The Fascinating Truth About Aspartame, Cancer, & Neurotoxicity
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Is Aspartame’s Reputation Well-Deserved?
In Tuesday’s newsletter, we asked you for your health-related opinions on aspartame, and got the above-depicted, below-described, set of responses:
- About 47% said “It is an evil carcinogenic neurotoxin”
- 20% said “It is safe-ish, but has health risks that are worse than sugar”
- About 19% said “It is not healthy, but better than sugar”
- About 15% said “It’s a perfectly healthy replacement for sugar”
But what does the science say?
Aspartame is carcinogenic: True or False?
False, assuming consuming it in moderation. In excess, almost anything can cause cancer (oxygen is a fine example). But for all meaningful purposes, aspartame does not appear to be carcinogenic. For example,
❝The results of these studies showed no evidence that these sweeteners cause cancer or other harms in people.❞
~ NIH | National Cancer Institute
Source: Artificial Sweeteners and Cancer
Plenty of studies and reviews have also confirmed this; here are some examples:
- Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria
- Aspartame, low-calorie sweeteners and disease: Regulatory safety and epidemiological issues
- Aspartame: A review of genotoxicity data
Why then do so many people believe it causes cancer, despite all the evidence against it?
Well, there was a small study involving giving megadoses to rats, which did increase their cancer risk. So of course, the popular press took that and ran with it.
But those results have not been achieved outside of rats, and human studies great and small have all been overwhelmingly conclusive that moderate consumption of aspartame has no effect on cancer risk.
Aspartame is a neurotoxin: True or False?
False, again assuming moderate consumption. If you’re a rat being injected with a megadose, your experience may vary. But a human enjoying a diet soda, the aspartame isn’t the part that’s doing you harm, so far as we know.
For example, the European Food Safety Agency’s scientific review panel concluded:
❝there is still no substantive evidence that aspartame can induce such effects❞
~ Dr. Atkin et al (it was a pan-European team of 21 experts in the field)
Source: Report on the Meeting on Aspartame with National Experts
See also,
❝The data from the extensive investigations into the possibility of neurotoxic effects of aspartame, in general, do not support the hypothesis that aspartame in the human diet will affect nervous system function, learning or behavior.
The weight of existing evidence is that aspartame is safe at current levels of consumption as a nonnutritive sweetener.❞
and
❝The safety testing of aspartame has gone well beyond that required to evaluate the safety of a food additive.
When all the research on aspartame, including evaluations in both the premarketing and postmarketing periods, is examined as a whole, it is clear that aspartame is safe, and there are no unresolved questions regarding its safety under conditions of intended use.❞
Source: Regulatory Toxicology & Pharmacology | Aspartame: Review of Safety
Why then do many people believe it is a neurotoxin? This one can be traced back to a chain letter hoax from about 26 years ago; you can read it here, but please be aware it is an entirely debunked hoax:
Urban Legends | Aspartame Hoax
Take care!
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Salmon vs Tuna – Which is Healthier?
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Our Verdict
When comparing salmon to tuna, we picked the tuna.
Why?
It’s close, and there are merits and drawbacks to both!
In terms of macros, tuna is higher in protein, while salmon is higher in fats. How healthy are the fats, you ask? Well, it’s a mix, because while there are plenty of “good” fats in salmon, salmon is also 10x higher in saturated fat and 150% higher in cholesterol.
So when it comes to fats, if you want to eat fish and have the healthiest fats, one option is to skip the salmon, and instead serve tuna with some extra virgin olive oil.
We’ll call this section a clear win for tuna.
On the vitamin front, they are close to equal. Salmon has more of some vitamins, tuna has more of others; all in all we’d say the balance is in salmon’s favor, but by the time a portion of salmon is giving you 350% of your daily requirement, does it really matter that the same portion of tuna is “only” giving you 294% of the daily requirement? It goes like that for a lot of the vitamins they both contain.
Still, we’ll call this section a nominal win for salmon.
In the category of minerals, tuna is much higher in iron while salmon is higher in calcium. The rest of the minerals they both have, tuna is comfortably higher—and since the “% of RDA in a portion” figures are double-digit here rather than triple, those margins are relevant this time.
We’ll call this section a moderate win for tuna.
Both fish carry a risk of mercury poisoning, but this varies more by location than by fish, so it hasn’t been a consideration in this head-to-head.
Totting up the sections, this a modest but clear win for tuna.
Want to learn more?
You might like to read:
Farmed Fish vs Wild-Caught: Important Differences!
Take care!
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Five Flavors & Five Benefits
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Five Flavors Of Good Health
Schisandra chinensis, henceforth Schisandra, is also called the “five flavor fruit”, for covering the culinary bases of sweet, salt, bitter, sour, and pungent.
It can be eaten as a fruit (small red berries), juiced from the fruit, or otherwise extracted into supplements (dried powder of the fruit being a common one).
It has long enjoyed usage in various traditional medicines, especially in China and Siberia.
So, what are its health claims, and how does the science stack up?
Menopause
Most of the studies are mouse studies, and we prefer studies on humans, so here’s a small (n=36) randomized clinical trial that concluded…
❝Schisandra chinensis can be a safe and effective complementary medicine for menopausal symptoms, especially for hot flushes, sweating, and heart palpitations❞
~ Dr. Joon Young Park & Dr. Kye Hyun Kim
Read more: A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms
Antioxidant (and perhaps more)
Like many berries, it’s a good source of lignans offering antioxidant effects:
Antioxidant Effects of Schisandra chinensis Fruits and Their Active Constituents
Lignans usually have anticancer effects too (which is reasonably, given what is antioxidant is usually anticancer and anti-inflammatory as well, by the same mechanism) but those have not yet been studied in schisandra specifically.
Antihepatotoxicity
In other words, it’s good for your liver. At least, so animal studies tell us, because human studies haven’t been done yet for this one. The effect is largely due to its antioxidant properties, but it seems especially effective for the liver—which is not surprising, giving the liver’s regeneration mechanism.
Anyway, here’s a fascinating study that didn’t even need to use the fruit itself, just the pollen from the plant, it was that potent:
Athletics enhancer
While it’s not yet filling the shelves of sports nutrition stores, we found a small (n=45) study with healthy post-menopausal women who took either 1g of schisandra (experimental group) or 1g of starch (placebo group), measured quadriceps muscle strength and resting lactate levels over the course of a 12 week intervention period, and found:
❝Supplementation of Schisandra chinensis extract can help to improve quadriceps muscle strength as well as decrease lactate level at rest in adult women ❞
Anti-Alzheimers & Anti-Parkinsons
The studies for this are all in vitro, but that’s because it’s hard to find volunteers willing to have their brains sliced and looked at under a microscope while they’re still alive.
Nevertheless, the results are compelling, and it seems uncontroversial to say that schisandra, or specifically Schisandrin B, a compound it contains, has not only anti-inflammatory properties, but also neuroprotective properties, and specifically blocks the formation of excess amyloid-β peptides in the brain (which are critical for the formation of amyloid plaque, as found in the brains of Alzheimer’s patients):
Is it safe?
For most people, yes! Some caveats:
- As it can stimulate the uterus, it’s not recommended if you’re pregant.
- Taking more than the recommended amount can worsen symptoms of heartburn, GERD, ulcers, or other illnesses like that.
And as ever, do speak with our own doctor/pharmacist if unsure, as your circumstances may vary and we cannot cover all possibilities here.
Where can I get some?
We don’t sell it, but here for your convenience is an example product on Amazon
Enjoy!
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How Your Brain Chooses What To Remember
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During the day, your brain is simply too busy to encode memories without interfering with normal processing. At night, however…
The filing system
The brain decides which memories to keep based on significance, using sharp brain wave ripples as an internal bookmarking system. Everyday memories fade, while important events are tagged in this manner for consolidation during sleep.
How does it do this? It starts in the hippocampus, which records experiences during wakefulness and replays them repeatedly at high speed during sleep, preparing them for transfer to the neocortex.
How do we know? Uniform Manifold Approximation & Projection (UMAP) for dimension reduction is a tool that condenses 400-dimensional neural activity data into 3D for visualization. Mice navigating a maze showed hippocampal activity encoding location and learning progression; it also showed neural patterns reflecting maze layout and task mastery.
What this means in practical terms: you need to get good sleep if you don’t want to lose your memories!
For more on all of this, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
How To Boost Your Memory Immediately (Without Supplements)
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7 Tips To Burn Fat & Build Muscle At The Same Time
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Cori Lefkowith, of “Redefining Strength” and “Strong At Any Age” fame, has her formula to share:
Know your priorities
We’ll not keep the 7 tips a mystery; they are:
- Determine your primary goal: decide whether your main focus is losing fat while building muscle or building muscle while trimming up. This choice will influence your calorie intake, macros, and cardio approach.
- Start tracking: spend 7–14 days logging your current food intake, including calories, protein, carbs, and fats, without taking any particular action to change them yet. Understanding your baseline will help tailor your diet and exercise plan.
- Prioritize strength training: focus on strength work over cardio to build muscle. Avoid turning strength sessions into cardio by rushing between sets—allow adequate rest for muscle progression.
- Center your meals on protein: adjust your protein intake based on your primary goal. For fat loss while gaining muscle, aim for 40-45% of calories from protein. For building muscle while losing fat, aim for 30-40% protein, with attention to maintaining sufficient carbs.
- Set your calories: after adjusting protein, fine-tune your calorie intake. However, make only small changes (e.g. 100 calories up or down) and reassess every 2–3 weeks to avoid extreme deficits or surpluses.
- Adjust your cardio: prioritize strength training but use walking as low-impact cardio. Avoid excessive cardio that may hinder muscle gains, and use strategic HIIT sessions if needed.
- Ditch the scale: avoid using the scale as your sole measure of progress. Instead, rely on measurements, progress photos, and how your clothes fit to track body recomposition effectively.
For more on all of these, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
Can You Gain Muscle & Lose Fat At The Same Time? ← we got this question in our Q&A day not long back, and here was our answer. We went for a less numbers-based approach, and a more principles-based approach. Both ways work, so by all means pick whichever method you personally find better suits how you like to do things!
Take care!
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Surgery won’t fix my chronic back pain, so what will?
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This week’s ABC Four Corners episode Pain Factory highlighted that our health system is failing Australians with chronic pain. Patients are receiving costly, ineffective and risky care instead of effective, low-risk treatments for chronic pain.
The challenge is considering how we might reimagine health-care delivery so the effective and safe treatments for chronic pain are available to millions of Australians who suffer from chronic pain.
One in five Australians aged 45 and over have chronic pain (pain lasting three or more months). This costs an estimated A$139 billion a year, including $12 billion in direct health-care costs.
The most common complaint among people with chronic pain is low back pain. So what treatments do – and don’t – work?
Opioids and invasive procedures
Treatments offered to people with chronic pain include strong pain medicines such as opioids and invasive procedures such as spinal cord stimulators or spinal fusion surgery. Unfortunately, these treatments have little if any benefit and are associated with a risk of significant harm.
Spinal fusion surgery and spinal cord stimulators are also extremely costly procedures, costing tens of thousands of dollars each to the health system as well as incurring costs to the individual.
Addressing the contributors to pain
Recommendations from the latest Australian and World Health Organization clinical guidelines for low back pain focus on alternatives to drug and surgical treatments such as:
- education
- advice
- structured exercise programs
- physical, psychological or multidisciplinary interventions that address the physical or psychological contributors to ongoing pain.
Pain education is central. Monkey Business Images/Shutterstock Two recent Australian trials support these recommendations and have found that interventions that address each person’s physical and psychological contributors to pain produce large and sustained improvements in pain and function in people with chronic low back pain.
The interventions have minimal side effects and are cost-effective.
In the RESOLVE trial, the intervention consists of pain education and graded sensory and movement “retraining” aimed to help people understand that it’s safe to move.
In the RESTORE trial, the intervention (cognitive functional therapy) involves assisting the person to understand the range of physical and psychological contributing factors related to their condition. It guides patients to relearn how to move and to build confidence in their back, without over-protecting it.
Why isn’t everyone with chronic pain getting this care?
While these trials provide new hope for people with chronic low back pain, and effective alternatives to spinal surgery and opioids, a barrier for implementation is the out-of-pocket costs. The interventions take up to 12 sessions, lasting up to 26 weeks. One physiotherapy session can cost $90–$150.
In contrast, Medicare provides rebates for just five allied health visits (such as physiotherapists or exercise physiologists) for eligible patients per year, to be used for all chronic conditions.
Private health insurers also limit access to reimbursement for these services by typically only covering a proportion of the cost and providing a cap on annual benefits. So even those with private health insurance would usually have substantial out-of-pocket costs.
Access to trained clinicians is another barrier. This problem is particularly evident in regional and rural Australia, where access to allied health services, pain specialists and multidisciplinary pain clinics is limited.
Higher costs and lack of access are associated with the increased use of available and subsidised treatments, such as pain medicines, even if they are ineffective and harmful. The rate of opioid use, for example, is higher in regional Australia and in areas of socioeconomic disadvantage than metropolitan centres and affluent areas.
So what can we do about it?
We need to reform Australia’s health system, private and public, to improve access to effective treatments for chronic pain, while removing access to ineffective, costly and high-risk treatments.
Better training of the clinical workforce, and using technology such as telehealth and artificial intelligence to train clinicians or deliver treatment may also improve access to effective treatments. A recent Australian trial, for example, found telehealth delivered via video conferencing was as effective as in-person physiotherapy consultations for improving pain and function in people with chronic knee pain.
Advocacy and improving the public’s understanding of effective treatments for chronic pain may also be helpful. Our hope is that coordinated efforts will promote the uptake of effective treatments and improve the care of patients with chronic pain.
Christine Lin, Professor, University of Sydney; Christopher Maher, Professor, Sydney School of Public Health, University of Sydney; Fiona Blyth, Professor, University of Sydney; James Mcauley, Professor of Psychology, UNSW Sydney, and Mark Hancock, Professor of Physiotherapy, Macquarie University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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How To Know When You’re Healing Emotionally
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The healing process can be humbling but rewarding, leading to deep fulfillment and inner peace. Discomfort in healing can be part of growth and self-integration. Because of that, progress sometimes looks and/or feels like progress… And sometimes it doesn’t. Here’s how to recognize it, though:
Small but important parts of a bigger process
Nine signs indicating you are healing:
- Allowing emotions: you acknowledge and process both negative and positive emotions instead of suppressing them.
- Improved boundaries: you improve at expressing and maintaining boundaries, overcoming fear of rejection, guilt, and shame.
- Acceptance of past: you accept difficult past experiences and their impact, reducing their hold over you.
- Less reactivity: you become less reactive and more thoughtful in responses, practicing emotional self-regulation.
- Non-linear healing: you understand that healing involves ups and downs and isn’t a straightforward journey.
- Stepping out of your comfort zone: you start taking brave steps that previously induced fear or anxiety.
- Handling disappointments: you accept setbacks and respond to them healthily, without losing motivation.
- Inner peace: you develop a sense of wholeness, and forgiveness for yourself and others, reducing self-sabotage.
- Welcoming support: you become more open to seeking and accepting help, moving beyond pride and shame.
In short: healing (especially the very first part: accepting that something needs healing) can be uncomfortable but lead to much better places in life. It’s okay if healing is slow; everyone’s journey is different, and doing your best is enough.
For more on each of these, enjoy:
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Want to learn more?
You might also like:
Why You Can’t Just “Get Over” Trauma
Take care!
Don’t Forget…
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Learn to Age Gracefully
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