
From immunotherapy to mRNA vaccines – the latest science on melanoma treatment explained
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More than 16,000 Australians will be diagnosed with melanoma each year. Most of these will be caught early, and can be cured by surgery.
However, for patients with advanced or metastatic melanoma, which has spread from the skin to other organs, the outlook was bleak until the advent of targeted therapies (that attack specific cancer traits) and immune therapies (that leverage the immune system). Over the past decade, these treatments have seen a significant climb in the number of advanced melanoma patients surviving for at least five years after diagnosis, from less than 10% in 2011 to around 50% in 2021.
While this is great news, there are still many melanoma patients who cannot be treated effectively with current therapies. Researchers have developed two exciting new therapies that are being evaluated in clinical trials for advanced melanoma patients. Both involve the use of immunotherapy at different times and in different ways.
The first results from these trials are now being shared publicly, offering insight into the future of melanoma treatment.

Immunotherapy before surgery
Immunotherapy works by boosting the power of a patient’s immune system to help kill cancer cells. One type of immunotherapy uses something called “immune checkpoint inhibitors”.
Immune cells carry “immune checkpoint” proteins, which control their activity. Cancer cells can interact with these checkpoints to turn off immune cells and hide from the immune system. Immune checkpoint inhibitors block this interaction and help keep the immune system activated to fight the cancer.
Results from an ongoing phase 3 trial using immune checkpoint inhibitors were recently published in the New England Journal of Medicine.
This trial used two types of immune checkpoint inhibitors: nivolumab, which blocks an immune checkpoint called PD-1, and ipilimumab, which blocks CTLA-4.

Some 423 patients (including many from Australia) were enrolled in the trial, and participants were randomly assigned to one of two groups.
The first group had surgery to remove their melanoma, and were then given immunotherapy (nivolumab) to help kill any remaining cancer cells. Giving a systemic (whole body) therapy such as immunotherapy after surgery is a standard way of treating melanoma. The second group received immunotherapy first (nivolumab plus ipilimumab) and then underwent surgery. This is a new approach to treating these cancers.
Based on previous observations, the researchers had predicted that giving patients immunotherapy while the whole tumour was still present would activate the tumour-fighting abilities of the patient’s immune system much better than giving it once the tumour had been removed.
Sure enough, 12 months after starting therapy, 83.7% of patients who received immunotherapy before surgery remained cancer-free, compared to 57.2% in the control group who received immunotherapy after surgery.
Based on these results, Australian of the year Georgina Long – who co-led the trial with Christian Blank from The Netherlands Cancer Institute – has suggested this method of immunotherapy before surgery should be considered a new standard of treatment for higher risk stage 3 melanoma. She also said a similar strategy should be evaluated for other cancers.
The promising results of this phase 3 trial suggest we might see this combination treatment being used in Australian hospitals within the next few years.
mRNA vaccines
Another emerging form of melanoma therapy is the post-surgery combination of a different checkpoint inhibitor (pembrolizumab, which blocks PD-1), with a messenger RNA vaccine (mRNA-4157).
While checkpoint inhibitors like pembrolizumab have been around for more than a decade, mRNA vaccines like mRNA-4157 are a newer phenomenon. You might be familiar with mRNA vaccines though, as the biotechnology companies Pfizer-BioNTech and Moderna released COVID vaccines based on mRNA technology.
mRNA-4157 works basically the same way – the mRNA is injected into the patient and produces antigens, which are small proteins that train the body’s immune system to attack a disease (in this case, cancer, and for COVID, the virus).
However, mRNA-4157 is unique – literally. It’s a type of personalised medicine, where the mRNA is created specifically to match a patient’s cancer. First, the patient’s tumour is genetically sequenced to figure out what antigens will best help the immune system to recognise their cancer. Then a patient-specific version of mRNA-4157 is created that produces those antigens.
The latest results of a three-year, phase 2 clinical trial which combined pembrolizumab and mRNA-4157 were announced this past week. Overall, 2.5 years after starting the trial, 74.8% of patients treated with immunotherapy combined with mRNA-4157 post-surgery remained cancer-free, compared to 55.6% of those treated with immunotherapy alone. These were patients who were suffering from high-risk, late-stage forms of melanoma, who generally have poor outcomes.
It’s worth noting these results have not yet been published in peer-reviewed journals. They’re available as company announcements, and were also presented at some cancer conferences in the United States.
Based on the results of this trial, the combination of pembrolizumab and the vaccine progressed to a phase 3 trial in 2023, with the first patients being enrolled in Australia. But the final results of this trial are not expected until 2029.
It is hoped this mRNA-based anti-cancer vaccine will blaze a trail for vaccines targeting other types of cancer, not just melanoma, particularly in combination with checkpoint inhibitors to help stimulate the immune system.
Despite these ongoing advances in melanoma treatment, the best way to fight cancer is still prevention which, in the case of melanoma, means protecting yourself from UV exposure wherever possible.
Sarah Diepstraten, Senior Research Officer, Blood Cells and Blood Cancer Division, WEHI (Walter and Eliza Hall Institute of Medical Research) and John (Eddie) La Marca, Senior Research Officer, Blood Cells and Blood Cancer, WEHI (Walter and Eliza Hall Institute of Medical Research)
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Peanuts vs Pecans – Which is Healthier?
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Our Verdict
When comparing peanuts to pecans, we picked the peanuts.
Why?
Peanuts are an oft-underrated nut!
In terms of macros, peanuts have more than 2.5x the protein and slightly more carbs, while pecans have very slightly more fiber and a lot more fat, of which, mostly healthy monounsaturated and polyunsaturated fats, though it’s worth noting that peanuts’ fats are equally healthy and have a similar general profile, just, less fat per 100g than pecans do. There’s a lot going for both of these very different nuts here, so we’ll call this category a tie.
In the category of vitamins, peanuts have more of vitamins B2, B3, B5, B6, B7, B9, E, and choline, while pecans have more of vitamins C and K (of which they are still not a very good source, but peanuts have none so they can technically claim it for those two vitamins); thus, a clear win for peanuts here, especially as most of its vitamins had very large margins of difference over pecans, and peanuts are a good source of all the vitamins mentioned for them.
When it comes to minerals, peanuts have more calcium, iron, magnesium, phosphorus, potassium, and selenium, while pecans have more manganese and zinc. Another win for peanuts!
Adding up the sections makes for a clear win for peanuts, but by all means enjoy either or both (diversity is good), unless you are allergic, in which case, please don’t!
Want to learn more?
You might like:
Why You Should Diversify Your Nuts
Enjoy!
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The Toe-Tapping Tip For Better Balance
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Balance is critical for health especially in older age, since it’s amazing how much else can go dramatically and suddenly wrong after a fall. So, here’s an exercise to give great balance and stability:
How to do it
You will need:
- Something to hold onto, such as a countertop
- A target on the floor, such as a mark or a coin
The steps:
- Lift one leg up, bring your foot forward, and tap the object in front of you.
- Then, bring that foot back to where it started.
- Next, switch to the other leg and tap.
- Alternate between your right and left legs, shifting back and forth.
- Your goal is to do this for 10 repetitions on each leg without holding on.
How it works:
Whenever you tap, you have to lift one leg up and reach it out in front of you. Doing this requires you to stand on one leg while moving a weight (namely: your other leg), which is something many people, especially upon getting older, are hesitant to do. If you’re unable to stand on one leg, let alone move your center of gravity (per the counterbalance of the other leg) while doing so, you may end up shuffling and walking with your feet sliding across the ground—something you really want to avoid.
For more on all of this plus a visual demonstration, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Fall Special ← this is about not falling, or, failing that, minimizing injury if you do
Take care!
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Blueberries vs Mangos – Which is Healthier?
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Our Verdict
When comparing blueberries to mangos, we picked the mangos.
Why?
Both have their merits and it was close!
In terms of macros, blueberries have a tiny bit more fiber and mangos have slightly more protein, but the numbers are all close enough that it’s fairest to call this round a tie.
In the category of vitamins, blueberries have more of vitamins B1 and K, while mangos have more of vitamins A, B3, B5, B6, B7, B9, C, and E, winning.
Looking at minerals next, blueberries have more iron, manganese, and zinc, while mangos have more calcium, copper, magnesium, phosphorus, potassium, and selenium, winning again.
In other considerations, blueberries are higher in polyphenols, so that is a point in their favor.
Adding up the sections makes for an overall win for mangos, but as we say, both have their merits, so by all means do enjoy either or both, as diversity is best!
Want to learn more?
You might like:
21 Most Beneficial Polyphenols & What Foods Have Them
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Stop Using The Wrong Hairbrush For Your Hair Type
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When you brush your hair, you’re either making it healthier or damaging it, depending on what you’re using and how. To avoid pulling your hair out, and to enjoy healthy hair of whatever kind you have and whatever length suits you, it pays to know a little about different brushes, and the different techniques involved.
Head-to-head
Brush shapes and sizes are designed to achieve different effects in hair, not just for decoration. For example:
- Rat tail combs are excellent for parting and sectioning hair with clean lines. The rat tail part is actually more important than the comb part.
- Regular combs are multipurpose but best for use with flat irons, ensuring straighter hair for a longer time.
- Wide-tooth combs should not be used for detangling as they can cause breakage; instead, use a proper detangling brush. Speaking of detangling…
- Detangling brushes are essential for daily use. Whichever you use, start brushing from the bottom to prevent tangles from stacking and worsening. As for kinds of detangling brush:
- The “Tangle Teaser” is a good beginner option, but it may not detangle well for thicker hair.
- Wet Brush (this is a brand name, and is not about any inherent wetness) is the recommended detangling brush for most people. It can be used on wet or dry hair.
- Mason Pearson brush is a luxury detangling brush (see it here on Amazon) that works slightly more quickly and efficiently, but is expensive and not necessary for most people.
- Teasing brushes are for adding volume by backcombing—but require skill to prevent visible tangles. Best avoided for most people.
- Ceramic round brushes are the best for blow-drying, because they hold tension and help hair dry smoother and shinier.
- Blow-dryer brushes are great for easy blow-drying but should not be used on dry hair, to avoid damage.
- Denman brushes are for people with natural curls, enhancing curls without straightening them like a Wet brush would.
For more on all of these brushes, plus visual demonstrations, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
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Is Sugar The New Smoking?
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small 😎
❝Could you do a this or that of which. Is worse, smoking cigarettes or having a sweet tooth? Also, perhaps have us evaluate one part of newsletter at a time, rather than overall. I especially appreciate your book reviews and often find them through my library system.❞
We’re glad you enjoy the book reviews! We certainly enjoy reading many books to write about them for you.
As for the idea having readers evaluate one part of the newsletter at a time, rather than overall, there is a technical limitation that embedded polls are very large, data-wise, so if we were to do a poll for each section, the email would then get clipped by gmail and other email providers. However, you are always more than welcome to do as you’ve done, and include comments about what section(s) you took the most value from.
Now, onto your main question/request: as it doesn’t quite fit the usual format for our This vs That section, we’ve opted to do it as a main feature here 🙂
So, let’s get into it…
Not a zero-sum game
First, let’s be clear that for most people there is no pressing reason that this should be an either/or decision. There is nothing inherent to quitting either one that makes the other loom larger.
However, that said, if you’re (speaking generally here, and not making any presumptions about the asker) currently smoking regularly and partaking of a lot of added sugar, then you may be wondering which you should prioritize quitting first—as it is indeed generally recommended to only try to quit one thing at a time.
Indeed, we wrote previously, as a guideline for “what to do in one what order”:
Not sure where to start? We suggest this order of priorities, unless you have a major health condition that makes something else a higher priority:
- If you smoke, stop
- If you drink, reduce, or ideally stop
- Improve your diet
About that diet…
Worry less about what to exclude, and instead focus on adding more variety of fruit/veg.
See also: Level-Up Your Fiber Intake! (Without Difficulty Or Discomfort)
That said, if you’re looking for things to cut, sugar is a top candidate (and red meat is in clear second place albeit some way below)
That’s truncated from a larger list, but those were the top items.
You can read the rest in full, here: The Best Few Interventions For The Best Health: These Top 5 Things Make The Biggest Difference
The flipside of this “you can quit both” reality is that the inverse is also true: much like how having one disease makes it more likely we will get another, unhealthy habits tend to come in clusters too, as each will weaken our resolve with regard to the others. Thus, there is a sort of “comorbidity of habits” that occurs.
The good news is: the same can be said for healthy habits, so they (just like unhealthy habits) can support each other, stack, and compound. This means that while it may seem harder to quit two bad habits than one, in actual fact, the more bad habits you quit, the more it’ll become easy to quit the others. And similarly, the more good habits you adopt, the more it’ll become easy to adopt others.
See also: How To Really Pick Up (And Keep!) Those Habits
So, let’s keep that in mind, while we then look at the cases against smoking, and sugar:
The case against smoking
This is perhaps one of the easiest cases to make in the entirety of the health science world, and the only difficult part is knowing where to start, when there’s so much.
The World Health Organization leads with these key facts, on its tobacco fact sheet:
- Tobacco kills up to half of its users who don’t quit.
- Tobacco kills more than 8 million people each year, including an estimated 1.3 million non-smokers who are exposed to second-hand smoke.
- Around 80% of the world’s 1.3 billion tobacco users live in low- and middle-income countries.
- In 2020, 22.3% of the world’s population used tobacco: 36.7% of men and 7.8% of women.
- To address the tobacco epidemic, WHO Member States adopted the WHO Framework Convention on Tobacco Control (WHO FCTC) in 2003. Currently 182 countries are Parties to this treaty.
- The WHO MPOWER measures are in line with the WHO FCTC and have been shown to save lives and reduce costs from averted healthcare expenditure.
Source: World Health Organization | Tobacco
Now, some of those are just interesting sociological considerations (well, they are of practical use to the WHO whose job it is to offer global health policy guidelines, but for us at 10almonds, with the more modest goal of helping individual people lead their best healthy lives, there’s not so much that we can do with the Framework Convention on Tobacco Control, for example), but for the individual smoker, the first two are really very serious, so let’s take a closer look:
❝Tobacco kills up to half of its users who don’t quit.❞
A bold claim, backed up by at least three very large, very compelling studies:
- Mortality in relation to smoking: 50 years’ observations on male British doctors
- Tobacco smoking and all-cause mortality in a large Australian cohort study: findings from a mature epidemic with current low smoking prevalence
- Global burden of disease due to smokeless tobacco consumption in adults: an updated analysis of data from 127 countries
❝Tobacco kills more than 8 million people each year, including an estimated 1.3 million non-smokers who are exposed to second-hand smoke.❞
The WHO’s cited source for this was gatekept in a way we couldn’t access (and so probably most of our readers can’t either), but take a look at what the CDC has to say for the US alone (bearing in mind the US’s population of a little over 300,000,000, which is just 3.75% of the global population of a little over 8,000,000,000):
❝smoking causes more than 480,000 deaths [in the US] annually, with an estimated 41,000 deaths from secondhand smoke exposure, and it can reduce a person’s life expectancy by 10 years. Quitting smoking before the age of 40 reduces the risk of dying from smoking-related disease by about 90%❞
If we now remember that third bullet point, that said “Around 80% of the world’s 1.3 billion tobacco users live in low- and middle-income countries.”, then we can imagine the numbers are worse for many other countries, including large-population countries that have a lower median income than the US, such as India and Brazil.
Source for the CDC comment: Tobacco-Related Mortality
See also: AAMC | Smoking is still the leading cause of preventable death in the U.S.
We only have so much room here, but if that’s not enough…
More than 100 reasons to quit tobacco
The case against sugar
We reviewed an interesting book about this:
The Case Against Sugar – by Gary Taubes
But suffice it to say, added sugar is a big health problem; not in the same league as tobacco, but it’s big, because of how it messes with our metabolism (and when our metabolism goes wrong, everything else goes wrong):
From Apples to Bees, and High-Fructose Cs: Which Sugars Are Healthier, And Which Are Just The Same?
The epidemiology of sugar consumption and related mortality is harder to give clear stats about than smoking, because there’s not a clear yes/no indicator, and cause and effect are harder to establish when the waters are so muddied by other factors. But for comparison, we’ll note that compared to the 480,000 deaths caused by tobacco in the US annually, the total death to diabetes (which is not necessarily “caused by sugar consumption”, but there’s at least an obvious link when it comes to type 2 diabetes and refined carbohydrates) was 101,209 deaths due to diabetes in 2022:
National Center for Health Statistics | Diabetes
Now, superficially, that looks like “ok, so smoking is just under 5x more deadly”, but it’s important to remember that almost everyone eats added sugar, whereas a minority of people smoke, and those are mortality per total US population figures, not mortality per user of the substance in question. So in fact, smoking is, proportionally to how many people smoke, many times more deadly than diabetes, which currently ranks 8th in the “top causes of death” list.
Note: we recognize that you did say “having a sweet tooth” rather than “consuming added sugar”, but it’s worth noting that artificial sweeteners are not a get-out-of-illness-free card either:
Let’s get back to sugar though, as while it’s a very different beast than tobacco, it is arguably addictive also, by multiple mechanisms of addiction:
The Not-So-Sweet Science Of Sugar Addiction
That said, those mechanisms of addiction are not necessarily as strong as some others, so in the category of what’s easy or hard to quit, this is on the easier end of things—not that that means it’s easy, just, quitting many drugs is harder. In any case, it can be done:
When It’s More Than “Just” Cravings: Beat Food Addictions!
In summary
Neither are good for the health, but tobacco is orders of magnitude worse, and should be the priority to quit, unless your doctor(s) tell you otherwise because of your personal situation, and even then, try to get multiple opinions to be sure.
Take care!
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16 Signs & Symptoms Of Kidney Disease
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Chronic kidney disease is often called a silent killer, because 90% of people don’t notice they have it until the disease has progressed to an extreme level.
While none of these signs or symptoms are guaranteed to appear, especially in the early phases, if they do show up then they are cause for getting a check-up done:
Watch out for…
These should serve as alarm bells:
- Foamy urine: persistent dense foam (like beer head) in urine suggests protein (albumin) leakage due to kidney filter damage
- Swelling (pitting edema): especially in the legs, feet, or around the eyes, caused by low blood albumin leading to fluid leakage into tissues
- Nocturia (peeing at night): frequent nighttime urination due to kidneys losing the ability to concentrate urine
- Half-and-half nails: nails with a distinct brownish band on the distal half, linked to chronic kidney disease
- Calcinosis cutis: hard white-yellow skin bumps from calcium phosphate deposits due to high blood phosphate
- Artery calcification: hardened arteries visible on X-ray caused by phosphate-induced bone-like deposits in blood vessel walls
- Muscle cramps: especially at night, due to low calcium, low magnesium, or high blood acidity from impaired kidney function
- Osteoporosis: weak, brittle bones from calcium being leached out due to disrupted calcium regulation—may cause height loss or fractures
- Itchy skin: intense, often nighttime itching caused by uremic toxins irritating nerves or accumulating in skin
- Restless legs syndrome: irresistible urge to move legs at night due to iron deficiency from chronic inflammation and hepcidin overproduction
- Metallic taste in mouth: due to urea breakdown in saliva causing ammonia and other metallic-tasting compounds
- Loss of appetite: also, potentially, nausea and vomiting triggered by toxins activating brain regions that sense food poisoning
- Easy bruising: from reduced platelet stickiness, leading to frequent unexplained bruises, gum bleeding, or nosebleeds
- Uremic frost: white crystalline powder on the skin in advanced kidney failure due to urea excreted through sweat
- Pericarditis: inflammation of the sac around the heart causing chest pain and a scratchy sound due to uremic toxins
- Fatigue (anemia): low red blood cell count from reduced erythropoietin production by kidneys, leading to extreme tiredness
Attentive readers will have noticed two things here:
- Many of these could indicate a lot of other things (e.g. fatigue can be almost anything, osteoporosis isn’t something one sees unless one checks for it, loss of appetite can be many things, etc), which helps mask kidney disease.
- Dr. Deshauer says “17 signs” in her title, so where’s the 17th? The answer is that she listed in 17th place “no symptoms”, because many people have no noticeable symptoms until the disease reaches moderate or advanced stages.
Both of those factors contribute to kidney disease’s “silent killer” status, but with good vigilance, we can stay as healthy as possible.
For more on each of these, plus some visual illustrations where appropriate, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Keeping Your Kidneys Healthy (Especially After 60) ← there’s a lot more to it than just hydration!
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