Boost Your Digestive Enzymes

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We’ll Try To Make This Easy To Digest

Do you have a digestion-related problem?

If so, you’re far from alone; around 40% of Americans have digestive problems serious enough to disrupt everyday life:

New survey finds forty percent of Americans’ daily lives are disrupted by digestive troubles

…which puts Americans just a little over the global average of 35%:

Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019

Mostly likely on account of the Standard American Diet, or “SAD” as it often gets abbreviated in scientific literature.

There’s plenty we can do to improve gut health, for example:

Today we’re going to be examining digestive enzyme supplements!

What are digestive enzymes?

Digestive enzymes are enzymes that break down food into stuff we can use. Important amongst them are:

  • Protease: breaks down proteins (into amino acids)
  • Amylase: breaks down starches (into sugars)
  • Lipase: breaks down fats (into fatty acids)

All three are available as popular supplements to aid digestion. How does the science stack up for them?

Protease

For this, we only found animal studies like this one, but the results have been promising:

Exogenous protease supplementation to the diet enhances growth performance, improves nitrogen utilization, and reduces stress

Amylase

Again, the studies for this alone (not combined with other enzymes) have been solely from animal agriculture; here’s an example:

The Effect of Exogenous Amylase Supplementation on the Nutritional Value of Peas

Lipase

Unlike for protease and amylase, now we have human studies as well, and here’s what they had to say:

❝Lipase supplementation significantly reduced stomach fullness without change of EGG.

Furthermore, lipase supplementation may be helpful in control of FD symptom such as postprandial symptoms❞

~ Dr. Seon-Young Park & Dr. Jong-Sun Rew

Read more: Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?

(short answer: yes, it is)

More studies found the same, such as:

Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects

All together now!

When we look at studies for combination supplementation of digestive enzymes, more has been done, and/but it’s (as you might expect) less specific.

The following paper gives a good rundown:

Pancrelipase Therapy: A Combination Of Protease, Amylase, & Lipase

Is it safe?

For most people it is quite safe, but if taking high doses for a long time it can cause problems, and also there may be complications if you have diabetes, are otherwise immunocompromised, or have some other conditions (listed towards the end of the above-linked paper, along with further information that we can’t fit in here).

As ever, check with your doctor/pharmacist if you’re not completely sure!

Want some?

We don’t sell them, but for your convenience, here’s an example product on Amazon that contains all three

Enjoy!

We’ll Try To Make This Easy To Digest

Do you have a digestion-related problem?

If so, you’re far from alone; around 40% of Americans have digestive problems serious enough to disrupt everyday life:

New survey finds forty percent of Americans’ daily lives are disrupted by digestive troubles

…which puts Americans just a little over the global average of 35%:

Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019

Mostly likely on account of the Standard American Diet, or “SAD” as it often gets abbreviated in scientific literature.

There’s plenty we can do to improve gut health, for example:

Today we’re going to be examining digestive enzyme supplements!

What are digestive enzymes?

Digestive enzymes are enzymes that break down food into stuff we can use. Important amongst them are:

  • Protease: breaks down proteins (into amino acids)
  • Amylase: breaks down starches (into sugars)
  • Lipase: breaks down fats (into fatty acids)

All three are available as popular supplements to aid digestion. How does the science stack up for them?

Protease

For this, we only found animal studies like this one, but the results have been promising:

Exogenous protease supplementation to the diet enhances growth performance, improves nitrogen utilization, and reduces stress

Amylase

Again, the studies for this alone (not combined with other enzymes) have been solely from animal agriculture; here’s an example:

The Effect of Exogenous Amylase Supplementation on the Nutritional Value of Peas

Lipase

Unlike for protease and amylase, now we have human studies as well, and here’s what they had to say:

❝Lipase supplementation significantly reduced stomach fullness without change of EGG.

Furthermore, lipase supplementation may be helpful in control of FD symptom such as postprandial symptoms❞

~ Dr. Seon-Young Park & Dr. Jong-Sun Rew

Read more: Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?

(short answer: yes, it is)

More studies found the same, such as:

Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects

All together now!

When we look at studies for combination supplementation of digestive enzymes, more has been done, and/but it’s (as you might expect) less specific.

The following paper gives a good rundown:

Pancrelipase Therapy: A Combination Of Protease, Amylase, & Lipase

Is it safe?

For most people it is quite safe, but if taking high doses for a long time it can cause problems, and also there may be complications if you have diabetes, are otherwise immunocompromised, or have some other conditions (listed towards the end of the above-linked paper, along with further information that we can’t fit in here).

As ever, check with your doctor/pharmacist if you’re not completely sure!

Want some?

We don’t sell them, but for your convenience, here’s an example product on Amazon that contains all three

Enjoy!

Don’t Forget…

Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

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  • Running or yoga can help beat depression, research shows – even if exercise is the last thing you feel like

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    At least one in ten people have depression at some point in their lives, with some estimates closer to one in four. It’s one of the worst things for someone’s wellbeing – worse than debt, divorce or diabetes.

    One in seven Australians take antidepressants. Psychologists are in high demand. Still, only half of people with depression in high-income countries get treatment.

    Our new research shows that exercise should be considered alongside therapy and antidepressants. It can be just as impactful in treating depression as therapy, but it matters what type of exercise you do and how you do it.

    Walk, run, lift, or dance away depression

    We found 218 randomised trials on exercise for depression, with 14,170 participants. We analysed them using a method called a network meta-analysis. This allowed us to see how different types of exercise compared, instead of lumping all types together.

    We found walking, running, strength training, yoga and mixed aerobic exercise were about as effective as cognitive behaviour therapy – one of the gold-standard treatments for depression. The effects of dancing were also powerful. However, this came from analysing just five studies, mostly involving young women. Other exercise types had more evidence to back them.

    Walking, running, strength training, yoga and mixed aerobic exercise seemed more effective than antidepressant medication alone, and were about as effective as exercise alongside antidepressants.

    But of these exercises, people were most likely to stick with strength training and yoga.

    Antidepressants certainly help some people. And of course, anyone getting treatment for depression should talk to their doctor before changing what they are doing.

    Still, our evidence shows that if you have depression, you should get a psychologist and an exercise plan, whether or not you’re taking antidepressants.

    Join a program and go hard (with support)

    Before we analysed the data, we thought people with depression might need to “ease into it” with generic advice, such as “some physical activity is better than doing none.”

    But we found it was far better to have a clear program that aimed to push you, at least a little. Programs with clear structure worked better, compared with those that gave people lots of freedom. Exercising by yourself might also make it hard to set the bar at the right level, given low self-esteem is a symptom of depression.

    We also found it didn’t matter how much people exercised, in terms of sessions or minutes a week. It also didn’t really matter how long the exercise program lasted. What mattered was the intensity of the exercise: the higher the intensity, the better the results.

    Yes, it’s hard to keep motivated

    We should exercise caution in interpreting the findings. Unlike drug trials, participants in exercise trials know which “treatment” they’ve been randomised to receive, so this may skew the results.

    Many people with depression have physical, psychological or social barriers to participating in formal exercise programs. And getting support to exercise isn’t free.

    We also still don’t know the best way to stay motivated to exercise, which can be even harder if you have depression.

    Our study tried to find out whether things like setting exercise goals helped, but we couldn’t get a clear result.

    Other reviews found it’s important to have a clear action plan (for example, putting exercise in your calendar) and to track your progress (for example, using an app or smartwatch). But predicting which of these interventions work is notoriously difficult.

    A 2021 mega-study of more than 60,000 gym-goers found experts struggled to predict which strategies might get people into the gym more often. Even making workouts fun didn’t seem to motivate people. However, listening to audiobooks while exercising helped a lot, which no experts predicted.

    Still, we can be confident that people benefit from personalised support and accountability. The support helps overcome the hurdles they’re sure to hit. The accountability keeps people going even when their brains are telling them to avoid it.

    So, when starting out, it seems wise to avoid going it alone. Instead:

    • join a fitness group or yoga studio
    • get a trainer or an exercise physiologist

    • ask a friend or family member to go for a walk with you.

    Taking a few steps towards getting that support makes it more likely you’ll keep exercising.

    Let’s make this official

    Some countries see exercise as a backup plan for treating depression. For example, the American Psychological Association only conditionally recommends exercise as a “complementary and alternative treatment” when “psychotherapy or pharmacotherapy is either ineffective or unacceptable”.

    Based on our research, this recommendation is withholding a potent treatment from many people who need it.

    In contrast, The Royal Australian and New Zealand College of Psychiatrists recommends vigorous aerobic activity at least two to three times a week for all people with depression.

    Given how common depression is, and the number failing to receive care, other countries should follow suit and recommend exercise alongside front-line treatments for depression.

    I would like to acknowledge my colleagues Taren Sanders, Chris Lonsdale and the rest of the coauthors of the paper on which this article is based.

    If this article has raised issues for you, or if you’re concerned about someone you know, call Lifeline on 13 11 14.The Conversation

    Michael Noetel, Senior Lecturer in Psychology, The University of Queensland

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Putting a Halt to Feeling Lost, Anxious, Stressed & Unhappy

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Starting From the Middle

    Today’s video (below) dives straight into the heart of the issue, examining the victim mindset, with Dr. Gabor Maté immediately, and quite vulnerably, sharing his personal experiences conquering feelings of despair and anxiety.

    As one of the comments on the video says, Dr. Maté is a “person who teaches about something because they experience it themselves”. And it shows through his approach.

    With raw honesty, Dr. Maté empathizes with those grappling with inner turmoil, offering hope by emphasizing the power of healing in the present moment.

    What is His Method?

    Explained simply, Dr. Maté urges individuals to seek trauma-informed care and therapies that address underlying wounds; he emphasizes the pitfalls of relying solely on medication, and instead highlights the idea that triggers can be seen as opportunities for self-reflection and growth. He urges individuals to approach their triggers with compassionate curiosity rather than self-judgment.

    In short, Dr Maté’s empathetic approach immediately calms the viewer, whilst providing knowledge crucial to self-improvement.

    Let this video act as a reminder that we should take our mental health as seriously as our general health.

    How was the video? If you’ve discovered any great videos yourself that you’d like to share with fellow 10almonds readers, then please do email them to us!

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  • Dioscorea Villosa: Hormones, Arthritis, & Skin

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    On A Wild Yam Chase?

    We recently came across a supplement blend that had wild yam extract as a minor ingredient. Our plucky (and usually very knowledgable) researcher had never heard of its use before, so she set about doing her thing. This is what she found…

    What health claims are made?

    Wild yam extract (Dioscorea villosa) is traditionally sold and used for:

    • Balancing hormones
    • Combating arthritis
    • Anti-aging effects for the skin

    Does it balance hormones?

    First, as a quick catch-up, we’ll drop a previous article of ours for your convenience:

    What Does “Balance Your Hormones” Even Mean?

    We couldn’t find almost any studies into wild yam extract’s hormone-balancing effects, but we did find one study, and:

    ❝Symptom scores showed a minor effect of both placebo and active treatment on diurnal flushing number and severity and total non-flushing symptom scores, and on nocturnal sweating after placebo, but no statistical difference between placebo and active creams.

    This study suggests that short-term treatment with topical wild yam extract in women suffering from menopausal symptoms is free of side-effects, but appears to have little effect on menopausal symptoms❞

    …which is a very thorough, polite, sciencey way of saying “wow, this does so many different kinds of nothing”

    Source: Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women

    On the one hand, this was a small study (n=23). On the other hand, it was also literally the only study we could find.

    Does it combat arthritis?

    Maybe! We again didn’t find much research into this but we did find two in vitro studies that suggests that diosgenin (which can be derived from wild yam extract) helps:

    And we also found a rodent study that found that wild yam extract specifically helped against “acetic acid-induced writhing and formalin-induced pain“, and put that down to anti-inflammatory properties:

    Read: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

    So, none of these studies tell us much about whether it would be helpful for humans—with or without arthritis, and hopefully without “acetic acid-induced writhing and formalin-induced pain”.

    However, they do suggest that it would be reasonable to test in humans next.

    You might prefer:

    Does it keep skin young?

    Again, research is thin on the ground, but we did find some! A study with wild-yam-derived diosgenin found that it didn’t make anything worse, and otherwise performed a similar role to vitamin A:

    Read: Novel effects of diosgenin on skin aging

    That was on rats with breast cancer though, so its applicability to healthy humans may be tenuous (while in contrast, simply getting vitamin A instead is a known deal).

    Summary

    • Does it balance hormones? It probably does little to nothing in this regard
    • Does it combat arthritis? It probably has anti-inflammatory effects, but we know of no studies in humans. There are much more well-established anti-inflammatories out there.
    • Does it keep the skin young? We know that it performs a role similar to vitamin A for rats with breast cancer, and didn’t make anything worse for them. That’s the extent of what we know.

    Where can I get some?

    In the unlikely event that the above research review has inspired you with an urge to buy wild yam extract, here is an example product for your convenience.

    Some final words…

    If you are surprised that we’re really not making any effort to persuade you of its merits, please know that (outside of the clearly-marked sponsor section, which helps us keep the lights on, so please do visit those) we have no interest in selling you anything. We’re genuinely just here to inform 🙂

    If you are wondering why we ran this article at all if the supplement has negligible merits, it’s because science is science, knowledge is knowledge, and knowing that something has negligible merit can be good knowledge to have!

    Also, running articles like this from time to time helps you to know that when we do sing the praises of something, it’s with good reason

    Take care!

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  • I’m feeling run down. Why am I more likely to get sick? And how can I boost my immune system?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It has been a long winter, filled with many viruses and cost-of-living pressures, on top of the usual mix of work, study, life admin and caring responsibilities.

    Stress is an inevitable part of life. In short bursts, our stress response has evolved as a survival mechanism to help us be more alert in fight or flight situations.

    But when stress is chronic, it weakens the immune system and makes us more vulnerable to illnesses such as the common cold, flu and COVID.

    Pexels/Ketut Subiyanto

    Stress makes it harder to fight off viruses

    When the immune system starts to break down, a virus that would normally have been under control starts to flourish.

    Once you begin to feel sick, the stress response rises, making it harder for the immune system to fight off the disease. You may be sick more often and for longer periods of time, without enough immune cells primed and ready to fight.

    In the 1990s, American psychology professor Sheldon Cohen and his colleagues conducted a number of studies where healthy people were exposed to an upper respiratory infection, through drops of virus placed directly into their nose.

    These participants were then quarantined in a hotel and monitored closely to determine who became ill.

    One of the most important factors predicting who got sick was prolonged psychological stress.

    Cortisol suppresses immunity

    “Short-term stress” is stress that lasts for a period of minutes to hours, while “chronic stress” persists for several hours per day for weeks or months.

    When faced with a perceived threat, psychological or physical, the hypothalamus region of the brain sets off an alarm system. This signals the release of a surge of hormones, including adrenaline and cortisol.

    Human brain illustration
    The hypothalamus sets off an alarm system in response to a real or perceived threat. stefan3andrei/Shutterstock

    In a typical stress response, cortisol levels quickly increase when stress occurs, and then rapidly drop back to normal once the stress has subsided. In the short term, cortisol suppresses inflammation, to ensure the body has enough energy available to respond to an immediate threat.

    But in the longer term, chronic stress can be harmful. A Harvard University study from 2022 showed that people suffering from psychological distress in the lead up to their COVID infection had a greater chance of experiencing long COVID. They classified this distress as depression, probable anxiety, perceived stress, worry about COVID and loneliness.

    Those suffering distress had close to a 50% greater risk of long COVID compared to other participants. Cortisol has been shown to be high in the most severe cases of COVID.

    Stress causes inflammation

    Inflammation is a short-term reaction to an injury or infection. It is responsible for trafficking immune cells in your body so the right cells are present in the right locations at the right times and at the right levels.

    The immune cells also store a memory of that threat to respond faster and more effectively the next time.

    Initially, circulating immune cells detect and flock to the site of infection. Messenger proteins, known as pro-inflammatory cytokines, are released by immune cells, to signal the danger and recruit help, and our immune system responds to neutralise the threat.

    During this response to the infection, if the immune system produces too much of these inflammatory chemicals, it can trigger symptoms such as nasal congestion and runny nose.

    Man blows nose
    Our immune response can trigger symptoms such as a runny nose. Alyona Mandrik/Shutterstock

    What about chronic stress?

    Chronic stress causes persistently high cortisol secretion, which remains high even in the absence of an immediate stressor.

    The immune system becomes desensitised and unresponsive to this cortisol suppression, increasing low-grade “silent” inflammation and the production of pro-inflammatory cytokines (the messenger proteins).

    Immune cells become exhausted and start to malfunction. The body loses the ability to turn down the inflammatory response.

    Over time, the immune system changes the way it responds by reprogramming to a “low surveillance mode”. The immune system misses early opportunities to destroy threats, and the process of recovery can take longer.

    So how can you manage your stress?

    We can actively strengthen our immunity and natural defences by managing our stress levels. Rather than letting stress build up, try to address it early and frequently by:

    1) Getting enough sleep

    Getting enough sleep reduces cortisol levels and inflammation. During sleep, the immune system releases cytokines, which help fight infections and inflammation.

    2) Taking regular exercise

    Exercising helps the lymphatic system (which balances bodily fluids as part of the immune system) circulate and allows immune cells to monitor for threats, while sweating flushes toxins. Physical activity also lowers stress hormone levels through the release of positive brain signals.

    3) Eating a healthy diet

    Ensuring your diet contains enough nutrients – such as the B vitamins, and the full breadth of minerals like magnesium, iron and zinc – during times of stress has a positive impact on overall stress levels. Staying hydrated helps the body to flush out toxins.

    4) Socialising and practising meditation or mindfulness

    These activities increase endorphins and serotonin, which improve mood and have anti-inflammatory effects. Breathing exercises and meditation stimulate the parasympathetic nervous system, which calms down our stress responses so we can “reset” and reduce cortisol levels.

    Sathana Dushyanthen, Academic Specialist & Lecturer in Cancer Sciences & Digital Health| Superstar of STEM| Science Communicator, The University of Melbourne

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Lyme Disease At-A-Glance

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s Q&A Day at 10almonds!

    Have a question or a request? You can always hit “reply” to any of our emails, or use the feedback widget at the bottom!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small

    ❝Good info as always…was wondering if you have any recommendations for fighting Lyme disease naturally along wDr advice? Dr’s aren’t real keen on alternatives so always interested. Thanks❞

    That depends on whether we’re looking at prevention or cure!

    Prevention:

    • Try not to get bitten by Lyme-disease-carrying ticks. Boots and long socks are your friends. As are long-gauntletted gloves for gardening.
    • If you are in a high-risk area and/or engage in high-risk activities, check your body daily.
      • This is because it usually takes 36–48 hours of being attached for a tick to cause an infection
      • Obviously best if you can get a partner or close friend to help you with this, unless you have mastered some advanced pretzel positions of yoga.
    • Contrary to many folk remedies, the safest way to remove a tick is with tweezers (carefully!).
    • If you find and remove a tick, or otherwise suspect you have developed symptoms, go to your doctor immediately (not next week; today; time really counts for this).

    Cure:

    • No. Sorry. Regretfully, antibiotics are the only known effective treatment.

    However! As with almost any kind of recovery, getting good rest, including good quality sleep, will hasten things. Also sensible is reducing stress if possible, and anything that could worsen inflammation.

    Read: Beyond Supplements: The Real Immune-Boosters!

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  • Why You Can’t Skimp On Amino Acids

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    Our body requires 20 amino acids (the building blocks of protein), 9 of which it can’t synthesize (thus called: “essential”) and absolutely must get from food. Normally, we get these amino acids from protein in our diet, and we can also supplement them by taking amino acid supplements if we wish.

    Specifically, we require (per kg of bodyweight) a daily average of:

    1. Histidine: 10 mg
    2. Isoleucine: 20 mg
    3. Leucine: 39 mg
    4. Lysine: 30 mg
    5. Methionine: 10.4 mg
    6. Phenylalanine*: 25 mg
    7. Threonine: 15 mg
    8. Tryptophan: 4 mg
    9. Valine: 26 mg

    *combined with the non-essential amino acid tyrosine

    Source: Protein and Amino Acid Requirements In Human Nutrition: WHO Technical Report

    Why this matters

    A lot of attention is given to protein, and making sure we get enough of it, especially as we get older, because the risk of sarcopenia (muscle mass loss) increases with age:

    Protein vs Sarcopenia

    However, not every protein comes with a complete set of essential amino acids, and/or have only trace amounts of of some amino acids, meaning that a dietary deficiency can arrive if one’s diet is too restrictive.

    And, if we become deficient in even just one amino acid, then bad things start to happen quite soon. We only have so much space, so we’re going to oversimplify here, but:

    1. Histidine: is needed to produce histamine (vital for immune responses, amongst other things), and is also important for maintaining the myelin sheaths on nerve cells.
    2. Isoleucine: is very involved in muscle metabolism and makes up the bulk of muscle tissue.
    3. Leucine: is critical for muscle synthesis and repair, as well as wound healing in general, and blood sugar regulation.
    4. Lysine: is also critical in muscle synthesis, as well as calcium absorption and hormone production, as well as making collagen.
    5. Methionine: is very important for energy metabolism, zinc absorption, and detoxification.
    6. Phenylalanine: is a necessary building block of a lot of neurotransmitters, as well as being a building block of some amino acids not listed here (i.e., the ones your body synthesizes, but can’t without phenylalanine).
    7. Threonine: is mostly about collagen and elastin production, and is also very important for your joints, as well as fat metabolism.
    8. Tryptophan: is the body’s primary precursor to serotonin, so good luck making the latter without the former.
    9. Valine: is mostly about muscle growth and regeneration.

    So there you see, the ill effects of deficiency can range from “muscle atrophy” to “brain stops working” and “bones fall apart” and more. In short, any essential amino acid deficiency not remedied will ultimately result in death; we literally become non-viable as organisms without these 9 things.

    What to do about it (the “life hack” part)

    Firstly, if you eat a lot of animal products, those are “complete” proteins, meaning that they contain all 9 essential amino acids in sensible quantities. The reason that all animal products have these, is because they are just as essential for the other animals as they are for us, so they, just like us, must consume (and thus contain) them.

    However, a lot of animal products come with other health risks:

    Do We Need Animal Products To Be Healthy? ← this covers which animal products are definitely very health-risky, and which are probably fine according to current best science

    …so many people may prefer to get more (or possibly all) dietary protein from plants.

    However, plants, unlike us, do not need to consume all 9 essential amino acids, and this may or may not contain them all.

    Soy is famously a “complete” protein insofar as it has all the amino acids we need.

    But what if you’re allergic to soy?

    Good news! Peas are also a “complete” protein and will do the job just fine. They’re also usually cheaper.

    Final note

    An oft-forgotten thing is that some other amino acids are “conditionally essential”, meaning that while we can technically synthesize them, sometimes we can’t synthesize enough and must get them from our diet.

    The conditions that trigger this “conditionally essential” status are usually such things as fighting a serious illness, recovering from a serious injury, or pregnancy—basically, things where your body has to work at 110% efficiency if it wants to get through it in one piece, and that extra 10% has to come from somewhere outside the body.

    Examples of commonly conditionally essential amino acids are arginine and glycine.

    Arginine is critical for a lot of cell-signalling processes as well as mitochondrial function, as well as being a precursor to other amino acids, including creatine.

    As for glycine?

    Check out: The Sweet Truth About Glycine

    Enjoy!

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