
Toothpastes & Mouthwashes: Which Help And Which Harm?
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Toothpastes and mouthwashes: which kinds help, and which kinds harm?
You almost certainly brush your teeth. You might use mouthwash. A lot of people floss for three weeks at a time, often in January.
There are a lot of options for oral hygiene; variations of the above, and many alternatives too. This is a big topic, so rather than try to squeeze it all in one, this will be a several-part series.
For today, let’s look at toothpastes and mouthwashes, to start!
Toothpaste options
Toothpastes may contain one, some, or all of the following, so here are some notes on those:
Fluoride
Most toothpastes contain fluoride; this is generally recognized as safe though is not without its controversies. The fluoride content is the reason it’s recommended not to swallow toothpaste, though.
The fluoride in toothpaste can cause some small problems if overused; if you see unusually white patches on your teeth (your teeth are supposed to be ivory-colored, not truly white), that is probably a case of localized overcalcification because of the fluoride, and yes, you can have too much of a good thing.
Overall, the benefits are considered to far outweigh the risks, though.
Baking soda
Whether by itself or as part of a toothpaste, baking soda is a safe and effective choice, not just for cosmetic purposes, but for boosting genuine oral hygiene too:
- Enhanced plaque removal to improve gingival health: 3-month randomized clinical study of the effects of baking soda toothpaste on plaque and gingivitis
- The effects of two baking-soda toothpastes in enhancing mechanical plaque removal and improving gingival health: A 6-month randomized clinical study
- The efficacy of baking soda dentifrice in controlling plaque and gingivitis: A systematic review
Activated charcoal
Activated charcoal is great at removing many chemicals from things it touches. That includes the kind you might see on your teeth in the form of stains.
A topical aside on safety: activated charcoal is a common ingredient in a lot of black-colored Halloween-themed foods and drinks around this time of year. Beware, if you ingest these, there’s a good chance of it also cleaning out any meds you are taking. Ask your pharmacist about your own personal meds, but meds that (ingested) activated charcoal will usually remove include:
- Oral HRT / contraceptives
- Antidepressants (many kinds)
- Heart medications (at least several major kinds)
Toothpaste, assuming you are spitting-not-swallowing, won’t remove your medications though. Nor, in case you were worrying, will it strip tooth enamel, even if you have extant tooth enamel erosion:
Source: Activated charcoal toothpastes do not increase erosive tooth wear
However, it’s of no special extra help when it comes to oral hygiene itself, just removing stains.
So, if you’d like to use it for cosmetic reasons, go right ahead. If not, no need.
Hydrogen peroxide
This is generally not a good idea, speaking for the health. For whitening, yes, it works. But for health, not so much:
To be clear, when they say “alter”, they mean “in a bad way”. It increases inflammation and tissue damage.
If buying commercially-available whitening toothpaste made with hydrogen peroxide, the academic answer is that it’s a lottery, because brands’ proprietorial compounding processes vary widely and constantly with little oversight and even less transparency:
Is whitening toothpaste safe for dental health?: RDA-PE method
Mouthwash options
In the case of fluoride and hydrogen peroxide, the same advice (for and against) goes as per toothpaste.
Alcohol
There has been some concern about the potential carcinogenic effect of alcohol-based mouthwashes. According to the best current science, this one’s not an easy yes-or-no, but rather:
- If there are no other cancer risk factors, it does not seem to increase cancer risk
- If there are other cancer risk factors, it does make the risk worse
Read more:
- Does the use of alcohol mouthwash increase the risk of developing oral cancer?
- Alcohol-based mouthwash as a risk factor of oral cancer: A systematic review
Non-Alcohol
Non-alcoholic mouthwashes are not without their concerns either. In this case, the potential problem is changing the oral microbiome (we are supposed to have one!), and specifically, that the spread of what it kills and what it doesn’t may result in an imbalance that causes a lowering of the pH of the mouth.
Put differently: it makes your saliva more acidic.
Needless to say, that can cause its own problems for teeth. The research on this is still emerging, with regard to whether the benefits outweigh the problems, but the fact that it has this effect seems to be a consensus. Here’s an example paper; there are others:
Effects of Chlorhexidine mouthwash on the oral microbiome
Flossing, scraping, and alternatives
These are important (and varied, and interesting) enough to merit their own main feature, rather than squeezing them in at the end.
So, watch this space for a main feature on these soon!
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Watch Out For Furanocoumarins!
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This class of organic compounds can affect many different medications, in some cases stopping them from working, and in some cases causing you to overdose.
It’s naturally occurring, and found in certain fruit.
Agent of chaos
The fact that furanocoumarins can have very different (often opposite) effects on different drugs, makes it a lot harder to predict in its behavior than, for example, alcohol.
In particular, we’ve talked before about the very high furanocoumarin content of grapefruit (including: grapefruit juice), which has come up sometimes in our This or That section.
For example:
❝Another thing to bear in mind is that grapefruit contains furanocoumarin, which can inhibit cytochrome P-450 3A4 isoenzyme and P-glycoptrotein transporters in the intestine and liver—slowing down their drug metabolism capabilities, thus effectively increasing the bioavailability of many drugs manifold.
This may sound superficially like a good thing (improving bioavailability of things we want), but in practice it means that in the case of many drugs, if you take them with (or near in time to) grapefruit or grapefruit juice, then congratulations, you just took an overdose.
This happens with a lot of meds for blood pressure, cholesterol (including statins), calcium channel-blockers, anti-depressants, benzo-family drugs, beta-blockers, and more. Oh, and Viagra, too. Which latter might sound funny, but remember, Viagra’s mechanism of action is blood pressure modulation, and that is not something you want to mess around with unduly.
So, do check with your pharmacist to know if you’re on any meds that would be affected by grapefruit or grapefruit juice!
PS: the same substance is quite available in pummelos and sour oranges (but not meaningfully in sweet oranges); you can see a chart here showing the relative furanocoumarin contents of many citrus fruits, or lack thereof as the case may be, as it is for lemons and most limes).❞
Other drugs, however, will be decreased in their effects.
For example, for antihistamines like fexofenadine, grapefruit juice inhibits transport proteins that help absorb the drug, reducing its effectiveness
Here’s a cheatsheet
Caveat: this is a non-exhaustive list!
Medicines whose effects can INCREASE Medicines whose effects can DECREASE Cholesterol-lowering statins: simvastatin, lovastatin, atorvastatin (higher risk of muscle pain or damage) Antihistamines: e.g: fexofenadine (less effective) Blood pressure-lowering drugs: felodipine, nifedipine, nicardipine, nisoldipine, amlodipine, verapamil Blood pressure meds: e.g: aliskiren (levels drop sharply, making it less effective) Anti-anxiety and sleep medicines: midazolam, triazolam, alprazolam, diazepam, clonazepam Beta-blockers: celiprolol, talinolol, acebutolol (weaker heart-rate control) Erectile-dysfunction drugs: sildenafil, tadalafil, vardenafil Chemotherapy: e.g: etoposide (reduced absorption, which lowers effectiveness) Heart-rhythm drugs: amiodarone, dronedarone, quinidine, disopyramide, propafenone (increased risk of irregular heartbeat or toxicity) Thyroid medicine: levothyroxine (delayed absorption, usually not a huge problem) Immune-suppressing drugs: cyclosporine, tacrolimus, sirolimus Mental-health medicines: buspirone, quetiapine, sertraline (increased side effects) Pain medicines: oxycodone, methadone (overdose risk) Source: Expanded List Of Medications That Interact With Grapefruit ← as you can see, we had to clip the “increase” list for brevity; we kept it short by a) grouping them the way we did b) prioritizing the medications that are most common and whose interactions have the strongest adverse effect
Important note on timing
Of the many ways these interactions can occur, the two most common are:
- Blocking the enzyme (CYP3A4) in the gut that normally helps break down many drugs—this causes increases in drug levels.
- Blocking the transporter protein (OATP1A2) that helps the body absorb other medicines—this causes decreases in drug levels.
The enzyme-blocking effect can last up to 3 days, so skipping grapefruit for only a few hours won’t help! You need to avoid it entirely.
See: Drug-grapefruit juice interactions: two mechanisms are clear but individual responses vary
For medicines affected by OATP inhibition (like fexofenadine), leaving a 4-hour gap usually* avoids the problem.
See: Fruit juice inhibition of uptake transport: a new type of food–drug interaction
*Not a guarantee, because individuals’ physiology can and sometimes will vary.
Want to learn more?
That’s all we have room to say about furanocoumarins for now, but let’s quickly mention a very common (and very affective!) herbal supplement that has almost as many medication interactions as grapefruit does (albeit, for completely different reasons, many of which mechanisms of action are not yet fully understood):
St. John’s wort can weaken the effects of many medicines, including crucially important medicines such as:
- Antidepressants
- Birth control pills
- Cyclosporine, which prevents the body from rejecting transplanted organs
- Some heart medications, including digoxin and ivabradine
- Some HIV drugs, including indinavir and nevirapine
- Some cancer medications, including irinotecan and imatinib
- Warfarin, an anticoagulant (blood thinner)
- Certain statins, including simvastatin
And for our main article on St. John’s Wort, check out:
Flower Power: St. John’s Wort’s Drug-Level Effectiveness (The Herbal Supplement That Rivals Prozac)
Take care!
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Can Smartphone Apps Help Reduce Drinking?
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Ranging from streak-tracking and “what gets measured gets done”, through daily limits (if not abstaining completely), to cognitive behavioral therapy (CBT) and more, the number of apps promising to help us reduce/quit drinking (or reduce/quit use of some other addictive substance) is growing.
But, do they work?
They can, but…
It depends on what you’re looking for:
- Simple stuff like streak-tracking, you can’t really go wrong, and an app is just a more private version of marks on a wall calendar.
- Tracking daily amounts, becomes rather like a nutrition-tracker. It’s useful if you use it, and if you’re honest with it.
- More direct-engagement therapeutic options, with CBT-style approaches being the most common, can be quite mixed bag.
We previously addressed this latter item in the broader sense, i.e. not just related to addictions, here:
Can An AI Program Deliver Useful Psychotherapy?
The article’s well-worth reading and looks and some specific science, but a general summary could be “yes it can, but it probably won’t”.
One of the reasons for this is that generative AI (like ChatGPT et al.) is programmed to be very agreeable, and this can cause huge problems in therapy. For example (as discussed in the above article), it might errantly support someone’s suicide plans, because to the the AI, it’s just being supportive and encouraging. In contrast, if one tries to ask GenAI to not be so agreeable, often it will overcompensate, as with a recent wearable that got a lot of negative reviews from how it was marketed as a little friend, and instead it is being obnoxiously confrontational. Its rationale: “it’s the job of a friend to say the hard truths that others won’t”.
When it comes to addiction treatment, this can lead to such things as:
- “Yes, you’re right, you’ve been doing very well, and you do deserve a treat, one drink is probably fine”
- “You’ve failed, again. Maybe the only thing you’re good at quitting is sobriety?”
Neither of which approaches are helpful. A human therapist must walk a fine without messing up, and AI isn’t there yet.
Researchers (Dr. Alex Russel et al.) looked at the plethora of apps on the market for this, and found that most apps don’t use validated behaviour-change strategies and instead rather rely on bold, scientific-sounding claims without substance. This is not too surprising in context, since app stores often promote ad-driven products instead of evidence-based ones, making the better tools harder to find.
Some things that Dr. Russell and her team advise we look for:
- Research citations: peer-reviewed studies or transparent scientific references.
- Expert involvement: development in collaboration with a licensed clinician, university, or professional organisation.
- Independent evaluation: published assessments showing real-world effectiveness.
- Data protection standards: clear explanations of storage, privacy, and compliance with regulations such as HIPAA.
- No exaggerated promises: avoids phrases like “guaranteed results” or vague “clinically proven” claims without saying what, exactly, has been proven.
The paper also talks about some of the problems with AI that we discussed above, along with more, including for example how an AI’s casual tone can downplay serious risks, that simply incorrect health information can be given, because GenAI is glorified autocorrect in the sense that it works on what people have written out in the world most often, and repeats that, whether it’s true or not, and that it will find itself wildly unprepared to deal with a real human crisis situation.
You can find the paper itself, here: The Need for Oversight Over Apps for Substance Use Reduction
Want a better way?
Check out:
- How To Reduce Or Quit Alcohol
- Addiction Myths That Are Hard To Quit
- What Happens To Your Body When You Stop Drinking Alcohol ← in case you think “it’s too late for me now”, this is a very inspiring timeline
Finally, if you’d like a much deeper dive, then we’ve reviewed a number of books on beating addictions, but here’s an excellent one that’s quite different from most:
Quit Drinking – by Rebecca Dolton ← you’ll see what the difference is
Take care!
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The Hidden Weapon Against Depression (How To Do Behavioral Activation)
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Dr. Tracey Marks, psychiatrist, explains:
A cycle of action
Depression is:
- not fun
- self-reinforcing in nature
That is to say: depression disrupts thoughts, feelings, behaviors, and by extension, physical wellbeing. The resultant withdrawal from activities further removes psychological rewards, and worsens depression in a spiralling feedback loop.
Behavioral activation (BA) is an underused but effective intervention that encourages re-engaging in meaningful activities (no matter how little you feel like doing them) to break the cycle of depression.
This is very different from CBT, because instead of changing thoughts directly, it modifies behavior to indirectly improve thinking and self-perception. That said, there’s no reason you can’t do both if you want to, but let’s be reasonable; a person in the throes of depression is usually not leaping at every opportunity with full enthusiasm, so maybe one thing at a time is sufficient.
How it works: even small constructive activities provide positive reinforcement, and can start a healthier loop. Additionally, if applicable (and it’s best if it is), exercise also helps by boosting brain-derived neurotrophic factor (BDNF).
Step-by-step:
- Monitor activity: keep track for a week, noting morning/afternoon/evening activities and mood ratings (e.g. 1–10, or if you use a bullet-journalling app*, then whatever scale it uses is fine), focusing on intentional activities rather than basic bodily functions
- Review activity: identify what boosted or lowered mood, which activities increased connection, and which gave a sense of accomplishment
- Reflect on values: reconnect with core values that give meaning; use assessments or workbooks if needed
- Plan activities: list items from the tracker, your values, essential daily living tasks, and an activity menu for new ideas
- Schedule and commit: use the tracker to plan; expect gradual progress, with motivation and energy increasing over time
*This writer—who has found BA immensely useful personally for getting out of depressive episodes—uses Daylio, which has a customizable 1–5 scale (as well as customizable activities** to track). Personally I modified “3” on the scale to be able to mark two different kinds of “middling” days moodwise; I draw a distinction between days that are middling because they were emotionally flat, and days that were middling because they had a mixture of highs and lows that, for bullet-journalling purposes, cancels out to “middling”. That way, I still get my overall mood chart in the graph, but I can also scroll through my days and see if, for example, I have been emotionally flat for a time (big warning sign of depression) rather than “my day was mixed in nature” (perfectly normal healthy part of the human experience).
**As with Dr. Marks’ advice, I do mostly track intentional activities (e.g. gardening, exercise, wash hair, meditation, see sunrise, see friends, etc), though I also track my sleep (e.g. good sleep, bad sleep, medium sleep, wake early), and some physiological things such as crying, and cramps (because if I track crying for several days and then cramps, I can probably attribute it at least in part to hormones), because these things have bearing on how I then interpret the data—which is part of how the “monitor” and “review” parts of BA work.
One of the great things about BA is that you can do it by yourself, but you also can enlist help, e.g. from a partner, friends, family, etc. When experiencing depression, it’s easy to imagine that either everyone hates you or, at best, nobody cares—but usually there will be people who will be glad to help if given the opportunity.
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Behavioral Activation Against Depression & Anxiety
Take care!
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Dr. Kim Foster’s Method For Balancing Hormones Naturally
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Not just sex hormones, but also hormones like cortisol (the stress hormone), and thyroid hormones (for metabolism regulation) too! The body is most of the time self-regulating when it comes to hormones, but there are things that we can do to help our body look after us correctly.
In short, if we give our body what it needs, it will (usually, barring serious illness!) give us what we need.
Dr. Foster recommends…
Foods:
- Healthy fats (especially avocados and nuts)
- Lean proteins (especially poultry, fish, and legumes)
- Fruits & vegetables (especially colorful ones)
- Probiotics (especially fermented foods like sauerkraut, kimchi, etc)
- Magnesium-rich foods (especially dark leafy greens, nuts, and yes, dark chocolate)
Teas:
- Camomile tea (especially beneficial against cortisol overproduction)
- Nettle tea (especially beneficial for estrogen production)
- Peppermint tea (especially beneficial for gut health, thus indirect hormone benefits)
Stress reduction:
- Breathing exercises (especially mindfulness exercises)
- Yoga (especially combining exercise with stretches)
- Spending time in nature (especially green spaces)
Dr. Foster explains more about all of these things, along with more illustrative examples, so if you can, do enjoy her video:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to read more about this topic?
You might like our main feature: What Does “Balance Your Hormones” Even Mean?
Enjoy!
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Is honey good for you? Can it speed recovery if you’re sick or injured?
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Honey is often praised for a range of health benefits, from soothing a sore throat and helping you get to sleep to healing woulds and lowering risk factors for diabetes and heart disease.
Honey’s acidity has the potential to prevent bacterial growth, while its density and stickiness generates osmotic pressure (in the same way as quicksand) which restrain bacteria.
Other compounds in honey contribute anti-inflammatory and antioxidant effects.
But do the claims about honey for specific health problems and injuries stack up to science? Let’s check what the evidence says.
abe livi/Unsplash First, what’s in honey?
Honey contains up to 20% water. The remaining 80% is made of simple sugars: monasaccharides that we rapidly digest. Fructose (32-28%) and glucose (26-31%) are the main ones, followed by small amounts of sucrose and others.
This can increase blood sugar levels to varying degrees. The glycemic index (GI) measures how fast blood sugars rise after eating or drinking. The GI of different Australian honeys ranges from 35 (low) to 72 (high), though most food labels don’t contain GI information.
Honey also has traces of vitamins (A, B1, B2, B6, C), minerals (potassium, magnesium, iron, zinc), amino acids (protein) and enzymes from plant, bee and insect secretions.
Nutrients vary depending on where the honeybees collected pollen, the time of honey harvest and how long it has been stored.
Can honey heal wounds?
A 2015 Cochrane review update assessed the effects of honey in treating acute burns, lacerations and chronic wounds, compared to topical treatments or other dressings.
It found high-quality evidence that honey dressings healed second-degree burns 4–5 days faster than conventional dressings. There was moderate-quality evidence that wounds infected after surgery healed faster with honey.
A 2020 review evaluated antimicrobial activity of Manuka and medical-grade honeys against a range of multi-drug resistant bacterial species. It found all honeys were effective against most species and could be considered for use in antibiotic-resistant infections.
Only sterilised medical-grade honey that has been processed to remove contaminants, and meets safety and antibacterial standards, should be used, with guidance from your doctor.
Does honey help adults sleep?
Research on the effects of honey on sleep is limited.
One trial compared sleep quality of 68 adults admitted to hospital. Half were given a mixture of milk (150mL) and honey (30g) twice a day, and half were not.
Those in the honey-mixture group said they slept better after day three. But these results could be biased, because participants were aware they were getting honey-milk and drinking it can be associated with feeling of comfort.
Can it soothe sore throats and coughs, or help kids sleep?
Five studies in children have compared honey mixtures to over-the-counter cough medicines or no medication. Each study linked honey to better sleep and less severe coughs in children.
But before you rush out to stock up on honey, there are major limitations related to the honey used. The quantity and type of honey given varies across the studies, with no certainty about which components are present. So the results need to be interpreted with caution.
Chemical analysis of some honey varieties found traces of the “feel-good” brain chemical serotonin and the hormone melatonin, which affects sleep and circadian rhythm. But the researchers concluded the small amounts detected were more likely to affect activity of the bees, rather than affecting human behaviour.
What about for diabetes, heart disease and cancer care?
For diabetes, a 2023 review of 48 clinical trials found honey had some positive effects on a range of risk factors, including glucose tolerance and wound healing. However, the honey dose and type weren’t standardised, so the researchers concluded that honey could be used in addition to, but not instead of, regular medications.
For heart disease, a 2022 analysis combining findings from trials evaluated the impact of honey on blood fats. It found no effect on several risk factors for heart disease: total cholesterol, triglycerides (another type of blood fat), low-density lipoprotein (LDL or bad) cholesterol or high-density lipoprotein (HDL or good) cholesterol.
However a 2025 meta-analysis of propolis (bee glue) did find significant reductions in triglycerides, LDL (bad) cholesterol, fasting blood sugars, insulin and systolic blood pressure (the top number on a reading). But given most propolis supplement trials have only lasted a few months and supplements are expensive, that money is likely better spent on healthy foods.
For cancer patients, a 2023 review found honey alleviated ulceration and inflammation in the mouth following chemotherapy or radiotherapy, and it reduced some of the toxic effects of chemotherapy.
Can it affect your mind?
Some honeys have psychotropic, or mind-altering effects. “Mad honey” comes from plant nectar of Rhododendron species and naturally contains grayanotoxins, which have pharmacological and toxic effects.
These include nausea, dizziness, low blood pressure, severe bradycardia (an abnormally slow heart rate), neurological complications and even life-threatening cardiac arrhythmia (irregular heart beat).
It’s illegal to import or sell “mad honey” in Australia but Nepal and Turkey have historically used it for medicinal and psychoactive properties.
Who shouldn’t have honey?
Although commercial honey is pasteurised, the process does not kill spores of the bacteria Clostridium botulinum. This is why babies under one year and immunocompromised people shouldn’t have honey.
Clare Collins, Laureate Professor in Nutrition and Dietetics, University of Newcastle
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Gooseberries vs Grapefruit – Which is Healthier?
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Our Verdict
When comparing gooseberries to grapefruit, we picked the gooseberries.
Why?
In terms of macros, gooseberries have 3x the fiber and a tiny bit more protein, while grapefruit has more carbs; an easy win for gooseberries.
In the category of vitamins, gooseberries have more of vitamins B3, B6, and E, while grapefruit has more of vitamins A and B9, yielding a modest win to gooseberries in this round.
Looking at minerals, gooseberries have more calcium copper, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc, while grapefruit is not higher in any minerals, making this round a one-sided win for gooseberries.
In other considerations, gooseberries have more polyphenols, so that’s another point in their favor.
One more consideration that’s not shown in the nutritional values, is that grapefruit contains high levels of furanocoumarin, which can inhibit cytochrome P-450 3A4 isoenzyme and P-glycoptrotein transporters in the intestine and liver—slowing down their drug metabolism capabilities, thus effectively increasing the bioavailability of many drugs manifold.
This may sound superficially like a good thing (improving bioavailability of things we want), but in practice it means that in the case of many drugs, if you take them with (or near in time to) grapefruit or grapefruit juice, then congratulations, you just took an overdose. This happens with a lot of meds for blood pressure, cholesterol (including statins), calcium channel-blockers, anti-depressants, benzo-family drugs, beta-blockers, and more. Oh, and Viagra, too. Which latter might sound funny, but remember, Viagra’s mechanism of action is blood pressure modulation, and that is not something you want to mess around with unduly. So, do check with your pharmacist to know if you’re on any meds that would be affected by grapefruit or grapefruit juice!
PS: the same substance is quite available in pummelos and sour oranges (but not meaningfully in sweet oranges); you can see a chart here showing the relative furanocoumarin contents of many citrus fruits, or lack thereof as the case may be, as it is for lemons and most limes).
In any case, adding up the sections makes for a clear overall win for gooseberries, but by all means do enjoy either or both (if grapefruit isn’t contraindicated for you because of the medications interactions)!
Want to learn more?
You might like:
Watch Out For Furanocoumarins!
Enjoy!
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