Will there soon be a cure for HIV?

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Human immunodeficiency virus, or HIV, is a chronic health condition that can be fatal without treatment. People with HIV can live healthy lives by taking antiretroviral therapy (ART), but this medication must be taken daily in order to work, and treatment can be costly. Fortunately, researchers believe a cure is possible.

 In July, a seventh person was reportedly cured of HIV following a 2015 stem cell transplant for acute myeloid leukemia. The patient stopped taking ART in 2018 and has remained in remission from HIV.

Read on to learn more about HIV, the promise of stem cell transplants, and what other potential cures are on the horizon.

What is HIV?

HIV infects and destroys the immune system’s cells, making people more susceptible to infections. If left untreated, HIV will severely impair the immune system and progress to acquired immunodeficiency syndrome (AIDS). People living with untreated AIDS typically die within three years.

People with HIV can take ART to help their immune systems recover and to reduce their viral load to an undetectable level, which slows the progression of the disease and prevents them passing the virus to others.

How can stem cell transplants cure HIV?

Several people have been cured of HIV after receiving stem cell transplants to treat leukemia or lymphoma. Stem cells are produced by the spongy tissue located in the center of some bones, and they can turn into new blood cells.

A mutation on the CCR5 gene prevents HIV from infecting new cells and creates resistance to the virus, which is why some HIV-positive people have received stem cells from donors carrying this mutation. (One person was reportedly cured of HIV after receiving stem cells without the CCR5 mutation, but further research is needed to understand how this occurred.)

Despite this promising news, experts warn that stem cell transplants can be fatal, so it’s unlikely this treatment will be available to treat people with HIV unless a stem cell transplant is needed to treat cancer. People with HIV are at an increased risk for blood cancers, such as Hodgkin lymphoma and non-Hodgkin lymphoma, which stem cell transplants can treat.

Additionally, finding compatible donors with the CCR5 mutation who share genetic heritage with patients of color can be challenging, as donors with the mutation are typically white.

What are other potential cures for HIV?

In some rare cases, people who started ART shortly after infection and later stopped treatment have maintained undetectable levels of HIV in their bodies. There have also been some people whose bodies have been able to maintain low viral loads without any ART at all.

Researchers are studying these cases in their search for a cure.

Other treatment options researchers are exploring include:

  • Gene therapy: In addition to stem cell transplants, gene therapy for HIV involves removing genes from HIV particles in patients’ bodies to prevent the virus from infecting other cells.
  • Immunotherapy: This treatment is typically used in cancer patients to teach their immune systems how to fight off cancer. Research has shown that giving some HIV patients antibodies that target the virus helps them reach undetectable levels of HIV without ART.
  • mRNA technology: mRNA, a type of genetic material that helps produce proteins, has been used in vaccines to teach cells how to fight off viruses. Researchers are seeking a way to send mRNA to immune system cells that contain HIV.

When will there be a cure for HIV?

The United Nations and several countries have pledged to end HIV and AIDS by 2030, and a 2023 UNAIDS report affirmed that reaching this goal is possible. However, strategies to meet this goal include HIV prevention and improving access to existing treatment alongside the search for a cure, so we still don’t know when a cure might be available.

How can I find out if I have HIV?

You can get tested for HIV from your primary care provider or at your local health center. You can also purchase an at-home HIV test from a drugstore or online. If your at-home test result is positive, follow up with your health care provider to confirm the diagnosis and get treatment.

For more information, talk to your health care provider.

This article first appeared on Public Good News and is republished here under a Creative Commons license.

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  • How Walking Affects Your Body
    …and do you really need to take 10,000 steps per day? A step in the right direction There are many benefits of walking, including: As for that about 10,00 steps? Although 10,000 steps per day is a popular target*, research shows that for most people, health benefits occur with any increase in daily steps, and…

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  • Strong Woman Era – by Saffron Hooton

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The premise here is to embrace strength without compromising femininity, and as such, the author gives a simple guide to strength training, along with assorted energizing pep-talks along the way.

    It’s a short read, about 150 pages if we count only the book content itself, and that’s with large print, easy-reading line spacing, generous margins, and a lot of artwork.

    On which note, the artwork really is that: artwork; even for the exercises, it’s not actually particularly informational, and adds only a very general idea of what one point in the exercise might look like. Which is unfortunate, because the explanations can also be a little unclear in places.

    The style is upbeat and motivational with a sort of 90s girl-power feel to it. There’s no hard science, claims are made without sources (reasonable claims, but still, we’d rather have seen sources), and certainly nothing is complicated. In fact, some parts could probably have stood to be a bit more complicated—in other words, some things were perhaps oversimplified a little where a more comprehensive treatment might have been helpful.

    Bottom line: this is a very aesthetically pleasing book; it’ll look great on your shelf and can be quite nice to flip through. At 8oz, it can be used as a paperweight, but not a doorstop.

    Click here to check out Strong Woman Era, and brighten up your bookshelf!

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  • Sciatica Flares “Out of Nowhere”? Here’s What’s Really Triggering It

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Amy Konvalin explains what’s really going on:

    The tipping point

    Sciatica is irritation* of the sciatic nerve formed from the L4–S2 nerve roots, and it runs from your lower back through (on each side) your buttock and down your leg, sometimes reaching your foot.

    *Yes, this may seem like a very mild word for it, given how it feels when experiencing it, but physiologically, that’s what’s happening.

    A flare-up usually starts with a mechanical irritation that triggers your nervous system into a fight or flight response, causing your muscles and tissues to tighten and increase pressure on the nerve (with overcompensation often being something that causes further harm and pain).

    There are usually some early warning signs: most people have subtle signs beforehand, like reduced range of motion, increasing muscle tension, stiffness, or mild nerve symptoms. Additionally, your body may signal issues through tight hips, poor lower back movement, weak abdominal activation, shallow breathing, pelvic tension, or just general stiffness.

    However, flare-ups often seem sudden because a small movement (like bending or reaching) becomes the tipping point after underlying tension and dysfunction have already been built up.

    One thing that a lot of people don’t know is some less obvious triggers, including:

    • Stress sensitizes your nervous system, increases muscular tension, and makes your body more reactive, so even simple movements can trigger a flare-up.
    • Insufficient sleep reduces your body’s ability to recover and handle physical and emotional stress, increasing your risk of irritation and flare-ups.
    • Long periods of sitting reduce movement, create tissue stiffness, and alter your biomechanics, which can compress or irritate the sciatic nerve too.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Sciatica Exercises & Home Treatment – by Dr. George Best

    Take care!

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  • Why 10,000 Steps Might Be Making Your Pain Worse (+ What To Do Instead)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Walking can be pleasant, but (unless you’re walking on rough terrain) in biomechanical terms it’s very repetitive, and doesn’t challenge muscles enough to build strength or improve balance.

    So, wear and tear can occur, but development won’t happen much after a certain very base level.

    Dr. Alyssa Kuhn, arthritis expert, explains how to fix that:

    Different Movements

    If you sometimes find yourself struggling with stairs, low chairs, or daily movement, that usually means your muscles lack the correct strength. As with any kind of strength training, your muscles need to be challenged with increasing resistance, not just the same repetitive movement, or else they will have no reason to get stronger.

    Dr. Kuhn recommends these exercises in particular:

    • Chair stands: sit at the edge of a chair, stand up, and sit back down to work your thighs, glutes, hamstrings, feet, and ankles. To make it easier, raise the seat height or use the chair arms for support. Alternatively to make it harder, hold a weight to your chest. Goal: 8–12 reps, 2–3 sets; optional 30-second test for number of stands.
    • Step-back with knee march: step one leg backwards, then bring your knee up to your chest before repeating to build your hips, glutes, core, and balance. To make it easier, shorten your step and knee lift, and hold a chair for support. To make it harder, take a bigger step, make a faster knee drive, and step up onto a stool. Goal: 10–12 reps per side, 2–3 sets.
    • Balance with weight pass: stand on one leg (or use your back toes as a sort kickstand for balance purposes, without putting much weight there) and pass a weight or object hand-to-hand. To make it harder, use a heavier weight and hold it further from your body. Goal: 20–30 passes or 30–60 seconds per side, 2–3 sets.

    For more on all of this plus visual demonstrations, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    How To Make Downhill Walking Easier On The Knees

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  • Elderhood – by Dr. Louise Aronson

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Where does “middle age” end, and “old age” begin? By the United States’ CDC’s categorization, human life involves:

    • 17 stages of childhood, deemed 0–18
    • 5 stages of adulthood, deemed 18–60
    • 1 stage of elderhood, deemed 60+

    Isn’t there something missing here? Do we just fall off some sort of conveyor belt on our sixtieth birthdays, into one big bucket marked “old”?

    Yesterday you were 59 and enjoying your middle age; today you have, apparently, the same medical factors and care needs as a 114-year-old.

    Dr. Louise Aronson, a geriatrician, notes however that medical science tends to underestimate the differences found in more advanced old age, and underresearch them. That elders consume half of a country’s medicines, but are not required to be included in clinical trials. That side effects not only are often different than for younger adults, but also can cause symptoms that are then dismissed as “Oh she’s just old”.

    She explores, mostly through personal career anecdotes, the well-intentioned disregard that is frequently given by the medical profession, and—importantly—how we might overcome that, as individuals and as a society.

    Bottom line: if you are over the age of 60, love someone over the age of 60, this is a book for you. Similarly if you and/or they plan to live past the age of 60, this is also a book for you.

    Click here to check out Elderhood, and empower yours!

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  • How many vegetables influence brain waves and control brain states?

    Is it OK if my child eats lots of fruit but no vegetables?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Does it seem like most vegetables you serve your children end up left on the plate, or worse, strewn across the floor? But mention dessert, and your fruit skewers are polished off in an instant.

    Or maybe the carrot and cucumber sticks keep coming home in your child’s lunchbox untouched, yet the orange slices are nowhere to be seen.

    If you’re facing these struggles with your child, you’re not alone. Many children prefer fruit to vegetables.

    So if your child eats lots of fruit but minimal or no vegetables, is that OK? And how can you get them to eat more veggies?

    Children have an innate preference for fruit

    The Australian Dietary Guidelines’ recommended daily intakes for vegetables and fruit depend on a child’s age.

    A chart showing the serving amounts of fruit and veg for ages 4-18.
    Fruit and vegetable serving sizes by age. The Conversation.
    National Health and Medical Research Council, CC BY-SA

    Consumption among Australian children falls well below recommendations. Around 62.6% of children aged over two meet the recommended daily fruit intake, but only 9% meet the recommended vegetable intake.

    This is not surprising given children have a natural preference for fruit. At least in part, this is due to its sweetness and texture, whether crispy, crunchy or juicy. The texture of fruit has been linked to a positive sensory experience among children.

    Vegetables, on the other hand, are more of an acquired taste, and certain types, such as cruciferous vegetables, can be perceived by children as bitter.

    The reason children often prefer fruit over vegetables could also be related to the parents’ preferences. Some research has even suggested we develop food preferences before birth based on what our mother consumes during pregnancy.

    Balance is key

    So, a preference for fruit is common. But is it OK if your child eats lots of fruit but little to no vegetables? This is a question we, as dietitians, get asked regularly.

    You might be thinking, at least my child is eating fruit. They could be eating no veggies and no fruit. This is true. But while it’s great your child loves fruit, vegetables are just as important as part of a balanced eating pattern.

    Vegetables provide us with energy, essential vitamins and minerals, as well as water and fibre, which help keep our bowels regular. They also support a strong immune system.

    If your child is only eating fruit, they are missing some essential nutrients. But the same is true if they are eating only veggies.

    Fruit likewise provides the body with a variety of essential vitamins and minerals, as well as phytochemicals, which can help reduce inflammation.

    Evidence shows healthy consumption of fruit and vegetables protects against chronic diseases including high blood pressure, heart disease and stroke.

    Consumed together, fruit and vegetables in a variety of colours provide different nutrients we need, some of which we can’t get from other foods. We should encourage kids to eat a “rainbow” of fruit and vegetables each day to support their growth and development.

    What if my child eats too much fruit?

    If your child is eating slightly more fruit than what’s recommended each day, it’s not usually a problem.

    Fruit contains natural sugar which is good for you. But too much of a good thing, even if it’s natural, can create problems. Fruit also contains virtually no fat and very little to no protein, both essential for a growing child.

    When overindulging in fruit starts to displace other food groups such as vegetables, dairy products and meat, that’s when things can get tricky.

    6 tips to get your kids to love vegetables

    1. Get them involved

    Take your child with you when you go shopping. Let them choose new vegetables. See if you can find vegetables even you haven’t tried, so you’re both having a new experience. Then ask them to help you with preparing or cooking the vegetables using a recipe you have chosen together. This will expose your child to veggies in a positive way and encourage them to eat more.

    2. Sensory learning

    Try to expose your child to vegetables rather than hiding them. Kids are more likely to eat veggies when they see, smell and feel them. This is called sensory learning.

    3. Have fun with food

    Use colourful vegetables of different sizes and textures. Make them fun by creating scenes or faces on your child’s plate. Add edible flowers or mint for decoration. You can even serve this with a side of veggie-based dip such as hummus or guacamole for some bonus healthy fats.

    4. Teach them to grow their own

    Teach your child how to grow their own vegetables. Evidence shows kids are more inclined to try the food they have helped and watched grow. You don’t need to have a big backyard to do this. A windowsill with a pot plant is a perfect start.

    5. Lead by example

    Your child learns from you, and your eating habits will influence theirs. Ensure they see you eating and enjoying veggies, whether in meals or as snacks.

    6. Practise persistence

    If your child refuses a particular vegetable once, don’t give up. It can take many attempts to encourage children to try a new food.The Conversation

    Yasmine Probst, Associate Professor, School of Medical, Indigenous and Health Sciences, University of Wollongong; Olivia Wills, Accredited Practising Dietitian, PhD candidate, University of Wollongong, and Shoroog Allogmanny, Accredited Practising Dietitian, PhD candidate, University of Wollongong

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • How (& Why) To Pistol Squat, For Beginners

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Pistol squats involve a lot of balance, strength, and flexibility, making them ideal for building and maintaining those things. But, how to get started?

    One bit at a time

    Unless you find the whole thing easy already, it’s good to train the individual parts:

    • Deep, narrow squats: train deep narrow squats with good form; work up to adding 50% bodyweight.
    • Ankle mobility: start every workout with dynamic mobility; stretch and strengthen ankles 2x/week.
    • Hamstring flexibility: do dynamic and static stretches plus strengthen in a lengthened position.
    • Hip flexor strength: train nearly every workout using leg lifts, hanging raises, or dip bar lifts.
    • Balance: train with single-leg exercises like deep step-ups to build stability.

    With those well-trained and in good order, put it all together:

    • Stand on one leg, keep hips level, and lift the other leg without raising your hip.
    • Keep the squatting knee forward without letting it collapse inward/outward.
    • Maintain an upright torso, avoid leaning forward or relaxing at the bottom.
    • Push up with your quad from the bottom without bouncing.

    If that’s still tricky (and it probably will be at first, we mention it in this order just because it’s good to know what you’re working towards), here’s how she recommends working up to the final combination of everything together:

    • Start with box-supported pistol squats using a kickstand.
    • Gradually lower the box height; progress from bent leg to straight leg lifts.
    • Move to freestanding reps with balance assistance if needed.
    • Use negatives (lower slowly, push up with both legs) to train full range of motion.
    • Combine variations to complete full sets, prioritizing the hardest version you can manage.

    For more on all of this plus visual demonstrations, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    The Secret To Better Squats: Foot, Knee, & Ankle Mobility

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