Boost Your Digestive Enzymes

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We’ll Try To Make This Easy To Digest

Do you have a digestion-related problem?

If so, you’re far from alone; around 40% of Americans have digestive problems serious enough to disrupt everyday life:

New survey finds forty percent of Americans’ daily lives are disrupted by digestive troubles

…which puts Americans just a little over the global average of 35%:

Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019

Mostly likely on account of the Standard American Diet, or “SAD” as it often gets abbreviated in scientific literature.

There’s plenty we can do to improve gut health, for example:

Today we’re going to be examining digestive enzyme supplements!

What are digestive enzymes?

Digestive enzymes are enzymes that break down food into stuff we can use. Important amongst them are:

  • Protease: breaks down proteins (into amino acids)
  • Amylase: breaks down starches (into sugars)
  • Lipase: breaks down fats (into fatty acids)

All three are available as popular supplements to aid digestion. How does the science stack up for them?

Protease

For this, we only found animal studies like this one, but the results have been promising:

Exogenous protease supplementation to the diet enhances growth performance, improves nitrogen utilization, and reduces stress

Amylase

Again, the studies for this alone (not combined with other enzymes) have been solely from animal agriculture; here’s an example:

The Effect of Exogenous Amylase Supplementation on the Nutritional Value of Peas

Lipase

Unlike for protease and amylase, now we have human studies as well, and here’s what they had to say:

❝Lipase supplementation significantly reduced stomach fullness without change of EGG.

Furthermore, lipase supplementation may be helpful in control of FD symptom such as postprandial symptoms❞

~ Dr. Seon-Young Park & Dr. Jong-Sun Rew

Read more: Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?

(short answer: yes, it is)

More studies found the same, such as:

Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects

All together now!

When we look at studies for combination supplementation of digestive enzymes, more has been done, and/but it’s (as you might expect) less specific.

The following paper gives a good rundown:

Pancrelipase Therapy: A Combination Of Protease, Amylase, & Lipase

Is it safe?

For most people it is quite safe, but if taking high doses for a long time it can cause problems, and also there may be complications if you have diabetes, are otherwise immunocompromised, or have some other conditions (listed towards the end of the above-linked paper, along with further information that we can’t fit in here).

As ever, check with your doctor/pharmacist if you’re not completely sure!

Want some?

We don’t sell them, but for your convenience, here’s an example product on Amazon that contains all three

Enjoy!

We’ll Try To Make This Easy To Digest

Do you have a digestion-related problem?

If so, you’re far from alone; around 40% of Americans have digestive problems serious enough to disrupt everyday life:

New survey finds forty percent of Americans’ daily lives are disrupted by digestive troubles

…which puts Americans just a little over the global average of 35%:

Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019

Mostly likely on account of the Standard American Diet, or “SAD” as it often gets abbreviated in scientific literature.

There’s plenty we can do to improve gut health, for example:

Today we’re going to be examining digestive enzyme supplements!

What are digestive enzymes?

Digestive enzymes are enzymes that break down food into stuff we can use. Important amongst them are:

  • Protease: breaks down proteins (into amino acids)
  • Amylase: breaks down starches (into sugars)
  • Lipase: breaks down fats (into fatty acids)

All three are available as popular supplements to aid digestion. How does the science stack up for them?

Protease

For this, we only found animal studies like this one, but the results have been promising:

Exogenous protease supplementation to the diet enhances growth performance, improves nitrogen utilization, and reduces stress

Amylase

Again, the studies for this alone (not combined with other enzymes) have been solely from animal agriculture; here’s an example:

The Effect of Exogenous Amylase Supplementation on the Nutritional Value of Peas

Lipase

Unlike for protease and amylase, now we have human studies as well, and here’s what they had to say:

❝Lipase supplementation significantly reduced stomach fullness without change of EGG.

Furthermore, lipase supplementation may be helpful in control of FD symptom such as postprandial symptoms❞

~ Dr. Seon-Young Park & Dr. Jong-Sun Rew

Read more: Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?

(short answer: yes, it is)

More studies found the same, such as:

Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects

All together now!

When we look at studies for combination supplementation of digestive enzymes, more has been done, and/but it’s (as you might expect) less specific.

The following paper gives a good rundown:

Pancrelipase Therapy: A Combination Of Protease, Amylase, & Lipase

Is it safe?

For most people it is quite safe, but if taking high doses for a long time it can cause problems, and also there may be complications if you have diabetes, are otherwise immunocompromised, or have some other conditions (listed towards the end of the above-linked paper, along with further information that we can’t fit in here).

As ever, check with your doctor/pharmacist if you’re not completely sure!

Want some?

We don’t sell them, but for your convenience, here’s an example product on Amazon that contains all three

Enjoy!

Don’t Forget…

Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

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  • Fisetin: The Anti-Aging Assassin

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Out With The Old…

    Fisetin is a flavonoid (specifically, a flavonol), but it’s a little different than most. While it has the usual antioxidant, anti-inflammatory, and anti-cancer properties you might reasonably expect from flavonoids, it has an extra anti-aging trick up its sleeve that most don’t.

    ❝Fisetin is a flavonol that shares distinct antioxidant properties with a plethora of other plant polyphenols. Additionally, it exhibits a specific biological activity of considerable interest as regards the protection of functional macromolecules against stress which results in the sustenance of normal cells cytoprotection. Moreover, it shows potential as an anti-inflammatory, chemopreventive, chemotherapeutic and recently also senotherapeutic agent❞

    ~ Dr. Grynkiewicz & Dr. Demchuk

    Let’s briefly do some due diligence on its expected properties, and then we’ll take a look at its bonus anti-aging effects.

    The flavonol that does-it-ol

    Because of the similar mechanisms involved, there are three things that often come together, which are:

    • Antioxidant
    • Anti-inflammatory
    • Anticancer

    This list often gets expanded to also include:

    • Anti-aging

    …although that is usually the last thing to get tested out of that list.

    In today’s case, let’s kick it off with…

    ❝Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects❞

    ~ Dr. Harish Pal et al.

    Read more: Fisetin and Its Role in Chronic Diseases

    Understanding its anticancer mechanisms

    The way that fisetin fights cancer is basically “all the ways”, and this will be important when we get to its special abilities shortly:

    ❝Being a potent anticancer agent, fisetin has been used to inhibit stages in the cancer cells (proliferation, invasion),prevent cell cycle progression, inhibit cell growth, induce apoptosis, cause polymerase (PARP) cleavage, and modulate the expressions of Bcl‐2 family proteins in different cancer cell lines (HT‐29, U266, MDA‐MB‐231, BT549, and PC‐3M‐luc‐6), respectively. Further, fisetin also suppresses the activation of the PKCα/ROS/ERK1/2 and p38 MAPK signaling pathways, reduces the NF‐κB activation, and down‐regulates the level of the oncoprotein securin. Fisetin also inhibited cell division and proliferation and invasion as well as lowered the TET1 expression levels. ❞

    ~ Dr. Muhammad Imran et al.

    Read more: Fisetin: An anticancer perspective

    There’s also more about it than we even have room to quote, here:

    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review

    Now For What’s New And Exciting: Senolysis

    All that selectivity that fisetin exhibits when it comes to “this cell gets to live, and this one doesn’t” actions?

    It makes a difference when it comes to aging, too. Because aging and cancer happen by quite similar mechanisms; they’re both DNA-copying errors that get copied forward, to our detriment.

    • In the case of cancer, it’s a cell line that accidentally became immortal and so we end up with too many of them multiplying in one place (a tumor)
    • In the case of aging, it’s the cellular equivalent of “a photocopy of a photocopy of a photocopy” gradually losing information as it goes

    In both cases…

    The cell must die if we want to live

    Critically, and which quality differentiates it from a lot of other flavonoids, fisetin has the ability to selectively kill senescent cells.

    To labor the photocopying metaphor, this means there’s an office worker whose job it is to say “this photocopy is barely legible, I’m going to toss this, and then copy directly from the clearest copy we have instead”, thus keeping the documents (your DNA) in pristine condition.

    In fisetin’s case, this was first tested in mouse (in vivo) studies, and in human tissue (in vitro) studies, before moving to human clinical studies:

    ❝Of the 10 flavonoids tested, fisetin was the most potent senolytic.

    The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit.❞

    ~ Dr. Matthew Yousefzadeh et al.

    Read in full: Fisetin is a senotherapeutic that extends health and lifespan

    There’s lots more science that’s been done to it since that first groundbreaking study though; here’s a more recent example:

    Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection

    Want some?

    We don’t sell it, but here for your convenience is an example product on Amazon

    Enjoy!

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  • Latest Alzheimer’s Prevention Research Updates

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    Questions and Answers at 10almonds

    Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!

    This newsletter has been growing a lot lately, and so have the questions/requests, and we love that! In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    I am now in the “aging” population. A great concern for me is Alzheimers. My father had it and I am so worried. What is the latest research on prevention?

    One good thing to note is that while Alzheimer’s has a genetic component, it doesn’t appear to be hereditary per se. Still, good to be on top of these things, and it’s never too early to start with preventive measures!

    You might like a main feature we did on this recently:

    See: How To Reduce Your Alzheimer’s Risk

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  • Procrastination, and how to pay off the to-do list debt

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    Procrastination, and how pay off the to-do list debt

    Sometimes we procrastinate because we feel overwhelmed by the mountain of things we are supposed to be doing. If you look at your to-do list and it shows 60 overdue items, it’s little wonder if you want to bury your head in the sand!

    “What difference does it make if I do one of these things now; I will still have 59 which feels as bad as having 60”

    So, treat it like you might a financial debt, and make a repayment plan. Now, instead of 60 overdue items today, you have 1/day for the next 60 days, or 2/day for the next 30 days, or 3/day for the next 20 days, etc. Obviously, you may need to work out whether some are greater temporal priorities and if so, bump those to the top of the list. But don’t sweat the minutiae; your list doesn’t have to be perfectly ordered, just broadly have more urgent things to the top and less urgent things to the bottom.

    Note: this repayment plan means having set repayment dates.

    Up front, sit down and assign each item a specific calendar date on which you will do that thing.

    This is not a deadline! It is your schedule. You’ll not try to do it sooner, and you won’t postpone it for later. You will just do that item on that date.

    A productivity app like ToDoist can help with this, but paper is fine too.

    What’s important here, psychologically, is that each day you’re looking not at 60 things and doing the top item; you’re just looking at today’s item (only!) and doing it.

    Debt Reduction/Cancellation

    Much like you might manage a financial debt, you can also look to see if any of your debts could be reduced or cancelled.

    We wrote previously about the “Getting Things Done” system. It’s a very good system if you want to do that; if not, no worries, but you might at least want to borrow this one idea….

    Sort your items into:

    Do / Defer / Delegate / Ditch

    • Do: if it can be done in under 2 minutes, do it now.
    • Defer: defer the item to a specific calendar date (per the repayment plan idea we just talked about)
    • Delegate: could this item be done by someone else? Get it off your plate if you reasonably can.
    • Ditch: sometimes, it’s ok to realize “you know what, this isn’t that important to me anymore” and scratch it from the list.

    As a last resort, consider declaring bankruptcy

    Towards the end of the dot-com boom, there was a fellow who unintentionally got his 5 minutes of viral fame for “declaring email bankruptcy”.

    Basically, he publicly declared that his email backlog had got so far out of hand that he would now not reply to emails from before the declaration.

    He pledged to keep on top of new emails only from that point onwards; a fresh start.

    We can’t comment on whether he then did, but if you need a fresh start, that can be one way to get it!

    In closing…

    Procrastination is not usually a matter of laziness, it’s usually a matter of overwhelm. Hopefully the above approach will help reframe things, and make things more manageable.

    Sometimes procrastination is a matter of perfectionism, and not starting on tasks because we worry we won’t do them well enough, and so we get stuck in a pseudo-preparation rut. If that’s the case, our previous main feature on perfectionism may help:

    Perfectionism, And How To Make Yours Work For You

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Related Posts

  • Goji Berries: Which Benefits Do They Really Have?
  • Why Has Nobody Told Me This Before? – by Dr. Julie Smith

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Superficially, this can be called a “self-help” book, but that undersells it rather. It’s a professionally-written (as in, by a professional psychologist) handbook full of resources. Its goal? Optimizing your mental health to help you stay resilient no matter what life throws your way.

    While the marketing of this book is heavily centered around Dr. Smith’s Internet Celebrity™ status, a lot of her motivation for writing it seems to be precisely so that she can delve deeper into the ideas that her social media “bites” don’t allow room for.

    Many authors of this genre pad their chapters with examples; there are no lengthy story-telling asides here, and her style doesn’t need them. She knows her field well, and knows well how to communicate the ideas that may benefit the reader.

    The main “meat” of the book? Tips, tricks, guides, resources, systems, flowcharts, mental frameworks, and “if all else fails, do this” guidance. The style of the book is clear and simple, with very readable content that she keeps free from jargon without “dumbing down” or patronizing the reader.

    All in all, a fine set of tools for anyone’s “getting through life” toolbox.

    Get Your Personal Copy Of “Why Has Nobody Told Me This Before?” on Amazon Now!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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  • The Complete Anti-Inflammatory Diet for Beginners – by Dorothy Calimeris and Lulu Cook

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    First, about the authors: notwithstanding the names, Calimeris is the cook, and Cook is the nutritionist (and an RDN at that).

    As for the book: we get a good primer on the science of inflammation, what it is, why it happens, what things are known to cause/trigger it, and what things are known to fight it. They do also go outside of nutrition a bit for this, speaking briefly on other lifestyle factors too, but the main focus is of course nutrition.

    As for the recipes: while distinctly plants-forward (as one might expect of an anti-inflammatory eating book), it’s not outright vegan or even vegetarian, indeed, in the category of main dishes, there are sections for:

    • Vegetarian and vegan
    • Fish and shellfish
    • Poultry and meat

    …as well as, before and after those, sections for breakfast and brunch and snacks and sweets. As well as a not-to-be-underestimated section, for sauces, condiments, and dressings. This is important, because those are quite often the most inflammatory parts of an otherwise healthy meal! So being able to make anti-inflammatory versions is a real boon.

    The recipes are mostly not illustrated, but the steps are very clearly described and easy to follow.

    Bottom line: if inflammation is currently on your to-tackle list, this book will be an excellent companion in the kitchen.

    Click here to check out The Complete Anti-Inflammatory Diet For Beginners, and give your immune system some care!

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    Learn to Age Gracefully

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  • Grains: Bread Of Life, Or Cereal Killer?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Going Against The Grain?

    In Wednesday’s newsletter, we asked you for your health-related opinion of grains (aside from any gluten-specific concerns), and got the above-depicted, below-described, set of responses:

    • About 69% said “They are an important cornerstone of a healthy balanced diet”
    • About 22% said “They can be enjoyed in moderation, but watch out”
    • About 8% said “They are terrible health-drainers that will kill us”

    So, what does the science say?

    They are terrible health-drainers that will kill us: True or False?

    True or False depending on the manner of their consumption!

    There is a big difference between the average pizza base and a bowl of oats, for instance. Or rather, there are a lot of differences, but what’s most critical here?

    The key is: refined and ultraprocessed grains are so inferior to whole grains as to be actively negative for health in most cases for most people most of the time.

    But! It’s not because processing is ontologically evil (in reality: some processed foods are healthy, and some unprocessed foods are poisonous). although it is a very good general rule of thumb.

    So, we need to understand the “why” behind the “key” that we just gave above, and that’s mostly about the resultant glycemic index and associated metrics (glycemic load, insulin index, etc).

    In the case of refined and ultraprocessed grains, our body gains sugar faster than it can process it, and stores it wherever and however it can, like someone who has just realised that they will be entertaining a houseguest in 10 minutes and must tidy up super-rapidly by hiding things wherever they’ll fit.

    And when the body tries to do this with sugar from refined grains, the result is very bad for multiple organs (most notably the liver, but the pancreas takes quite a hit too) which in turn causes damage elsewhere in the body, not to mention that we now have urgently-produced fat stored in unfortunate places like our liver and abdominal cavity when it should have gone to subcutaneous fat stores instead.

    In contrast, whole grains come with fiber that slows down the absorption of the sugars, such that the body can deal with them in an ideal fashion, which usually means:

    • using them immediately, or
    • storing them as muscle glycogen, or
    • storing them as subcutaneous fat

    👆 that’s an oversimplification, but we only have so much room here.

    For more on this, see:

    Glycemic Index vs Glycemic Load vs Insulin Index

    And for why this matters, see:

    Which Sugars Are Healthier, And Which Are Just The Same?

    And for fixing it, see:

    How To Unfatty A Fatty Liver

    They can be enjoyed in moderation, but watch out: True or False?

    Technically True but functionally False:

    • Technically true: “in moderation” is doing a lot of heavy lifting here. One person’s “moderation” may be another person’s “abstemiousness” or “gluttony”.
    • Functionally false: while of course extreme consumption of pretty much anything is going to be bad, unless you are Cereals Georg eating 10,000 cereals each day and being a statistical outlier, the issue is not the quantity so much as the quality.

    Quality, we discussed above—and that is, as we say, paramount. As for quantity however, you might want to know a baseline for “getting enough”, so…

    They are an important cornerstone of a healthy balanced diet: True or False?

    True! This one’s quite straightforward.

    3 servings (each being 90g, or about ½ cup) of whole grains per day is associated with a 22% reduction in risk of heart disease, 5% reduction in all-cause mortality, and a lot of benefits across a lot of disease risks:

    ❝This meta-analysis provides further evidence that whole grain intake is associated with a reduced risk of coronary heart disease, cardiovascular disease, and total cancer, and mortality from all causes, respiratory diseases, infectious diseases, diabetes, and all non-cardiovascular, non-cancer causes.

    These findings support dietary guidelines that recommend increased intake of whole grain to reduce the risk of chronic diseases and premature mortality.❞

    ~ Dr. Dagfinn Aune et al.

    Read in full: Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies

    We’d like to give a lot more sources for the same findings, as well as papers for all the individual claims, but frankly, there are so many that there isn’t room. Suffice it to say, this is neither controversial nor uncertain; these benefits are well-established.

    Here’s a very informative pop-science article, that also covers some of the things we discussed earlier (it shows what happens during refinement of grains) before getting on to recommendations and more citations for claims than we can fit here:

    Harvard School Of Public Health | Whole Grains

    “That’s all great, but what if I am concerned about gluten?”

    There certainly are reasons you might be, be it because of a sensitivity, allergy, or just because perhaps you’d like to know more.

    Let’s first mention: not all grains contain gluten, so it’s perfectly possible to enjoy naturally gluten-free grains (such as oats and rice) as well as gluten-free pseudocereals, which are not actually grains but do the same job in culinary and nutritional terms (such as quinoa and buckwheat, despite the latter’s name).

    Finally, if you’d like to know more about gluten’s health considerations, then check out our previous mythbusting special:

    Gluten: What’s The Truth?

    Enjoy!

    Don’t Forget…

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    Learn to Age Gracefully

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