The End of Heart Disease – by Dr. Joel Fuhrman
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We’ve previously reviewed another of Dr. Fuhrman’s books, “Eat To Live”, and this time, he’s focusing specifically on preventing/reversing heart disease.
Dr. Fuhrman takes the stance that our food can either kill or heal us, and we get to choose which. As such, nutrition is central to his heart-healthy plan; he mostly leaves matters of exercise, sleep, etc to other sources.
His dietary approach is mostly uncontroversial: for example, advices include: enjoy nutritionally dense foods, skip processed foods, eat at least mostly plants, skip the added salt. A slightly more controversial aspect is that he advocates for avoiding cooking oils, including the healthiest oils, including olive and avocado, which are by current scientific consensus considered heart-healthy in moderation. As in, not even just heart-neutral, but rather, they actively improve triglycerides.
He compares different cardioprotective diets, and while he’s not unbiased, he does provide 40 pages of scholarly references, so we may understand that at the very least, his approach is sound.
There are also recipes—94 pages of them—for any who might wonder “how do I cook without…?” and some ingredient he would rather you omit.
The style is information-dense (and this is a 448-page book) but still very readable.
Bottom line: if you’re serious about improving your heart health, this book can help a lot with that.
Click here to check out The End Of Heart Disease, and end heart disease for yourself!
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10% Human – by Dr. Alanna Collen
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The title, of course, is a nod to how by cell count, we are only about 10% human, and the other 90% are assorted microbes.
Dr. Collen starts with the premise that “all diseases begin in the gut” which is perhaps a little bold, but as a general rule of thumb, the gut is, in fairness, implicated in most things—even if not being the cause, it generally plays at least some role in the pathogenesis of disease.
The book talks us through the various ways that our trillions of tiny friends (and some foes) interact with us, from immune-related considerations, to nutrient metabolism, to neurotransmitters, and in some cases, direct mind control, which may sound like a stretch but it has to do with the vagus nerve “gut-brain highway”, and how microbes have evolved to tug on its strings just right. Bearing in mind, most of these microbes have very short life cycles, which means evolution happens for them so much more rapidly than it does for us—something that Dr. Collen, with her PhD in evolutionary biology, has plenty to say about.
There is a practical element too: advice on how to avoid the many illnesses that come with having our various microbiomes (it’s not just the gut!) out of balance, and how to keep everything working together as a team.
The style is quite light pop-science and, once we get past the first chapter (which is about the history of the field), quite a pleasant read as Dr. Collen has an enjoyable and entertaining tone.
Bottom line: if you’d like to understand more about all the things that come together to make us functionally 100% human, then this book is an excellent guide to that.
Click here to check out 10% Human, and learn about how we interact with ourselves!
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Spark – by Dr. John Ratey
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We all know that exercise is good for mental health as well as physical. So, what’s so revolutionary about this “revolutionary new science of exercise and the brain”?
A lot of it has to do with the specific neuroscience of how exercise has not only a mood-boosting effect (endorphins) and neuroprotective effect (helping to guard against cognitive decline), but also promotes neuroplasticity… e.g., the creation and strengthening of neural pathways, as well as boosting the structure of the brain in some parts such as the cerebellum.
The book also covers not just “exercise has these benefits”, but also the “how this works” of all kinds of brain benefits, including:
- against Alzheimer’s
- mitigating ADHD
- managing menopause
- dealing with addiction
…and more. And once we understand how something works, we’re far more likely to be motivated to actually do the kinds of exercises that give the specific benefits we want/need. Which is very much the important part!
In short: this book will tell you what you need to know to get you doing the exercises you need to enjoy those benefits—very much worth it!
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Fisetin: The Anti-Aging Assassin
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Out With The Old…
Fisetin is a flavonoid (specifically, a flavonol), but it’s a little different than most. While it has the usual antioxidant, anti-inflammatory, and anti-cancer properties you might reasonably expect from flavonoids, it has an extra anti-aging trick up its sleeve that most don’t.
❝Fisetin is a flavonol that shares distinct antioxidant properties with a plethora of other plant polyphenols. Additionally, it exhibits a specific biological activity of considerable interest as regards the protection of functional macromolecules against stress which results in the sustenance of normal cells cytoprotection. Moreover, it shows potential as an anti-inflammatory, chemopreventive, chemotherapeutic and recently also senotherapeutic agent❞
~ Dr. Grynkiewicz & Dr. Demchuk
Let’s briefly do some due diligence on its expected properties, and then we’ll take a look at its bonus anti-aging effects.
The flavonol that does-it-ol
Because of the similar mechanisms involved, there are three things that often come together, which are:
- Antioxidant
- Anti-inflammatory
- Anticancer
This list often gets expanded to also include:
- Anti-aging
…although that is usually the last thing to get tested out of that list.
In today’s case, let’s kick it off with…
❝Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects❞
Read more: Fisetin and Its Role in Chronic Diseases
Understanding its anticancer mechanisms
The way that fisetin fights cancer is basically “all the ways”, and this will be important when we get to its special abilities shortly:
❝Being a potent anticancer agent, fisetin has been used to inhibit stages in the cancer cells (proliferation, invasion),prevent cell cycle progression, inhibit cell growth, induce apoptosis, cause polymerase (PARP) cleavage, and modulate the expressions of Bcl‐2 family proteins in different cancer cell lines (HT‐29, U266, MDA‐MB‐231, BT549, and PC‐3M‐luc‐6), respectively. Further, fisetin also suppresses the activation of the PKCα/ROS/ERK1/2 and p38 MAPK signaling pathways, reduces the NF‐κB activation, and down‐regulates the level of the oncoprotein securin. Fisetin also inhibited cell division and proliferation and invasion as well as lowered the TET1 expression levels. ❞
Read more: Fisetin: An anticancer perspective
There’s also more about it than we even have room to quote, here:
Now For What’s New And Exciting: Senolysis
All that selectivity that fisetin exhibits when it comes to “this cell gets to live, and this one doesn’t” actions?
It makes a difference when it comes to aging, too. Because aging and cancer happen by quite similar mechanisms; they’re both DNA-copying errors that get copied forward, to our detriment.
- In the case of cancer, it’s a cell line that accidentally became immortal and so we end up with too many of them multiplying in one place (a tumor)
- In the case of aging, it’s the cellular equivalent of “a photocopy of a photocopy of a photocopy” gradually losing information as it goes
In both cases…
The cell must die if we want to live
Critically, and which quality differentiates it from a lot of other flavonoids, fisetin has the ability to selectively kill senescent cells.
To labor the photocopying metaphor, this means there’s an office worker whose job it is to say “this photocopy is barely legible, I’m going to toss this, and then copy directly from the clearest copy we have instead”, thus keeping the documents (your DNA) in pristine condition.
In fisetin’s case, this was first tested in mouse (in vivo) studies, and in human tissue (in vitro) studies, before moving to human clinical studies:
❝Of the 10 flavonoids tested, fisetin was the most potent senolytic.
The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit.❞
~ Dr. Matthew Yousefzadeh et al.
Read in full: Fisetin is a senotherapeutic that extends health and lifespan
There’s lots more science that’s been done to it since that first groundbreaking study though; here’s a more recent example:
Want some?
We don’t sell it, but here for your convenience is an example product on Amazon
Enjoy!
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The Science of Self-Learning – by Peter Hollins
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Teaching oneself new things is often the most difficult kind of bootstrapping, especially when one is unsure of such critical things as:
- Where to begin? How, for that matter, do we find where to begin?
- What can/should a learning journey look like?
- What challenges should we expect, and how will we overcome them?
Hollins answers all of these questions and more. The greatest value of this book is perhaps in its clear presentation of concrete step-by-step instructions. Hollins gives illustrated examples too, but most importantly, he gives models that can be applied to any given type of learning.
The book also covers the most difficult problems most people face when trying to learn something by themselves, including:
- Keeping oneself on-task (maintaining discipline)
- Measuring progress (self-testing beyond memorization)
- Keeping a fair pace of progress (avoiding plateaus)
- How to know when one’s knowledge is sufficient or not (avoiding Dunning-Kruger Club)
All in all, if you’re looking to learn a new subject or skill, this could be a first step that saves you a lot of time later!
Get your copy of the Science of Self-Learning on Amazon today!
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Healthy Kids, Happy Kids – by Dr. Elisa Song
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If you have young children or perhaps grandchildren, you probably care deeply about those children and their wellbeing, but there can often be a lot more guesswork than would be ideal, when it comes to ensuring they be and remain healthy.
Nevertheless, a lot of common treatments for children are based (whether parents know it or not—and often they dont) on what is most convenient for the parent, not necessarily what is best for the child. Dr. Song looks to correct that.
Rather than dosing kids with acetaminophen or even antibiotics, assuming eczema can be best fixed with a topical cream (treating the symptom rather than the cause, much?), and that some things like asthma “just are”, and “that’s unfortunate”, Dr. Song takes us on a tour of pediatric health, centered around the gut.
Why the gut? Well, it’s pretty central to us as adults, and it’s the same for kids, except one difference: their gut microbiome is changing even more quickly than ours (along with the rest of their body), and as such, is even more susceptible to little nudges for better or for worse, having a big impact in either direction. So, might as well make it a good one!
After an explanatory overview, most of the book is given over to recognizing and correcting what things can go wrong, including the top 25 acute childhood conditions, and the most critical chronic ones, and how to keep things on-track as a team (the child is part of the team! An important part!).
The style of the book is very direct and instructional; easy to understand throughout. It’s a lot like being in a room with a very competent pediatrician who knows her stuff and explains it well, thus neither patronizing nor mystifying.
Bottom line: if there are kids in your life, be they yours or your grandkids or someone else, this is a fine book for giving them the best foundational health.
Click here to check out Healthy Kids, Happy Kids, and take care of yours!
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Complex PTSD – by Pete Walker
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We’ve written before about Complex PTSD, but there’s a lot more to be said than we can fit into an article or two.
Pete Walker, a licensed marriage and family therapist, does an excellent job and pulls no punches, starting from the book’s dedication and carrying the hard-hitting seriousness all the way through to the Appendices.
To this end, it absolutely may not be an easy book to read at times (emotionally speaking), especially if you have C-PTSD. On the other hand, you may also find it a very validating 300-odd pages of “Yes, he is telling my life story in words, now this makes sense!”
That said, it’s mostly not an anecdotes-based book and nor is it just a feelsy ride; it’s also a textbook and a how-to manual. It’s a textbook of how and why things come about the way they do, and a manual of how to effectively manage C-PTSD, and find peace. There’s no silver bullet here, but there is a very comprehensive guide, and chapters full of tools to use (and no, not the same CBT things you’ve probably read a hundred times, this is C-PTSD-specific stuff).
Bottom line: this is the C-PTSD book; if you buy only one book on the topic, make it this one.
Click here to check out Complex PTSD: From Surviving To Thriving, and indeed thrive!
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