Astaxanthin: Super-Antioxidant & Neuroprotectant

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Think Pink For Brain Health!

Astaxanthin is a carotenoid that’s found in:

  • certain marine microalgae
  • tiny crustaceans that eat the algae
  • fish (and flamingos!) that eat the crustaceans

Yes, it’s the one that makes things pink.

But it does a lot more than that…

Super-antioxidant

Move over, green tea! Astaxanthin has higher antioxidant activity than most carotenoids. For example, it is 2–5 times more effective than alpha-carotene, lutein, beta-carotene, and lycopene:

Antioxidant activities of astaxanthin and related carotenoids

We can’t claim credit for naming it a super-antioxidant though, because:

Astaxanthin: A super antioxidant from microalgae and its therapeutic potential

Grow new brain cells

Axtaxanthin is a neuroprotectant, but that’s to be expected from something with such a powerful antioxidant ability.

What’s more special to astaxanthin is that it assists continued adult neurogenesis (creation of new brain cells):

❝The unique chemical structure of astaxanthin enables it to cross the blood-brain barrier and easily reach the brain, where it may positively influence adult neurogenesis.

Furthermore, astaxanthin appears to modulate neuroinflammation by suppressing the NF-κB pathway, reducing the production of pro-inflammatory cytokines, and limiting neuroinflammation associated with aging and chronic microglial activation.

By modulating these pathways, along with its potent antioxidant properties, astaxanthin may contribute to the restoration of a healthy neurogenic microenvironment, thereby preserving the activity of neurogenic niches during both normal and pathological aging. ❞

Source: Dietary Astaxanthin: A Promising Antioxidant and Anti-Inflammatory Agent for Brain Aging and Adult Neurogenesis

That first part is very important, by the way! There are so many things that our brain needs, and we can eat, but the molecules are unable to pass the blood-brain barrier, meaning they either get wasted, or used elsewhere, or dismantled for their constituent parts. In this case, it zips straight into the brain instead.

See also:

How To Grow New Brain Cells (At Any Age)

(Probably) good for the joints, too

First, astaxanthin got a glowing report in a study we knew not to trust blindly:

A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis

…and breathe. What a title that was! But, did you catch why it’s not to be trusted blindly? It was down at the bottom…

❝Conflict of interest statement

NOVAREX Co., Ltd. funded the study. Valensa International provided the FlexPro MD® ingredients, and NOVAREX Co., Ltd. encapsulated the test products (e.g., both FlexPro MD® and placebo)❞

Studies where a supplement company funded the study are not necessarily corrupt, but they can certainly sway publication bias, i.e. the company funds a bunch of studies and then pulls funding from the ones that aren’t going the way it wants.

So instead let’s look at:

Astaxanthin attenuates joint inflammation induced by monosodium urate crystals

and

Astaxanthin ameliorates cartilage damage in experimental osteoarthritis

…which had no such conflicts of interest.

They agree that astaxanthin indeed does the things (attenuates joint inflammation & ameliorates cartilage damage).

However, they are animal studies (rats), so we’d like to see studies with humans to be able to say for sure how much it helps these things.

Summary of benefits

Based on the available research, astaxanthin…

  • is indeed a super-antioxidant
  • is a neuroprotective agent
  • also assists adult neurogenesis
  • is probablygood for joints too

How much do I take, and is it safe?

A 2019 safety review concluded:

❝Recommended or approved doses varied in different countries and ranged between 2 and 24 mg.

We reviewed 87 human studies, none of which found safety concerns with natural astaxanthin supplementation, 35 with doses ≥12 mg/day.❞

Source: Astaxanthin: How much is too much? A safety review

In short: for most people, it’s very safe and well-tolerated. If you consume it to an extreme, you will likely turn pink, much as you would turn orange if you did the same thing with carrots. But aside from that, the risks appear to be minimal.

However! If you have a seafood allergy, please take care to get a supplement that’s made from microalgae, not one that’s made from krill or other crustaceans, or from other creatures that eat those.

Where can I get it?

We don’t sell it, but here’s an example product on Amazon, for your convenience

Enjoy!

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  • The Kitchen Prescription – by Saliha Mahmood Ahmed

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    One of the biggest challenges facing anyone learning to cook more healthily, is keeping it tasty. What to cook when your biggest comfort foods all contain things you “should” avoid?

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    All in all, a fine addition to anyone’s kitchen!

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  • 3 signs your diet is causing too much muscle loss – and what to do about it

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    When trying to lose weight, it’s natural to want to see quick results. So when the number on the scales drops rapidly, it seems like we’re on the right track.

    But as with many things related to weight loss, there’s a flip side: rapid weight loss can result in a significant loss of muscle mass, as well as fat.

    So how you can tell if you’re losing too much muscle and what can you do to prevent it?

    EvMedvedeva/Shutterstock

    Why does muscle mass matter?

    Muscle is an important factor in determining our metabolic rate: how much energy we burn at rest. This is determined by how much muscle and fat we have. Muscle is more metabolically active than fat, meaning it burns more calories.

    When we diet to lose weight, we create a calorie deficit, where our bodies don’t get enough energy from the food we eat to meet our energy needs. Our bodies start breaking down our fat and muscle tissue for fuel.

    A decrease in calorie-burning muscle mass slows our metabolism. This quickly slows the rate at which we lose weight and impacts our ability to maintain our weight long term.

    How to tell you’re losing too much muscle

    Unfortunately, measuring changes in muscle mass is not easy.

    The most accurate tool is an enhanced form of X-ray called a dual-energy X-ray absorptiometry (DXA) scan. The scan is primarily used in medicine and research to capture data on weight, body fat, muscle mass and bone density.

    But while DEXA is becoming more readily available at weight-loss clinics and gyms, it’s not cheap.

    There are also many “smart” scales available for at home use that promise to provide an accurate reading of muscle mass percentage.

    Woman stands on scales
    Some scales promise to tell us our muscle mass. Lee Charlie/Shutterstock

    However, the accuracy of these scales is questionable. Researchers found the scales tested massively over- or under-estimated fat and muscle mass.

    Fortunately, there are three free but scientifically backed signs you may be losing too much muscle mass when you’re dieting.

    1. You’re losing much more weight than expected each week

    Losing a lot of weight rapidly is one of the early signs that your diet is too extreme and you’re losing too much muscle.

    Rapid weight loss (of more than 1 kilogram per week) results in greater muscle mass loss than slow weight loss.

    Slow weight loss better preserves muscle mass and often has the added benefit of greater fat mass loss.

    One study compared people in the obese weight category who followed either a very low-calorie diet (500 calories per day) for five weeks or a low-calorie diet (1,250 calories per day) for 12 weeks. While both groups lost similar amounts of weight, participants following the very low-calorie diet (500 calories per day) for five weeks lost significantly more muscle mass.

    2. You’re feeling tired and things feel more difficult

    It sounds obvious, but feeling tired, sluggish and finding it hard to complete physical activities, such as working out or doing jobs around the house, is another strong signal you’re losing muscle.

    Research shows a decrease in muscle mass may negatively impact your body’s physical performance.

    3. You’re feeling moody

    Mood swings and feeling anxious, stressed or depressed may also be signs you’re losing muscle mass.

    Research on muscle loss due to ageing suggests low levels of muscle mass can negatively impact mental health and mood. This seems to stem from the relationship between low muscle mass and proteins called neurotrophins, which help regulate mood and feelings of wellbeing.

    So how you can do to maintain muscle during weight loss?

    Fortunately, there are also three actions you can take to maintain muscle mass when you’re following a calorie-restricted diet to lose weight.

    1. Incorporate strength training into your exercise plan

    While a broad exercise program is important to support overall weight loss, strength-building exercises are a surefire way to help prevent the loss of muscle mass. A meta-analysis of studies of older people with obesity found resistance training was able to prevent almost 100% of muscle loss from calorie restriction.

    Relying on diet alone to lose weight will reduce muscle along with body fat, slowing your metabolism. So it’s essential to make sure you’ve incorporated sufficient and appropriate exercise into your weight-loss plan to hold onto your muscle mass stores.

    Woman uses weights at the gym
    Strength-building exercises help you retain muscle. BearFotos/Shutterstock

    But you don’t need to hit the gym. Exercises using body weight – such as push-ups, pull-ups, planks and air squats – are just as effective as lifting weights and using strength-building equipment.

    Encouragingly, moderate-volume resistance training (three sets of ten repetitions for eight exercises) can be as effective as high-volume training (five sets of ten repetitions for eight exercises) for maintaining muscle when you’re following a calorie-restricted diet.

    2. Eat more protein

    Foods high in protein play an essential role in building and maintaining muscle mass, but research also shows these foods help prevent muscle loss when you’re following a calorie-restricted diet.

    But this doesn’t mean just eating foods with protein. Meals need to be balanced and include a source of protein, wholegrain carb and healthy fat to meet our dietary needs. For example, eggs on wholegrain toast with avocado.

    3. Slow your weight loss plan down

    When we change our diet to lose weight, we take our body out of its comfort zone and trigger its survival response. It then counteracts weight loss, triggering several physiological responses to defend our body weight and “survive” starvation.

    Our body’s survival mechanisms want us to regain lost weight to ensure we survive the next period of famine (dieting). Research shows that more than half of the weight lost by participants is regained within two years, and more than 80% of lost weight is regained within five years.

    However, a slow and steady, stepped approach to weight loss, prevents our bodies from activating defence mechanisms to defend our weight when we try to lose weight.

    Ultimately, losing weight long-term comes down to making gradual changes to your lifestyle to ensure you form habits that last a lifetime.

    At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can register here to express your interest.

    Nick Fuller, Charles Perkins Centre Research Program Leader, University of Sydney

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Chickpeas vs Black Beans – Which is Healthier?

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    Our Verdict

    When comparing chickpeas to black beans, we picked the black beans.

    Why?

    They’re both great! But we consider the nutritional profile of black beans to be better:

    In terms of macros, black beans have a little more protein, while chickpeas have more carbohydrates. Generally speaking, people are not usually short of carbs in their diet, so we’ll go with the one with more protein. Black beans also have more fiber, which is important for heart health and more.

    In the category of micronutrients, black beans have twice as much potassium and twice as much calcium, as well as twice as much magnesium. Chickpeas, meanwhile are better for manganese and slightly higher in B vitamins, but B vitamins are everywhere (especially vitamin B5, pantothenic acid; that’s literally where its name comes from, it means “from everywhere”), so we don’t consider that as much of a plus as the black beans doubling up on potassium, calcium, and magnesium.

    So, do enjoy both, but if you’re going to pick, or lean more heavily on one, we recommend the black beans

    Further reading

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    We’ve talked about mindful eating before at 10almonds, so here’s a book about it. You may wonder how much there is to say!

    As it happens, there’s quite a bit. The authors, a Buddhist monk (Hanh) and a Harvard nutritionist (Dr. Cheung) explore the role of mindful eating in our life.

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    Most of the same advices can be applied equally to other aspects of health, in any case. A lot of that comes from the book’s Buddhist principles, including the notion that:

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    2. Suffering has a cause
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    When comparing swordfish to tuna, we picked the tuna.

    Why?

    Today in “that which is more expensive is not necessarily the healthier”…

    Considering the macros first, swordfish has more than 8x more total fat, about 9x more saturated fat, and yes, more cholesterol. On the other hand, tuna has more protein. An easy win for tuna.

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    Farmed Fish vs Wild Caught: Important Differences

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