
Caffeine For Memory Loss Reversal!
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There’s a lot of popular confusion about coffee (and/or caffeine)’s health benefits and risk, a good number of which we’ve cleared up here:
The Bitter Truth About Coffee (or is it?) ← this is a mythbusting edition, focussing on coffee specifically, rather than caffeine in general.
…as well as here, focussing on caffeine rather than coffee: Caffeine: Cognitive Enhancer Or Brain-Wrecker?
When it comes to the brain, usually the benefits are considered to come more from coffee (or tea)’s antioxidant strengths, rather than the caffeine, aside from that yes, it’s a stimulant and so it will boost your brain in the short term, just like the rest of your body.
And as for sleep? Well, coffee doesn’t have a good reputation, even if its negative effects have been greatly overstated:
How Much Does Caffeine Affect Sleep, Really?
But it turns out, there’s another side to the coin…
Memory problems? Caffeine to the rescue!
Researchers (Dr. Lik-Wei Wong et al.) investigated how caffeine affects memory deficits caused by sleep deprivation, focusing on a specific brain circuit, not just general alertness.
First, the damage: five hours of sleep deprivation impaired a certain part* of the hippocampus, weakening synaptic plasticity and reducing the ability to recognize familiar individuals (social memory). This happened because sleep deprivation increased adenosine signaling, which dampens neural activity and disrupts proteins critical for learning and memory.
*Lest this be too mysterious: it was the CA2 region
Now, caffeine’s effect: caffeine is an adenosine blocker, so (of course) it blocked adenosine receptors and thus restored synaptic plasticity in the CA2 region, reversing both neural deficits and social memory impairment. Notably, the recovery was pathway-specific rather than global, meaning caffeine didn’t overstimulate the brain in non-sleep-deprived subjects.
In other words: sleep deprivation selectively disrupts memory circuits, and caffeine can reverse these disruptions at both molecular and behavioral levels
You can read the paper in full, here: Caffeine reverses sleep deprivation-induced synaptic and social memory deficits via adenosine receptor modulation in the male mouse hippocampal CA2 region
You may be thinking: “Oh, it’s a mouse study! Male mice at that! What if I am not male, and/or not a mouse?”
And in this case, that’s not too much of a concern. Yes, there are differences between a mouse brain and human brain, and yes, there are hormone-mediated sex differences in the brain, but neither of those two differences should impact this, as memory storing and retrieval, and adenosine signalling, is the same regardless, so far as research currently shows.
This caffeine benefit is particularly worthy of note, because generally speaking, as we get older and we might worry about our memory failing us, this is exactly the kind of memory loss that most people fear most. People don’t fear being unable to memorize pi to n places, they fear not recognizing their loved ones, or even on a lesser level, just getting confused in social settings.
See also: Is It Dementia?
Want to learn more?
If you’d like to improve your memory without caffeine, then consider:
How To Boost Your Memory Immediately (Without Supplements)
Enjoy!
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How much weight do you actually need to lose? It might be a lot less than you think
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If you’re one of the one in three Australians whose New Year’s resolution involved losing weight, it’s likely you’re now contemplating what weight-loss goal you should actually be working towards.
But type “setting a weight loss goal” into any online search engine and you’ll likely be left with more questions than answers.
Sure, the many weight-loss apps and calculators available will make setting this goal seem easy. They’ll typically use a body mass index (BMI) calculator to confirm a “healthy” weight and provide a goal weight based on this range.
Your screen will fill with trim-looking influencers touting diets that will help you drop ten kilos in a month, or ads for diets, pills and exercise regimens promising to help you effortlessly and rapidly lose weight.
Most sales pitches will suggest you need to lose substantial amounts of weight to be healthy – making weight loss seem an impossible task. But the research shows you don’t need to lose a lot of weight to achieve health benefits.
Using BMI to define our target weight is flawed
We’re a society fixated on numbers. So it’s no surprise we use measurements and equations to score our weight. The most popular is BMI, a measure of our body weight-to-height ratio.
BMI classifies bodies as underweight, normal (healthy) weight, overweight or obese and can be a useful tool for weight and health screening.
But it shouldn’t be used as the single measure of what it means to be a healthy weight when we set our weight-loss goals. This is because it:
- fails to consider two critical factors related to body weight and health – body fat percentage and distribution
- does not account for significant differences in body composition based on gender, ethnicity and age.
How does losing weight benefit our health?
Losing just 5–10% of our body weight – between 6 and 12kg for someone weighing 120kg – can significantly improve our health in four key ways.
1. Reducing cholesterol
Obesity increases the chances of having too much low-density lipoprotein (LDL) cholesterol – also known as bad cholesterol – because carrying excess weight changes how our bodies produce and manage lipoproteins and triglycerides, another fat molecule we use for energy.
Having too much bad cholesterol and high triglyceride levels is not good, narrowing our arteries and limiting blood flow, which increases the risk of heart disease, heart attack and stroke.
But research shows improvements in total cholesterol, LDL cholesterol and triglyceride levels are evident with just 5% weight loss.
2. Lowering blood pressure
Our blood pressure is considered high if it reads more than 140/90 on at least two occasions.
Excess weight is linked to high blood pressure in several ways, including changing how our sympathetic nervous system, blood vessels and hormones regulate our blood pressure.
Essentially, high blood pressure makes our heart and blood vessels work harder and less efficiently, damaging our arteries over time and increasing our risk of heart disease, heart attack and stroke.
Losing weight can lower your blood pressure.
Prostock-studio/ShutterstockLike the improvements in cholesterol, a 5% weight loss improves both systolic blood pressure (the first number in the reading) and diastolic blood pressure (the second number).
A meta-analysis of 25 trials on the influence of weight reduction on blood pressure also found every kilo of weight loss improved blood pressure by one point.
3. Reducing risk for type 2 diabetes
Excess body weight is the primary manageable risk factor for type 2 diabetes, particularly for people carrying a lot of visceral fat around the abdomen (belly fat).
Carrying this excess weight can cause fat cells to release pro-inflammatory chemicals that disrupt how our bodies regulate and use the insulin produced by our pancreas, leading to high blood sugar levels.
Type 2 diabetes can lead to serious medical conditions if it’s not carefully managed, including damaging our heart, blood vessels, major organs, eyes and nervous system.
Research shows just 7% weight loss reduces risk of developing type 2 diabetes by 58%.
4. Reducing joint pain and the risk of osteoarthritis
Carrying excess weight can cause our joints to become inflamed and damaged, making us more prone to osteoarthritis.
Observational studies show being overweight doubles a person’s risk of developing osteoarthritis, while obesity increases the risk fourfold.
Small amounts of weight loss alleviate this stress on our joints. In one study each kilogram of weight loss resulted in a fourfold decrease in the load exerted on the knee in each step taken during daily activities.
Losing weight eases stress on joints.
Shutterstock/Rostislav_SedlacekFocus on long-term habits
If you’ve ever tried to lose weight but found the kilos return almost as quickly as they left, you’re not alone.
An analysis of 29 long-term weight-loss studies found participants regained more than half of the weight lost within two years. Within five years, they regained more than 80%.
When we lose weight, we take our body out of its comfort zone and trigger its survival response. It then counteracts weight loss, triggering several physiological responses to defend our body weight and “survive” starvation.
Just as the problem is evolutionary, the solution is evolutionary too. Successfully losing weight long-term comes down to:
losing weight in small manageable chunks you can sustain, specifically periods of weight loss, followed by periods of weight maintenance, and so on, until you achieve your goal weight
making gradual changes to your lifestyle to ensure you form habits that last a lifetime.
Setting a goal to reach a healthy weight can feel daunting. But it doesn’t have to be a pre-defined weight according to a “healthy” BMI range. Losing 5–10% of our body weight will result in immediate health benefits.
At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can register here to express your interest.
Nick Fuller, Charles Perkins Centre Research Program Leader, University of Sydney
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Gooseberries vs Raspberries – Which is Healthier?
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Our Verdict
When comparing gooseberries to raspberries, we picked the raspberries.
Why?
Like most (non-poisonous) berries, both are great! But…
In terms of macros, raspberries have more fiber for approximately the same carbs and protein, winning in this category.
In the category of vitamins, gooseberries have more of vitamins A, B1, and B6, while raspberries have more of vitamins B2, B3, B5, B7, B9, and E, winning this round, too.
Looking at minerals, gooseberries have more potassium and selenium, while raspberries have more copper, iron, magnesium, manganese, and zinc, winning a third round.
In other considerations, both are good sources of polyphenols, but raspberries have more, especially quercetin of various kinds.
Adding up the sections makes for a clear overall win for raspberries, but by all means enjoy either or both, as diversity is good!
Want to learn more?
You might like:
Fight Inflammation & Protect Your Brain, With Quercetin
Enjoy!
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When You Know What You “Should” Do (But Knowing Isn’t The Problem)
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When knowing what to do isn’t the problem
Often, we know what we need to do. Sometimes, knowing isn’t the problem!
The topic today is going to be a technique used by therapeutic service providers to help people to enact positive changes in their lives.
While this is a necessarily dialectic practice (i.e., it involves a back-and-forth dialogue), it’s still perfectly possible to do it alone, and that’s what we’ll be focussing on in this main feature.
What is Motivational Interviewing?
❝Motivational interviewing (MI) is a technique that has been specifically developed to help motivate ambivalent patients to change their behavior.❞
Read in full: Motivational Interviewing: An Evidence-Based Approach for Use in Medical Practice
It’s mostly used for such things as helping people reduce or eliminate substance abuse, or manage their weight, or exercise more, things like that.
However, it can be employed for any endeavour that requires motivation and sustained willpower to carry it through.
Three Phases
Motivational Interviewing traditionally has three phases:
- Exploring and understanding the issue at hand
- Guiding and deciding importance and goals
- Choosing and setting an action plan
In self-practice, maybe you can already know and understand what it is that you want/need to change.
If not, consider asking yourself such questions as:
- What does a good day look like? What does a bad day look like?
- If things are not good now, when were they good? What changed?
- If everything were perfect now, what would that look like? How would you know?
Once you have a clear idea of where you want to be, the next thing to know is: how much do you want it? And how confident are you in attaining it?
This is a critical process:
- Give your answers numerically on a scale from 0 to 10
- Whatever your score, ask yourself why it’s not lower. For example, if you scored your motivation 4 and your confidence 2, what factors made your motivation not a lower number? What factors made your confidence not a lower number?
- In the unlikely event that you gave yourself a 0, ask whether you can really afford to scrap the goal. If you can’t, find something, anything, to bring it to at least a 1.
- After you’ve done that, then you can ask yourself the more obvious question of why your numbers aren’t higher. This will help you identify barriers to overcome.
Now you’re ready to choose what to focus on and how to do it. Don’t bite off more than you can chew; it’s fine to start low and work up. You should revisit this regularly, just like you would if you had a counsellor helping you.
Some things to ask yourself at this stage of the motivational self-interviewing:
- What’s a good SMART goal to get you started?
- What could stop you from achieving your goal?
- How could you overcome that challenge?
- What is your backup plan, if you have to scale back your goal for some reason?
A conceptual example: if your goal is to stick to a whole foods Mediterranean diet, but you are attending a wedding next week, then now is the time to decide in advance 1) what personal lines-in-the-sand you will or will not draw 2) what secondary, backup plan you will make to not go too far off track.
The same example in practice: wedding menus often offer meat/fish/vegetarian options, so you might choose the fish or vegetarian, and as for sugar and alcohol, you might limit yourself to “a small slice of wedding cake only; coffee/cheese option instead of dessert”, and “alcohol only for toasts”.
Giving yourself the permission well in advance for small (clearly defined and boundaried!) diversions from the plan, will stop you from falling into the trap of “well, since today’s a cheat-day now…”
Secret fourth stage
The secret here is to keep going back and reassessing at regular intervals. Set your own calendar; you might want to start out weekly and then move to monthly when you’re more strongly on-track.
For this reason, it’s good to keep a journal with your notes from your self-interview sessions, the scores you gave yourself, the goals and plans you set, etc.
When conducting your regular review, be sure to examine what worked for you, and what didn’t (and why). That way, you can practice trial-and-improvement as you go.
Want to learn more?
We only have so much room here, but there are lots of resources out there.
Here’s a high-quality page that:
- explains motivational interviewing in more depth than we have room for here
- offers a lot of free downloadable resource packs and the like
Check it out: Motivational Interviewing Theory & Resources
Enjoy!
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The Keratin Toothpaste That Rebuilds Enamel
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
“When it’s gone, it’s gone” is the common belief when it comes to tooth enamel. Nevertheless, there are such things as hydroxyapatite toothpaste which is not only as pathogen-killing as fluoride, but also has the added bonus of being based on one of the main minerals our teeth are made of (hydroxyapatite is a calcium phosphate compound), so it does aid in rebuilding,
There are pros and cons to both, by the way: Fluoride Toothpaste vs Non-Fluoride Toothpaste – Which is Healthier? ← with interesting numbers on the toxicity of each!
In that comparison (we compared fluoride to hydroxyapatite) we picked the fluoride on the basis of “they both do the job equally well, and they’re both very safe, but technically everything has a toxicity level, and fluoride’s is the relatively safest of these two very safe products”.
However, that’s assuming for the general job of “keeping teeth healthy”. If your teeth need remineralizing, hydroxyapatite will better promote that.
For more details, see: Tooth Remineralization: How To Heal Your Teeth Naturally
So, what’s this about keratin?
As you may be aware, keratin is a protein that can be used to make everything from your eyelashes to the horn of a rhinoceros to the wool of a lamb. Also, less usefully, sebaceous cysts, which (despite the name) or not filled with sebum, but keratin. See: How To Get Rid Of A Sebaceous Cyst
Researchers (Dr. Sara Gamea et al.) have discovered that when combined with calcium and phosphate from saliva (or, indeed, from hydroxyapatite), keratin self-organizes into a crystal-like framework that mimics natural enamel, gradually forming a dense, mineralized barrier over tooth surfaces.
And, which will be a huge relief to many, the keratin layer blocks nerve channels responsible for pain, protects against acid erosion, and prevents further enamel loss, offering both immediate comfort and long-term defense.
You can read the paper in full here: Biomimetic Mineralization of Keratin Scaffolds for Enamel Regeneration
While it’s not on the shelves just yet (discoveries do not leap straight from laboratories to supermarkets), Dr. Gamea and her team expect that the material could appear in consumer toothpaste or dentist-applied gels (like nail varnish) within a few years.
Why a few years? Because that’s how science and industry works: a discovery is made, and while that study is peer-reviewed, the important thing then is for others to also test it and see if they get the same results. So, that’ll require teams of scientists to
beg on their hands and kneesapply for grant money (often tied to the academic year), perform the studies (which will typically take months), get their work published (they hope), and finally get a commercial interest to take it up and mass produce it, and then a distributor to distribute it, and a retailer to retail it, all with contract negotiations in between each step.So, while you’re waiting…
Want to learn more?
You might also like to read our own three-part series on dental health:
- Toothpastes & Mouthwashes: Which Help And Which Harm?
- Flossing Without Flossing?
- Less Common Oral Hygiene Options ← we recommend the miswak! Not only does it clean the teeth as well as or better than traditional brushing, but also it changes the composition of saliva to improve the oral microbiome, effectively turning your saliva into a biological mouthwash that kills unwanted microbes and is comfortable for the ones that should be there.
Take care!
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Celery vs Chard – Which is Healthier?
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Our Verdict
When comparing celery to chard, we picked the chard.
Why?
In terms of macros, chard has more fiber, carbs, and protein, making it the more nutrient-dense option and thus the winner of the macros category.
In the category of vitamins, celery has more of vitamins B5 and B9, while chard has more of vitamins A, B1, B2, B3, B6, C, E, K, and choline—another win for chard.
When it comes to minerals, celery is not higher in any minerals, while chard has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc. One more very clear win for chard!
Looking at polyphenols, celery has very little to boast, about 3mg/100g furanocoumarins and nothing else, while chard has an impressive array of polyphenols, with 9mg/100g kaempferol and 7.5mg/100g quercetin atop the list of 12 polyphenols. Yet another win for chard.
Adding up the sections is not difficult arithmetic today: chard sweeps every category. But by all means enjoy either or both; diversity is good!
Want to learn more?
You might like:
Dr. Greger’s Daily Dozen ← the “dozen” in question includes getting a good amount of of leafy greens per day
Enjoy!
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Artichoke vs Edamame – Which is Healthier?
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Our Verdict
When comparing artichoke to edamame, we picked the edamame.
Why?
Artichoke is great, but edamame is better by most metrics:
In terms of macros, artichoke has slightly more carbs and fiber, while edamame has a lot more protein; the scale of difference makes this first round a win for edamame.
In the category of vitamins, artichoke has slightly more of vitamins B3 and C, while edamame has a lot more of vitamins B1, B2, B5, B6, B7, B9, E, and K, winning easily.
Looking at minerals, artichoke is not higher in any minerals, while edamame has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and zinc, sweeping another round for edamame.
Adding up the sections makes for a very clear overall win for edamame, but by all means do enjoy either or both, as diversity is best!
Want to learn more?
You might like:
Why You Can’t Skimp On Amino Acids ← edamame is a good source of all essential amino acids
Enjoy!
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