Genetic Risk Factors For Long COVID
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Some people, after getting COVID, go on to have Long COVID. There are various contributing factors to this, including:
- Lifestyle factors that impact general disease-proneness
- Immune-specific factors such as being immunocompromised already
- Genetic factors
We looked at some modifiable factors to improve one’s disease-resistance, yesterday:
And we’ve taken a more big-picture look previously:
Beyond Supplements: The Real Immune-Boosters!
Along with some more systemic issues:
Why Some People Get Sick More (And How To Not Be One Of Them)
But, for when the “don’t get COVID” ship has sailed, one of the big remaining deciding factors with regard to whether one gets Long COVID or not, is genetic
The Long COVID Genes
For those with their 23andMe genetic data to hand…
❝Study findings revealed that three specific genetic loci, HLA-DQA1–HLA-DQB1, ABO, and BPTF–KPAN2–C17orf58, and three phenotypes were at significantly heightened risk, highlighting high-priority populations for interventions against this poorly understood disease.❞
For those who don’t, then first: you might consider getting that! Here’s why:
Genetic Testing: Health Benefits & Methods
But also, all is not lost meanwhile:
The same study also found that individuals with genetic predispositions to chronic fatigue, depression, and fibromyalgia, as well as other phenotypes such as autoimmune conditions and cardiometabolic conditions, are at significantly higher risk of long-COVID than individuals without these conditions.
Good news, bad news
Another finding was that women and non-smokers were more likely to get Long COVID, than men and smokers, respectively.
Does that mean that those things are protective against Long COVID, which would be very counterintuitive in the case of smoking?
Well, yes and no; it depends on whether you count “less likely to get Long COVID because of being more likely to just die” as protective against Long COVID.
(Incidentally, estrogen is moderately immune-enhancing, while testosterone is moderately immune-suppressing, so the sex thing was not too surprising. It’s also at least contributory to why women get more autoimmune disorders, while men get more respiratory infections such as colds and the like)
Want to know more?
You can read the paper itself, here:
*GWAS = Genome-Wide Association Study
Take care!
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Managing Chronic Pain (Realistically!)
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Realistic chronic pain management
We’ve had a number of requests to do a main feature on managing chronic pain, so here it is!
A quick (but important) note before we begin:
Obviously, not all chronic pain is created equal. Furthermore, we know that you, dear reader with chronic pain, have been managing yours for however long you have, learning as you go. You also doubtlessly know your individual condition inside out.
We also know that people with chronic health conditions in general are constantly beset by well-meaning unsolicited advice from friends and family, asking if you’ve heard about [thing you heard about 20 years ago] that will surely change your life and cure you overnight.
It’s frustrating, and we’re going to try to avoid doing that here, while still offering the advice that was asked for. We ask you, therefore, to kindly overlook whatever you already knew, and if you already knew it all, well, we salute you and will not be surprised if that’s the case for at least some readers. Chronic pain’s a… Well, it’s a chronic pain.
All that said, let’s dive in…
How are you treating your body right now?
Are you hydrated; have you eaten; are you standing/sitting/lying in a position that at least should be comfortable for you in principle?
The first two things affect pain perception; the latter can throw a spanner in the works if something’s not quite right.
Move your body (gently!)
You know your abilities, so think about the range of motion that you have, especially in the parts of your body that hurt (if that’s “everywhere”, then, our sympathies, and we hope you find the same advice applies). Think about your specific muscles and joints as applicable, and what the range of motion is “supposed” to be for each. Exercise your range of motion as best you can (gently!) to the point of its limit(s) and/or pain.
- If you take it past that limit, there is a good chance you will make it worse. You don’t want that.
- If you don’t take it to the limit, there is a good chance your range of movement will deteriorate, and your “safe zone” (i.e., body positions that are relatively free from pain) will diminish. You definitely don’t want that, either.
Again, moderation is key. Yes, annoying as the suggestion may be, such things as yoga etc can help, if done carefully and gently. You know your limits; work with those, get rest between, and do what you can.
For most people this will at least help keep the pain from getting worse.
Hot & Cold
Both of these things could ease your pain… Or make it worse. There is an element of “try it and see”, but here’s a good general guide:
Here’s How to Choose Between Using Ice or Heat for Pain
Meditation… Or Distraction
Meditating really does help a lot of people. In the case of pain, it can be counterintuitively helpful to focus for a while on the sensation of the pain… But in a calm, detached fashion. Without judgement.
“Yes, I am experiencing pain. Yes, it feels like I’m being stabbed with hot knives. Yes, this is tortuous; wow, I feel miserable. This truly sucks.”
…it doesn’t sound like a good experience, does it? And it’s not, but paying it attention this way can paradoxically help ease things. Pain is, after all, a messenger. And in the case of chronic pain, it’s in some ways a broken messenger, but what a messenger most needs is to be heard.
The above approach a) is good b) may have a limit in how long you can sustain it at a time, though. So…
The opposite is a can be a good (again, short-term) approach too. Call a friend, watch your favorite movie, play a video game if that’s your thing. It won’t cure anything, but it can give you a little respite.
Massage
Unless you already know this makes your pain worse, this is a good thing to try. It doesn’t have to be a fancy spa; if the nature of your pain and condition permits, you can do self-massage. If you have a partner or close friend who can commit to helping, it can be very worth them learning to give a good massage. There are often local courses available, and failing that, there is also YouTube.
Here’s an example of a good video for myofascial release massage, which can ease a lot of common kinds of chronic pain:
Some quick final things to remember:
- If you find something helps, then it helps, do that.
- That goes for mobility aids and other disability aids too, even if it was designed for a different disability. If it helps, it helps. You’re not stealing anyone’s thunder (or resources) by using something that makes your life easier. We’re not in this life to suffer!
- There is no such thing as “this pain is not too much”. The correct amount of pain is zero. Maybe your body won’t let you reach zero, but more than that is “too much” already.
- You don’t have to be suffering off the scale to deserve relief from pain
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5 Ways to Beat Menopausal Weight Gain!
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As it turns out, “common” does not mean “inevitable”!
Health Coach Kait’s advice
Her 5 tips are…
- Understand your metabolism: otherwise you’re working the dark and will get random results. Learn about how different foods affect your metabolism, and note that hormonal changes due to menopause can mean that some food types have different effects now.
- Eat enough protein: one thing doesn’t change—protein helps with satiety, thus helping to avoid overeating.
- Focus on sleep: prioritizing sleep is essential for hormone regulation, and that means not just sex hormones, but also food-related hormones such as insulin, ghrelin, and leptin.
- Be smart about carbs: taking a lot of carbs at once can lead to insulin spikes and thus metabolic disorder, which in turn leads to fat in places you don’t want it (especially your liver and belly). Enjoying a low-carb diet, and/or pairing your carbs with proteins and fats, does a lot to help avoid insulin spikes too. Not mentioned in the video, but we’re going to mention here: don’t underestimate fiber’s role either, especially if you take it before the carbs, which is best for blood sugars, as it gives a buffer to the digestive process, thus slowing down absorption of carbs.
- Build muscle: if trying to avoid/lose fat, it’s tempting to focus on cardio, but we generally can’t exercise our way out of having fat, whereas having more muscle increases the body’s metabolic base rate, burning fat just by existing. So for this reason, enjoy muscle-building resistance exercises at least a few times per week.
For more information on each of these, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Visceral Belly Fat & How To Lose It
Take care!
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The Magic of L-theanine
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All The Benefits Of Caffeine And More, Without The Drawbacks? What’s The Catch?
It just takes one extra supplement.
For many of us, our morning brew is practically a ritual, but caffeine can also cause all kinds of problems ranging from caffeine jitters to caffeine crashes to caffeine addiction and withdrawal. Surely, something could be better?
Well, yes it could! You doubtlessly know about green tea’s antioxidant properties, but its amino acid, l-theanine (which can be taken as a supplement with coffee, if you don’t enjoy green tea) has so much more to offer:
- L-theanine has been found to reduce stress responses—and let’s face it, when we most want/need a coffee is often when facing stress
- It also reduces anxiety, making it a very safe “downer” without the problems of, for example, alcohol—or other potentially addictive substances
- It’s far more than just that, though! Paradoxically, l-theanine also improves alertness (what other calming things promote alertness? Not so many)
- Part of its trick is that it also improves accuracy—whereas stimulants like caffeine may produce a twitchy, jumpy, responsiveness, l-theanine’s signature effect is a calm state of sharp readiness. Caffeine works by stimulating the adrenal gland and increasing blood pressure, while simultaneously blocking adenosine receptors so that your body doesn’t notice its own tiredness—which is why you’re likely to crash later, when the tiredness that had been masked, all hits at once. Instead, l-theanine taken with caffeine acts as a moderator of that, making for a longer, gentler curve. In terms of subjective experience, what this can mean for many people is: no more caffeine jitters!
- All this means that while l-theanine can boost all kinds of cognitive function, including alertness and accuracy, many like to take in the evening as it can also promote a good night’s sleep, ready to be at your best the next day.
- How much to take? 200mg is a commonly used dosage, which in supplement terms is usually a single capsule. A lot easier to take than the 40 cups of green tea that this dosage would otherwise be!
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Elderhood – by Dr. Louise Aronson
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Where does “middle age” end, and “old age” begin? By the United States’ CDC’s categorization, human life involves:
- 17 stages of childhood, deemed 0–18
- 5 stages of adulthood, deemed 18–60
- 1 stage of elderhood, deemed 60+
Isn’t there something missing here? Do we just fall off some sort of conveyor belt on our sixtieth birthdays, into one big bucket marked “old”?
Yesterday you were 59 and enjoying your middle age; today you have, apparently, the same medical factors and care needs as a 114-year-old.
Dr. Louise Aronson, a geriatrician, notes however that medical science tends to underestimate the differences found in more advanced old age, and underresearch them. That elders consume half of a country’s medicines, but are not required to be included in clinical trials. That side effects not only are often different than for younger adults, but also can cause symptoms that are then dismissed as “Oh she’s just old”.
She explores, mostly through personal career anecdotes, the well-intentioned disregard that is frequently given by the medical profession, and—importantly—how we might overcome that, as individuals and as a society.
Bottom line: if you are over the age of 60, love someone over the age of 60, this is a book for you. Similarly if you and/or they plan to live past the age of 60, this is also a book for you.
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When Age Is A Flexible Number
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Aging, Counterclockwise!
In the late 1970s, Dr. Ellen Langer hypothesized that physical markers of aging could be affected by psychosomatic means.
Note: psychosomatic does not mean “it’s all in your head”.
Psychosomatic means “your body does what your brain tells it to do, for better or for worse”
She set about testing that, in what has been referred to since as…
The Counterclockwise Study
A small (n=16) sample of men in their late 70s and early 80s were recruited in what they were told was a study about reminiscing.
Back in the 1970s, it was still standard practice in the field of psychology to outright lie to participants (who in those days were called “subjects”), so this slight obfuscation was a much smaller ethical aberration than in some famous studies of the same era and earlier (cough cough Zimbardo cough Milgram cough).
Anyway, the participants were treated to a week in a 1950s-themed retreat, specifically 1959, a date twenty years prior to the experiment’s date in 1979. The environment was decorated and furnished authentically to the date, down to the food and the available magazines and TV/radio shows; period-typical clothing was also provided, and so forth.
- The control group were told to spend the time reminiscing about 1959
- The experimental group were told to pretend (and maintain the pretense, for the duration) that it really was 1959
The results? On many measures of aging, the experimental group participants became quantifiably younger:
❝The experimental group showed greater improvement in joint flexibility, finger length (their arthritis diminished and they were able to straighten their fingers more), and manual dexterity.
On intelligence tests, 63 percent of the experimental group improved their scores, compared with only 44 percent of the control group. There were also improvements in height, weight, gait, and posture.
Finally, we asked people unaware of the study’s purpose to compare photos taken of the participants at the end of the week with those submitted at the beginning of the study. These objective observers judged that all of the experimental participants looked noticeably younger at the end of the study.❞
Remember, this was after one week.
Her famous study was completed in 1979, and/but not published until eleven years later in 1990, with the innocuous title:
Higher stages of human development: Perspectives on adult growth
You can read about it much more accessibly, and in much more detail, in her book:
Counterclockwise: A Proven Way to Think Yourself Younger and Healthier – by Dr. Ellen Langer
We haven’t reviewed that particular book yet, so here’s Linda Graham’s review, that noted:
❝Langer cites other research that has made similar findings.
In one study, for instance, 650 people were surveyed about their attitudes on aging. Twenty years later, those with a positive attitude with regard to aging had lived seven years longer on average than those with a negative attitude to aging.
(By comparison, researchers estimate that we extend our lives by four years if we lower our blood pressure and reduce our cholesterol.)
In another study, participants read a list of negative words about aging; within 15 minutes, they were walking more slowly than they had before.❞
Read the review in full:
Aging in Reverse: A Review of Counterclockwise
The Counterclockwise study has been repeated since, and/but we are still waiting for the latest (exciting, much larger sample, 90 participants this time) study to be published. The research proposal describes the method in great detail, and you can read that with one click over on PubMed:
It was approved, and has now been completed (as of 2020), but the results have not been published yet; you can see the timeline of how that’s progressing over on ClinicalTrials.gov:
Clinical Trials | Ageing as a Mindset: A Counterclockwise Experiment to Rejuvenate Older Adults
Hopefully it’ll take less time than the eleven years it took for the original study, but in the meantime, there seems to be nothing to lose in doing a little “Citizen Science” for ourselves.
Maybe a week in a 20 years-ago themed resort (writer’s note: wow, that would only be 2004; that doesn’t feel right; it should surely be at least the 90s!) isn’t a viable option for you, but we’re willing to bet it’s possible to “microdose” on this method. Given that the original study lasted only a week, even just a themed date-night on a regular recurring basis seems like a great option to explore (if you’re not partnered then well, indulge yourself how best you see fit, in accord with the same premise; a date-night can be with yourself too!).
Just remember the most important take-away though:
Don’t accidentally put yourself in your own control group!
In other words, it’s critically important that for the duration of the exercise, you act and even think as though it is the appropriate date.
If you instead spend your time thinking “wow, I miss the [decade that does it for you]”, you will dodge the benefits, and potentially even make yourself feel (and thus, potentially, if the inverse hypothesis holds true, become) older.
This latter is not just our hypothesis by the way, there is an established potential for nocebo effect.
For example, the following study looked at how instructions given in clinical tests can be worded in a way that make people feel differently about their age, and impact the results of the mental and/or physical tests then administered:
❝Our results seem to suggest how manipulations by instructions appeared to be more largely used and capable of producing more clear performance variations on cognitive, memory, and physical tasks.
Age-related stereotypes showed potentially stronger effects when they are negative, implicit, and temporally closer to the test of performance. ❞
(and yes, that’s the same Dr. Francesco Pagnini whose name you saw atop the other study we cited above, with the 90 participants recreating the Counterclockwise study)
Want to know more about [the hard science of] psychosomatic health?
Check out Dr. Langer’s other book, which we reviewed recently:
The Mindful Body: Thinking Our Way to Chronic Health – by Dr. Ellen Langer
Enjoy!
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The Most Anti Aging Exercise
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We’ve referenced this (excellent) video before, but never actually put it under the spotlight in one of these features, so here we go!
Deep squats
It’s about deep squats, also called Slav squats, Asian squats, sitting squats, resting squats, or various other names. However, fear not; you don’t need to be Slavic or Asian to do it; you just need to practice.
As for why this is called “anti-aging”, by the way, it’s because being able to get up off the ground is one of the main tests of age-related mobility decline, and if you can deep-squat comfortably, then you can do that easily. And so long as you continue being able to deep-squat comfortably, you’ll continue to be able to get up off the ground easily too, because you have the strength in the right muscles, as well as the suppleness, comfort with range of motion, and balance (those stabilizing muscles are used constantly in a deep squat, whereas Western lifestyle sitting leaves those muscles very neglected and thus atrophied).
Epidemiological note: chairs, couches, and assorted modern conveniences reduce the need for squatting in daily life, leading to stiffness in joints, muscles, tendons, and ligaments. Many adults in developed countries struggle with deep squats due to lack of use, not aging. Which is a problem, because a lack of full range of motion in joints causes wear and tear, leading to chronic pain and degenerative joint diseases. People in countries where squatting is a common resting position have lower incidences of osteoarthritis, for example—contrary to what some might expect, squatting does not harm joints but rather protects them from arthritis and knee pain. Strengthening leg muscles through squatting can alleviate knee pain, whereas knee pain is often worsened by inactivity.
Notwithstanding the thumbnail, which is showing an interim position, one’s feet should be flat on the ground, by the way, and one’s butt should be nearby, just a few inches off the ground (in other words, the position that we see her in for most of this video).
Troubleshooting: if you’re accustomed to sitting in chairs a lot, then this may be uncomfortable at first. Zuzka advises us to go gently, and/but gradually increase our range of motion and (equally importantly) duration in the resting position.
You can use a wall or doorway to partially support you, at first, if you struggle with mobility or balance. Just try to gradually use it less, until you’re comfortable deep-squatting with no support.
Since this is not an intrinsically very exciting exercise, once you build up the duration for which you’re comfortable deep-squatting, it can be good to get in the habit of “sitting” this way (i.e. deep squatting, still butt-off-the-floor, but doing the job of sitting) while doing other things such as working (if you have an appropriate work set-up for that*), reading, or watching TV.
*this is probably easiest with a laptop placed on an object/surface of appropriate height, such as a coffee table or such. As a bonus, having your hands in front of you while working will also bring your center of gravity forwards a bit, making the position easier and more comfortable to maintain. This writer (hi, it’s me) prefers her standing desk for work in general, with a nice ergonomic keyboard and all that, but if using a laptop from time to time, then squatting is a very good option.
In terms of working up duration, if you can only manage seconds to start with, that’s fine. Just do a few more seconds each time, until it’s 30, 60, 120, and so on until it’s 5 minutes, 10, 15, and so on.
You can even start that habit-forming while you’re still in the “seconds at a time” stage! You can deep-squat just for some seconds while you:
- pick up something from the floor
- check on something in the oven
- get something out of the bottom of the fridge
…etc!
For more on all this, plus many visual demonstrations including interim exercises to get you there if it’s difficult for you at first, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Mobility For Now & For Later: Train For The Marathon That Is Your Life!
Take care!
Don’t Forget…
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