The Circadian Code – by Dr. Satchin Panda
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There’s a lot more to circadian rhythm than “sleep during these hours”. And there’s a lot more to bear in mind than “don’t have blue/white light at night”.
In fact, Dr. Satchin Panda explains, there’s a whole daily symphony of movements in our body as different biochemical processes wax and wane according to what time of day it is.
There are several important things he wants us to know about this:
- Our body needs to know what time it is, for those processes to work correctly
- Because of these daily peaks and troughs of various physiological functions, we get “correct” times for things we do every day. Not just sleeping/waking, but also:
- The best time to eat
- The best time to exercise
- The best time to do mental work
- The best times to take different kinds of supplements/medications
Dr. Panda also looks at what things empower, or disempower, our body to keep track of what time it is.
Bottom line: if you’d like to optimize your days and your health, this book has a lot of very valuable practicable tips.
Click here to check out The Circadian Code, and make the most of yours!
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The Many Benefits Of Taking PQQ
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We’re going to start this one by quoting directly from the journal “Current Research in Food Science”, because it provides a very convenient list of benefits for us to look at:
- PQQ is a potent antioxidant that supports redox balance and mitochondrial function, vital for energy and health.
- PQQ contributes to lipid metabolism regulation, indicating potential benefits for energy management.
- PQQ supplementation is linked to weight control, improved insulin sensitivity, and may help prevent metabolic disorders.
- PQQ may attenuate inflammation, bolster cognitive and cardiovascular health, and potentially assist in cancer therapies.
Future research should investigate PQQ dosages, long-term outcomes, and its potential for metabolic and cognitive health. The translation of PQQ research into clinical practice could offer new strategies for managing metabolic disorders, enhancing cognitive health, and potentially extending lifespan.
What is it?
It’s a redox-active (and thus antioxidant) quinone molecule, and essential vitamin co-factor, that not only helps mitochondria to do their thing, but also supports the creation of new mitochondria.
For more detail, you can read all about that here: Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway
It’s first and foremost made by bacteria, and/but it’s present in many foods, including kiwi fruit, spinach, celery, soybeans, human breast milk, and mouse breast milk.
You may be wondering why “mouse breast milk” makes the list. The causal reason is simply that research scientists do a lot of work with mice, and so it was discovered. If you would argue it is not a food because it is breast milk from another species, then ask yourself if you would have said the same if it came from a cow or goat—only social convention makes it different!
For any vegans reading: ok, you get a free pass on this one :p
This information sourced from: Pyrroloquinoline Quinone: Its Profile, Effects on the Liver and Implications for Health and Disease Prevention
On which note…
Against non-alcoholic fatty liver disease
From the above-linked study:
❝Antioxidant supplementation can reverse hepatic steatosis, suggesting dietary antioxidants might have potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).
An extraordinarily potent dietary antioxidant is pyrroloquinoline quinone (PQQ). PQQ is a ubiquitous, natural, and essential bacterial cofactor found in soil, plants, and interstellar dust. The major source of PQQ in mammals is dietary; it is common in leafy vegetables, fruits, and legumes, especially soy, and is found in high concentrations in human and mouse breast milk.
This chapter reviews chemical and biological properties enabling PQQ’s pleiotropic actions, which include modulating multiple signaling pathways directly (NF-κB, JNK, JAK-STAT) and indirectly (Wnt, Notch, Hedgehog, Akt) to improve liver pathophysiology. The role of PQQ in the microbiome is discussed, as PQQ-secreting probiotics ameliorate oxidative stress–induced injury systemwide. A limited number of human trials are summarized, showing safety and efficacy of PQQ❞
…which is all certainly good to see.
Source: Ibid.
Against obesity
And especially, against metabolic obesity, in other words, against the accumulation of visceral and hepatic fat, which are much much worse for the health than subcutaneous fat (that’s the fat you can physically squish and squeeze from the outside with your hands):
❝In addition to inhibiting lipogenesis, PQQ can increase mitochondria number and function, leading to improved lipid metabolism. Besides diet-induced obesity, PQQ ameliorates programing obesity of the offspring through maternal supplementation and alters gut microbiota, which reduces obesity risk.
In obesity progression, PQQ mitigates mitochondrial dysfunction and obesity-associated inflammation, resulting in the amelioration of the progression of obesity co-morbidities, including non-alcoholic fatty liver disease, chronic kidney disease, and Type 2 diabetes.
Overall, PQQ has great potential as an anti-obesity and preventive agent for obesity-related complications.❞
Read in full: Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression
Against aging
This one’s particularly interesting, because…
❝PQQ’s modulation of lactate acid and perhaps other dehydrogenases enhance NAD+-dependent sirtuin activity, along with the sirtuin targets, such as PGC-1α, NRF-1, NRF-2 and TFAM; thus, mediating mitochondrial functions. Taken together, current observations suggest vitamin-like PQQ has strong potential as a potent therapeutic nutraceutical❞
If you’re not sure about what NAD+ is, you can read about it here: NAD+ Against Aging
And if you’re not sure what sirtuins do, you can read about those here: Dr. Greger’s Anti-Aging Eight ← it’s at the bottom!
Want to try some?
As mentioned, it can be found in certain foods, but to guarantee getting enough, and/or if you’d simply like it in supplement form, here’s an example product on Amazon 😎
Enjoy!
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How Old Is Too Old For HRT?
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small 😎
❝I think you guys do a great job. Wondering if I can suggest a topic? Older women who were not offered hormone replacement therepy because of a long term study that was misread. Now, we need science to tell us if we are too old to benefit from begininng to take HRT. Not sure how old your readers are on average but it would be a great topic for older woman. Thanks❞
Thank you for the kind words, and the topic suggestion!
About the menopause and older age thereafter
We’ve talked a bit before about the menopause, for example:
What You Should Have Been Told About The Menopause Beforehand
And we’ve even discussed the unfortunate social phenomenon of post-menopausal women thinking “well, that’s over and done with now, time to forget about that”, because spoiler, it will never be over and done with—your body is always changing every day, and will continue to do so until you no longer have a body to change.
This means, therefore, that since changes are going to happen no matter what, the onus is on us to make the changes as positive (rather than negative) as possible:
Menopause, & When Not To Let Your Guard Down
About cancer risk
It sounds like you know this one, but for any who were unaware: indeed, there was an incredibly overblown and misrepresented study, and even that was about older forms of HRT (being conjugated equine estrogens, instead of bioidentical estradiol):
As for those who have previously had breast cancer or similar, there is also:
The Hormone Therapy That Reduces Breast Cancer Risk & More
Is it too late?
Fortunately, there is a quick and easy test to know whether you are too old to benefit:
First, find your pulse, by touching the first two fingers of one hand, against the wrist of the other. If you’re unfamiliar with where to find the pulse at the wrist, here’s a quick explainer.
Or if you prefer a video:
Click Here If The Embedded Video Doesn’t Load Automatically!
Did you find it?
Good; in that case, it’s not too late!
Scientists have tackled this question, looking at women of various ages, and finding that when comparing age groups taking HRT, disease risk changes do not generally vary much by age i.e., someone at 80 gets the same relative benefit from HRT as someone at 50, with no extra risks from the HRT. For example, if taking HRT at 50 reduces a risk by n% compared to an otherwise similar 50-year-old not on HRT, then doing so at 80 reduces the same risk by approximately the same percentage, compared to an otherwise similar 80-year-old not on HRT.
There are a couple of exceptions, such as in the case of already having advanced atherosclerotic lesions (in which specific case HRT could increase inflammation; not something it usually does), or in the case of using conjugated equine estrogens instead of modern bioidentical estradiol (as we talked about before).
Thus, for the most part, HRT is considered safe and effective regardless of age:
How old is too old for hormone therapy?
👆 that’s from 2015 though, so how about a new study, from 2024?
❝Compared with never use or discontinuation of menopausal hormone therapy after age 65 years, the use of estrogen monotherapy beyond age 65 years was associated with significant risk reductions in mortality (19% or adjusted hazards ratio, 0.81; 95% CI, 0.79-0.82), breast cancer (16%), lung cancer (13%), colorectal cancer (12%), congestive heart failure (CHF) (5%), venous thromboembolism (3%), atrial fibrillation (4%), acute myocardial infarction (11%), and dementia (2%).❞
❝Among senior Medicare women, the implications of menopausal hormone therapy use beyond age 65 years vary by types, routes, and strengths. In general, risk reductions appear to be greater with low rather than medium or high doses, vaginal or transdermal rather than oral preparations, and with estradiol rather than conjugated estrogen.❞
Read in full: Use of menopausal hormone therapy beyond age 65 years and its effects on women’s health outcomes by types, routes, and doses
As for more immediately-enjoyable benefits (improved mood, healthier skin, better sexual function, etc), yes, those also are benefits that people enjoy at least into their eighth decade:
See: Use of hormone therapy in Swedish women aged 80 years or older
What about…
Statistically speaking, most people who take HRT have a great time with it and consider it life-changing in a good way. However, nothing is perfect; sometimes going on HRT can have a shaky start, and for those people, there may be some things that need addressing. So for that, check out:
HRT Side Effects & Troubleshooting
And also, while estrogen monotherapy is very common, it is absolutely worthwhile to consider also taking progesterone alongside it:
Progesterone Menopausal HRT: When, Why, And How To Benefit
Enjoy!
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Clean – by Dr. James Hamblin
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Our skin is our largest organ, and it’s easy to forget that, and how much it does for us. All things considered, it’s good to take good care of it! But what if we sometimes take too much “care” of it?
Dr. James Hamblin, a medical doctor-turned-writer, has explored this a lot both personally and in research. Through such, he has come to the conclusion there’s definitely a “sweet spot” of personal hygiene:
- Too little, and the Bubonic plague sweeps through Europe, or other plagues sweep through other places when European invaders came.
- Too much, and we strip our skin of one of its greatest qualities: the ability to protect us.
Dr. Hamblin asks (and answers) such questions as:
- What is good hygiene, and what is neurotically doing ourselves multiple levels of harm because advertising companies shamed us into doing so?
- Is it good or bad to use a series of products, each to undo the problem caused by the previous?
- What the difference between a 5-step skincare routine, and a series of gratuitous iatrogenic damage?
- Which products clean us most helpfully, and which clean us most harmfully?
- How often should we bathe/shower, really?
If the book has a weak point, it’s that it’s written mostly with his body in mind. That makes a difference when it comes to hairwashing, for example. He’s a white guy with short hair. If you’re black and/or have long hair, for example, your haircare needs will be quite different. Similarly, many women engage in shaving/depilation in places that most men don’t, and the consequences of that choice (and implications for any extra washing needs/harms) aren’t covered.
Bottom line: notwithstanding the aforementioned blind-spots, this book will help readers reduce the amount of harm we are doing to our bodies with our washing routines, without sacrificing actual hygiene.
Click here to check out Clean and help your skin to help you!
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Energize! – by Dr. Michael Breus & Stacey Griffith
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We previously reviewed another book book by Dr. Breus, The Power Of When. So what’s different in this one?
While the chronotypes featured in The Power Of When also feature here (and sufficient explanation is given to make this a fine stand-alone book), this book has a lot to do with metabolism also. By considering a person’s genetically predisposed metabolic rate to be fast, medium, or slow (per being an ectomorph, mesomorph, or endomorph), and then putting that next to one’s sleep chronotype, we get 12 sub-categories that in this book each get an optimized protocol of sleep, exercise (further divided into: what kind of exercise when), and eating/fasting.
Which, in effect, amounts to a personalized coaching program for optimized energy!
The guidance is based on a combination of actual science plus “if this then that” observation-based principles—of the kind that could be described as science if they had been studied clinically instead of informally. Dr. Breus is a sleep scientist, by the way, and his co-author Stacey Griffith is a fitness coach. So between the two of them, they have sleep and exercise covered, and the fasting content is very reasonable and entirely consistent with current consensus of good practice.
The style is very pop-psychology, and very readable, and has a much more upbeat feel than The Power Of When, which seems to be because of Griffith’s presence as a co-author (most of the book is written from a neutral perspective, and some parts have first-person sections by each of the authors, so the style becomes distinct accordingly).
Bottom line: if you’d like to be more energized but [personal reason why not here] then this book may not fix all your problems, but it’ll almost certainly make a big difference and help you to stop sabotaging things and work with your body rather than against it.
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Signs Of Low Estrogen In Women: What Your Skin, Hair, & Nails Are Trying To Tell You
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Skin, hair, and nails are often thought of purely as a beauty thing, but in fact they can be indicative of a lot of other aspects of health. Dr. Andrea Suarez takes us through some of them in this video about the systemic (i.e., whole-body, not just related to sex things) effects of estrogen, and/or a deficiency thereof.
Beyond the cosmetic
Low estrogen levels are usual in women during and after untreated menopause, resulting in various changes in the skin, hair, and nails, that reflect deeper issues, down to bone health, heart health, brain health, and more. Since we can’t see our bones or hearts or brains without scans (or a serious accident/incident), we’re going to focus on the outward signs of estrogen deficiency.
Estrogen helps maintain healthy collagen production, skin elasticity, wound healing, and moisture retention, making it essential for youthful and resilient skin. Declining estrogen levels with menopause lead to a thinner epidermis, decreased collagen production, and more pronounced wrinkles. Skin elasticity also diminishes, which slows the skin’s ability to recover from stretching or deformation. Wound healing also becomes slower, increasing the risk of infections and extended recovery periods after injuries or surgeries—bearing in mind that collagen is needed in everything from our skin to our internal connective tissue (fascia) and joints and bones. So all those things are going to struggle to recover from injury (and surgery is also an injury) without it.
Other visible changes associated with declining estrogen include significant dryness as a result of reduced hyaluronic acid and glycosaminoglycan production, which are essential for moisture retention. The skin becomes more prone to irritation and increased water loss. Additionally, estrogen deficiency results in less resistance to oxidative stress, making the skin more susceptible to damage from environmental factors such as UV radiation and pollution, as well as any from-the-inside pollution that some may have depending on diet and lifestyle.
Acne and enlarged pores are associated with increased testosterone, but testosterone and estrogen are antagonistic in most ways, and in this case a decrease in estrogen will do the same, due increased unopposed androgen signaling affecting the oil glands. The loss of supportive collagen also causes the skin around pores to lose structure, making them appear larger. The reduction in skin hydration further exacerbates the visibility of pores and can contribute to the development of blackheads due to abnormal cell turnover.
Blood vessel issues tend to arise as estrogen levels drop, leading to a reduction in angiogenesis, i.e. the formation and integrity of blood vessels. This results in more fragile and leaky blood vessels, making the skin more prone to bruising, especially on areas frequently exposed to the sun, such as the backs of the hands. This weakened vasculature also further contributes to the slower wound healing that we talked about, due to less efficient delivery of growth factors.
Hair and nail changes often accompany estrogen deficiency. Women may notice hair thinning, increased breakage, and a greater likelihood of androgenic alopecia. The texture of the hair can change, becoming more brittle. Similarly, nails can develop ridges, split more easily, and become more fragile due to reduced collagen and keratin production, which also affects the skin around the nails.
As for what to do about it? Management options for estrogen-deficient skin include:
- Bioidentical hormone replacement therapy (HRT), which can improve skin elasticity, boost collagen production, and reduce dryness and fragility, as well as addressing the many more serious internal things that are caused by the same deficiency as these outward signs.
- Low-dose topical estrogen cream, which can help alleviate skin dryness and increase skin strength, won’t give the systemic benefits (incl. to bones, heart, brain, etc) that only systemic HRT can yield.
- Plant-based phytoestrogens, which are not well-evidenced, but may be better than nothing if nothing is your only other option. However, if you are taking anything other form of estrogen, don’t use phytoestrogens as well, or they will compete for estrogen receptors, and do the job not nearly so well while impeding the bioidentical estrogen from doing its much better job.
And for all at any age, sunscreen continues to be one of the best things to put on one’s skin for general skin health, and this is even more true if running low on estrogen.
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
These Signs Often Mean These Nutrient Deficiencies (Do You Have Any?)
Take care!
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A drug that can extend your life by 25%? Don’t hold your breath
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Every few weeks or months, the media reports on a new study that tantalisingly dangles the possibility of a new drug to give us longer, healthier lives.
The latest study centres around a drug involved in targeting interleukin-11, a protein involved in inflammation. Blocking this protein appeared to help mice stave off disease and extend their life by more than 20%.
If only defying the ravages of time could be achieved through such a simple and effort-free way – by taking a pill. But as is so often the case, the real-world significance of these findings falls a fair way short of the hype.
Halfpoint/Shutterstock The role of inflammation in disease and ageing
Chronic inflammation in the body plays a role in causing disease and accelerating ageing. In fact, a relatively new label has been coined to represent this: “inflammaging”.
While acute inflammation is an important response to infection or injury, if inflammation persists in the body, it can be very damaging.
A number of lifestyle, environmental and societal drivers contribute to chronic inflammation in the modern world. These are largely the factors we already know are associated with disease and ageing, including poor diet, lack of exercise, obesity, stress, lack of sleep, lack of social connection and pollution.
While addressing these issues directly is one of the keys to addressing chronic inflammation, disease and ageing, there are a number of research groups also exploring how to treat chronic inflammation with pharmaceuticals. Their goal is to target and modify the molecular and chemical pathways involved in the inflammatory process itself.
What the latest research shows
This new interleukin-11 research was conducted in mice and involved a number of separate components.
In one component of this research, interleukin-11 was genetically knocked out in mice. This means the gene for this chemical mediator was removed from these mice, resulting in the mice no longer being able to produce this mediator at all.
In this part of the study, the mice’s lives were extended by over 20%, on average.
Another component of this research involved treating older mice with a drug that blocks interleukin-11.
Injecting this drug into 75-week old mice (equivalent to 55-year-old humans) was found to extend the life of mice by 22-25%.
These treated mice were less likely to get cancer and had lower cholesterol levels, lower body weight and improved muscle strength and metabolism.
From these combined results, the authors concluded, quite reasonably, that blocking interleukin-11 may potentially be a key to mitigating age-related health effects and improving lifespan in both mice and humans.
Why you shouldn’t be getting excited just yet
There are several reasons to be cautious of these findings.
First and most importantly, this was a study in mice. It may be stating the obvious, but mice are very different to humans. As such, this finding in a mouse model is a long way down the evidence hierarchy in terms of its weight.
Research shows only about 5% of promising findings in animals carry over to humans. Put another way, approximately 95% of promising findings in animals may not be translated to specific therapies for humans.
Second, this is only one study. Ideally, we would be looking to have these findings confirmed by other researchers before even considering moving on to the next stage in the knowledge discovery process and examining whether these findings may be true for humans.
We generally require a larger body of evidence before we get too excited about any new research findings and even consider the possibility of human trials.
Third, even if everything remains positive and follow-up studies support the findings of this current study, it can take decades for a new finding like this to be translated to successful therapies in humans.
Until then, we can focus on doing the things we already know make a huge difference to health and longevity: eating well, exercising, maintaining a healthy weight, reducing stress and nurturing social relationships.
Hassan Vally, Associate Professor, Epidemiology, Deakin University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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