A Supplement To Rival St. John’s Wort Against Depression

10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

Do You Feel The SAMe?

S-Adeonsyl-L-Methionone (SAMe) is a chemical found naturally in the body, and/but enjoyed widely as a supplement. The main reasons people take it are:

  • Improve mood (antidepressant effect)
  • Improve joints (reduce osteoarthritis symptoms)
  • Improve liver (detoxifying effect)

Let’s see what the science says for each of those claims…

Does it improve mood?

It seems to perform comparably to St. John’s Wort (which is good; it performs comparably to Prozac).

Best of all, it does this with fewer contraindications (St. John’s Wort has so many contraindications).

Here’s how they stack up:

St. John’s wort and S-Adenosyl Methionine as “natural” alternatives to conventional antidepressants in the era of the suicidality boxed warning: what is the evidence for clinically relevant benefit?

This looks very promising, though it’d be nice to see a larger body of research, to be sure.

Does it reduce osteoarthritis symptoms?

The good news: it performs comparably to ibuprofen, with fewer side effects!

The bad news: it also performs comparably to placebo!

Read into that what you will about ibuprofen’s usefulness vs OA symptoms.

Read all about it:

S-Adenosylmethionine for osteoarthritis of the knee or hip

If you were hoping for something for OA or similar symptoms, you might like our previous main features:

Does it help against liver disease?

According to adverts for SAMe: absolutely!

According to science: we don’t know

The science for this is so weak that it’d be unworthy of mention if it weren’t for the fact that SAMe is so widely sold as good against hepatotoxicity.

To be clear: maybe it really is great! Science hasn’t yet disproved its usefulness either.

It is popularly assumed to be beneficial due to there being an association between lower levels of SAMe in the body (remember, it is also produced inside our bodies) and development of liver disease, especially cholestasis.

Here’s an example of what pretty much every study we found was like (inconclusive research based mostly on mice):

S-adenosylmethionine in liver health, injury, and cancer

For other options for liver health, consider:

How To Unfatty A Fatty Liver

Is it safe?

Safety trials have been done ranging from 3 months to 2 years, with no serious side effects coming to light. So, it appears quite safe.

That said, as with anything, there are contraindications, such as:

  • if you have bipolar disorder, skip this unless directed by your health care provider, because it may worsen the symptoms of mania
  • if you are on SSRIs or other serotonergic drugs, it may interact with those
  • if you are immunocompromised, you might want to skip it can increase the risk of P. carinii growth in such cases

As always, do speak with your doctor/pharmacist for personalized advice.

Summary

SAMe’s evidence-based qualities seem to stack up as follows:

  • Against depression: good
  • Against osteoarthritis: weak
  • Against liver disease: unknown

As for safety, it has been found quite safe for most people.

Where can I get it?

We don’t sell it, but here is an example product on Amazon, for your convenience

Enjoy!

Don’t Forget…

Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

Recommended

  • Creatine: Very Different For Young & Old People
  • Psychology Sunday: Family Estrangement & How To Fix It
    Family estrangement is a common issue, with over 43% of people experiencing it. Understanding what went wrong and taking responsibility are key steps in reconciliation.

Learn to Age Gracefully

Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:

  • Fennel vs Onion – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing fennel to onion, we picked the fennel.

    Why?

    First note, in case you didn’t see the picture: we are talking about white onions here (also called brown onions, by virtue of their attire).

    Looking at the macros, fennel has nearly 2x the fiber and a little more protein, while onion has more carbs. An easy win in this category for the fennel.

    In the category of vitamins, fennel has more of vitamins A, B2, B3, B5, B9, C, E, K, and choline (most of them by generous margins and some by especially large margins, we are talking, for example, 480x the vitamin A, 29x the vitamin E, and 157x the vitamin K), while onions have more of vitmains B1 and B6. Another clear win for fennel.

    When it comes to minerals, fennel has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc, while onion is not higher in any minerals. No prizes for guessing: fennel wins this category too.

    You may be curious as to how they add up on the polyphenol front, and the answer is, they don’t, much. Wonderful as these two vegetables are, an abundance of polyphenols is not amongst their strengths; fennel has some lignans and onion has some flavonols, but we’re talking tiny numbers here (in contrast, red onion would have aced it with 120mg/100g quercetin, amongst others, but red onion wasn’t on trial today).

    Adding up the sections makes a clear win for fennel today.

    Want to learn more?

    You might like to read:

    What’s Your Plant Diversity Score?

    Take care!

    Share This Post

  • Leek vs Scallions – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing leek to scallions, we picked the leek.

    Why?

    In terms of macros, scallions might have a point: scallions have the lower glycemic index, thanks to leek having more carbs for the same amount of fiber. That said, leek already has a low glycemic index, so this is not a big deal.

    When it comes to vitamins, leek has more of vitamins B1, B2, B3, B5, B6, B9, E, and choline, while scallions have more of vitamins A, C, and K. Noteworthily, a cup of chopped leek already provides the daily dose of vitamins A and K, and the difference in levels of vitamin C is minimal. All in all, an easy 8:3 win for leeks here, even without taking that into account.

    In the category of minerals, leek has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, and selenium, while scallions have a little more zinc.

    Both of these allium-family plants (i.e., related to garlic) have an abundance of polyphenols, especially kaempferol.

    Of course, enjoy whatever goes best with your meal, but if you’re looking for nutritional density, then leek is where it’s at.

    Want to learn more?

    You might like to read:

    The Many Health Benefits Of Garlic

    Take care!

    Share This Post

  • Metabolic Health Roadmap – by Brenda Wollenberg

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The term “roadmap” is often used in informative books, but in this case, Wollenberg (a nutritionist with decades of experience) really does deliver what can very reasonably be described as a roadmap:

    She provides chapters in the form of legs of a journey [to better metabolic health], and those legs are broadly divided into an “information center” to deliver new information, a “rest stop” for reflection, “roadwork” to guide the reader through implementing the information we just learned, in a practical fashion, and finally “traveller assistance” to give additional support / resources, as well as any potential troubleshooting, etc.

    The information and guidance within are all based on very good science; a lot is what you will have read already about blood sugar management (generally the lynchpin of metabolic health in general), but there’s also a lot about leveraging epigenetics for our benefit, rather than being sabotaged by such.

    There’s a little guidance that falls outside of nutrition (sleep, exercise, etc), but for the most part, Wollenberg stays within her own field of expertise, nutrition.

    The style is idiosyncratic; it’s very clear that her goal is providing the promised roadmap, and not living up to any editor’s wish or publisher’s hope of living up to industry standard norms of book formatting. However, this pays off, because her delivery is clear and helpful while remaining personable and yet still bringing just as much actual science, and this makes for a very pleasant and informative read.

    Bottom line: if you’d like to improve your metabolic health, as well as get held-by-the-hand through your health-improvement journey by a charming guide, this is very much the book for you!

    Click here to check out the Metabolic Health Roadmap, and start taking steps!

    Share This Post

Related Posts

  • Creatine: Very Different For Young & Old People
  • 15 Easy Japanese Habits That Will Transform Your Health

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The original title says “no-cost habits”, but in fairness, for most of us food is not usually free (alas). So, we will say “easy” instead, because they are indeed easy to build into your life:

    15 Healthy Habits To Adopt

    We’ll not keep them a mystery; they are:

    1. Intermittent fasting: naturally fasting for at least 12 hours overnight improves digestion and sleep quality.
    2. Fermented foods: regularly consuming fermented foods (like kimchi, or even just sauces like miso and shio koji) supports gut health.
    3. Rice & legumes over wheat: choosing wholegrain rice as a staple reduces bloating and benefits skin health (lentils are even better).
    4. Big breakfast, light dinner: eating a heavier breakfast and a lighter dinner gives energy in the morning and allows digestion to rest at night.
    5. Balancing indulgences: enjoying social meals without guilt and balancing food intake the next day.
    6. Daily gentle exercise: doing at least 15 minutes of yoga, Pilates, or light walking for long-term health.
    7. Daily baths: taking a warm bath boosts blood circulation and relaxation.
    8. Eating seasonal & diverse foods: including a variety of fresh, seasonal ingredients for balanced nutrition.
    9. Consistent morning routine: waking up at the same time, cleansing and moisturizing, and having a proper breakfast.
    10. Enjoying soup with meals: consuming nutrient-rich soups with vegetables and protein to prevent overeating.
    11. Chewing food thoroughly: eating slowly and chewing well aids digestion and enhances enjoyment.
    12. Light seasoning in food: avoiding overly salty or flavorful meals to appreciate natural tastes.
    13. Maintaining good posture: paying attention to posture during daily activities for better overall health.
    14. Prioritizing protein intake: eating protein-rich foods like tofu, beans, eggs, and fish, to maintain skin firmness as well as muscletone.
    15. Confidence in aging: focusing on internal well-being over external opinions and embracing health at every age.

    For more on each of these, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    What’s Your Ikigai?

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:

  • The Happy Menopause – by Jackie Lynch

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The author, a nutritionist, takes the approach that just as no two menopauses are exactly the same, how it is managed needs to be personalized too.

    Thus, rather than simply “do this, do that”, she sets about talking the reader through identifying what things are likely to influence what symptoms, and then then actually testing them to see if a given adjustment is helpful or not. Lest this sound like a lot of work, she does invariably start from a place of “Most women…”, which means that on average, the reader will still get the right thing first try. However, in the cases of not being average, this book has the less common cause-and-effect pairings down as well. To this end, the book is mostly arranged by symptom, so it’s quite easy to find a particular thing one might be looking to fix.

    As for HRT, she takes the very respectable position that she is a nutritionist and as such, that matter is not her wheelhouse, and so she restrains herself to her own field of expertise, nutrition. Her intent is that the information in this book should be useful to all, HRT or no HRT.

    The style is very light pop science, making this very easily readable and comprehensible to all.

    Bottom line: if you have unwanted menopause symptoms, and would like to not be suffering from those, this book offers a natural approach, so give it a try!

    Click here to check out The Happy Menopause, and menopause happily!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:

  • Fully Present – by Dr. Susan Smalley and Diana Winston

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    “The Science and the Art of…” tends to be a bit of a fuzzy obfuscation, but in this case, it’s accurate, especially in this presentation. The authors are, indeed, a scientist and an artist—and both practitioners, meeting in the middle.

    As such, we get the clinical insights of a researcher and professor of psychiatry, and the grounded-yet-spiritual insights of an erstwhile Buddhist nun.

    While the book is pop psychology in essence, the format is much more that of a textbook than a self-help book. Will it be useful for helping yourself anyway, though? Yes, absolutely, if you apply the information contained within.

    Don’t be fooled into thinking that a textbook format makes it dry, though—the writing is very compelling, and you’ll find yourself turning pages eagerly. There’s no time like the present, after all!

    Bottom line: if you find the scientific evidence-base for the usefulness of mindfulness appealing, but find a lot of guides a little fluffy, this one is perfectly balanced—and very well written, too.

    Click here to check out Fully Present, bring yourself into the moment, always!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails: