A Very Accessible New Way To Regenerate Your Gut

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In fact, a plurality of ways:

Polyamines to the rescue

Polyamines are small molecules (by which we mean: small even by molecular standards) made of more than one amino acid. They occur naturally in our bodies, and in many of the foods we eat.

We’ve written about some polyamines before:

No, not all polyamines have sperm-themed names, but that’s just where several important ones were first identified. What can we say; apparently scientists just loved looking at that stuff in the 1800s!

Another important polyamine has the delightful name putrescine, whose name comes from…

The smell of death: evidence that putrescine elicits threat management mechanisms

Scientists (Dr. Nadja Gebert et al.) have identified why these polyamines and more should ideally form a good part of our diet.

Specifically, they found that after intestinal damage, the body increases its own polyamine levels, such as spermidine and putrescine to support protein homeostasis and regeneration. Upon testing further, they found that boosting the polyamine metabolism with dietary interventions and/or oral supplementation (which one might consider a dietary intervention in any case) restores regenerative capacity in aged intestinal cells.

In other words, the aging intestine remains capable of repair at the molecular level—it just needs the right molecular trigger to kick-start its regenerative capacity again.

And there’s more! Per the study authors,

❝By analyzing proteins and metabolites in intestinal tissue and conducting experiments to show how the intestine recovers after damage caused by 5-fluorouracil, we were able to determine that the reduced regenerative capacity of older intestinal cells is not an unavoidable effect of aging. Rather, it is directly related to a disruption in proteostasis.

Aging is not an irreversible process. If we understand how cells lose their balance—and how we can restore it—we may not be able to stop aging, but we can significantly mitigate its effects on our bodies.❞

You can read the paper in full, here: Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis

And if you’re wondering how to get more polyamines in your diet, then here you go:

Top 12 Food Sources Of Each Of The Most Important Polyamines

And if you’d rather go for a supplement-based approach then check out:

The Orchid That Renovates Your Gut (Gently) ← along with where to get it!

Want to learn more?

For a much more detailed overview of healing your gut, you might like this book that we reviewed a little while back:

Heal Your Gut, Save Your Brain – by Dr. Partha Nandi

Enjoy!

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  • How Much Does Caffeine Affect Sleep, Really?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We have written before about the health benefits (and risks) of coffee; for most people, the benefits far outweigh the risks, but individual cases may vary:

    The Bitter Truth About Coffee (or is it?) ← this is a mythbusting edition

    Speaking of bitterness; coffee has abundant polyphenols, which means an abundance of benefits that we discuss in the links above and below this line 😉

    See also: Why Bitter Is Better: Enjoy Bitter Foods For Your Heart & Brain ← while it says foods in the title, this does cover coffee too.

    For mythbusting on caffeine specifically, enjoy: Caffeine: Cognitive Enhancer Or Brain-Wrecker?

    There are also gut health benefits from drinking coffee, and what’s good for our gut is invariably good for our heart and brain:

    Coffee & Your Gut ← gut bacteria do not, by the way, have a preference about how you make your coffee or whether it is caffeinated or not

    Aaaaaand, we recently shared new research on how coffee appears to be protective against frailty in older age. We say “appears to be”, because it was a longitudinal study and so technically we cannot say categorically that the link was causal, but the association is very strong, to the point that it’d take quite some explaining if it’s anything other than the coffee consumption that caused it.

    You can read about that here: Coffee vs Frailty!

    But what about sleep?

    Common sense has of course long served to tell us: taking a stimulant before bed can disrupt your sleep. Shocking, breaking news!

    Except, even we at 10almonds have never actually examined the science for this. After all, it seems so obvious; it’s like how one does not need a peer-reviewed study to conclude that water is wet.

    However…

    A study was conducted, and found that, upon investigating, caffeine indeed disrupts sleep, by an average of two hours per night!

    Except…

    That study, from 1974, had 6 participants (in fact the abstract says “subjects”, but that is how scientists referred to people in the 70s), and the methodology went:

    ❝…comparison being made with decaffeinated coffee and with no drink prior to sleep, using each condition five times in a balanced order on non-consecutive nights.

    After caffeine the mean total sleep time decreased on average by 2 h, the mean sleep latency increased to 66 minutes. The number of awakenings increased and the mean total intervening wakefulness was more than doubled after caffeine.❞

    Read in full: Effect of caffeine on sleep

    Did you spot the problem? Aside from “n=6 is not a relevant sample size”… The methodology of using each condition five times in a balanced order on non-consecutive nights means that not only did they completely break from placebo (there is no mention of whether they even tried to blind or double-blind this) but also, think about this:

    • It’s your first night at a sleep clinic. You take caffeine before bed, and you don’t sleep well; perhaps because of the caffeine or the strange environment.
    • It’s the next night at a sleep clinic. Last night you slept 2 hours less than normal, so you absolutely crash out this time, and sleep extra to compensate.
    • It’s the third night at a sleep clinic. Having overslept the previous morning, you’re not too tired tonight, and so you don’t sleep as much.
    • The study only lasts 10 days so this pattern doesn’t get a long time to diminish.

    See also: What’s Really Keeping You Awake? The Brain’s Role in Sleepless Nights

    A more recent study was almost equally tiny (n=10) because it was just a pilot study, but used a better methodology with a double-blind control group design. For the first 7 days, all participants consumed caffeinated coffee. In the following 7 days, subjects consumed caffeinated or decaffeinated coffee according to their assigned group. This study found:

    ❝There were no significant differences (p > 0.05) among the data of the two groups identified. No significant changes (p > 0.05) were found in the sleep quality of either group during the study.

    This study confirms that caffeine abstinence in the evening might not be helpful in sleep promotion. It highlights the need to implement evidence-based practice in health promotion.❞

    Read in full: The effects of caffeine abstinence on sleep: A pilot study

    What caffeine actually does, in the context of sleep

    Now we’ll get into some meatier science, by which we mean that the same size is enough (n=40) to give us real statistical significance, and also it compared the effects on younger adults (20–27 years) and middle-aged adults (41–58 years), and monitored their brains with electroencephalography (EEG) during REM sleep and non-REM sleep.

    They found:

    • Caffeine reduced alpha and theta waves, linked to deep sleep.
    • Caffeine increased beta waves, associated with wakefulness* and mental activity.

    *Note: it increased these beta waves during sleep. It did not affect sleep quantity, it merely changed its quality. And, not necessarily badly, because that’s needed too (such as for memory consolidation and other mental faculties), but meaningfully.

    They also found that these effects were more pronounced in young adults (ages 20–27) than in middle-aged participants (41–58).

    You can read the paper in full here: Caffeine induces age-dependent increases in brain complexity and criticality during sleep

    And you can learn about brain waves during sleep, here: Alpha, beta, theta: what are brain states and brain waves? And can we control them?

    And for getting into hacking some of these: Non-Sleep Deep Rest: A Neurobiologist’s Take ← How to get many benefits of sleep stages, while awake!

    We’re running out of space today, but before we go, we’ll mention this larger (n=99) longer (12 months) study into matcha green tea instead. Of those 99 participants, the study included 64 with subjective cognitive decline and 35 with mild cognitive impairment; these were randomized, with 49 receiving 2 g of matcha and 50 receiving a placebo daily, and to quote from the conclusions in the paper:

    Despite the presence of caffeine, which disrupts sleep, matcha demonstrated a sleep-enhancing effect. This beneficial effect is attributed to theanine, a constituent of matcha.

    The present study suggests regular consumption of matcha could improve emotional perception and sleep quality in older adults with mild cognitive decline❞

    Read in full: Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months

    Don’t love coffee?

    Two excellent alternatives are green tea (and/or green tea extract), and green coffee extract. You can read about them both here:

    Enjoy!

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  • Younger For Life – by Dr. Anthony Youn

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve reviewed anti-aging books before, so what makes this one different? Mostly, it’s the very practical focus.

    Which is not to say there’s not also good science in here; there is. But the focus is on what everything means for the reader, not what happened with a certain cohort of lab mice. Instead, he looks at the causes of aging, the process of aging, and what interventions to implement to address those, and reverse many of them.

    Some parts are more general lifestyle interventions that 10almonds readers will know well already, but other parts are very specific advices, protocols, and regimes; in particular his skincare section is well worth reading. As for nutrition, there’s even a respectable recipes section, so this book does have it all!

    The final section of the book is dedicated to plastic surgeries (the author is a plastic surgeon who believes that most people should not need those, and would do well to stick to the advices in the rest of the book). We suspect this last part of the book will be of least interest to 10almonds readers.

    Bottom line: if you’re of the view that getting older should come with as little as possible physical deterioration along the way, then this book can help a lot with that.

    Click here to check out Younger For Life, and feel great!

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  • What Is “75 Hard”?

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    This is Andy Frisella. He’s not a doctor, scientist, nutritionist, personal trainer, or professional athlete, but he has kicked off a viral fitness challenge, so let’s take a look at it:

    What it is

    Firstly, Frisella asserts that it’s not a fitness challenge, but rather, he describes it as a “transformative mental toughness program”.

    Here’s what it consists of:

    • Follow a healthy diet plan with no deviations from it (i.e. no “cheat days”)
    • Abstain from alcohol
    • Exercise 2x per day, 45 minutes each
    • One of the exercise sessions each day must be outside
    • No rest days
    • Drink 3.5 liters of water per day

    And the duration? 75 days, hence the name of the fitness challenge transformative mental toughness program.

    Why it is

    Frisella’s rationale is:

    • we must cultivate mental toughness by doing hard things
    • allowing ourselves any deviation would be a sign of mental weakness
    • if we allow ourselves to deviate, it becomes a habit

    For this reason, he does not “allow” any substitutions, for example if somebody wants to do such-and-such a thing slightly differently instead. We put “allow” in quotation marks because of course, he’s not the boss of you, but per the rules of his challenge, at least.

    These reasonings are in and of themselves somewhat sound, however, we at 10almonds would argue:

    • before doing hard things, it is good to first consider “is it a good idea?” (amputating your leg using only a spork is a “hard thing”, and demonstrates incredible mental toughness, but that doesn’t make it a good idea)
    • while being able to decide to do a thing and then do it is great characteristic to have, it’s good to first consider science; for example, restrictive diets with no flexibility simply do not work, and our bodies do require adequate rest, especially if being pushed through hard things, or problems will happen (injuries, illnesses, etc).
    • while it’s true that allowing ourselves to deviate can become a habit, it’s good to first consider what habits we want to make, and make those habits, instead of potentially unsustainable or even simply unpleasant ones.

    See also: What Flexible Dieting Really Means: When Flexibility Is The Dish Of The Day

    And for that matter: How To Really Pick Up (And Keep!) Those Habits

    Want a “75 Gentle” instead?

    If you like the idea of making new habits, but are not sure if extreme (and perhaps arbitrary) standards are the ones you want to hold, check out:

    Cori Lefkowith’s 25 Healthy Habits That Will Change Your Life

    Take care!

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  • Women’s Strength Training Anatomy Workouts – by Frédéric Delavier

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve previously reviewed another book of Delavier’s, “Women’s Strength Training Anatomy“, which itself is great. This book adds a lot of practical advice to that one’s more informational format, but to gain full benefit of this one does not require having read that one.

    A common reason that many women avoid strength-training is because they do not want to look muscular. Largely this is based on a faulty assumption, since you will never look like a bodybuilder unless you also eat like a bodybuilder, for example.

    However, for those for whom the concern remains, today’s book is an excellent guide to strength-training with aesthetics in mind as well as functionality.

    The exercises are divided into sections, thus: round your glutes / tone your quadriceps / shape your hamstrings / trim your calves / flatten your abs / curve your shoulders / develop a pain-free upper back / protect your lower back / enhance your chest / firm up your arms.

    As you can see, a lot of these are mindful of aesthetics, but there’s nothing here that’s antithetical to function, and some (especially for example “develop a pain-free upper back” and “protect your lower back“) are very functional indeed.

    Bottom line: Delavier’s anatomy and exercise books are top-tier, and this one is no exception. If you are a woman and would like to strength-train (or perhaps you already do, and would like to refine your training), then this book is an excellent choice.

    Click here to check out Women’s Strength Training Anatomy Workouts, and have the body you want!

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  • Do kids really need vitamin supplements?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Walk down the health aisle of any supermarket and you’ll see shelves lined with brightly packaged vitamin and mineral supplements designed for children.

    These products promise to support immunity, boost brain development and promote healthy growth – leading many parents to believe they’re a necessary addition to their child’s diet.

    For parents of fussy eaters in particular, supplements may feel like a quick and reassuring solution. But are they actually needed?

    Anastassiya Bezhekeneva/Getty Images

    The nutrients children really need

    It’s true that children require a broad range of vitamins and minerals – such as vitamins A, B, C, D, E, and K, along with folate, calcium, iodine, iron and zinc – for healthy development. These nutrients play essential roles in brain and nerve development, vision, bone strength, immune function, metabolism and maintaining a healthy weight.

    However, for most healthy children, these nutrients can and should come from food – not from supplements.

    Even children with selective eating habits typically receive adequate nutrition from everyday foods, many of which are fortified. Common staples such as breakfast cereals, milk and bread are often enriched with key nutrients such as B vitamins, iron, calcium and iodine.

    What the science says about supplements

    Although many children’s supplements claim to support immunity, growth, or overall wellbeing, there is little robust scientific evidence that they improve health outcomes or prevent illness in otherwise healthy children.

    Leading health bodies advise that children who consume a varied diet do not need additional supplementation.

    Research consistently shows that getting vitamins and minerals through whole foods is superior to taking them in supplement form. Foods provide these nutrients along with fibre, enzymes, and bioactive compounds, such as phytochemicals and healthy fats, which enhance absorption, metabolism and overall efficacy in ways isolated supplements cannot replicate.

    Potential risks and unintended consequences

    Parents should also be aware that supplements are not risk-free.

    Fat-soluble vitamins – such as A, D, E and K – can accumulate in the body if consumed in excess. If they reach toxic levels, they can cause cause health issues. In the case of A and B vitamins, these issues can be severe and even cause death.

    High doses of other water-soluble vitamins, such as vitamin C, may not be dangerous, but can cause side effects like diarrhoea or interfere with the absorption of other nutrients.

    Many children’s supplements are flavoured or sweetened to make them more appealing. While this might make them easier to administer, it also introduces added sugars and artificial ingredients into children’s diets – potentially undermining healthy eating habits.

    There is also a psychological dimension to consider. Routinely giving children supplements in response to normal eating behaviours, such as fussiness or selective food preferences, may inadvertently teach them that pills are a substitute for a nutritious diet, rather than a temporary aid.

    So, what should parents do?

    The most reliable way to provide children with essential vitamins and minerals is through a varied and balanced diet. This means including dairy, meat, poultry, fish, wholegrains, nuts, seeds, legumes, and a colourful array of fruits and vegetables.

    If you’re regularly negotiating with a pint-sized dictator over a single pea, rest assured you’re far from alone. Research shows nearly half of children go through a phase of picky eating – a behaviour rooted in our evolutionary past.

    Early humans developed an aversion to unfamiliar or bitter foods as a survival mechanism to avoid potential toxins. At the same time, they learned to seek out and store energy-rich, palatable foods to survive periods of scarcity.

    So, how can parents gently encourage toddlers to embrace healthier, more colourful food options?

    • Mix things up. Blend less nutritious beige or white foods with healthier ingredients. For example, add cannellini beans and cauliflower into mashed potatoes to boost nutrient content without sacrificing familiarity.
    • Make healthy swaps. Gradually replace white bread, pasta and rice with wholegrain versions. Start by mixing brown rice into a serving of white rice to ease the transition.
    • Use familiarity to your advantage. Pair new, colourful foods with familiar favourites. Offer fruit dipped in yoghurt or add a vibrant red or green sauce to pasta, making new flavours less intimidating.

    By taking these small, strategic steps, parents can support their child’s nutrition and help them develop a positive relationship with food – no matter how selective their tastes may be.

    That said, there are cases where supplementation may be appropriate – such as children with diagnosed nutritional deficiencies, specific medical conditions, or highly restricted diets.

    In these instances, parents should seek advice from a qualified health professional, such as a GP or paediatric dietitian. Warning signs may include symptoms such as persistent constipation or signs of impaired growth.

    But for most children, vitamin supplements aren’t necessary – they may be doing more harm than good.

    Nick Fuller is the author of Healthy Parents, Healthy Kids – Six Steps to Total Family Wellness. His free, practical recipe ideas for a nutritious, varied diet can be found at feedingfussykids.com.

    Nick Fuller, Clinical Trials Director, Department of Endocrinology, RPA Hospital, University of Sydney

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Does my sunscreen actually work? Here’s what’s behind the latest SPF concerns

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s been a tough time for sunscreens recently. Earlier this year, testing on behalf of consumer organisation Choice found several sunscreens were not delivering the sun protection you’d expect. One product claimed a sun protection factor (SPF) of 50+, but when tested had an SPF as low as 4.

    This triggered a series of events. Some sunscreen manufacturers paused or recalled their products. Other recalls have followed.

    Media investigations have alleged issues related to how sunscreens are tested and formulated.

    This week, the Therapeutic Goods Administration (TGA) said several sunscreens share a “base formula” made by a single manufacturer. It said preliminary testing had shown some sunscreens made with this base formula may be as low as SPF 4.

    It’s no wonder consumers are confused about whether their sunscreens actually work.

    Here’s what we know about this week’s TGA announcement and what could be behind it.

    Catherine Falls Commercial/Getty

    Why the concern about sunscreen SPF?

    Since SPFs were introduced, they have been a clear sign for consumers about how much sun protection to expect.

    But testing a product’s SPF is tricky. The usual test uses sunscreen on real people’s skin, exposes them to ultraviolet (UV) light, and checks how much redness develops over time.

    Because people’s skin reacts differently, and because labs and testers vary, results can be inconsistent. For instance, products tested at one lab might show a high SPF, but might really offer much less protection when tested by another.

    A sunscreen with a lower-than-claimed SPF may still offer some protection. But there would be a higher chance of sunburn, DNA damage and developing skin cancer.

    What’s a base formula?

    The TGA’s latest concerns relate to a “base formula” shared by several sunscreens. The base formula (also called the core or vehicle) is like the foundation of a sunscreen and includes:

    • solvents/carrier liquids (water, oils, silicones)
    • emulsifiers, surfactants, stabilisers (all of which allow components to blend and not separate)
    • thickeners or gels
    • preservatives, antioxidants
    • pigments, tints, fragrances, texture enhancers.

    Other ingredients are added to the base, especially UV filters. The base can also be sold to third parties with the UV filters already added. Some products include extras, such as photostabilisers to help the UV filters last longer in the sun.

    The base must do several jobs well. It must:

    • spread UV filters evenly (no clumps or separation)
    • remain stable over time
    • protect the UV filters from breaking down in the sun
    • still feel good on the skin (spread easily, stick well).

    Many brands use the same base and then add small differences, for instance colour or scent.

    While UV filters are crucial, they cannot do their job well without a strong and well-designed base layer. So any product built on a weak or faulty base formula risks underperforming. And because many sunscreens share the same base, many products and brands can be affected.

    The TGA has identified at least 21 products that use the same base formula.

    How might a base formula fail?

    We don’t know why the TGA is concerned about this specific base formula. But generally speaking, a base formula might fail for several reasons, including:

    • poor dispersion or aggregation: UV filters can clump or settle, leaving unprotected spots
    • photodegradation: without good stabilisers, filters break down in sunlight
    • chemical incompatibility: additives, pigments, or fragrances may interact badly with UV filters
    • dilution by inert ingredients: too much filler reduces the effective concentration of active UV filters
    • physical instability: over time, the formula might separate, change viscosity, or crystallise
    • manufacturing or packaging stress: insufficient mixing, exposure to heat or light during production, or poor packaging can degrade the base.

    However, not every product with that base will necessarily fail. Performance of the sunscreen and subsequent protection may differ depending on ingredient tweaks, care taken during manufacture, from batch to batch, and how it’s stored.

    How do I check if my sunscreen’s affected?

    The TGA provides information about affected brands and products on its website, as does Choice.

    Individually affected brands may publish recall notices, refund offers and batch details.

    You can also contact the company with your batch number and ask if yours is affected.

    What if my brand’s affected?

    If your sunscreen is affected:

    • don’t rely on it for sun protection, especially for long exposure
    • return it to where you bought it for a refund or replacement. Some brands are offering refunds or vouchers
    • watch for further TGA updates, as more products may be added to recall lists as investigations continue
    • talk to a health professional if you’re worried about skin damage or past sun exposure.

    What’s the take-home message?

    These recent issues do not mean all sunscreens are unreliable. But they do highlight how important sunscreen design, formulation and regulatory checks are. The TGA’s investigations may even lead to stronger testing, better formulation standards, and clearer consumer guidance.

    However, until we have the full picture of all brands affected, it might be wise to pick trusted brands – ones that publish test results, have transparent practices and have good reputations.

    Finally, sunscreen is just one component of sun safety. Layer your defences. Also wear protective clothing, hats and sunnies, seek shade, and stay out of the sun for prolonged periods if you can.

    Mike Climstein, Associate Professor, Faculty of Health, Southern Cross University; Michael Stapelberg, Adjunct Associate Professor, Faculty of Health, Southern Cross University, and Nedeljka Rosic, Senior Lecturer, Faculty of Health, Southern Cross University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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