Aspirin, CVD Risk, & Potential Counter-Risks

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Aspirin Pros & Cons

In Tuesday’s newsletter, we asked your health-related opinion of aspirin, and got the above-depicted, below-described set of responses:

  • About 42% said “Most people can benefit from low-dose daily use to lower CVD risk”
  • About 31% said “It’s safe for occasional use as a mild analgesic, but that’s all”
  • About 28% said “We should avoid aspirin; it can cause liver and/or kidney damage”

So, what does the science say?

Most people can benefit from low-dose daily aspirin use to lower the risk of cardiovascular disease: True or False?

True or False depending on what we mean by “benefit from”. You see, it works by inhibiting platelet function, which means it simultaneously:

  • decreases the risk of atherothrombosis
  • increases the risk of bleeding, especially in the gastrointestinal tract

When it comes to balancing these things and deciding whether the benefit merits the risk, you might be asking yourself: “which am I most likely to die from?” and the answer is: neither

While aspirin is associated with a significant improvement in cardiovascular disease outcomes in total, it is not significantly associated with reductions in cardiovascular disease mortality or all-cause mortality.

In other words: speaking in statistical generalizations of course, it may improve your recovery from minor cardiac events but is unlikely to help against fatal ones

The current prevailing professional (amongst cardiologists) consensus is that it may be recommended for secondary prevention of ASCVD (i.e. if you have a history of CVD), but not for primary prevention (i.e. if you have no history of CVD). Note: this means personal history, not family history.

In the words of the Journal of the American College of Cardiology:

❝Low-dose aspirin (75-100 mg orally daily) might be considered for the primary prevention of ASCVD among select adults 40 to 70 years of age who are at higher ASCVD risk but not at increased bleeding risk (S4.6-1–S4.6-8).

Low-dose aspirin (75-100 mg orally daily) should not be administered on a routine basis for the primary prevention of ASCVD among adults >70 years of age (S4.6-9).

Low-dose aspirin (75-100 mg orally daily) should not be administered for the primary prevention of ASCVD among adults of any age who are at increased risk of bleeding (S4.6-10).❞

~ Dr. Donna Arnett et al. (those section references are where you can find this information in the document)

Read in full: Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology

Or if you’d prefer a more pop-science presentation:

Many older adults still use aspirin for CVD prevention, contrary to clinical guidance

Aspirin can cause liver and/or kidney damage: True or False?

True, but that doesn’t mean we must necessarily abstain, so much as exercise caution.

Aspirin is (at recommended doses) not usually hepatotoxic (toxic to the liver), but there is a strong association between aspirin use in children and the development of Reye’s syndrome, a disease involving encephalopathy and a fatty liver. For this reason, most places have an official recommendation that aspirin not be used by children (cut-off age varies from place to place, for example 12 in the US and 16 in the UK, but the key idea is: it’s potentially dangerous for those who are not fully grown).

Aspirin is well-established as nephrotoxic (toxic to the kidneys), however, the toxicity is sufficiently low that this is not expected to be a problem to otherwise healthy adults taking it at no more than the recommended dose.

For numbers, symptoms, and treatment, see this very clear and helpful resource:

An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose

Take care!

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  • Brain Food? The Eyes Have It!

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Brain Food? The Eyes Have It!

    This is Dr. Michael Greger, M.D. FACLM, of “Dr. Greger’s Daily Dozen” and “How Not To Die” fame, and he wants us to protect our brains (and while we’re at it, our eyesight).

    And the secret is…

    Lutein.

    This is a carotenoid, which is super important for the eyes and brain. Not to be confused with carrots, which despite the name are usually not a good source of carotenoids!

    They do however contain lots of beta-carotene, a form of vitamin A, but that (and the famous WW2-era myth born of deliberate disinformation by the British government) isn’t what we’re covering today.

    We say “eyes and brain” but really, the eyes are just an extension of the brain in any case.

    Pedantry aside, what Dr. Greger wants you to know about lutein is how important it is for the protection of your brain/eyes, both against cognitive decline and against age-related macular degeneration (the most common cause of eyesight loss in old age).

    Important take-away info:

    Want to know more about the Dr. Greger’s Daily Dozen approach to health?

    See the Website / Get the App (Android & iOS) / Get the Science Book / Get the Cookbook!

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  • Sleep Smarter – by Shawn Stevenson

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    You probably know to avoid blue light before bed, put a curfew on the caffeine, and have fresh bedding. So, what does this book offer that’s new?

    As the subtitle suggests, it’s 21 tips for better sleep, so if even half of them are new, then it’ll still be adding value.

    This is a book review, not a book summary, but to give an idea of the kind of thing you might not already know: there’s a section on bedroom houseplants! For example…

    • Which plants filter the air best according to NASA, rather than “according to tradition”
    • Which plants will thrive in what will hopefully be a cool dark environment
    • Which plants produce oxygen even at night, rather than just during the day

    The writing style is personable without losing clarity or objectivity:

    • We read personal anecdotes, and we read science
    • We get “I tried this”, and we get “this sleep study found such-and-such”
    • We get not just the “what”, but also the “why” and the “how”

    We get the little changes that make a big differencesometimes the difference between something working or not!

    Bottom line: if you’d like to get better sleep and a blue light filter hasn’t wowed you and changed your life, this book will bring your sleep knowledge (and practice) to the next level.

    Click here to check out Sleep Smarter, and if those 21 ways improve your sleep 5% each, just think what that total can do for your life!

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  • Fruit, Fiber, & Leafy Greens… On A Low-FODMAP Diet!

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Fiber For FODMAP-Avoiders

    First, let’s quickly cover: what are FODMAPs?

    FODMAPs are fermentable oligosaccharides, disaccharides, monosaccharides, and polyols.

    In plainer English: they’re carbohydrates that are resistant to digestion.

    This is, for most people most of the time, a good thing, for example:

    When Is A Fiber Not A Fiber? When It’s A Resistant Starch.

    Not for everyone…

    However, if you have inflammatory bowel syndrome (IBS), including ulcerative colitis, Crohn’s disease, or similar, then suddenly a lot of common dietary advice gets flipped on its head:

    Dietary Intolerances & More

    While digestion-resistant carbohydrates making it to the end parts of our digestive tract are good for our bacteria there, in the case of people with IBS or similar, it can be a bit too good for our bacteria there.

    Which can mean gas (a natural by-product of bacterial respiration) accumulation, discomfort, water retention (as the pseudo-fiber draws water in and keeps it), and other related symptoms, causing discomfort, and potentially disease such as diarrhea.

    Again: for most people this is not so (usually: quite the opposite; resistant starches improve things down there), but for those for whom it’s a thing, it’s a Big Bad Thing™.

    Hold the veg? Hold your horses.

    A common knee-jerk reaction is “I will avoid fruit and veg, then”.

    Superficially, this can work, as many fruit & veg are high in FODMAPs (as are fermented dairy products, by the way).

    However, a diet free from fruit and veg is not going to be healthy in any sustainable fashion.

    There are, however, options for low-FODMAP fruit & veg, such as:

    Fruits: bananas (if not overripe), kiwi, grapefruit, lemons, limes, melons, oranges, passionfruit, strawberries

    Vegetables: alfalfa, bell peppers, bok choy, carrots, celery, cucumbers, eggplant, green beans, kale, lettuce, olives, parsnips, potatoes (and sweet potatoes, yams etc), radishes, spinach, squash, tomatoes*, turnips, zucchini

    *our stance: botanically it’s a fruit, but culinarily it’s a vegetable.

    For more on the science of this, check out:

    Strategies for Producing Low FODMAPs Foodstuffs: Challenges and Perspectives ← table 2 is particularly informative when it comes to the above examples, and table 3 will advise about…

    Bonus

    Grains: oats, quinoa, rice, tapioca

    …and wheat if the conditions in table 3 (linked above) are satisfied

    (worth mentioning since grains also get a bad press when it comes to IBS, but that’s mostly because of wheat)

    See also: Gluten: What’s The Truth?

    Enjoy!

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    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    A lot of ADHD literature is based on the assumption that the reader is a 30-something parent of a child with ADHD. This book, on the other hand, addresses all ages, and includes just as readily the likelihood that the person with ADHD is the reader, and/or the reader’s partner.

    The authors cover such topics as:

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  • Why Some People Get Sick More (And How To Not Be One Of Them)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Some people have never yet had COVID (so far so good, this writer included); others are on their third bout already; others have not been so lucky and are no longer with us to share their stories.

    Obviously, even the healthiest and/or most careful person can get sick, and it would be folly to be complacent and think “I’m not a person who gets sick; that happens to other people”.

    Nor is COVID the only thing out there to worry about; there’s always the latest outbreak-du-jour of something, and there are always the perennials such as cold and flu—which are also not to be underestimated, because both weaken us to other things, and flu has killed very many, from the 50,000,000+ in the 1918 pandemic, to the 700,000ish that it kills each year nowadays.

    And then there are the combination viruses:

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    • perhaps they have an inflammatory/autoimmune disease of some kind (e.g. lupus, rheumatoid arthritis, type 1 diabetes), or…
    • perhaps they are taking immunosuppressants for some reason (e.g. because they had an organ transplant), or…
    • perhaps they have a primary infection that leaves them vulnerable to secondary infections. Most infections will do this to some degree or another, but some are worse for it than others; untreated HIV is a clear example. The HIV itself may not kill people, but (if untreated) the resultant AIDS will leave a person open to being killed by almost any passing opportunistic pathogen. Pneumonia of various kinds being high on the list, but it could even be something as simple as the common cold, without a working immune system to fight it.

    See also: How To Prevent (Or Reduce) Inflammation

    And for that matter, since pneumonia is a very common last-nail-in-the-coffin secondary infection (especially: older people going into hospital with one thing, getting a secondary infection and ultimately dying as a result), it’s particularly important to avoid that, so…

    See also: Pneumonia: What We Can & Can’t Do About It

    Secondly, some people are not immunocompromised per the usual definition of the word, but their immune system is, arguably, compromised.

    Cortisol, the stress hormone, is an immunosuppressant. We need cortisol to live, but we only need it in small bursts here and there (such as when we are waking up the morning). When high cortisol levels become chronic, so too does cortisol’s immunosuppressant effect.

    Top things that cause elevated cortisol levels include:

    • Stress
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    See also: Lower Your Cortisol! (Here’s Why & How)

    Other modifiable factors

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    What if they fail? How can we boost the immune system?

    We talked about not sabotaging the immune system, but what about actively boosting it? The answer is yes, we certainly can (barring serious medical reasons why not), as there are some very important lifestyle factors too:

    Beyond Supplements: The Real Immune-Boosters!

    One final last-line thing…

    Since if we do get an infection, it’s better to know sooner rather than later… A recent study shows that wearable activity trackers can (if we pay attention to the right things) help predict disease, including highlighting COVID status (positive or negative) about as accurately (88% accuracy) as rapid screening tests. Here’s a pop-science article about it:

    Wearable activity trackers show promise in detecting early signals of disease

    Take care!

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  • HBD: The Human Being Diet – by Petronella Ravenshear

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We don’t often review diet books, so why did this one catch our attention? The answer lies in its comprehensive nature without being excessively long and complex.

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    Don’t Forget…

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