The Other Alzheimer’s Risk Factor
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The usually-listed 7 known risk factors of dementia (in general, not just Alzheimer’s) do not include today’s item. For a recap, those were:
The 7 Known Risk Factors For Dementia
The bonus risk factor
This idea is not completely novel; it’s been known for a while that traumatic brain injury (TBI) can increase the risk of dementia, but it has generally been chalked up to “if you damage an organ, then that organ does not function so well afterwards”.
However, in the case of Alzheimer’s, it seems there’s something deeper at play. Specifically, a study that found…
❝…traumatic brain injury alters the small vessels in the brain, resulting in an accumulation of amyloid beta—a hallmark of Alzheimer’s disease.
The findings suggest that vascular dysfunction could be an early driver in neurodegenerative disorders rather than being caused by neuronal damage.❞
This association held true even in quite young patients!
The study from Sweden looked at brain tissue from TBI patients (who had had to have brain tissue removed for medical reasons due to bleeding and swelling), and found that the (traumatic) changes to the vascular smooth muscle cells were associated with increased aggregation of amyloid-β.
In terms of establishing cause and effect: since it could be safely concluded the amyloid-β had not caused the TBI (which all had external explanations such as “car crash” or such), it can be deduced that almost* certainly the TBI caused the amyloid-β aggregation.
*because little to nothing in science is every truly certain. As in life in general, really; the difference is that scientists admit it!
You may be wondering: what was the control? It would be a very generous group of citizens indeed who would volunteer bits of their brains that hadn’t needed removing. However, the answer is that the control brain bits came from a biobank, and were from uninjured patients with no history of TBI or neurodegenerative disorders, and who had died from systemic, unrelated causes. Having been dead for a matter of hours, and the fixation time for the brain bits from the living people taking long enough that everybody’s brain bits had been out of their respective living bodies for a similar length of time, this was deemed an acceptable, if imperfect, control.
You can read the study in its entirety here; it is fascinating:
The practical take-away
The practical take-away, of course, is: look after your brain
Not just in the sense of eat fiber, get healthy fats, move more, get good sleep, stay intellectually stimulated, etc*, but also in the sense of “keep your brain physically safe”.
Now, you may think that you already try not to get into car crashes, and perhaps you do not compete in contact sports, but do be aware that one of the leading causes of TBI in older people is, ignominiously, falling down.
And if you think “that only happens to older/other people”, then be aware: there’s a first time for everything and you are not immune. With that in mind, do check out:
Fall Special! ← the seasonal title notwithstanding, this is about not falling down in the first place, and being less injurable if you do fall down
*This was a modest and vague list for brevity’s sake, so for much more detail, enjoy:
How To Reduce Your Alzheimer’s Risk ← this is rather more comprehensive
Want to know more?
Here you can read about the largest study of its kind into lifestyle factors and Alzheimer’s disease:
Alzheimer’s Causative Factors To Avoid ← the methods and conclusions of Dr. David Snowdon’s famous “Nun Study”
Take care!
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Outlive – by Dr. Peter Attia
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We know, we know; this diet, that exercise, don’t smoke or drink, get decent sleep”—a lot of books don’t go beyond this level of advice!
What Dr. Attia offers is a multi-vector approach that covers the above and a lot more.
Themes of the book include:
- The above-mentioned things, of course
- Rethinking medicine for the age of chronic disease
- The pros and cons of…
- caloric restriction
- dietary restriction
- intermittent fasting
- Pre-emptive interventions for…
- specific common cause-of-death conditions
- specific common age-related degenerative conditions
- The oft-forgotten extra pillar of longevity: mental health
The last one in the list there is covered mostly in the last chapter of the book, but it’s there as a matter of importance, not as an afterthought. As Dr. Attia puts it, not only are you less likely to take care of your physical health if you are (for example) depressed, but also… “Longevity is meaningless if your life sucks!”
So, it’s important to do things that promote and maintain good physical and mental health.
Bottom line: if you’re interested in happy, healthy, longevity, this is a book for you.
Click here to check out Dr. Attia’s “Outlive” on Amazon today!
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Pomegranate vs Strawberry – Which is Healthier?
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Our Verdict
When comparing pomegranate to strawberries, we picked the pomegranate.
Why?
Both are good, but…
In terms of macros, pomegranate has more fiber, carbs, and protein, making it the winner in this category.
In the category of vitamins, pomegranate has more of vitamins B1, B2, B5, B6, B7, B9, E, and K, while strawberries have more of vitamins A, B3, and C, giving pomegranates an 8:3 victory here.
Looking at minerals, pomegranate has more copper, phosphorus, potassium, selenium, and zinc, while strawberries have more calcium, iron, and manganese, meaning pomegranates lead 5:3 in this round.
In other considerations, both have plenty of polyphenols, though pomegranate peel specifically has some extra beneficial properties (since the peel is quite tough as-is, it can be steeped for tea, or else dried and ground to a powder for use as a supplement), making this round either a tie or a win for pomegranates, depending on whether or not we count the peel-only benefits.
Either way, adding up the sections makes for a clear overall win for pomegranates, but by all means enjoy either or both, as diversity is good!
Want to learn more?
You might like:
Pomegranate’s Health Gifts Are Mostly In Its Peel
Enjoy!
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Breast cancer screening is ripe for change. We need to assess a woman’s risk – not just her age
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Australia’s BreastScreen program offers women regular mammograms (breast X-rays) based on their age. And this screening for breast cancer saves lives.
But much has changed since the program was introduced in the early 90s. Technology has developed, as has our knowledge of which groups of women might be at higher risk of breast cancer. So how we screen women for breast cancer needs to adapt.
In a recent paper, we’ve proposed a fundamental shift away from an age-based approach to a screening program that takes into account women’s risk of breast cancer.
We argue we could save more lives if screening tests and schedules were personalised based on someone’s risk.
We don’t yet know exactly how this might work in practice. We need to consult with all parties involved, including health professionals, government and women, and we need to begin Australian trials.
But here’s why we need to rethink how we screen for breast cancer in Australia.
Pablo Heimplatz/Unsplash Why does breast screening need to change?
Australia’s BreastScreen program was introduced in 1991 and offers women regular mammograms based on their age. Women aged 50–74 are targeted, but screening is available from the age of 40.
The program is key to Australia’s efforts to reduce the burden of breast cancer, providing more than a million screens each year.
Women who attend BreastScreen reduce their risk of dying from breast cancer by 49% on average.
Breast screening saves lives because it makes a big difference to find breast cancers early, before they spread to other parts of the body.
Despite this, around 75,000 Australian women are expected to die from breast cancer over the next 20 years if we continue with current approaches to breast cancer screening and management.
Who’s at high risk, and how best to target them?
International evidence confirms it is possible to identify groups of women at higher risk of breast cancer. These include:
- women with denser breasts (where there’s more glandular and fibrous tissue than fatty tissue in the breasts) are more likely to develop breast cancer, and their cancers are harder to find on standard mammograms
- women whose mother, sisters, grandmother or aunts have had breast or ovarian cancer, especially if there are multiple relatives and the cancers occurred at young ages
- women who have been found to carry genetic mutations that lead to a higher risk of breast cancer (including women with multiple moderate risk mutations, as indicated by what’s known as a polygenic risk score).
For some higher-risk women, could MRI be an option? VesnaArt/Shutterstock Women in these and other high-risk groups might warrant a different form of screening. This could include screening from a younger age, screening more frequently, and offering more sensitive tests such as digital breast tomosynthesis (a 3D version of mammography), MRI or contrast-enhanced mammography (a type of mammography that uses a dye to highlight cancerous lesions).
But we don’t yet know:
- how to best identify women at higher risk
- which screening tests should be offered, how often and to whom
- how to staff and run a risk-based screening program
- how to deliver this in a cost-effective and equitable way.
The road ahead
This is what we have been working on, for Cancer Council Australia, as part of the ROSA Breast project.
This federally funded project has estimated and compared the expected outcomes and costs for a range of screening scenarios.
For each scenario we estimated the benefits (saving lives or less intense treatment) and harms (overdiagnosis and rates of investigations in women recalled for further investigation after a screening test who are found to not have breast cancer).
Of 160 potential screening scenarios we modelled, we shortlisted 19 which produced the best outcomes for women and were the most cost effective. The shortlisted scenarios tended to involve either targeted screening technologies for higher-risk women or screening technologies other than mammography for all screened women.
For example, in our estimates, making no change to the target age range or screening intervals but offering a more sensitive screening test to the 20% of women deemed to be at highest risk would save 113 lives over ten years.
Alternatively, commencing targeted screening from age 40 and offering a more sensitive screening test annually to the 20% of women at highest risk, and three-yearly screening (of the current kind) to the 30% of women at lowest risk, would save 849 lives over ten years.
However, less frequent screening of the lower risk group was expected to lead to small increases in breast cancer deaths in that group.
How do we best assess women for their risk of breast cancer? At this stage, there’s no one answer. Tint Media/Shutterstock We also outlined 25 recommendations to put into action, and set out a five-year roadmap of how to get there. This includes:
- a large scale trial to find out what is feasible, effective and affordable in Australia
- making sure women at higher risk in different parts of Australia are offered suitable options regardless of where they live and who they see
- better data collection and reporting to support risk-based screening
- testing how we assess women for their risk of breast cancer, including whether these assessments work as intended and make sense to women from a range of backgrounds
- clinical studies of screening technologies to determine the best delivery models and associated costs
- ongoing engagement with groups including women, health professionals and government.
Breast cancer screening review out soon
Federal health minister Mark Butler said a review of the BreastScreen program would consider our recommendations. The results of this review are expected soon.
We’re not alone in calling for a move towards risk-based breast cancer screening. This is backed by national and international submissions to government, policy briefing documents and the Breast Cancer Network Australia.
We’ve provided an evidence-based roadmap towards better screening for breast cancer. Now is the time to commit to this journey.
We acknowledge Louiza Velentzis from the Daffodil Centre, and Paul Grogan and Deborah Bateson from the University of Sydney, who co-authored the paper mentioned in this article.
Carolyn Nickson, Adjunct Associate Professor, The Daffodil Centre, a joint venture between the University of Sydney and Cancer Council NSW, and Associate Professor, Melbourne School of Population and Global Health, University of Melbourne, University of Sydney; Bruce Mann, Professor of Surgery, Specialist Breast Surgeon, The University of Melbourne, and Karen Canfell, Professor & NHMRC Leadership Fellow, Sydney School of Public Health, University of Sydney
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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F*ck You Chaos – by Dominika Choroszko
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We’ve all read decluttering books. Some may even have decluttering books cluttering bookshelves. This one’s a little different, though:
Dominika Choroszko looks at assessing, decluttering, and subsequently organizing:
- Your home
- Your mind
- Your finances
In other words
- she starts off like Marie Kondo, and…
- phases through doing the jobs of Queer Eye’s “Fab Five”, before…
- sitting us down with some CBT worksheets, and…
- finally going through finances à la Martin Lewis.
By the time we’ve read the book, it’s as though Mary Poppins has breezed through our house, head, and bank account, leaving everything “practically perfect in every way”.
Of course, it’s on us to actually do the work, but as many of us struggle with “how” and the ever-dreaded “but where to begin”, Choroszko’s whirlwind impetus and precision guidance (many very direct practical steps to take) really grease the wheels of progress.
In short, this could be the book that kickstarts your next big “getting everything into better order” drive, with a clear step-by-step this-then-this-then-this linear process.
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The World’s Shortest Weight Loss Course
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The third part of this is what most people are missing:
As easy as 1-2-3?
A lot of things that work very quickly are either not sustainable, or are optical illusions (e.g. loss of water weight) or both.
That doesn’t mean you can or should wait forever for something to magically work, though. Instead, you want something that will offer you consistent measurable progress. Here’s a step-by-step guide to one such approach:
First, the foundation:
• Eat in a small deficit: consume about 15% fewer calories than maintenance, with 18% from protein—any eating style that achieves this works.
• Move more: increase daily steps by 1,000 per month until reaching 6,000–10,000 a day; everyday movement burns more than workouts alone.
• Improve psychology: consistency matters more than fluctuations on the scale. Common blockers include emotional eating, unresolved beliefs about thinness, and lack of deeper motivation beyond appearance.Next, the optimization:
• Improve food quality: aim for 80% whole foods and 20% “anything goes”, reducing junk food gradually.
• Enjoy movement: pick fun, low-impact, medium-intensity activities (like hiking or dancing) to protect joints and build long-term habits.
• Prioritize sleep: add even just 15 minutes at a time, levelling up to another 15 minutes each month, until you reach 8–9 hours per night—vital for metabolic health, brain health, and health on the whole*.Finally, the continuation:
• Be prepared: expect progress to stall every few months; this is biological, not failure. These plateaus are inevitable (but not insurmountable, as you’ll see).
• Overcome plateaus: by adjusting one factor at a time—calories, carbs, protein, sensitivities, exercise type, or temporary maintenance eating.*Yes, even at your age, whatever age that may be. The idea that “older people need less sleep” is a myth, based on the observation of “older people get less sleep”.
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Want to learn more?
You might also like:
How To Lose Weight (Healthily!) ← our own main feature on this, which is very compatible with the above method, while having more tips and some very useful resources
Take care!
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Is thunderstorm asthma becoming more common?
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When spring arrives, so do warnings about thunderstorm asthma. But a decade ago, most of us hadn’t heard of it.
So where did thunderstorm asthma come from? Is it a new phenomenon?
In 2016, the world’s most catastrophic thunderstorm asthma event took Melbourne by surprise. An increase in warnings and monitoring is partly a response to this.
But there are also signs climate change may be exacerbating the likelihood of thunderstorm asthma, with more extreme weather, extended pollen seasons and a rise in Australians reporting hay fever.
A landmark catastrophe
The first time many Australians heard of thunderstorm asthma was in November 2016, when a major event rocked Melbourne.
During a late night storm, an estimated 10,000 people were rushed to hospitals with severe asthma attacks. With thousands of calls on emergency lines, ambulances and emergency departments were unprepared to handle the rapid increase in people needing urgent medical care. Tragically, ten of those people died.
This was the most catastrophic thunderstorm asthma event in recorded history and the first time deaths have ever occurred anywhere in the world.
In response, the Victorian Department of Health implemented initiatives, including public awareness campaigns and improvements to health and emergency services, to be ready for future thunderstorm asthma events.
A network of pollen monitoring stations was also set up across the state to gather data that helps to predict future events.
A problem for decades
While this event was unexpected, it wasn’t the first time we’d had thunderstorm asthma in Australia – we’ve actually known about it for decades.
Melbourne reported its first instance of thunderstorm asthma back in 1984, only a year after this phenomenon was first discovered in Birmingham in the United Kingdom.
Thunderstorm asthma has since been reported in other parts of Australia, including Canberra and New South Wales. But it is still most common in Melbourne. Compared to any other city (or country) the gap is significant: over a quarter of all known events worldwide have occurred in Melbourne.
Why Melbourne?
Melbourne’s location makes it a hotspot for these kinds of events. Winds coming from the north of Melbourne tend to be dry and hot as they come from deserts in the centre of Australia, while winds from the south are cooler as they come from the ocean.
When hot and cool air mix above Melbourne, it creates the perfect conditions for thunderstorms to form.
Northern winds also blow a lot of pollen from farmlands into the city, in particular grass pollen. This is not only the most common cause of seasonal hay fever in Melbourne but also a major trigger of thunderstorm asthma.
Why grass pollen?
There’s a particular reason grass pollen is the main culprit behind thunderstorm asthma in Australia. During storms there is a lot of moisture in the air. Grass pollen will absorb this moisture, making it swell up like a water balloon.
If pollen absorbs too much water whilst airborne, it can burst or “rupture,” releasing hundreds of microscopic particles into the air that can be swept by powerful winds.
Normally, when you breathe in pollen it gets stuck in your upper airway – for example, your nose and throat. This is what causes typical hay fever symptoms such as sneezing or runny nose.
But the microscopic particles released from ruptured grass pollen are much smaller and don’t get stuck as easily in the upper airway. Instead, they can travel deep into your airways until they reach your lungs. This may trigger more severe symptoms, such as wheezing or difficulty breathing, even in people with no prior history of asthma.
So who is at risk?
You might think asthma is the biggest risk factor for thunderstorm asthma. In fact, the biggest risk factor is hay fever.
Up to 99% of patients who went to the emergency department during the Melbourne 2016 event had hay fever, while a majority (60%) had no prior diagnosis of asthma.
Every single person hospitalised was allergic to at least one type of grass pollen. All had a sensitivity to ryegrass.
Is thunderstorm asthma becoming more common?
Thunderstorm asthma events are rare, with just 26 events officially recorded worldwide.
However there is evidence these events could become more frequent and severe in coming years, due to climate change. Higher temperatures and pollution could be making plants produce more pollen and pollen seasons last much longer.
Extreme weather events, including thunderstorms, are also expected to become more common and severe.
In addition, there are signs rates that hay fever may be increasing. The number of Australians reporting allergy symptoms have risen from 15% in 2008 to 24% in 2022. Similar trends in other countries has been linked to climate change.
How can I prepare?
Here are three ways you can reduce your risk of thunderstorm asthma:
- stock up on allergy medication and set up an asthma action plan with your GP
- check daily pollen forecasts for the estimated pollen level and risk of a thunderstorm asthma event in your local area
- on days with high pollen or a high risk of thunderstorm asthma, spend less time outside or wear a surgical face mask to reduce your symptoms.
Kira Morgan Hughes, PhD Candidate in Allergy and Asthma, School of Life and Environmental Sciences, Deakin University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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