
The All-New Pain Therapy That “Switches Off Pain” Without Addiction
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When it comes to painkilling medications, they can generally be categorized into two broad kinds:
- non-opioids (e.g. ibuprofen, paracetamol/acetaminophen, aspirin)
- ones that actually work for something more serious than a headache
That’s an oversimplification of course, but as a strong general rule, when there is serious painkilling to be done, that’s when doctors consider it’s time to break out the opioids.
Nor are all opioids created equal—there’s a noteworthy difference between codeine and morphine, for instance—but the problems of opioids are typically the same (tolerance, addiction, and eventual likelihood of overdose when one tries to take enough to make it work after developing a tolerance), and it becomes simply a matter of degree.
See also: I’ve been given opioids after surgery to take at home. What do I need to know?
But what if we’d like those benefits, without the tolerance, ease of addiction, and possibility of overdose?
The genetic advantage
Researchers (Dr. Corinna Oswell et al.) developed a targeted gene therapy that reduces pain by acting directly on specific brain circuits instead of broadly affecting the entire brain like opioids do.
In other words: this gene therapy reproduces pain relief without activating addiction-related brain pathways or dulling normal sensations.
Specifically, the therapy makes use of a brain-specific “off switch”, which dampens pain signals in the anterior cingulate cortex (a key brain area involved in the experience of pain). This way, it can target opioid-sensitive neurons and alter their activity, effectively recreating the beneficial effects of opioids at a circuit level, without having the usual adverse effects associated with opioids on the systemic level.
If you’re wondering how soon you can get it, that bad news is that the therapy is still in preclinical research, and further studies are needed before human clinical trials can confirm safety and effectiveness.
But it’s very promising so far; in animal models, the treatment provided sustained pain relief and reversed abnormal brain activity linked to chronic pain without impairing reflexes or sensory detection.
You can find the paper itself, here: Mimicking opioid analgesia in cortical pain circuits
So, how rapidly is science advancing? Well, this research comes a little more than a year after, a different team of scientists were pioneering a potential gene therapy for pain, with results that were very promising at the time, but not a patch on what we’ve been talking about today:
Structure-guided design of a peripherally restricted chemogenetic system
…which you can read about in pop-science terms (with diagrams!) here:
New gene therapy could alleviate chronic pain, researchers find
So… Pretty quickly, but we always love to see new advances!
Want to learn more?
If you’re looking for alternatives while you wait, we’ve written quite a bit about pain management, including:
- Before You Reach For That Tylenol…
- How To Stop Pain Spreading
- How To Dial Down Your Pain
- Managing Chronic Pain (Realistically!)
- Get The Right Help For Your Pain
- The 7 Approaches To Pain Management
- Science-Based Alternative Pain Relief (When Painkillers Aren’t Helping, These Things Might)
Take care!
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Broccoli vs Asparagus – Which is Healthier?
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Our Verdict
When comparing broccoli to asparagus, we picked the broccoli.
Why?
Both are great! But broccoli does distinguish itself:
In terms of macros, broccoli has slightly more protein, carbs, and fiber. The two vegetables have the same glycemic index. We’ll call this a slight win for broccoli based mainly on the higher fiber, but it’s not by a huge amount.
When it comes to vitamins, broccoli has more of vitamins B5, B6, B9, C, K, and choline, whereas asparagus has more of vitamins A, B1, B2, B3, and E. This would already be a 6:5 marginal win for broccoli, but it’s worth bearing in mind that broccoli’s margins are greater, especially with broccoli having around 15x the amount of vitamin C. So, a clear win for broccoli, respectable as asparagus may be.
In the category of minerals, broccoli has more calcium, magnesium, manganese, phosphorus, potassium, and selenium, while asparagus boasts more copper, iron, and zinc. A 6:3 win for broccoli here.
Both vegetables also contain generous amounts of antioxidant polyphenols and other beneficial phytochemicals, often a little different from each other, so that’s a case for enjoying both.
Still, if you’re going to pick just one, we recommend the broccoli!
Want to learn more?
You might like to read:
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The Common Meds That Make You Much More Susceptible To Heatstroke
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…and other items from this week’s health news:
The heat is on
As the temperatures hit record highs again, some people will be more susceptible to heat exhaustion and heatstroke than others, because of a lot of common mediations impair our body’s ability to deal with such temperatures.
This includes medications that (as their intended effect or, more commonly, as a side effect):
- change circulation (especially vasoconstrictors)
- change temperature perception (and thus reduce the body’s ability to respond to the actual temperature)
- have a diuretic effect (so you pee away your hydration, and dehydrate more quickly)
- raise the body temperature directly (often by increasing the metabolism in some fashion, such as stimulants or thyroid meds)
- reduce sweating (an important cooling mechanism)
- reduce thirst (so people dehydrate without realizing it)
Here’s a non-exhaustive list of meds that make us more vulnerable to heatstroke: amitriptyline, amoxapine, aripiprazole, asenapine, benztropine, bupropion, cariprazine, citalopram, chlorpromazine, clozapine, desipramine, desvenlafaxine, diphenhydramine, doxepin, duloxetine, escitalopram, fluoxetine, fluphenazine, haloperidol, iloperidone, imipramine, lithium, loxapine, lurasidone, nortriptyline, olanzapine, paliperidone, paroxetine, perphenazine, promethazine, quetiapine, risperidone, sertraline, thiothixene, thioridazine, trazodone, trifluoperazine, trihexyphenidyl, venlafaxine, vilazodone, vortioxetine, ziprasidone
Here’s an equally non-exhaustive list of the same meds, this time by brand names: Abilify, Asendin, Artane, Aventyl, Benadryl, Brintellix, Celexa, Clozaril, Cogentin, Cymbalta, Desyrel, Elavil, Effexor, Eskalith, Fanapt, Fetzima, Geodon, Haldol, Invega, Latuda, Lexapro, Loxitane, Navane, Norpramin, Oleptro, Pamelor, Paxil, Phenergan, Pristiq, Prolixin, Prozac, Rexulti, Risperdal, Saphris, Seroquel, Sinequan, Silenor, Stelazine, Thorazine, Tofranil, Trilafon, Viibryd, Vraylar, Wellbutrin, Zoloft, Zyprexa, Zyban
Note that this doesn’t mean you shouldn’t take your meds as prescribed; it just means that if you’re on one or more of these meds, or any medication(s) that have similar effects, you will need to be extra careful.
When spending time in the sun (honestly a good thing to avoid in high heat, but if you’re going to do it, you might as well do it as safely as possible), it’s also best to have a “buddy system” (e.g. partner, friend, etc) to notice when the other one is not doing well—as heat exhaustion and heatstroke can impair our ability to notice it in ourselves.
Read in full: These 8 Common Medications May Increase Your Risk of Heat Stroke, Experts Explain ← the title says “8 common medications” but what the article actually discusses is 8 kinds of medications that do this
Related: Sun, Sea, And Sudden Killers To Avoid: Stay Safe From Heat Exhaustion & Heatstroke!
The one-shot vs malaria
As the temperatures rise each year and mosquitos spread further north than they used to, people in what have historically been temperate climates are now having to worry about mosquito-borne illnesses when this was never previously a risk unless travelling. This risk will, barring serious preventative measures being taken, likely only increase each year now.
So, what’s to be done about it?
Researchers (Dr. Eleanor Stride et al.) have developed a new vaccine delivery system using programmable microcapsules that can release booster doses over time from a single injection. This addresses a key issue in global health: many people miss booster shots due to limited healthcare access, reducing vaccine effectiveness. So, being able to get it all done at once is a big benefit.
Researchers can precisely control the timing of booster release, ranging from two weeks to several months after injection, and in preclinical trials, the “single shot” method using the malaria vaccine provided protection comparable to traditional two-dose regimens. Now, of course, it moves to the next testing stages:
Read in full: Single-shot malaria vaccine delivery system could transform global immunization
Related: Dodging Dengue In The US ← also a mosquito-borne illness, also on the rise in the US; practical tips here beyond the obvious, too
Hot tubs for immune health?
Ok, when the weather isn’t too hot to enjoy such…
Researchers (Dr. Jessica Atencio et al.) have found that the health benefits of going to sauna don’t require going to a sauna, and in fact can be gained from a hot tub, albeit with some caveats:
❝There’s no doubt in my mind that if people are willing to do some heat therapy, it’s going to align with improved health, as long as it’s done in moderation.
We always say that exercise is the primary nonpharmacological treatment that people should be doing to promote health, but some people can’t or just won’t exercise; heat therapy is good supplementation❞
Since it’s the hot water, not the bubbles, that confer the beneficial effects, this also means that (notwithstanding the article title) simply enjoying a hot bath will provide the same boost:
Read in full: Hot tubs outperform saunas in boosting blood flow and immune power
Related: How Useful Is Hydrotherapy?
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Why We Remember – by Dr. Charan Ranganath
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As we get older, forgetfulness can become more of a spectre; the threat that one day it could be less “where did I put my sunglasses?” and more “who is this person claiming to be my spouse?”.
Dr. Ranganath explores in this work the science of memory, from a position of neurobiology, but also in application. How and why we remember, and how and why we forget, and how and why both are important.
There is a practical element to the book too; we read about things that increase our tendency to remember (and things that increase our tendency to forget), and how we can leverage that information to curate our memory in an active, ongoing basis.
The style of the book is quite casual in tone for such a serious topic, but there’s plenty of hard science too; indeed there are 74 pages of bibliography cited.
Bottom line: while filled with a lot of science, this is also a very human book, and a helpful guide to building and preserving our memory.
Click here to check out “Why We Remember”, and learn how to hold on to what matters the most!
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The Big Book of Kombucha – by Hannah Crum & Alex LaGory
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If you’ve been thinking “I should get into kombucha”, then this is the universe prompting you, because with in this book’s 400 pages is all the information you need and more.
Because, it’s understandable to be wary when starting out, from “what if my jar explodes” to “what if I poison my family”, but the authors (and photographer) take every care to ensure that everything goes perfectly, guiding us through everything from start to finish, including very many high-quality color photos of what things should (and shouldn’t) look like.
On which note, that does mean that to enjoy the color you should get a physical copy or Kindle Fire, not a Kindle e-ink version (as then it’d be black and white).
There’s also a comprehensive section on troubleshooting, as well as hundreds of recipes for all kinds of flavors and occasions.
Bottom line: in the category of books that could reasonably be called “The Bible of…”, this one’s the “The Bible of Kombucha”.
Click here to check out The Big Book Of Kombucha, and get brewing!
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Eat to Beat Disease – by Dr. William Li
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Dr. William Li asks the important question: is your diet feeding disease, or defeating it?
Because everything we put in our bodies makes our health just a little better—or just a little worse. Ok, sometimes a lot worse.
But for most people, when it comes to diet, it’s a death of a thousand cuts of unhealthy food. And that’s what he looks to fix with this book.
The good news: Dr. Li (while not advocating for unhealthy eating, of course), focuses less on what to restrict, and more on what to include. This book covers hundreds of such healthy foods, and ideas (practical, useful ones!) on incorporating them daily, including dozens of recipes.
He mainly looks at five ways our food can help us with…
- Angiogenesis (blood vessel replacement)
- Regeneration (of various bodily organs and systems)
- Microbiome health (and all of its knock-on effects)
- DNA protection (and thus slower cellular aging)
- Immunity (defending the body while also reducing autoimmune problems)
The style is simple and explanatory; Dr. Li is a great educator. Reading this isn’t a difficult read, but you’ll come out of it feeling like you just did a short course in health science.
Bottom line: if you’d like an easy way to improve your health in an ongoing and sustainable way, then this book can help you do just that.
Click here to check out Eat To Beat Disease, and eat to beat disease!
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Self-Defense – by Dr. Daniel Davis
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The author, a professor of immunology, sets out to bust some immune health myths in a time when those myths are spreading even faster (and sometimes with more mutations along the way) than the latest flu or COVID variants.
Writing from a position of stable academia rather than the latest flashy platform, he covers many topics including the roles of vitamins (especially: what vitamins C and D can and can’t do for you), the gut microbiome, weight and adiposity, exercise (especially: the right kinds, and where the “sweet spot” is when it comes to amount, because yes, exercise is good in general, but too much of certain kinds can harm immune health), stress management, sleep, and aging (i.e. how immune health changes as we age).
You’ll notice that vaccines are conspicuous by their absence in that list; while these are touched on from time to time, the focus here is on immune health overall, which vaccines only meaningfully affect in one way: giving our immune systems advance knowledge of pathogens to come. So the position of this book on that is “yes, obviously get your vaccines, but that doesn’t take much explaining, and doesn’t merit an entire chapter just to say it”.
Dr. Davis does also indulge, at the end of the book, in something that a lot of other research scientists do too, which is: discussion of what’s in the pipeline in terms of research and development (in this case, in the field of immunology).
The style is polished pop-science in long-form prose; written for a lay audience, and/but with the steady tone of academia; no hype and little to nothing in the way of personal touches. So, we get very little jargon (which makes for easy reading), but it’s also a little dry (which makes it very put-downable, in the sense of being the opposite of a “couldn’t put it down” book). There is a respectable bibliography, plus
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