CLA for Weight Loss?
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Conjugated Linoleic Acid for Weight Loss?
You asked us to evaluate the use of CLA for weight loss, so that’s today’s main feature!
First, what is CLA?
Conjugated Linoleic Acid (CLA) is a fatty acid made by grazing animals. Humans don’t make it ourselves, and it’s not an essential nutrient.
Nevertheless, it’s a popular supplement, mostly sold as a fat-burning helper, and thus enjoyed by slimmers and bodybuilders alike.
❝CLA reduces bodyfat❞—True or False?
True! Contingently. Specifically, it will definitely clearly help in some cases. For example:
- This study found it doubled fat loss in chickens
- It significantly increased delipidation of white adipose tissue in these mice
- The mice in this study enjoyed a 43–88% reduction in (fatty) weight gain
- Over the course of a six-week weight-loss program, these mice got 70% more weight loss on CLA, compared to placebo
- In this study, pigs that took CLA on a high-calorie diet gained 50% less weight than those not taking CLA
- On a heart-unhealthy diet, these hamsters taking CLA gained much less white adipose tissue than their comrades not taking CLA
- Another study with pigs found that again, CLA supplementation resulted in much less weight gained
- These hamsters being fed a high-cholesterol diet found that those taking CLA ended up with a leaner body mass than those not taking CLA
- This study with mice found that CLA supplementation promoted fat loss and lean muscle gain
Did you notice a theme? It’s Animal Farm out there!
❝CLA reduces bodyfat in humans❞—True or False?
False—practically. Technically it appears to give non-significantly better results than placebo.
A comprehensive meta-analysis of 18 different studies (in which CLA was provided to humans in randomized, double-blinded, placebo-controlled trials and in which body composition was assessed by using a validated technique) found that, on average, human CLA-takers lost…
Drumroll please…
00.00–00.05 kg per week. That’s between 0–50g per week. That’s less than two ounces. Put it this way: if you were to quickly drink an espresso before stepping on the scale, the weight of your very tiny coffee would cover your fat loss.
The reviewers concluded:
❝CLA produces a modest loss in body fat in humans❞
Modest indeed!
See for yourself: Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans
But what about long-term? Well, as it happens (and as did show up in the non-human animal studies too, by the way) CLA works best for the first four weeks or so, and then effects taper off.
Another review of longer-term randomized clinical trials (in humans) found that over the course of a year, CLA-takers enjoyed on average a 1.33kg total weight loss benefit over placebo—so that’s the equivalent of about 25g (0.8 oz) per week. We’re talking less than a shot glass now.
They concluded:
❝The evidence from RCTs does not convincingly show that CLA intake generates any clinically relevant effects on body composition on the long term❞
A couple of other studies we’ll quickly mention before closing this section:
- CLA supplementation does not affect waist circumference in humans (at all).
- Amongst obese women doing aerobic exercise, CLA supplementation has no effect (at all) on body fat reduction compared to placebo
What does work?
You may remember this headline from our “What’s happening in the health world” section a few days ago:
Research reveals self-monitoring behaviors and tracking tools key to long-term weight loss success
On which note, we’ve mentioned before, we’ll mention again, and maybe one of these days we’ll do a main feature on it, there’s a psychology-based app/service “Noom” that’s very personalizable and helps you reach your own health goals, whatever they might be, in a manner consistent with any lifestyle considerations you might want to give it.
Curious to give it a go? Check it out at Noom.com (you can get the app there too, if you want)
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Signs Of Low Estrogen In Women: What Your Skin, Hair, & Nails Are Trying To Tell You
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Skin, hair, and nails are often thought of purely as a beauty thing, but in fact they can be indicative of a lot of other aspects of health. Dr. Andrea Suarez takes us through some of them in this video about the systemic (i.e., whole-body, not just related to sex things) effects of estrogen, and/or a deficiency thereof.
Beyond the cosmetic
Low estrogen levels are usual in women during and after untreated menopause, resulting in various changes in the skin, hair, and nails, that reflect deeper issues, down to bone health, heart health, brain health, and more. Since we can’t see our bones or hearts or brains without scans (or a serious accident/incident), we’re going to focus on the outward signs of estrogen deficiency.
Estrogen helps maintain healthy collagen production, skin elasticity, wound healing, and moisture retention, making it essential for youthful and resilient skin. Declining estrogen levels with menopause lead to a thinner epidermis, decreased collagen production, and more pronounced wrinkles. Skin elasticity also diminishes, which slows the skin’s ability to recover from stretching or deformation. Wound healing also becomes slower, increasing the risk of infections and extended recovery periods after injuries or surgeries—bearing in mind that collagen is needed in everything from our skin to our internal connective tissue (fascia) and joints and bones. So all those things are going to struggle to recover from injury (and surgery is also an injury) without it.
Other visible changes associated with declining estrogen include significant dryness as a result of reduced hyaluronic acid and glycosaminoglycan production, which are essential for moisture retention. The skin becomes more prone to irritation and increased water loss. Additionally, estrogen deficiency results in less resistance to oxidative stress, making the skin more susceptible to damage from environmental factors such as UV radiation and pollution, as well as any from-the-inside pollution that some may have depending on diet and lifestyle.
Acne and enlarged pores are associated with increased testosterone, but testosterone and estrogen are antagonistic in most ways, and in this case a decrease in estrogen will do the same, due increased unopposed androgen signaling affecting the oil glands. The loss of supportive collagen also causes the skin around pores to lose structure, making them appear larger. The reduction in skin hydration further exacerbates the visibility of pores and can contribute to the development of blackheads due to abnormal cell turnover.
Blood vessel issues tend to arise as estrogen levels drop, leading to a reduction in angiogenesis, i.e. the formation and integrity of blood vessels. This results in more fragile and leaky blood vessels, making the skin more prone to bruising, especially on areas frequently exposed to the sun, such as the backs of the hands. This weakened vasculature also further contributes to the slower wound healing that we talked about, due to less efficient delivery of growth factors.
Hair and nail changes often accompany estrogen deficiency. Women may notice hair thinning, increased breakage, and a greater likelihood of androgenic alopecia. The texture of the hair can change, becoming more brittle. Similarly, nails can develop ridges, split more easily, and become more fragile due to reduced collagen and keratin production, which also affects the skin around the nails.
As for what to do about it? Management options for estrogen-deficient skin include:
- Bioidentical hormone replacement therapy (HRT), which can improve skin elasticity, boost collagen production, and reduce dryness and fragility, as well as addressing the many more serious internal things that are caused by the same deficiency as these outward signs.
- Low-dose topical estrogen cream, which can help alleviate skin dryness and increase skin strength, won’t give the systemic benefits (incl. to bones, heart, brain, etc) that only systemic HRT can yield.
- Plant-based phytoestrogens, which are not well-evidenced, but may be better than nothing if nothing is your only other option. However, if you are taking anything other form of estrogen, don’t use phytoestrogens as well, or they will compete for estrogen receptors, and do the job not nearly so well while impeding the bioidentical estrogen from doing its much better job.
And for all at any age, sunscreen continues to be one of the best things to put on one’s skin for general skin health, and this is even more true if running low on estrogen.
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
These Signs Often Mean These Nutrient Deficiencies (Do You Have Any?)
Take care!
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Plums vs Strawberries – Which is Healthier?
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Our Verdict
When comparing plums to strawberries, we picked the strawberries.
Why?
Both are great! Absolutely top-tier fruits. However, even within the top tier, there are distinctions:
In terms of of macros, plums have more carbs while strawberries have more fiber; we’ll take the extra fiber for the win here.
In the category of vitamins, plums have more of vitamins A, B1, B2, and K, while strawberries have more of vitamins B6, B9, C, E, and choline, thus scoring a marginal win for strawberries in this round.
When it comes to minerals, plums have (slightly) more copper, while strawberries have more calcium, iron, magnesium, manganese, phosphorus, selenium, and zinc. One more win for strawberries.
In terms of phytochemicals, plums have a higher total mass of polyphenols, and so win this round, although strawberries scored well too.
Adding up the sections makes for an overall win for strawberries, but by all means enjoy either or both; diversity is good!
Want to learn more?
You might like:
Top 8 Fruits That Prevent & Kill Cancer
Enjoy!
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Dr. Patrick Walsh’s Guide to Surviving Prostate Cancer – by Dr. Patrick Walsh & Janet Farrar Worthington
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Prostate cancer is not glamorous or fun, and neither is this book.
Nevertheless, it’s a disease that affects 12% of men in general, and 60% of men aged 60+, with that percentage climbing every year after that.
So, if you have a prostate or love someone who has one, this book is worthwhile reading—yes, even as a preventative.
Like many cancers, prostate cancer is easy to treat if caught very early, becomes harder to treat as it goes, and almost impossible to cure if it gets as far as metastasis (i.e., it spread). Like all cancers, it’s better off avoided entirely if possible.
This book covers all the stages:
- How to avoid it
- How to check for it
- How to “nip it in the bud”
- Why some might want to delay treatment (!)
- What options are available afterwards
This latter is quite extensive, and covers not just surgery, but radiation, thermo- or cryoablation, and hormone therapy.
And as for surgery, not just “remove the tumor”, but other options like radical prostatectomy, and even orchiectomy. Not many men will choose to have their testicles removed to stop them from feeding the prostate, but the point is that this book is comprehensive.
It’s asking whenever possible “is there another option?” and exploring all options, with information and without judgment, at each stage.
The writing style (likely co-author Worthington’s influence; she is an award-winning science-writer) is very “for the layman”, and that’s really helpful in demystifying a lot of what can be quite opaque in the field of oncology.
Bottom line: absolutely not an enjoyable read, but a potentially lifesaving one, especially given the odds we mentioned up top.
Click here to check out Dr. Patrick Walsh’s Guide To Surviving Prostate Cancer, and be prepared!
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When A Period Is Very Late (Post-Menopause)
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Knowledge Is
PowerSafety, Post-Menopause TooNote: this article will be most relevant for a subset of our subscribership, but it’s a very large subset, so we’re going to go ahead and address the reader as “you”.
If, for example, you are a man and this doesn’t apply to you, we hope it will interest you anyway (we imagine there are women in your life).
PS: the appendicitis check near the end, works for anyone with an appendix
We’ve talked before about things that come with (and continue after) menopause:
- What You Should Have Been Told About The Menopause Beforehand
- What Menopause Does To The Heart
- Alzheimer’s Sex Differences May Not Be What They Appear
But what’s going on if certain menstrual symptoms reappear post-menopause (e.g. after more than a year with no menstruation)?
Bleeding
You should not, of course, be experiencing vaginal bleeding post-menopause. You may have seen “PSA” style posts floating around social media warning that this is a sign of cancer. And, it can be!
But it’s probably not.
Endometrial cancer (the kind that causes such bleeding) affects 2–3% of women, and of those reporting post-menopausal bleeding, the cause is endometrial cancer only 9% of those times.
So in other words, it’s not to be ignored, but for 9 people out of 10 it won’t be cancer:
Read more: Harvard Health | Postmenopausal bleeding: Don’t worry—but do call your doctor
Other more likely causes are uterine fibroids or polyps. These are unpleasant but benign, and can be corrected with surgery if necessary.
The most common cause, however is endometrial and/or vaginal atrophy resulting in tears and bleeding.
Tip: Menopausal HRT will often correct this.
Read more: The significance of “atrophic endometrium” in women with postmenopausal bleeding
(“atrophic endometrium” and “endometrial atrophy” are the same thing)
In summary: no need to panic, but do get it checked out at your earliest convenience. This is not one where we should go “oh that’s weird” and ignore.
Cramps
If you are on menopausal HRT, there is a good chance that these are just period cramps. They may feel different than they did before, because you didn’t ovulate and thus you’re not shedding a uterine lining now, but your body is going to do its best to follow the instructions given by the hormones anyway (hormones are just chemical messengers, after all).
If it is just this, then they will probably settle down to a monthly cycle and become quite predictable.
Tip: if it’s the above, then normal advice for period cramps will go here. We recommend ginger! It’s been found to be as effective as Novafen (a combination drug of acetaminophen (Tylenol), caffeine, and ibuprofen), in the task of relieving menstrual pain:
See: Effect of Ginger and Novafen on menstrual pain: A cross-over trial
It could also be endometriosis. Normally this affects those of childbearing age, but once again, exogenous hormones (as in menopausal HRT) can fool the body into doing it.
If you are not on menopausal HRT (or sometimes even if you are), uterine fibroids (as discussed previously) are once again a fair candidate, and endometriosis is also still possible, though less likely.
Special last note
Important self-check: if you are experiencing a sharp pain in that general area and are worrying if it is appendicitis (also a possibility), then pressing on the appropriately named McBurney’s point is a first-line test for appendicitis. If, after pressing, it hurts a lot more upon removal of pressure (rather than upon application of pressure), this is considered a likely sign of appendicitis. Get thee to a hospital, quickly.
And if it doesn’t? Still get it checked out at your earliest convenience, of course (better safe than sorry), but you might make an appointment instead of calling an ambulance.
Take care!
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Capsaicin For Weight Loss And Against Inflammation
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Capsaicin’s Hot Benefits
Capsaicin, the compound in hot peppers that makes them spicy, is a chemical irritant and a neurotoxin. However, humans being humans, we decided to eat them for fun.
In contrast to many other ways in which humans recreationally enjoy things that are objectively poisonous, consuming capsaicin (in moderation) is considered to have health benefits, such as aiding weight loss (by boosting metabolism) and reducing inflammation.
Let’s see what the science says…
First: is it safe?
Capsaicin is classified as “Generally Recognized As Safe”. That said, the same mechanism that causes them to boost metabolism, does increase blood pressure:
Mechanisms underlying the hypertensive response induced by capsaicin
If you are in good cardiovascular health, this increase should be slight and not pose any threat, unless for example you enter a chili-eating contest when not acclimated to such:
Capsaicin and arterial hypertensive crisis
As ever, if unsure, do check with your doctor first, especially if you are taking any blood pressure medications, or otherwise have known blood pressure issues.
Does it really boost metabolism?
It certainly does; it works by increasing oxygen consumption and raising body temperature, both of which mean more calories will be burned for the same amount of work:
Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications
This means, of course, that chili peppers enjoy the status of being functionally a “negative calorie” food, and a top-tier one at that:
Chili pepper as a body weight-loss food
Here’s a good quality study that showed a statistically significant* fat loss improvement over placebo:
*To put it in numbers, the benefit was:
- 5.91 percentage points lower body fat percentage than placebo
- 6.68 percentage points greater change in body fat mass than placebo
See also: Difference between percentages and percentage points
For those who prefer big reviews than single studies, we’ve got you covered:
Does it really reduce inflammation?
Counterintuitive as it may seem, yes. By means of reducing oxidative stress. Given that things that reduce oxidative stress tend to reduce inflammation, and in turn tend to reduce assorted disease risks (from diabetes to cancer to Alzheimer’s), this probably has more knock-on benefits too, but we don’t have room to explore all of those today.
Fresh peppers are best for this, but dried peppers (such as when purchased as a ground spice in the supermarket, or when purchased as a capsule-based supplement) still have a very respectable anti-inflammatory effect:
- Capsaicinoids, Polyphenols and Antioxidant Activities of Capsicum annuum: Comparative Study of the Effect of Ripening Stage and Cooking Methods
- A Review on the Effect of Drying on Antioxidant Potential of Fruits and Vegetables
How much should we take?
It’s recommended to start at a low dose and gradually increase it, but 2–6mg of capsaicin per day is the standard range used in studies.
If you’re getting this from peppers, then for example cayenne pepper (a good source of capsaicin) contains around 2.5mg of capsaicin per 1 gram of cayenne.
In the case of capsules, if for example you don’t like eating hot pepper, this will usually mean taking 2–6 capsules per day, depending on dosage.
Make sure to take it with plenty of water!
Where can we get it?
Fresh peppers or ground spice from your local grocery store is fine. Your local health food store probably sells the supplements, too.
If you’d like to buy it online, here is an example product on Amazon.
Note: options on Amazon were more limited than usual, so this product is not vegan, and probably not halal or kosher, as the capsule contains an unspecified gelatin.
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How to Stop Negative Thinking – by Daniel Paul
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Just think positive thoughts” is all well and good, but it doesn’t get much mileage in the real world, does it?
What Daniel Paul offers is a lot better than that. Taking a CBT approach, he recommends tips and tricks, gives explanations and exercises, and in short, puts tools in the reader’s toolbox.
But it doesn’t stop at just stopping negative thinking. Rather, it takes a holistic approach to also improve your general life…
- Bookending your day with a good start and finish
- Scheduling a time for any negative thinking that does need to occur (again with the useful realism!)
- Inviting the reader to take on small challenges, of the kind that’ll have knock-on effects that add and multiply and compound as we go
The format is very easy-reading, and we love that there are clear section headings and chapter summaries, too.
Bottom line: definitely a book with the potential to improve your life from day one, and that’ll keep you coming back to it as a cheatsheet and references source.
Get your copy of “How to Stop Negative Thinking” from Amazon today!
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