobility For It
Take care!
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Comida Casera – by Dora Ramírez
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The author, a classically trained Mexican chef, adopted a plant-based diet for health reasons, and was concerned she’d have to forego many of her favorite dishes.
However! When it comes down to it, most of the flavor in most dishes comes from the plants (especially but not only: the spices and herbs), and when it comes to meat and dairy, that’s mostly for the texture.
So, she set about veganizing her recipes, keeping all the flavor while changing some of of the texture-giving components. Where once there was cow cheese, now there’s almond cheese. Where once there was animal cream, same deal. Meat, meanwhile, is replaced with rich, fibrous plants with all the same seasonings. Healthy oils add fats that used to be heavily saturated animal fats.
In short, the experience has been kept the same or made tastier, and the health profile has been considerably improved.
Is it perfect, healthwise? Many recipes are! Some aren’t (see for example, those with fried corn tortillas involved, or an ice cream dish that still has its sugar content, etc), but overall, this is an incredibly healthy book of authentic Mexican vegan cooking.
Bottom line: if you like Mexican food and also like looking after your health, you’ll want a copy of this book.
Click here to check out Comida Casera, and enjoy all the flavor without sacrificing your health!
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How To Set Anxiety Aside
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How To Set Anxiety Aside
We’ve talked previously about how to use the “release” method to stop your racing mind.
That’s a powerful technique, but sometimes we need to be calm enough to use it. So first…
Breathe
Obviously. But, don’t underestimate the immediate power of focusing on your breath, even just for a moment.
There are many popular breathing exercises, but here’s one of the simplest and most effective, “4–4 breathing”:
- Breathe in for a count of four
- Hold for a count four
- Breathe out for a count of four
- Hold for a count of four
- Repeat
Depending on your lung capacity and what you’re used to, it may be that you need to count more quickly or slowly to make it feel right. Experiment with what feels comfortable for you, but the general goal should breathing deeply and slowly.
Identify the thing that’s causing you anxiety
We’ve also talked previously about how to use the RAIN technique to manage difficult emotions, and that’s good for handling anxiety too.
Another powerful tool is journaling.
Read: How To Use Journaling to Challenge Anxious Thoughts
If you don’t want to use any of those (very effective!) methods, that’s fine too—journaling isn’t for everyone.
You can leverage some of the same benefits by simply voicing your worries, even to yourself:
There’s an old folk tradition of “worry dolls”; these are tiny little dolls so small they can be kept in a pocket-size drawstring purse. Last thing at night, the user whispers their worries to the dolls and puts them back in their bag, where they will work on the person’s problem overnight.
We’re a health and productivity newsletter, not a dealer of magic and spells, but you can see how it works, right? It gets the worries out of one’s head, and brings about a helpful placebo effect too.
Focus on what you can control
- Most of what you worry about will not happen.
- Some of what you worry about may happen.
- Worrying about it will not help.
In fact, in some cases it may bring about what you fear, by means of the nocebo effect (like the placebo effect, but bad). Additionally, worrying drains your body and makes you less able to deal with whatever life does throw at you.
So while “don’t worry; be happy” may seem a flippant attitude, sometimes it can be best. However, don’t forget the other important part, which is actually focusing on what you can control.
- You can’t control whether your car will need expensive maintenance…
- …but you can control whether you budget for it.
- You can’t control whether your social event will go well or ill…
- …but you can control how you carry yourself.
- You can’t control whether your loved one’s health will get better or worse…
- …but you can control how you’re there for them, and you can help them take what sensible precautions they may.
…and so forth.
Look after your body as well!
Your body and mind are deeply reliant on each other. In this case, just as anxiety can drain your body’s resources, keeping your body well-nourished, well-exercised, and well-rested and can help fortify you against anxiety. For example, when it comes to diet, exercise, and sleep:
- Read: Fruit and vegetable intake is inversely associated with perceived stress across the adult lifespan
- Read: Exercise and anxiety: physical activity appears to be protective against anxiety disorders in clinical and non-clinical populations
- Read: Sleep problems predict and are predicted by generalized anxiety/depression
Don’t know where to start? How about the scientifically well-researched, evidence-based, 7-minute workout?
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Do Try This At Home: The 12-Week Brain Fitness Program
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12 Weeks To Measurably Boost Your Brain
This is Dr. Majid Fotuhi. From humble beginnings (being smuggled out of Iran in 1980 to avoid death in the war), he went on (after teaching himself English, French, and German, hedging his bets as he didn’t know for sure where life would lead him) to get his MD from Harvard Medical School and his PhD in neuroscience from Johns Hopkins University. Since then, he’s had a decades-long illustrious career in neurology and neurophysiology.
What does he want us to know?
The Brain Fitness Program
This is not, by the way, something he’s selling. Rather, it was a landmark 12-week study in which 127 people aged 60–80, of which 63% female, all with a diagnosis of mild cognitive impairment, underwent an interventional trial—in other words, a 12-week brain fitness course.
After it, 84% of the participants showed statistically significant improvements in cognitive function.
Not only that, but of those who underwent MRI testing before and after (not possible for everyone due to practical limitations), 71% showed either no further deterioration of the hippocampus, or actual growth above the baseline volume of the hippocampus (that’s good, and it means functionally the memory center of the brain has been rejuvenated).
You can read a little more about the study here:
As for what the program consisted of, and what Dr. Fotuhi thus recommends for everyone…
Cognitive stimulation
This is critical, so we’re going to spend most time on this one—the others we can give just a quick note and a pointer.
In the study this came in several forms and had the benefit of neurofeedback technology, but he says we can replicate most of the effects by simply doing something cognitively stimulating. Whatever challenges your brain is good, but for maximum effect, it should involve the language faculties of the brain, since these are what tend to get hit most by age-related cognitive decline, and are also what tends to have the biggest impact on life when lost.
If you lose your keys, that’s an inconvenience, but if you can’t communicate what is distressing you, or understand what someone is explaining to you, that’s many times worse—and that kind of thing is a common reality for many people with dementia.
To keep the lights brightly lit in that part of the brain: language-learning is good, at whatever level suits you personally. In other words: there’s a difference between entry-level Duolingo Spanish, and critically analysing Rumi’s poetry in the original Persian, so go with whatever is challenging and/but accessible for you—just like you wouldn’t go to the gym for the first time and try to deadlift 500lbs, but you also probably wouldn’t do curls with the same 1lb weights every day for 10 years.
In other words: progressive overloading is key, for the brain as well as for muscles. Start easy, but if you’re breezing through everything, it’s time to step it up.
If for some reason you’re really set against the idea of learning another language, though, check out:
Reading As A Cognitive Exercise ← there are specific tips here for ensuring your reading is (and remains) cognitively beneficial
Mediterranean diet
Shocking nobody, this is once again recommended. You might like to check out the brain-healthy “MIND” tweak to it, here:
Four Ways To Upgrade The Mediterranean Diet ← it’s the fourth one
Omega-3 supplementation
Nothing complicated here. The brain needs a healthy balance of these fatty acids to function properly, and most people have an incorrect balance (too little omega-3 for the omega-6 present):
What Omega-3 Fatty Acids Really Do For Us ← scroll to “against cognitive decline”
Increasing fitness
There’s a good rule of thumb: what’s healthy for your heart, is healthy for your brain. This is because, like every other organ in your body, the brain does not function well without good circulation bringing plenty of oxygen and nutrients, which means good cardiovascular health is necessary. The brain is extra sensitive to this because it’s a demanding organ in terms of how much stuff it needs delivering via blood, and also because of the (necessary; we’d die quickly and horribly without it) impediment of the blood-brain barrier, and the possibility of beta-amyloid plaques and similar woes (they will build up if circulation isn’t good).
How To Reduce Your Alzheimer’s Risk ← number two on the list here
Practising mindfulness medication
This is also straightforward, but not to be underestimated or skipped over:
No-Frills, Evidence-Based Mindfulness
Want to step it up? Check out:
Meditation Games That You’ll Actually Enjoy
Lastly…
Dr. Fotuhi wants us to consider looking after our brain the same way we look after our teeth. No, he doesn’t want us to brush our brain, but he does want us to take small measurable actions multiple times per day, every day.
You can’t just spend the day doing nothing but brushing your teeth for the entirety of January the 1st and then expect them to be healthy for the rest of the year; it doesn’t work like that—and it doesn’t work like that for the brain, either.
So, make the habits, and keep them going
Take care!
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Figs vs Strawberries – Which is Healthier?
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Our Verdict
When comparing figs to strawberries, we picked the figs.
Why?
Both are great! But…
In terms of macros, figs have more fiber, carbs, and protein, winning this round.
In the category of vitamins, figs have more of vitamins A, B1, B2, B3, B5, B6, B7, and K, while strawberries have more of vitamins B9, C, E, and choline. A 7:4 win for figs.
Looking at minerals, figs have more calcium, copper, magnesium, potassium, and zinc, while strawberries have more iron, manganese, phosphorus, and selenium, making a marginal 5:4 win for figs this time.
In other considerations, strawberries have a much higher polyphenol content, so that’s a point in their favor.
Adding up the sections makes for a clear overall win for figs, but by all means enjoy either or both; diversity is good!
Want to learn more?
You might like:
From Apples to Bees, and High-Fructose Cs: Which Sugars Are Healthier, And Which Are Just The Same?
Enjoy!
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The Vitamin Solution – by Dr. Romy Block & Dr. Arielle Levitan
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A quick note: it would be remiss of us not to mention that the authors of this book are also the founders of a vitamin company, thus presenting a potential conflict of interest.
That said… In this reviewer’s opinion, the book does seem balanced and objective, regardless.
We talk a lot about supplements here at 10almonds, especially in our Monday Research Review editions. And yesterday, we featured a book by a doctor who hates supplements. Today, we feature a book by two doctors who have made them their business.
The authors cover all the most common vitamins and minerals popularly enjoyed as supplements, and examine:
- why people take them
- factors affecting whether they help
- problems that can arise
- complicating factors
The “complicating factors” include, for example, the way many vitamins and/or minerals interplay with each other, either by requiring the presence of another, or else competing for resources for absorption, or needing to be delicately balanced on pain of diverse woes.
This is the greatest value of the book, perhaps; it’s where most people go wrong with supplementation, if they go wrong.
While both authors are medical doctors, Dr. Romy Block is an endocrinologist specifically, and she clearly brought a lot of extra attention to relevant metabolic/thyroid issues, and how vitamins and minerals (such as thiamin and iron) can improve or sabotage such, depending on various factors that she explains. Informative, and so far as this reviewer could see, objective and well-balanced.
Bottom line: supplementation is a vast and complex topic, but this book does a fine job of demystifying and simplifying it in a clear and objective fashion, without resorting to either scaremongering or hype.
Click here to check out The Vitamin Solution, and upgrade your knowledge!
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