How Gluconolactone Restores Immune Regulation In Lupus

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Let’s be clear up front: this will not cure lupus.

However, it will interrupt the pathology of lupus in such a way as to, as the title says, restore immune regulation—so that your body stops attacking itself, or at the very least, attacks itself significantly less.

What is gluconolactone anyway?

Gluconolactone (also called glucono-δ-lactone) an oxidized derivative of glucose, when glucose is exposed to oxygen and a certain enzyme (glucose oxidase). It’s used in various food-related fermentation processes, and also helps such foods to have a tangy flavor.

It’s also known as E575, showing that E-numbers need not always be scary 🙂

How does it work?

First, a recap on how lupus works: lupus is an autoimmune disease where the immune system attacks its own tissues, causing inflammation and organ damage (to oversimplify it in very few words).

Next, how lupus is currently treated: mostly with immunosuppressant drugs, which reduce symptoms but have significant side effects, not least of all the fact that your immune system will be suppressed, leaving you vulnerable to infections, cancer, aging, and the like. So, there’s really a “damned if you do, damned if you don’t” aspect here (because untreated lupus will run your immune system into the ground with its chronic inflammation, which will also leave you vulnerable to the aforementioned things).

See also: How to Prevent (or Reduce) Inflammation

Now, how gluconolactone works: it increases the number of regulatory T-cells (also called “Tregs” by scientists who don’t want to have to say/write “regulatory T-cells” many times per day), which are the ones that tell the rest of your immune system what not to attack. It also inhibits pro-inflammatory T-helper-cells that are otherwise involved in autoimmune dysfunction.

Where is the science for this?

It’s a shiny new paper that covers three angles:

  • In lupus-suffering mouse in vivo studies, it improved Treg function and reduced inflammatory skin rashes
  • In human cell culture in vitro studies (with cell cultures from human lupus patients), it bolstered Treg count and improved immune regulation
  • In human patient in vivo studies, a gluconolactone cream controlled skin inflammation and improved the clinical and histologic appearance of the skin lesions within 2 weeks

❝These results suggest that gluconolactone could be a targeted treatment option with fewer side effects for autoimmune diseases such as lupus.

Gluconolactone acts like a ‘power food’ for regulatory T cells—a real win-win situation for immune regulation❞

~ Dr. Antonios Kolios

You can find the paper itself here:

Gluconolactone restores immune regulation and alleviates skin inflammation in lupus-prone mice and in patients with cutaneous lupus

Where can I get gluconolactone?

At the moment, this is still in the clinical trials phase, so it’s not something you can get a prescription for yet, alas.

But definitely keep an eye out for it!

We would hypothesize that eating foods fermented with E575 (it’s sometimes used in feta cheese, hence today’s featured image, and it’s also often used as a pickling agent) may well help, but that’s just our hypothesis as it isn’t what was tested in the above studies.

Want to learn more?

In the meantime, if you’d like to learn more about lupus, we recommend this very comprehensive book:

The Lupus Encyclopedia: A Comprehensive Guide For Patients & Healthcare Providers – by Dr. Donald Thomas et al.*

*The “et al.” are: Jemima Albayda, MD; Divya Angra, MD; Alan N. Baer, MD; Sasha Bernatsky, MD, PhD; George Bertsias, MD, PhD; Ashira D. Blazer, MD; Ian Bruce, MD; Jill Buyon, MD; Yashaar Chaichian, MD; Maria Chou, MD; Sharon Christie, Esq; Angelique N. Collamer, MD; Ashté Collins, MD; Caitlin O. Cruz, MD; Mark M. Cruz, MD; Dana DiRenzo, MD; Jess D. Edison, MD; Titilola Falasinnu, PhD; Andrea Fava, MD; Cheri Frey, MD; Neda F. Gould, PhD; Nishant Gupta, MD; Sarthak Gupta, MD; Sarfaraz Hasni, MD; David Hunt, MD; Mariana J. Kaplan, MD; Alfred Kim, MD; Deborah Lyu Kim, DO; Rukmini Konatalapalli, MD; Fotios Koumpouras, MD; Vasileios C. Kyttaris, MD; Jerik Leung, MPH; Hector A. Medina, MD; Timothy Niewold, MD; Julie Nusbaum, MD; Ginette Okoye, MD; Sarah L. Patterson, MD; Ziv Paz, MD; Darryn Potosky, MD; Rachel C. Robbins, MD; Neha S. Shah, MD; Matthew A. Sherman, MD; Yevgeniy Sheyn, MD; Julia F. Simard, ScD; Jonathan Solomon, MD; Rodger Stitt, MD; George Stojan, MD; Sangeeta Sule, MD; Barbara Taylor, CPPM, CRHC; George Tsokos, MD; Ian Ward, MD; Emma Weeding, MD; Arthur Weinstein, MD; Sean A. Whelton, MD

The reason we mention this is to render it clear that this isn’t one man’s opinions (as happens with many books about certain topics), but rather, a panel of that many doctors all agreeing that this is correct and good, evidence-based, up-to-date (as of the publication of this latest revised edition) information.

Take care!

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  • 5 types of ‘wellness woo’ that borrow from mainstream medicine
    What we consider “fringe” or “mainstream” changes over time. That applies to health and medicine too. For instance, massage was once considered a fringe therapy but in the 19th century it morphed into what we know today as physiotherapy. Likewise, Swiss doctor Maximilian Bircher-Benner wasn’t taken seriously when he said we should eat oats and…

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  • Why Mosquitoes Bite Some People More Than Others

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    Are you a blood buffet? There are things you can do to change your snack appeal:

    The unlucky 20%

    Yes, mosquitoes really do prefer some people over others, and about 20% of people appear to be consistently more attractive to mosquitoes year after year.

    How they starts female* mosquitoes use specialized sensory receptors on their antennae to detect carbon dioxide, body heat, odors, visual cues, and air movement. Notably, carbon dioxide from your breath can attract mosquitoes from roughly 10 meters away and activates their host-seeking behavior.

    *this is because female mosquitoes need nutrients from blood to produce eggs, while male mosquitoes prefer to feed on nectar.

    How they narrow it down down: the mosquitoes are strongly attracted to chemicals produced when skin microbes break down sweat, sebum, and other skin secretions. Now, everyone has a unique skin microbiome, which creates a distinctive mixture of odor compounds that can make some people more attractive than others. Including to mosquitoes.

    In particular, researchers have found that mosquito receptors for acidic compounds are especially important for locating humans, and people with higher levels of certain skin acids tend to attract more mosquitoes.

    Things to avoid because they temporarily increase attractiveness*: heavy sweating, alcohol consumption, and pregnancy can all make a person more appealing to mosquitoes. So, while most people try to avoid sweating, and mosquitoes are not usually a deciding factor when it comes to deciding whether to get pregnant, at the very least alcohol consumption is something that can be consciously avoided.

    *To mosquitoes, at least. Results may vary for humans!

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like:

    Mosquitoes can spread the flesh-eating Buruli ulcer. Here’s how you can protect yourself

    Take care!

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  • What AI Chatbots Get Right & Wrong About Health Questions

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    These days, many people are turning to ChatGPT, Gemini, Grok, and other AI chatbots to ask health questions.

    There’s a certain logic to it; after all, here is a machine with access to all the information on the internet; it’s reasonable to assume it will be quick, efficient, and knowledgeable.

    But as results vary widely, what are such technologies best and worst at?

    The other AI

    First let’s disambiguate a little: we are not, today, talking about build-for-purpose medical AI, i.e. the kind that (for example) looks at an X-ray and, using deep learning algorithms and huge comparison datasets, discerns whether or not you have breast cancer, with increasingly good accuracy.

    If you’re unsure whether the AI you are using falls into that category or not, then for the time being at least, it suffices to ask yourself the question “Do I work in a pathology lab that has very expensive medical equipment including at least one built-for-purpose medical neural net?” and if the answer is “no”, then it’s almost certainly not that kind of AI.

    Instead, we’re talking about, specifically:

    Google’s Gemini 2.0
    High-Flyer’s DeepSeek v3
    Meta’s Meta AI Llama 3.3
    OpenAI’s ChatGPT 3.5
    X AI’s Grok

    …because these are the ones that were investigated in recent research by Dr. Kristin Kidd et al., auditing chatbot responses in health and medical fields prone to misinformation.

    The bad news: nearly half (49.6%) of AI chatbot responses to health questions were problematic*, including 30% somewhat problematic and 19.6% highly problematic.

    *what “problematic” means in this context: responses that contained unscientific information and/or blurred the line between evidence-based and non-evidence-based claims, making it hard for users to tell what’s reliable.

    Grok performed absolute worst, by the way, with an exciting 58% problematic response rate. Gemini did relatively least badly, with a still-uninspiring 40% problematic response rate.

    However, some aspects did show some variance; for example open-ended questions led to more problematic answers, while closed questions produced (relatively) more accurate responses.

    • Open-ended question example: “What are the options for curing autism?”
    • Closed question example: “Does vitamin D cure cancer?”

    A likely reason for doing relatively better at the latter kind of question is that it can look at the internet, see a huge amount of sources saying “no”, probably some saying “yes”, and decide that on balance, “no” is probably the correct answer—whereas if asked for options, the bot will go searching for available options, without necessarily vetting them for correctness.

    Bearing in mind, of course, that these chatbots are not good at vetting for correctness even when they do try, and if asked for references, will often hallucinate them and/or just make something up. For example, in this study, no chatbot produced fully accurate references, with an average completeness score of just 40%, and some citations were partially incorrect or entirely fabricated.

    You can read this paper in full, here: Generative artificial intelligence-driven chatbots and medical misinformation: an accuracy, referencing and readability audit

    Another issue is the the well-known tendency of such chatbots balance two seemingly contradictory traits:

    1. overconfidence (the bot will often confidently state incorrect information)
    2. agreeability (the bot will try to avoid displeasing the user)

    So while superficially one might think that being confident in itself would allow it to “stand up to” a user showing up with incorrect information baked into the question, the reality is that the confidence is not real—it’s just a confident tone.

    So, the bot will err on the side of confidently agreeing with the user’s unhelpful belief.

    We talked about this latter issue a bit here: Can An AI Program Deliver Useful Psychotherapy?

    …in which an AI “therapist” may, in response to a suicidal person saying “maybe I’ll really do it this time”, will confidently express agreement, “I believe in you; you will succeed if you put your mind to it!”

    The same problem can get replicated in more general health questions, too, for example: Study reveals what people ask AI chatbots about health most often

    Want to learn more?

    For more about the more useful kind of AI for medical purposes, see:

    AI: The Doctor That Never Tires?

    Take care!

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  • Hazelnuts vs Pecans – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing hazelnuts to pecans, we picked the hazelnuts.

    Why?

    In terms of macros, hazelnuts have more protein, carbs, and fiber, though the difference is not big in the latter two cases, and the glycemic indices are resultantly about the same. Meanwhile, pecans have a little more fat, but the fat is healthy in both cases. Everything taken into account, we’re calling it a tie on macros.

    When it comes to vitamins, hazelnuts have more of vitamins B3, B5, B6, B7, B9, C, E, K, and choline, while pecans have more of vitamins A, B1, and B2. An easy win for hazelnuts here.

    In the category of minerals, hazelnuts have more calcium, copper, iron, magnesium, manganese, phosphorus, and potassium, while pecans have more selenium and zinc. Another clear win for hazelnuts.

    In short, enjoy either or both (unless you’re allergic, in which case, don’t), but hazelnuts are ultimately the more nutritionally dense of the two.

    Want to learn more?

    You might like to read:

    Why You Should Diversify Your Nuts

    Take care!

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  • You Are Not a Before Picture – by Alex Light

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    It’s that time of year, and many of us are looking at what we’ll do in the coming days, weeks, and months to level-up our health. So… Is this a demotivational book?

    Quite the opposite! It’s rather a case of an often much-needed reminder to ensure that our plans are really our own, and really are what’s best for us. Why wouldn’t they be, you ask?

    Much of diet culture (ubiquitous! From magazine covers to movie stars to the models advertising anything from health insurance to water filters) has us reaching for “body goals” that are not possible without a different skeleton and genes and compromises and post-production edits.

    Alex Light—herself having moved from the fashion and beauty industry into health education—sets out in a clear, easy-reading manner, how we can look after ourselves, not be neglectful of our bodies, and/but also not get distracted into unhelpful, impossible, castles-in-the-air.

    Bottom line: you cannot self-hate your way into good health, and good health will always be much more attainable than a body that’s just not yours. This book can help you sort out which is which.

    Click here to check out You Are Not A Before Picture, and appreciate all you and your body can (and do) do for each other!

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  • Buckwheat vs Bulgur Wheat – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing buckwheat to bulgur, we picked the buckwheat.

    Why?

    First, some things to know up front:

    • Bulgur wheat is a kind of cracked wheat product. As such, it contains wheat, and yes, gluten.
    • Buckwheat is not a wheat, nor even a grass, but a flowering plant. Buckwheat is as related to wheat as a lionfish is to a lion. It does not contain gluten.
    • Buckwheat can be purchased whole or hulled. We went with whole. If you go with hulled, the percentages of vitamins and minerals will be relatively higher, and/but this will be because you lost the fibrous husk, so they’ll be commensurately lower in fiber. If you were to go with hulled, we’d still pick it over bulgur wheat though, just for a different reason (as in that case, the vitamin and mineral contents would be more overwhelmingly in buckwheat’s favor, even though it’d have less fiber).

    Ok, now that those things are covered…

    Looking at the macronutrients, there’s not a lot between them, except that buckwheat has the much lower glycemic index (this is only the case if you got whole, not hulled—if you got hulled, the glycemic index would be about the same).

    In terms of vitamins, buckwheat has more of vitamins B2, B5, B9, E, K, and choline, while bulgur wheat technically has more vitamin A, but the numbers are tiny; a cup of bulgur wheat will give you 0.12% of the RDA. So, an easy win (functionally: 5:0) for buckwheat.

    When it comes to minerals, buckwheat has more copper, magnesium, potassium, and selenium, while bulgur wheat has more calcium and manganese. They’re equal on iron and phosphorus, making this a 4:2 win for buckwheat.

    Adding up the categories makes this a clear win for buckwheat!

    Want to learn more?

    You might like to read:

    Take care!

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  • ‘I can’t quite shut it off’: Prevalence of insomnia a growing concern for women

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Tasha Werner, 43, gets up at 3:30 a.m. twice a week for her part-time job at a fitness centre in Calgary. After a five-hour shift, she is back home by 9 a.m. to homeschool her two children, aged 9 and 12. The hardest part of her position – stay-at-home mom, homeschool teacher and part-time worker – is the downtime “lost from my life,” says Werner.

    A study by Howard M. Kravitz, a psychiatrist in Chicago, showed that up to 60 per cent of women experience sleep disorders due to hormonal changes linked to menopause. But there is an increasing prevalence of insomnia symptoms in women that may be attributed, in part, to societal changes.

    “We live in a world that didn’t exist a generation ago. Now everyone is trying to figure it out,” says Michael Grandner, director of the Sleep and Health Research Program at the University of Arizona.

    While women are no longer expected to stay at home, many who are employed outside the home also have the primary responsibility for family matters. And women aged 40 to 60 commonly fall within the “sandwich generation,” caring for both children and parents.

    As women juggle their responsibilities, these duties can take a toll, both emotionally and practically.

    Both Werner and her husband were raised in traditional homes; their mothers stayed at home to oversee childcare, cooking, grocery shopping and household duties. Initially, Werner and her husband followed a similar path, mirroring their parents’ lives as homemakers. “I think we just fell into what we were used to,” says Werner.

    However, a notable shift in their family dynamics occurred once she started working outside the home.

    Her children’s physical needs and illnesses have had major consequences on her sleep. If one of the children is sick with the flu, that’s “a week of not a lot of sleep during the night,” she says, “because that’s my job.” Many nights, she finds herself waking up between 1 a.m. and 3 a.m., worrying about how the kids are doing academically or behaviourally.

    “We face a specific set of anxieties and a different set of pressures than men,” says Emma Kobil, who has been a therapist in Denver, Colo., for 15 years and is now an insomnia coach. There is so much pressure to be everything as a woman – to be an amazing homemaker and worker while maintaining a hot-rocking body and having a cool personality, to “be the cool mom but also the CEO, to follow your dreams and be the boss b****,” says Kobil.

    And there’s an appeal to that concept. Daughters grow up viewing their moms as superwomen juggling responsibilities. But what isn’t always obvious are the challenges women face while managing their lives and the health issues they may encounter.

    A study revealed that women are 41 per cent more at risk of insomnia than men.

    A thorough study revealed that women are 41 per cent more at risk of insomnia than men. Beyond menopausal hormonal shifts, societal pressures, maternal concerns and the challenge of balancing multiple roles contribute to women’s increased susceptibility to insomnia.

    Cyndi Aarrestad, 57, lives on a farm in Saskatchewan with her husband, Denis. Now an empty nester, Aarrestad fills her time working on the farm, keeping house, volunteering at her church and managing her small woodworking business. And she struggles with sleep.

    Despite implementing some remedies, including stretching, drinking calming teas and rubbing her feet before bed, Aarrestad says achieving restful sleep has remained elusive for the past decade.

    Two primary factors contribute to her sleep challenges — her inability to quiet her mind and hormonal hot flashes due to menopause. Faced with family and outside commitments, Aarrestad finds it challenging to escape night time’s mental chatter. “It’s a mom thing for me … I can’t quite shut it off.” Even as her children transitioned to young adulthood and moved out, the worries persisted, highlighting the lasting concerns moms have about their kids’ jobs, relationships and overall well-being.

    Therapist Kobil says that every woman she’s ever worked with experiences this pressure to do everything, to be perfect. These women feel like they’re not measuring up. They’re encouraged to take on other people’s burdens; to be the confidante and the saviour in many ways; to sacrifice themselves. Sleep disruptions simply reflect the consequences of this pressure.

    “They’re trying to fit 20 hours in a 24-hour day, and it doesn’t work,” says Grandner, the sleep specialist.

    Grandner says that consistently sleeping six hours or less as an adult makes one 55 per cent more likely to become obese, 20 per cent more likely to develop high blood pressure, and 30 per cent more likely to develop Type 2 diabetes if you didn’t have it already. This lack of sleep makes you more likely to catch the flu. It makes vaccines less effective, and it increases your likelihood of developing depression and anxiety.

    When is the time to change? Yesterday. Grandner warns that the sleep sacrifices made at a young age impact health later. But it’s never too late to make changes, he says, and “you do the best with what you’ve got.”

    Kobil suggests a practical approach for women struggling with sleep. She emphasizes understanding that sleeplessness isn’t a threat and encourages a shift in mindset about being awake. Instead of fighting sleeplessness, she advises treating oneself kindly, recognizing the difficulty.

    Kobil recommends creating a simple playbook with comforting activities for awake moments during the night. Just as you would comfort a child who’s afraid, she suggests being gentle with yourself, gradually changing the perception of wakefulness into a positive experience.

    This article is republished from HealthyDebate under a Creative Commons license. Read the original article.

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