GABA Against Stress/Anxiety

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A Neurotransmitter Less Talked-About

GABA is taken by many people as a supplement, mostly as a mood modifier, though its health claims go beyond the recreational—and also, we’re of the opinion that mental health is also just health, and if it works, it works. We’ll explore some of the claims and science behind them today…

What is GABA?

GABA stands for gamma-aminobutyric acid, and it’s a neurotransmitter. It’s a lot less talked-about than for example dopamine or serotonin, but it’s very important nonetheless.

We make it ourselves inside our body, and we can also get it from our food, or supplement it, and some drugs will also have an effect on its presence and/or activity in our body.

What foods is it found in?

  • Animals, obviously (just like in human brains*)
  • Fermented foods (many kinds)
  • Yeast
  • Tea
  • Tomatoes
  • Mulberries

For more details, see:

γ-Aminobutyric acid found in fermented foods and beverages: current trends

*However, we do not recommend eating human brains, due to the risk of CJD and prion diseases in general.

What claims are made about it and are they true?

For brevity, we’ll give a little spoiler up-front: all the popular claims for it appear to be valid, though there’s definitely room for a lot more human trials (we skipped over a lot of rodent studies today!).

So we’ll just drop some of its main benefits, and human studies to back those.

Reduction of stress and anxiety

GABA decreases task-related stress and anxiety within 30 minutes of being taken, both in subjective measures (i.e., self-reports) and in objective clinical physiological measures:

Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks

Cognitive enhancement

It’s not a does-everything nootropic like some, but it does have clear benefits to episodic memory:

❝GABA intake might help to distribute limited attentional resources more efficiently, and can specifically improve the identification and ordering of visual events that occur in close temporal succession

One of the things that makes this one important is that it also deals with the often-asked question of “does GABA pass the blood-brain barrier”:

❝The present findings do give further credence to the idea that oral ingestion does allow GABA to reach the brain and exert direct effects on cognition, which in the present case were specific to temporal attention.❞

Read more:

Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention

Potential for more

We take care to give good quality sources, so the following study comes with a big caveat that it has since been retracted. Why was it retracted, you wonder?

It’s about the sample; they cite “30 healthy adults”, but neglected tp mention that this figure was initially 46. What happened to the other 16 participants is unclear, but given that this was challenged and the challenge not answered, it was sufficient for the journal (Nature) to pull the study, in case of deliberate sample bias.

However! Running the numbers in their results section, a probability of 0.03 is very compelling unless the disappearance of 16 subjects was outright fraudulent (which we regrettably cannot know either way).

Here’s the study (so take it with a pinch of salt, considering the above), and taken at face value, it shows how GABA supplementation improves accurate reactions to fast-moving visual and auditory stimuli:

RETRACTED ARTICLE: γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial

…so, hopefully this experiment will be repeated, without disappearing participants!

The sweet spot

You may be wondering how something that slows a person down (having a relaxing effect) can also speed a person up. This has to do with what it is and isn’t affecting; think of it like a “focus mode” on your computer or other device that greys-out everything else a bit so that you can focus on what you’re doing.

It’s in some ways (by different neurochemical pathways, though) a similar effect to the “relaxed alertness” created by l-theanine supplementation.

There’s also a sweet spot whereby GABA is toning some things down just the right amount, without adversely affecting performance in areas we don’t want slowed down. For the science of this, see:

Too Little and Too Much: Hypoactivation and Disinhibition (Reduced GABAergic Inhibition) of Medial Prefrontal Cortex Cause Attentional Deficits

Is it safe?

GABA is “Generally Recognized As Safe”. However:

  • you should speak with your pharmacist if you are taking any medications for blood pressure or epilepsy, as GABA supplementation may cause them to work too well.
  • you should absolutely not take GABA with alcohol or opioids as (dose-dependent for all the substances involved, and also depending on your metabolic base rate and other factors) its acute depression of the CNS can mean you relax and slow down too much, and you may find yourself not breathing often enough to sustain life.

Aside from that, it is considered safe up to at least 1g/kg/day*. Given that popular doses are 120–750mg, and most people weigh more than 750g, this is very safe for most people:

United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)

Where can I get it?

We don’t sell it, but for your convenience, here’s an example product on Amazon

Enjoy!

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  • Your Simplest Life – by Lisa Turner

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We probably know how to declutter, and perhaps even do a “unnecessary financial expenditures” audit. So, what does this offer beyond that?

    A large portion of this book focuses on keeping our general life in a state of “flow”, and strategies include:

    • How to make sure you’re doing the right part of the 80:20 split on a daily basis
    • Knowing when to switch tasks, and when not to
    • Knowing how to plan time for tasks
    • No more reckless optimism, but also without falling foul of Parkinson’s Law (i.e. work expands to fill the time allotted to it)
    • Decluttering your head, too!

    When it comes to managing life responsibilities in general, Turner is very attuned to generational differences… Including the different challenges faced by each generation, what’s more often expected of us, what we’re used to, and how we probably initially learned to do it (or not).

    To this end, a lot of strategies are tailored with variations for each age group. Not often does an author take the time to address each part of their readership like that, and it’s really helpful that she does!

    All in all, a great book for simplifying your daily life.

    Click here to check out Your Simplest Life on Amazon today!

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  • Weight Vests Against Osteoporosis: Do They Really Build Bone?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Doug Lucas is a dual board-certified physician specializing in optimizing healthspan and bone health for women experiencing osteoporosis, perimenopause, and menopause. Here, he talks weight vests:

    Worth the weight?

    Dr. Lucas cites “Wolf’s Law”—bones respond to stress. A weighted vest adds stress, to help build bone density. That said, they may not be suitable for everyone (for example, in cases of severe osteoporosis or a recent vertebral fracture).

    He also cites some studies:

    • Erlanger Fitness Study (2004): participants with a weighted vest maintained or improved bone density compared to a control group, but there was no group with exercise alone, making it unclear if the vest itself had the biggest impact.
    • Newer studies (2016, 2017): showed improved outcomes for groups wearing a weighted vest, but again lacked an exercise-only group for comparison.
    • 2012 study: included three groups (control, weighted vest, exercise only). Results showed no significant bone density difference between vest and exercise-only groups, though the vest group showed better balance and motor control.

    Dr. Lucas concludes that weighted vests are a useful tool while nevertheless not being a magic bullet for bone health. In other words, they can complement exercise but you will also be fine without. If you do choose to level-up your exercise by using a weight vest, then starting with 5–10% of body weight in a vest is often recommended, but it depends on individual circumstances. If in doubt, start low and build up. Wearing the vest for daily activities can be effective, but improper use (awkward positions or improper impact training) can increase injury risk, so do be careful with that.

    For more on all of this, enjoy:

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    Want to learn more?

    You might also like to read:

    Take care!

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  • Fast Exercise – by Dr. Michael Mosley & Peta Bee

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve written before about the benefits of High-Intensity Interval Training (HIIT), but there’s more to say than we can fit in a short article!

    Dr. Michael Mosley, who hates exercise but knows his stuff when it comes to the benefits, teamed up with Peta Bee, who loves exercise and is a science journalist with degrees in sports science and nutrition, to bring us this book.

    In it, we learn a lot about:

    • the science of HIIT
    • what makes it so different from most kinds of exercise
    • exactly what benefits one can expect

    …in a very detailed clinical fashion (while still remaining very readable).

    By “very detailed clinical fashion”, here we mean “one minute of this kind of exercise this many times per week over this period of time will give this many extra healthy life-years”, for example, along with lots of research to back numbers, and explanations of the mechanisms of action (e.g. reducing inflammatory biomarkers of aging, increasing cellular apoptosis, improving cardiometabolic stats for reduced CVD risk, and many things)

    There’s also time/space given over to exactly what to do and how to do it, giving enough options to suit personal tastes/circumstances.

    Bottom line: if you’d like to make your exercise work a lot harder for you while you spend a lot less time working out, then this book will help you do just that!

    Click here to check out Fast Exercise, and enjoy the benefits!

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Related Posts

  • Goji Berries: Which Benefits Do They Really Have?
  • The Mental Health First-Aid That You’ll Hopefully Never Need

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Take Your Mental Health As Seriously As General Health!

    Sometimes, health and productivity means excelling—sometimes, it means avoiding illness and unproductivity. Both are essential, and today we’re going to tackle some ground-up stuff. If you don’t need it right now, great; we suggest to read it for when and if you do. But how likely is it that you will?

    • One in four of us are affected by serious mental health issues in any given year.
    • One in five of us have suicidal thoughts at some point in our lifetime.
    • One in six of us are affected to at least some extent by the most commonly-reported mental health issues, anxiety and depression, in any given week.

    …and that’s just what’s reported, of course. These stats are from a UK-based source but can be considered indicative generally. Jokes aside, the UK is not a special case and is not measurably worse for people’s mental health than, say, the US or Canada.

    While this is not an inherently cheery topic, we think it’s an important one.

    Depression, which we’re going to focus on today, is very very much a killer to both health and productivity, after all.

    One of the most commonly-used measures of depression is known by the snappy name of “PHQ9”. It stands for “Patient Health Questionnaire Nine”, and you can take it anonymously online for free (without signing up for anything; it’s right there on the page already):

    Take The PHQ9 Test Here! (under 2 minutes, immediate results)

    There’s a chance you took that test and your score was, well, depressing. There’s also a chance you’re doing just peachy, or maybe somewhere in between. PHQ9 scores can fluctuate over time (because they focus on the past two weeks, and also rely on self-reports in the moment), so you might want to bookmark it to test again periodically. It can be interesting to track over time.

    In the event that you’re struggling (or: in case one day you find yourself struggling, or want to be able to support a loved one who is struggling), some top tips that are useful:

    Accept that it’s a medical condition like any other

    Which means some important things:

    • You/they are not lazy or otherwise being a bad person by being depressed
    • You/they will probably get better at some point, especially if help is available
    • You/they cannot, however, “just snap out of it”; illness doesn’t work that way
    • Medication might help (it also might not)

    Do what you can, how you can, when you can

    Everyone knows the advice to exercise as a remedy for depression, and indeed, exercise helps many. Unfortunately, it’s not always that easy.

    Did you ever see the 80s kids’ movie “The Neverending Story”? There’s a scene in which the young hero Atreyu must traverse the “Swamp of Sadness”, and while he has a magical talisman that protects him, his beloved horse Artax is not so lucky; he slows down, and eventually stops still, sinking slowly into the swamp. Atreyu pulls at him and begs him to keep going, but—despite being many times bigger and stronger than Atreyu, the horse just sinks into the swamp, literally drowning in despair.

    See the scene: The Neverending Story movie clip – Artax and the Swamp of Sadness (1984)

    Wow, they really don’t make kids’ movies like they used to, do they?

    But, depression is very much like that, and advice “exercise to feel less depressed!” falls short of actually being helpful, when one is too depressed to do it.

    If you’re in the position of supporting someone who’s depressed, the best tool in your toolbox will be not “here’s why you should do this” (they don’t care; not because they’re an uncaring person by nature, but because they are physiologically impeded from caring about themself at this time), but rather:

    “please do this with me”

    The reason this has a better chance of working is because the depressed person will in all likelihood be unable to care enough to raise and/or maintain an objection, and while they can’t remember why they should care about themself, they’re more likely to remember that they should care about you, and so will go with your want/need more easily than with their own. It’s not a magic bullet, but it’s worth a shot.

    What if I’m the depressed person, though?

    Honestly, the same, if there’s someone around you that you do care about; do what you can to look after you, for them, if that means you can find some extra motivation.

    But I’m all alone… what now?

    Firstly, you don’t have to be alone. There are free services that you can access, for example:

    …which varyingly offer advice, free phone services, webchats, and the like.

    But also, there are ways you can look after yourself a little bit; do the things you’d advise someone else to do, even if you’re sure they won’t work:

    • Take a little walk around the block
    • Put the lights on when you’re not sleeping
    • For that matter, get out of bed when you’re not sleeping. Literally lie on the floor if necessary, but change your location.
    • Change your bedding, or at least your clothes
    • If changing the bedding is too much, change just the pillowcase
    • If changing your clothes is too much, change just one item of clothing
    • Drink some water; it won’t magically cure you, but you’ll be in slightly better order
    • On the topic of water, splash some on your face, if showering/bathing is too much right now
    • Do something creative (that’s not self-harm). You may scoff at the notion of “art therapy” helping, but this is a way to get at least some of the lights on in areas of your brain that are a little dark right now. Worst case scenario is it’ll be a distraction from your problems, so give it a try.
    • Find a connection to community—whatever that means to you—even if you don’t feel you can join it right now. Discover that there are people out there who would welcome you if you were able to go join them. Maybe one day you will!
    • Hiding from the world? That’s probably not healthy, but while you’re hiding, take the time to read those books (write those books, if you’re so inclined), learn that new language, take up chess, take up baking, whatever. If you can find something that means anything to you, go with that for now, ride that wave. Motivation’s hard to come by during depression and you might let many things slide; you might as well get something out of this period if you can.

    If you’re not depressed right now but you know you’re predisposed to such / can slip that way?

    Write yourself instructions now. Copy the above list if you like.

    Most of all: have a “things to do when I don’t feel like doing anything” list.

    If you only take one piece of advice from today’s newsletter, let that one be it!

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  • I’ve been given opioids after surgery to take at home. What do I need to know?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Opioids are commonly prescribed when you’re discharged from hospital after surgery to help manage pain at home.

    These strong painkillers may have unwanted side effects or harms, such as constipation, drowsiness or the risk of dependence.

    However, there are steps you can take to minimise those harms and use opioids more safely as you recover from surgery.

    Flystock/Shutterstock

    Which types of opioids are most common?

    The most commonly prescribed opioids after surgery in Australia are oxycodone (brand names include Endone, OxyNorm) and tapentadol (Palexia).

    In fact, about half of new oxycodone prescriptions in Australia occur after a recent hospital visit.

    Most commonly, people will be given immediate-release opioids for their pain. These are quick-acting and are used to manage short-term pain.

    Because they work quickly, their dose can be easily adjusted to manage current pain levels. Your doctor will provide instructions on how to adjust the dosage based on your pain levels.

    Then there are slow-release opioids, which are specially formulated to slowly release the dose over about half to a full day. These may have “sustained-release”, “controlled-release” or “extended-release” on the box.

    Slow-release formulations are primarily used for chronic or long-term pain. The slow-release form means the medicine does not have to be taken as often. However, it takes longer to have an effect compared with immediate-release, so it is not commonly used after surgery.

    Controlling your pain after surgery is important. This allows you get up and start moving sooner, and recover faster. Moving around sooner after surgery prevents muscle wasting and harms associated with immobility, such as bed sores and blood clots.

    Everyone’s pain levels and needs for pain medicines are different. Pain levels also decrease as your surgical wound heals, so you may need to take less of your medicine as you recover.

    But there are also risks

    As mentioned above, side effects of opioids include constipation and feeling drowsy or nauseous. The drowsiness can also make you more likely to fall over.

    Opioids prescribed to manage pain at home after surgery are usually prescribed for short-term use.

    But up to one in ten Australians still take them up to four months after surgery. One study found people didn’t know how to safely stop taking opioids.

    Such long-term opioid use may lead to dependence and overdose. It can also reduce the medicine’s effectiveness. That’s because your body becomes used to the opioid and needs more of it to have the same effect.

    Dependency and side effects are also more common with slow-release opioids than immediate-release opioids. This is because people are usually on slow-release opioids for longer.

    Then there are concerns about “leftover” opioids. One study found 40% of participants were prescribed more than twice the amount they needed.

    This results in unused opioids at home, which can be dangerous to the person and their family. Storing leftover opioids at home increases the risk of taking too much, sharing with others inappropriately, and using without doctor supervision.

    Kitchen cupboard full of stockpiled medicine
    Don’t stockpile your leftover opioids in your medicine cupboard. Take them to your pharmacy for safe disposal. Archer Photo/Shutterstock

    How to mimimise the risks

    Before using opioids, speak to your doctor or pharmacist about using over-the-counter pain medicines such as paracetamol or anti-inflammatories such as ibuprofen (for example, Nurofen, Brufen) or diclofenac (for example, Voltaren, Fenac).

    These can be quite effective at controlling pain and will lessen your need for opioids. They can often be used instead of opioids, but in some cases a combination of both is needed.

    Other techniques to manage pain include physiotherapy, exercise, heat packs or ice packs. Speak to your doctor or pharmacist to discuss which techniques would benefit you the most.

    However, if you do need opioids, there are some ways to make sure you use them safely and effectively:

    • ask for immediate-release rather than slow-release opioids to lower your risk of side effects
    • do not drink alcohol or take sleeping tablets while on opioids. This can increase any drowsiness, and lead to reduced alertness and slower breathing
    • as you may be at higher risk of falls, remove trip hazards from your home and make sure you can safely get up off the sofa or bed and to the bathroom or kitchen
    • before starting opioids, have a plan in place with your doctor or pharmacist about how and when to stop taking them. Opioids after surgery are ideally taken at the lowest possible dose for the shortest length of time.
    Woman holding hot water bottle (pink cover) on belly
    A heat pack may help with pain relief, so you end up using fewer painkillers. New Africa/Shutterstock

    If you’re concerned about side effects

    If you are concerned about side effects while taking opioids, speak to your pharmacist or doctor. Side effects include:

    • constipation – your pharmacist will be able to give you lifestyle advice and recommend laxatives
    • drowsiness – do not drive or operate heavy machinery. If you’re trying to stay awake during the day, but keep falling asleep, your dose may be too high and you should contact your doctor
    • weakness and slowed breathing – this may be a sign of a more serious side effect such as respiratory depression which requires medical attention. Contact your doctor immediately.

    If you’re having trouble stopping opioids

    Talk to your doctor or pharmacist if you’re having trouble stopping opioids. They can give you alternatives to manage the pain and provide advice on gradually lowering your dose.

    You may experience withdrawal effects, such as agitation, anxiety and insomnia, but your doctor and pharmacist can help you manage these.

    How about leftover opioids?

    After you have finished using opioids, take any leftovers to your local pharmacy to dispose of them safely, free of charge.

    Do not share opioids with others and keep them away from others in the house who do not need them, as opioids can cause unintended harms if not used under the supervision of a medical professional. This could include accidental ingestion by children.

    For more information, speak to your pharmacist or doctor. Choosing Wisely Australia also has free online information about managing pain and opioid medicines.

    Katelyn Jauregui, PhD Candidate and Clinical Pharmacist, School of Pharmacy, Faculty of Medicine and Health, University of Sydney; Asad Patanwala, Professor, Sydney School of Pharmacy, University of Sydney; Jonathan Penm, Senior lecturer, School of Pharmacy, University of Sydney, and Shania Liu, Postdoctoral Research Fellow, Faculty of Medicine and Dentistry, University of Alberta

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • 20 Easy Ways To Lose Belly Fat (Things To *Not* Do)

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    Waist circumference (and hip to waist ratio) has been found to be a much better indicator of metabolic health than BMI. So, while at 10almonds we generally advocate for not worrying too much about one’s BMI, there are good reasons why it can be good to trim up specifically the visceral belly fat. But how?

    What not to do…

    Autumn Bates is a nutritionist, and her tips include nutrition and other lifestyle factors; here are some that we agree with:

    For more, including to learn what she has against peanut butter, enjoy her video:

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    Want to know more?

    Check out our previous main feature:

    Visceral Belly Fat & How To Lose It

    Take care!

    Don’t Forget…

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