Taurine’s Benefits For Heart Health And More

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Taurine: Research Review

First, what is taurine, beyond being an ingredient in many energy drinks?

It’s an amino acid that many animals, including humans, can synthesize in our bodies. Some other animals—including obligate carnivores such as cats (but not dogs, who are omnivorous by nature) cannot synthesize taurine and must get it from food.

So, as humans are very versatile omnivorous frugivores by nature, we have choices:

  • Synthesize it—no need for any conscious action; it’ll just happen
  • Eat it—by eating meat, which contains taurine
  • Supplement it—by taking supplements, including energy drinks, which generally (but not always) use a bioidentical lab-made taurine. Basically, lab-made taurine is chemically identical to the kind found in meat, it’s just cheaper and doesn’t involve animals as a middleman.

What does it do?

Taurine does a bunch of essential things, including:

  • Maintaining hydration/electrolyte balance in cells
  • Regulating calcium/magnesium balance in cells
  • Forming bile salts, which are needed for digestion
  • Supporting the integrity of the central nervous system
  • Regulating the immune system and antioxidative processes

Thus, a shortage of taurine can lead to such issues as kidney problems, eye tissue damage (since the eyes are a particularly delicate part of the CNS), and cardiomyopathy.

If you want to read more, here’s an academic literature review:

Taurine: A “very essential” amino acid

On the topic of eye health, a 2014 study found that taurine is the most plentiful amino acid in the eye, and helps protect against retinal degeneration, in which they say:

❝We here review the evidence for a role of taurine in retinal ganglion cell survival and studies suggesting that this compound may be involved in the pathophysiology of glaucoma or diabetic retinopathy. Along with other antioxidant molecules, taurine should therefore be seriously reconsidered as a potential treatment for such retinal diseases❞

Read more: Taurine: the comeback of a neutraceutical in the prevention of retinal degenerations

Taurine for muscles… In more than sports!

We’d be remiss not to mention that taurine is enjoyed by athletes to enhance athletic performance; indeed, it’s one of its main selling-points:

See: Taurine in sports and exercise

But! It’s also useful for simply maintaining skeleto-muscular health in general, and especially in the context of age-related decline and chronic disease:

Taurine: the appeal of a safe amino acid for skeletal muscle disorders

On the topic of safety… How safe is it?

There’s an interesting answer to that question. Within safe dose ranges (we’ll get to that), taurine is not only relatively safe, but also, studies that looked to explore its risks found new benefits in the process. Specifically of interest to us were that it appears to promote better long-term memory, especially as we get older (as taurine levels in the brain decline with age):

Taurine, Caffeine, and Energy Drinks: Reviewing the Risks to the Adolescent Brain

^Notwithstanding the title, we assure you, the research got there; they said:

❝Interestingly, the levels of taurine in the brain decreased significantly with age, which led to numerous studies investigating the potential neuroprotective effects of supplemental taurine in several different experimental models❞

What experimental models were those? These ones:

…which were all animal studies, however.

The same systematic review also noted that not only was more research needed on humans, but also, existing studies have had a strong bias to male physiology (in both human and assorted other animal studies), so more diverse study is needed too.

What are the safe dose ranges?

Before we get to toxicity, let’s look at some therapeutic doses. In particular, some studies that found that 500mg 3x daily, i.e. 1.5g total daily, had benefits for heart health:

Bottom line on safety: 3g/day has been found to be safe:

Click here to see the findings of the risk assessment published in the Journal of Regulatory Toxicology and Pharmacology

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  • Stickers and wristbands aren’t a reliable way to prevent mosquito bites. Here’s why

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    Protecting yourself and family from mosquito bites can be challenging, especially in this hot and humid weather. Protests from young children and fears about topical insect repellents drive some to try alternatives such as wristbands, patches and stickers.

    These products are sold online as well as in supermarkets, pharmacies and camping stores. They’re often marketed as providing “natural” protection from mosquitoes.

    But unfortunately, they aren’t a reliable way to prevent mosquito bites. Here’s why – and what you can try instead.

    Why is preventing mosquito bites important?

    Mosquitoes can spread pathogens that make us sick. Japanese encephalitis and Murray Valley encephalitis viruses can have potentially fatal outcomes. While Ross River virus won’t kill you, it can cause potentially debilitating illnesses.

    Health authorities recommend preventing mosquito bites by: avoiding areas and times of the day when mosquitoes are most active; covering up with long sleeved shirts, long pants, and covered shoes; and applying a topical insect repellent (a cream, lotion, or spray).

    I don’t want to put sticky and smelly repellents on my skin!

    While for many people, the “sting” of a biting mosquitoes is enough to prompt a dose of repellent, others are reluctant. Some are deterred by the unpleasant feel or smell of insect repellents. Others believe topical repellents contain chemicals that are dangerous to our health.

    However, many studies have shown that, when used as recommended, these products are safe to use. All products marketed as mosquito repellents in Australia must be registered by the Australian Pesticides and Veterinary Medicines Authority; a process that provides recommendations for safe use.

    How do topical repellents work?

    While there remains some uncertainty about how the chemicals in topical insect repellents actually work, they appear to either block the sensory organs of mosquitoes that drive them to bite, or overpower the smells of our skin that helps mosquitoes find us.

    Diethytolumide (DEET) is a widely recommended ingredient in topical repellents. Picaridin and oil of lemon eucalyptus are also used and have been shown to be effective and safe.

    How do other products work?

    “Physical” insect-repelling products, such as wristbands, coils and candles, often contain a botanically derived chemical and are often marketed as being an alternative to DEET.

    However, studies have shown that devices such as candles containing citronella oil provide lower mosquito-bite prevention than topical repellents.

    A laboratory study in 2011 found wristbands infused with peppermint oil failed to provide full protection from mosquito bites.

    Even as topical repellent formulations applied to the skin, these botanically derived products have lower mosquito bite protection than recommended products such as those containing DEET, picaridin and oil of lemon eucalyptus.

    Wristbands infused with DEET have shown mixed results but may provide some bite protection or bite reduction. DEET-based wristbands or patches are not currently available in Australia.

    There is also a range of mosquito repellent coils, sticks, and other devices that release insecticides (for example, pyrethroids). These chemicals are primarily designed to kill or “knock down” mosquitoes rather than to simply keep them from biting us.

    What about stickers and patches?

    Although insect repellent patches and stickers have been available for many years, there has been a sudden surge in their marketing through social media. But there are very few scientific studies testing their efficacy.

    Our current understanding of the way insect repellents work would suggest these small stickers and patches offer little protection from mosquito bites.

    At best, they may reduce some bites in the way mosquito coils containing botanical products work. However, the passive release of chemicals from the patches and stickers is likely to be substantially lower than those from mosquito coils and other devices actively releasing chemicals.

    One study in 2013 found a sticker infused with oil of lemon eucalyptus “did not provide significant protection to volunteers”.

    Clothing impregnated with insecticides, such as permethrin, will assist in reducing mosquito bites but topical insect repellents are still recommended for exposed areas of skin.

    Take care when using these products

    The idea you can apply a sticker or patch to your clothing to protect you from mosquito bites may sound appealing, but these devices provide a false sense of security. There is no evidence they are an equally effective alternative to the topical repellents recommended by health authorities around the world. It only takes one bite from a mosquito to transmit the pathogens that result in serious disease.

    It is also worth noting that there are some health warnings and recommendations for their use required by Australian Pesticides and Veterinary Medicines Authority. Some of these products warn against application to the skin (recommending application to clothing only) and to keep products “out of reach of children”. This is a challenge if attached to young children’s clothing.

    Similar warnings are associated with most other topical and non-topical mosquito repellents. Always check the labels of these products for safe use recommendations.

    Are there any other practical alternatives?

    Topical insect repellents are safe and effective. Most can be used on children from 12 months of age and pose no health risks. Make sure you apply the repellent as a thin even coat on all exposed areas of skin.

    But you don’t need “tropical strength” repellents for short periods of time outdoors; a range of formulations with lower concentrations of repellent will work well for shorter trips outdoors. There are some repellents that don’t smell as strong (for example, children’s formulations, odourless formulations) or formulations that may be more pleasant to use (for example, pump pack sprays).

    Finally, you can always cover up. Loose-fitting long-sleeved shirts, long pants, and covered shoes will provide a physical barrier between you and mosquitoes on the hunt for your or your family’s blood this summer.The Conversation

    Cameron Webb, Clinical Associate Professor and Principal Hospital Scientist, University of Sydney

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • PFAS Exposure & Cancer: The Numbers Are High

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    PFAS & Cancer Risk: The Numbers Are High

    Dr Maaike Van Gerwen studies the effects of exposure to PFAS on cancer development.
    Image Credits Mount Sinai

    This is Dr. Maaike van Gerwen. Is that an MD or a PhD, you wonder? It’s both.

    She’s also Director of Research in the Department of Otolaryngology at Mount Sinai Hospital in New York, Scientific Director of the Program of Personalized Management of Thyroid Disease, and Member of the Institute for Translational Epidemiology and the Transdisciplinary Center on Early Environmental Exposures.

    What does she want us to know?

    She’d love for us to know about her latest research published literally today, about the risks associated with PFAS, such as the kind widely found in non-stick cookware:

    Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer risk

    Dr. van Gerwen and her team tested this several ways, and the very short and simple version of the findings is that per doubling of exposure, there was a 56% increased rate of thyroid cancer diagnosis.

    (The rate of exposure was not just guessed based on self-reports; it was measured directly from PFAS levels in the blood of participants)

    • PFAS exposure can come from many sources, not just non-stick cookware, but that’s a “biggie” since it transfers directly into food that we consume.
    • Same goes for widely-available microwaveable plastic food containers.
    • Relatively less dangerous exposures include waterproofed clothing.

    To keep it simple and look at the non-stick pans and microwavable plastic containers, doubling exposure might mean using such things every day vs every second day.

    Practical take-away: PFAS may be impossible to avoid completely, but even just cutting down on the use of such products is already reducing your cancer risk.

    Isn’t it too late, by this point in life? Aren’t they “forever chemicals”?

    They’re not truly “forever”, but they do have long half-lives, yes.

    See: Can we take the “forever” out of forever chemicals?

    The half-lives of PFOS and PFOA in water are 41 years and 92 years, respectively.

    In the body, however, because our body is constantly trying to repair itself and eliminate toxins, it’s more like 3–7 years.

    That might seem like a long time, and perhaps it is, but the time will pass anyway, so might as well get started now, rather than in 3–7 years time!

    Read more: National Academies Report Calls for Testing People With High Exposure to “Forever Chemicals”

    What should we use instead?

    In place of non-stick cookware, cast iron is fantastic. It’s not everyone’s preference, though, so you might also like to know that ceramic cookware is a fine option that’s functionally non-stick but without needing a non-stick coating. Check for PFAS-free status; they should advertise this.

    In place of plastic microwaveable containers, Pyrex (or equivalent) glass dishes (you can get them with lids) are a top-tier option. Ceramic containers (without metallic bits!) are also safely microwaveable.

    See also:

    Here’s a List of Products with PFAS (& How to Avoid Them)

    Take care!

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  • Aging Solo – by Ellen Dawson

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Many of us will face the challenge of “aging solo”, if indeed we’re not already. The premise of this book is that while it may indeed be a challenge, it can be an exciting challenge rather than a scary one.

    Thus, Dawson bids us empower ourselves to tackle it head on, proactively.

    To that end, she offers her “EMPOWER” framework:

    • Embrace the challenge of living solo
    • Manage money mindfully while welcoming desires
    • Prioritize vitality and live a vibrant life
    • Own your identity; build resilience and confidence
    • Weave bonds: build and maintain relationships (solo doesn’t mean lacking connections!
    • Energize yourself and discover new passions
    • Renew yourself and create a joyful environment

    Now, as listed, those may seem a little vague, but rest assured she goes into great detail in the book, with a whole chapter for each.

    For example, prioritizing vitality and energizing oneself can seem like a double-up, but the former chapter is about healthy living in the context of the solo life, while the latter chapter is more about avocation lifelong learning, overcoming fear of the unknown, and making sure to actually live this one precious life, not just go through the motions.

    The style is energetic and motivational, and yet backed up with 19 pages of scientific references.

    Bottom line: this book is, in essence, a roadmap for aging solo and creating the future we deserve, on our own terms. An enjoyable, practical, and uplifting read!

    Click here to check out Aging Solo, and thrive as a “Soloist”!

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  • Life Extension Multivitamins vs Centrum Multivitamins – Which is Healthier

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing Life Extension Multivitamins to Centrum Multivitamins, we picked the Life Extension.

    Why?

    The clue here was on the label: “two per day”. It’s not so that they can sell extra filler! It’s because they couldn’t fit it all into one.

    While the Centrum Multivitamins is a (respectably) run-of-the-mill multivitamin (and multimineral) containing reasonable quantities of most vitamins and minerals that people supplement, the Life Extension product has the same plus more:

    • More of the vitamins and minerals; i.e. more of them are hitting 100%+ of the RDA
    • More beneficial supplements, including:
      • Inositol, Alpha lipoic acid, Bio-Quercetin phytosome, phosphatidylcholine complex, Marigold extract, Apigenin, Lycopene, and more that we won’t list here because it starts to get complicated if we do.

    We’ll have to write some main features on some of those that we haven’t written about before, but suffice it to say, they’re all good things.

    Main take-away for today: sometimes more is better; it just necessitates then reading the label to check.

    Want to get some Life Extension Multivitamins (and/or perhaps just read the label on the back)? Here they are on Amazon

    PS: it bears mentioning, since we are sometimes running brands against each other head-to-head in this section: nothing you see here is an advertisement/sponsor unless it’s clearly marked as such. We haven’t, for example, been paid by Life Extension or any agent of theirs, to write the above. It’s just our own research and conclusion.

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  • Are You A Calorie-Burning Machine?

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    Burn, Calorie, Burn

    In Tuesday’s newsletter, we asked you whether you count calories, and got the above-depicted, below-described set of answers:

    • About 56% said “I am somewhat mindful of calories but keep only a rough tally”
    • About 32% said “I do not count calories / I don’t think it’s important for my health”
    • About 13% said “I rigorously check and record the calories of everything I consume”

    So what does the science say, about the merits of all these positions?

    A food’s calorie count is a good measure of how much energy we will, upon consuming the food, have to use or store: True or False?

    False, broadly. It can be, at best, a rough guideline. Do you know what a calorie actually is, by the way? Most people don’t.

    One thing to know before we get to that: there’s “cal” vs “kcal”. The latter is generally used when it comes to foodstuffs, and it’s what we’ll be meaning whenever we say “calorie” here. 1cal is 1/1000th of a kcal, that’s all.

    Now, for what a calorie actually is:

    A calorie is the amount of energy needed to raise the temperature of 1 liter of water by 1℃

    Question: so, how to we measure how much food is needed to do that?

    Answer: by using a bomb calorimeter! Which is the exciting name for the apparatus used to literally burn food and capture the heat produced to indeed raise the temperature of 1 liter of water by 1℃.

    If you’re having trouble imagining such equipment, here it is:

    Bomb Calorimeter: Definition, Construction, & Operation (with diagram and FAQs)

    The unfortunate implication of the above information

    A kilogram of sawdust contains about a 1000 kcal, give or take what wood was used and various other conditions.

    However, that does not mean you can usefully eat the sawdust. In other words:

    Calorie count tells us only how good something is at raising the temperature of water if physically burned.

    Now do you see why oils and sugars have such comparably high calorie counts?

    And while we may talk about “burning calories” as a metaphor, we do not, in fact, have a little wood stove inside us burning the food we eat.

    A calorie is a calorie: True or False?

    Definitely False! Building on from the above… We will get very little energy from sawdust; it’s not just that we can’t use it; we can’t store it either; it’ll mostly pass through as fiber.

    (however, please do not use sawdust to get your daily dose of fiber either, as it is not safe for human consumption and may give you diseases, depending on what is lurking in it)

    But let’s look at oil and sugar, two very high-calorie categories of food, because they’re really easy to physically burn and they give off a good flame.

    A bomb calorimeter may treat them quite equally, but to our body, they are metabolically very different indeed.

    For a start, most sugars will get absorbed and processed much more quickly than most oils, and that can overwhelm the liver (responsible for glycogen management), and lead to non-alcoholic fatty liver disease, diabetes, and more. Metabolic syndrome in general, and if you keep it up too much and you may find it’s now a lottery between dying of NAFLD, diabetes, or heart disease (it’ll usually be the heart disease that kills).

    See also:

    Meanwhile, we know all about the different kinds of nutritional profiles that oils can have, and some can promote having high energy without putting on fat, while others can strain the heart. Not even “a fat is a fat”, so “a calorie is a calorie” doesn’t get much mileage outside of a bomb calorimeter!

    See also:

    A calorie-controlled / calorie-restricted diet is an effective weight loss strategy: True or False?

    True, usually! Surprise!

    • On the one hand: calories are a wildly imprecise way to reckon the value of food, and using them as a guide to health can be dangerously misleading
    • On the other hand: the very activity of calorie-counting itself promotes mindful eating, which is very good for the health

    There is a strong difference between the mind of somebody who is carefully logging their pre-bedtime piece of chocolate and reflecting on its nutritional value, vs someone who isn’t sure whether this is their second or third glass of wine, nor how much the glass contained.

    So if you want to get most of the benefits of a calorie-controlled diet without counting calories, you may try taking a “mindful eating” approach to diet.

    However! If you want to do this for weight loss, be aware, that you will have to practice it all the time, not just for one meal here and there.

    You can read more on how to do “mindful eating” here:

    Dr. Rupy Aujla: The Kitchen Doctor | Mindful Eating & Interoception

    Take care!

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  • Come As You Are – by Dr. Emily Nagoski

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve all heard the jokes, things like: Q: “Why is the clitoris like Antarctica?” A: “Most men know it’s there; most don’t give a damn”

    But… How much do people, in general, really know about the anatomy and physiology of sexual function? Usually very little, but often without knowing how little we know.

    This book looks to change that. Geared to a female audience, but almost everyone will gain useful knowledge from this.

    The writing style is very easy-to-read, and there are “tl;dr” summaries for those who prefer to skim for relevant information in this rather sizeable (400 pages) tome.

    Yes, that’s “what most people don’t know”. Four. Hundred. Pages.

    We recommend reading it. You can thank us later!

    Get your copy of Come As You Are from Amazon today!

    Don’t Forget…

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