Age Later – by Dr. Nir Barzilai
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Dr. Barzilai discusses why we age, why supercentenarians age more slowly, and even, why it is so often the case that supercentenarians outside of Blue Zones have poor lifestyles (their longevity is because of protective genes that mitigate the harmful effects of those poor lifestyles—the ultimate in “survivorship bias”).
He also talks not just genetics, but also epigenetics, and thus gene expression. Bearing in mind, there’s a scale of modifiability there: with current tech, we can’t easily change a bad gene… But we often can just switch it off (or at least downregulate its expression). This is where studies in supercentenarians are helpful even for those who don’t have such fortunate genes—the supercentenarian studies show us which genes we want on or off, what gene expressions to aim for, etc. Further clinical studies can then show us what lifestyle interventions (exercise, diet, nutraceuticals, etc) can do that for us.
With regard to those lifestyle interventions, he does cover many, and that’s where a lot of the practical value of the book comes from. But it’s not just “do this, do that”; understanding the reasons behind why things work the way they do is important, so as to be more likely to do it right, and also to enjoy greater adherence (we tend to do things we understand more readily than things we have just been told to do).
There are areas definitely within the author’s blind spots—for example, when talking about menopausal HRT, he discusses at great length the results of the discredited WHI study, and considers it the only study of relevance. So, this is a reminder to not believe everything said by someone who sounds confident (Dr. Barzilai’s professional background is mostly in treating diabetes).
In terms of style, it is very much narrative; somewhat pop-science, but more “this doctor wants to tell stories”. So many stories. Now, the stories all have informational value, so this isn’t padding, but it is the style, so we mention it as such. As for citations, there aren’t any, so if you want to look up the science he mentions, you’re going to need a bit of digital sleuthery to find the papers from the clues in the stories.
Bottom line: if you’re interested in the science of aging and how that has been progressing for the past decades and where we’re at, this book will give you so many jumping-off points, and is an engaging read.
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Eat to Your Heart’s Content – by Dr. Sat Bains
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Making food heart-healthy and tasty is a challenge that vexes many, but it doesn’t have to be so difficult.
Dr. Sat Bains, a professional chef with multiple Michelin stars to his name, is an expert on “tasty”, and after surviving a heart attack himself, he’s become an expert on “heart-healthy” since then.
The book contains not only the recipes (of which there are 68, by the way), but also large sections of explanation of what makes various ingredients or methods heart-healthy or heart-unhealthy.
There’s science in there too, and these sections were written under the guidance of Dr. Neil Williams, a lecturer in physiology and nutrition.
You may be wondering as to why the author himself has a doctorate too; in fact he has three, none of which are relevant:
- Doctor of Arts
- Doctor of Laws
- Doctor of Hospitality (Honorary)
…but we prefix “Dr.” when people are that and he is that. The expertise we’re getting here though is really his culinary skill and extracurricular heart-healthy learning, plus Dr. Williams’ actual professional health guidance.
Bottom line: if you’d like heart-healthy recipes with restaurant-level glamour, this book is a fine choice.
Click here to check out Eat To Your Heart’s Content, and look after yours!
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The Ultimate Booster
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Winning The Biological Arms Race
The human immune system (and indeed, other immune systems, but we are all humans here, after all) is in a constant state of war with pathogens, and that war is a constant biological arms race:
- We improve our defenses and destroy the attackers; the 1% of pathogens that survived now “know” how to counter that trick.
- The pathogens wreak havoc in our systems; the n% of us that survive now have immune systems that “know” how to counter that trick.
Vaccines are a mighty tool in our favor here, because they’re the technology that stops our n% from also being a very low number.
With vaccines, we can effectively pass on established defenses onto the population at large, as this cute video explains very well and very simply in 57 seconds:
Click Here If The Embedded Video Doesn’t Load Automatically!
The problem with vaccines
The problem is that this accelerates the arms race. It’s like a chess game where we are able to respond to every move quickly (which is good for us), and/but this means passing the move over to our opponent sooner.
That problem’s hard to avoid, because the alternative has always been “let people die in much larger numbers”.
Traditional vs mRNA vaccines
A quick refresher before we continue to the big news of the day:
- Traditional vaccines use a disabled version of a pathogen to trigger an immune response that will teach the body to recognize the pathogen ready for when the full version shows up
- mRNA vaccines use a custom-made bit of genetic information to tell the body to make its own harmless fake pathogen and then respond to the harmless fake pathogen it made.
Note: this happens independently of the host’s DNA, so no, it does not change your DNA
See also: The Truth About Vaccines
Here’s a more detailed explainer (with a helpful diagram) using the COVID mRNA vaccine as an example:
Genome.gov | How does an mRNA vaccine work?
However, this still leaves us “chasing strains”, because as the pathogen (in this case, a virus) adapts, the vaccine has to be updated too, hence all the boosters.
This is a lot like a security update for your computer’s antivirus software. They’re annoying, but they do an important job.
No more “chasing strains”
The press conference soundbite on this sums it up well:
❝Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.❞
Read in full: Vaccine breakthrough means no more chasing strains
You may be wondering: what makes this one effective against any strain?
❝What I want to emphasize about this vaccine strategy is that it is broad.
It is broadly applicable to any number of viruses, broadly effective against any variant of a virus, and safe for a broad spectrum of people. This could be the universal vaccine that we have been looking for.
Viruses may mutate in regions not targeted by traditional vaccines. However, we are targeting their whole genome with thousands of small RNAs. They cannot escape this.❞
Importantly, this means it can be applied not just to one disease, let alone just one strain of COVID. Rather, it can be used for a wide variety of viruses that have similar viral functions—COVID / SARS in general, including influenza, and even viruses such as dengue.
How it does this: the above article explains in more detail, but in few words: it targets tiny strings of the genome that are present in all strains of the virus.
Illustrative example: if you wanted to block 10almonds (please don’t), you could block our email address.
But if we were malicious (we’re not) we could be sneaky and change it, so you’d have to block the new one, and the cycle repeats.
But if you were block all emails containing the tiny string of characters “10almonds”, changing our email address would no longer penetrate your defenses.
Now imagine also blocking strings such as “One-Minute Book Review” and “Today’s almonds have been activated by” and other strings we use in every email.
Now multiply this by thousands of strings (because genomes are much larger than our little newsletter), and you see its effectiveness!
Great! How can I get this?
It’s still in the testing stages for now; this is “breaking news” science, after all.
The study itself
…is paywalled for now, sadly, but if you happen to have institutional access, here it is:
Take care!
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Longevity… Simplified – by Dr. Howard Luks
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In the spirit of the book itself, we’ll keep this one simple:
The information in this book will not be new to regular readers of 10almonds, or at least, not if you’ve been with us for a while (because we can only cover so much per day, so long-time readers will have accumulated more knowledge).
On the other hand, the information is clear, correct, and very much stripped down to the most important basics. Not the very simplest basics, which would be an oversimplification to the point of inutility, but the most important basics.
To take an example, when it comes to exercise, he doesn’t say “exercise more” but rather that “a complete exercise program has four pillars: aerobic training, resistance training, balance training, and high-intensity interval training (HIIT)”, and then he goes about explaining, in clear and simple terms, how to do those.
The style is similar when it comes to diet, sleep, and body-part-specific chapters such as about heart health, brain health, and so forth.
Bottom line: if you’re a long-time 10almonds reader, you probably don’t need this one, but it’d be a great book for someone else who has expressed an interest in getting healthier, as it really is a top-tier “primer” in increasing health and healthspan.
Click here to check out Longevity… Simplified, and enjoy simplified longevity!
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Managing Chronic Pain (Realistically!)
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Realistic chronic pain management
We’ve had a number of requests to do a main feature on managing chronic pain, so here it is!
A quick (but important) note before we begin:
Obviously, not all chronic pain is created equal. Furthermore, we know that you, dear reader with chronic pain, have been managing yours for however long you have, learning as you go. You also doubtlessly know your individual condition inside out.
We also know that people with chronic health conditions in general are constantly beset by well-meaning unsolicited advice from friends and family, asking if you’ve heard about [thing you heard about 20 years ago] that will surely change your life and cure you overnight.
It’s frustrating, and we’re going to try to avoid doing that here, while still offering the advice that was asked for. We ask you, therefore, to kindly overlook whatever you already knew, and if you already knew it all, well, we salute you and will not be surprised if that’s the case for at least some readers. Chronic pain’s a… Well, it’s a chronic pain.
All that said, let’s dive in…
How are you treating your body right now?
Are you hydrated; have you eaten; are you standing/sitting/lying in a position that at least should be comfortable for you in principle?
The first two things affect pain perception; the latter can throw a spanner in the works if something’s not quite right.
Move your body (gently!)
You know your abilities, so think about the range of motion that you have, especially in the parts of your body that hurt (if that’s “everywhere”, then, our sympathies, and we hope you find the same advice applies). Think about your specific muscles and joints as applicable, and what the range of motion is “supposed” to be for each. Exercise your range of motion as best you can (gently!) to the point of its limit(s) and/or pain.
- If you take it past that limit, there is a good chance you will make it worse. You don’t want that.
- If you don’t take it to the limit, there is a good chance your range of movement will deteriorate, and your “safe zone” (i.e., body positions that are relatively free from pain) will diminish. You definitely don’t want that, either.
Again, moderation is key. Yes, annoying as the suggestion may be, such things as yoga etc can help, if done carefully and gently. You know your limits; work with those, get rest between, and do what you can.
For most people this will at least help keep the pain from getting worse.
Hot & Cold
Both of these things could ease your pain… Or make it worse. There is an element of “try it and see”, but here’s a good general guide:
Here’s How to Choose Between Using Ice or Heat for Pain
Meditation… Or Distraction
Meditating really does help a lot of people. In the case of pain, it can be counterintuitively helpful to focus for a while on the sensation of the pain… But in a calm, detached fashion. Without judgement.
“Yes, I am experiencing pain. Yes, it feels like I’m being stabbed with hot knives. Yes, this is tortuous; wow, I feel miserable. This truly sucks.”
…it doesn’t sound like a good experience, does it? And it’s not, but paying it attention this way can paradoxically help ease things. Pain is, after all, a messenger. And in the case of chronic pain, it’s in some ways a broken messenger, but what a messenger most needs is to be heard.
The above approach a) is good b) may have a limit in how long you can sustain it at a time, though. So…
The opposite is a can be a good (again, short-term) approach too. Call a friend, watch your favorite movie, play a video game if that’s your thing. It won’t cure anything, but it can give you a little respite.
Massage
Unless you already know this makes your pain worse, this is a good thing to try. It doesn’t have to be a fancy spa; if the nature of your pain and condition permits, you can do self-massage. If you have a partner or close friend who can commit to helping, it can be very worth them learning to give a good massage. There are often local courses available, and failing that, there is also YouTube.
Here’s an example of a good video for myofascial release massage, which can ease a lot of common kinds of chronic pain:
Some quick final things to remember:
- If you find something helps, then it helps, do that.
- That goes for mobility aids and other disability aids too, even if it was designed for a different disability. If it helps, it helps. You’re not stealing anyone’s thunder (or resources) by using something that makes your life easier. We’re not in this life to suffer!
- There is no such thing as “this pain is not too much”. The correct amount of pain is zero. Maybe your body won’t let you reach zero, but more than that is “too much” already.
- You don’t have to be suffering off the scale to deserve relief from pain
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What Happens To Your Body When You Eat Raw Garlic Everyday
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Garlic’s benefits are not all in its most talked-about active compound, allicin (some are in other parts of the garlic), but the allicin is certainly very potent. However, allicin breaks down easily, which means that cooking reduces its value greatly, meaning that for health purposes, it is best consumed raw. Pickled garlic cloves are great, by the way, and you should try them if you haven’t already.
Garlic’s benefits (aside from being delicious)
Benefits that can be expected include:
- Boosts immunity: allicin enhances white blood cell function, helping fight off colds and flu
- Supports heart health: lowers blood pressure, reduces cholesterol, and prevents blood clots, reducing the risk of heart disease and stroke
- Anti-cancer properties: it contains sulfur compounds that may inhibit cancer cell growth, particularly in the digestive system
- Improves digestion: stimulates digestive enzymes and promotes gut health, helping with better nutrient absorption and digestion
- Enhances brain function: antioxidants in garlic are neuroprotective, reducing cognitive decline
- Good for your skin: its antibacterial and anti-inflammatory properties can help improve skin health
- Regulates blood sugar levels: helps regulate blood sugar and improves insulin sensitivity
- Anti-inflammatory effects: contains compounds that reduce inflammation, helping to combat inflammatory diseases such as arthritis
- Supports weight loss: stimulates metabolism, suppresses appetite, and helps break down fats, aiding in weight management
- May protect against osteoporosis: increases estrogen levels in women, potentially reducing the risk of osteoporosis (no effect on estrogen levels if you don’t have ovaries)
The daily dose that this video recommends is 1–2 cloves of garlic or 3600mg of aged garlic extract as a supplement.
For more on all of these, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
The Many Health Benefits Of Garlic
Take care!
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Bushfire smoke affects children differently. Here’s how to protect them
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Bushfires are currently burning in Australian states including Victoria, Tasmania, Western Australia and South Australia. In some areas, fire authorities have warned residents about the presence of smoke.
Bushfire smoke is harmful to our health. Tiny particles of ash can lodge deep in the lungs.
Exposure to this type of smoke may worsen existing conditions such as asthma, and induce a range of health effects from irritation of the eyes, nose and throat to changes in the cardiovascular system.
Public health recommendations during smoke events tend to provide general advice, and don’t often include advice specifically geared at children. But children are not just little adults. They are uniquely vulnerable to environmental hazards such as bushfire smoke for a number of reasons.
Different physiology, different behaviour
Children’s lungs are still developing and maturing.
Airways are smaller in children, especially young children, which is associated with greater rates of particle deposition – when particles settle on the surfaces of the airways.
Children also breathe more air per kilogram of body weight compared with adults, and therefore inhale more polluted air relative to their size.
Further, children’s detoxification systems are still developing, so environmental toxins take longer to effectively clear from their bodies.
Meanwhile, children’s behaviour and habits may expose them to more environmental toxins than adults. For example, they tend to do more physical activity and spend more time outdoors. Higher levels of physical activity lead to more air inhaled per kilogram of body weight.
Also, a normal and important part of children’s early play is exploring their environment, including by putting things in their mouth. This can result in kids ingesting soil, dust and dirt, which often contain environmental contaminants.
For these reasons, it’s important to consider the specific needs of children when providing advice on what to do when there’s smoke in the air.
Keeping our environments healthy
The Australian government offers recommendations for minimising the health risks from exposure to bushfire smoke. The main advice includes staying indoors and keeping doors and windows closed.
This is great advice when the smoke is thick outside, but air pollutants may still accumulate inside the home. So it’s important to air your home once the smoke outside starts to clear. Take advantage of wind changes to open up and get air moving out of the house with a cross breeze.
Kids are natural scientists, so get them involved. For example, you and your child can “rate” the air each hour by looking at a landmark outside your home and rating how clearly you can see it. When you notice the haze is reducing, open up the house and clear the air.
Because air pollutants settle onto surfaces in our home and into household dust, an easy way to protect kids during smoky periods is to do a daily dust with a wet cloth and vacuum regularly. This will remove pollutants and reduce ingestion by children as they play. Frequent hand washing helps too.
Healthy bodies and minds
Research exploring the effects of bushfire smoke exposure on children’s health is sparse. However, during smoke events, we do see an increase in hospital visits for asthma, as well as children reporting irritation to their eyes, nose and throat.
If your child has asthma or another medical condition, ensure they take any prescribed medications on a regular schedule to keep their condition well controlled. This will minimise the risk of a sudden worsening of their symptoms with bushfire smoke exposure.
Make sure any action plans for symptom flare-ups are up to date, and ensure you have an adequate supply of in-date medication somewhere easy to locate and access.
Children may be anxious during a bushfire.
Media_Photos/ShutterstockKids can get worried during bushfires, and fire emergencies have been linked with a reduction in children’s mental health. Stories such as the Birdie’s Tree books can help children understand these events do pass and people help one another in times of difficulty.
Learning more about air pollution can help too. Our group has a children’s story explaining how air pollution affects our bodies and what can help.
It’s also important for parents and caregivers not to get too stressed, as children cope better when their parents manage their own anxiety and help their children do the same. Try to strike a balance between being vigilant and staying calm.
What about masks?
N95 masks can protect the wearer from fine particles in bushfire smoke, but their use is a bit complicated when it comes to kids. Most young children won’t be able to fit properly into an N95 mask, or won’t tolerate the tight fit for long periods. Also, their smaller airways make it harder for young children to breathe through a mask.
If you choose to use an N95 mask for your children, it’s best to save them for instances when high-level outdoor exposure is unavoidable, such as if you’re going outside when the smoke is very thick.
N95 masks should be replaced after around four hours or when they become damp.
If your child has an existing heart or lung condition, consult their doctor before having them wear an N95 mask.
Our team is currently recruiting for a study exploring the effects of bushfire smoke in children. If you live in south east Queensland and are interested in participating in the event of a bushfire or hazard reduction burn near your home, please express your interest here.
Dwan Vilcins, Group leader, Environmental Epidemiology, Children’s Health Environment Program, The University of Queensland; Nicholas Osborne, Associate Professor, School of Public Health, The University of Queensland, and Paul D. Robinson, Conjoint Professor in Respiratory and Sleep Medicine, Child Health Research Centre, The University of Queensland
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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