Whole – by Dr. T. Colin Campbell

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Most of us have at least a broad idea of what we’re supposed to be eating, what nutrients we should be getting. Many of us look at labels, and try to get our daily dose of this and that and the other.

And what we don’t get from food? There are supplements.

Dr. Campbell thinks we can do better:

Perhaps most critical in this book, where it stands out from others (we may already know, for example, that we should try to eat diverse plants and whole foods) is its treatment of why many supplements aren’t helpful.

We tend to hear “supplements are a waste of money” and sometimes they are, sometimes they aren’t. How to know the difference?

Key: things directly made from whole food sources will tend to be better. Seems reasonable, but… why? The answer lies in what else those foods contain. An apple may contain a small amount of vitamin C, less than a vitamin C tablet, but also contains a whole host of other things—tiny phytonutrients, whose machinations are mostly still mysteries to us—that go with that vitamin C and help it work much better. Lab-made supplements won’t have those.

There’s a lot more to the book… A chunk of which is a damning critique of the US healthcare system (the author argues it would be better named a sicknesscare system). We also learn about getting a good balance of macro- and micronutrients from our diet rather than having to supplement so much.

The style is conversational, while not skimping on the science. The author has had more than 150 papers published in peer-reviewed journals, and is no stranger to the relevant academia. Here, however, he focuses on making things easily comprehensible to the lay reader.

In short: if you’ve ever wondered how you’re doing at getting a good nutritional profile, and how you could do better, this is definitely the book for you.

Click here to check out “Whole” on Amazon today, and level up your daily diet!

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  • Five Advance Warnings of Multiple Sclerosis

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    Five Advance Warnings of Multiple Sclerosis

    First things first, a quick check-in with regard to how much you know about multiple sclerosis (MS):

    • Do you know what causes it?
    • Do you know how it happens?
    • Do you know how it can be fixed?

    If your answer to the above questions is “no”, then take solace in the fact that modern science doesn’t know either.

    What we do know is that it’s an autoimmune condition, and that it results in the degradation of myelin, the “insulator” of nerves, in the central nervous system.

    • How exactly this is brought about remains unclear, though there are several leading hypotheses including autoimmune attack of myelin itself, or disruption to the production of myelin.
    • Treatments look to reduce/mitigate inflammation, and/or treat other symptoms (which are many and various) on an as-needed basis.

    If you’re wondering about the prognosis after diagnosis, the scientific consensus on that is also “we don’t know”:

    Read: Personalized medicine in multiple sclerosis: hope or reality?

    this paper, like every other one we considered putting in that spot, concludes with basically begging for research to be done to identify biomarkers in a useful fashion that could help classify many distinct forms of MS, rather than the current “you have MS, but who knows what that will mean for you personally because it’s so varied” approach.

    The Five Advance Warning Signs

    Something we do know! First, we’ll quote directly the researchers’ conclusion:

    ❝We identified 5 health conditions associated with subsequent MS diagnosis, which may be considered not only prodromal but also early-stage symptoms.

    However, these health conditions overlap with prodrome of two other autoimmune diseases, hence they lack specificity to MS.❞

    So, these things are a warning, five alarm bells, but not necessarily diagnostic criteria.

    Without further ado, the five things are:

    1. depression
    2. sexual disorders
    3. constipation
    4. cystitis
    5. urinary tract infections

    ❝This association was sufficiently robust at the statistical level for us to state that these are early clinical warning signs, probably related to damage to the nervous system, in patients who will later be diagnosed with multiple sclerosis.

    The overrepresentation of these symptoms persisted and even increased over the five years after diagnosis.❞

    ~ Dr. Céline Louapre

    Read the paper for yourself:

    Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis

    Hot off the press! Published only yesterday!

    Want to know more about MS?

    Here’s a very comprehensive guide:

    National clinical guideline for diagnosis and management of multiple sclerosis

    Take care!

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  • Chaga Mushrooms’ Immune & Anticancer Potential

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    What Do Chaga Mushrooms Do?

    Chaga mushrooms, which also go by other delightful names including “sterile conk trunk rot” and “black mass”, are a type of fungus that grow on birch trees in cold climates such as Alaska, Northern Canada, Northern Europe, and Siberia.

    They’ve enjoyed a long use as a folk remedy in Northern Europe and Siberia, mostly to boost immunity, mostly in the form of a herbal tea.

    Let’s see what the science says…

    Does it boost the immune system?

    It definitely does if you’re a mouse! We couldn’t find any studies on humans yet. But for example:

    (cytokines are special proteins that regulate the immune system, and Chaga tells them to tell the body to produce more white blood cells)

    Wait, does that mean it increases inflammation?

    Definitely not if you’re a mouse! We couldn’t find any studies on humans yet. But for example:

    Anti-inflammatory things often fight cancer. Does chaga?

    Definitely if you’re a mouse! We couldn’t find any studies in human cancer patients yet. But for example:

    Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice

    While in vivo human studies are conspicuous by their absence, there have been in vitro human studies, i.e., studies performed on cancerous human cell samples in petri dishes. They are promising:

    I heard it fights diabetes; does it?

    You’ll never see this coming, but: definitely if you’re a mouse! We couldn’t find any human studies yet. But for example:

    Is it safe?

    Honestly, there simply have been no human safety studies to know for sure, or even to establish an appropriate dosage.

    Its only-partly-understood effects on blood sugar levels and the immune system may make it more complicated for people with diabetes and/or autoimmune disorders, and such people should definitely seek medical advice before taking chaga.

    Additionally, chaga contains a protein that can prevent blood clotting. That might be great by default if you are at risk of blood clots, but not so great if you are already on blood-thinning medication, or otherwise have a bleeding disorder, or are going to have surgery soon.

    As with anything, we’re not doctors, let alone your doctors, so please consult yours before trying chaga.

    Where can we get it?

    We don’t sell it (or anything else), but for your convenience, here’s an example product on Amazon.

    Enjoy!

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  • Considering taking Wegovy to lose weight? Here are the risks and benefits – and how it differs from Ozempic

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    The weight-loss drug Wegovy is now available in Australia.

    Wegovy is administered as a once-weekly injection and is approved specifically for weight management. It’s intended to be used in combination with a reduced-energy diet and increased physical activity.

    So how does Wegovy work and how much weight can you expect to lose while taking it? And what are the potential risks – and costs – for those who use it?

    Let’s look at what the science says.

    Halfpoint/Shutterstock

    What is Wegovy?

    Wegovy is a brand name for the medication semaglutide. Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1RA). This means it makes your body’s own glucagon-like peptide-1 hormone, called GLP-1 for short, work better.

    Normally when you eat, the body releases the GLP-1 hormone which helps signal to your brain that you are full. Semaglutides enhance this effect, leading to a feeling of fullness, even when you haven’t eaten.

    Another role of GLP-1 is to stimulate the body to produce more insulin, a hormone which helps lower the level of glucose (sugar) in the blood. That’s why semaglutides have been used for several years to treat type 2 diabetes.

    Pack of Wegovy injections
    Wegovy is self-injected once a week. S Becker/Shutterstock

    How does Wegovy differ from Ozempic?

    Like Wegovy, Ozempic is a semaglutide. The way Wegovy and Ozempic work in the body are essentially the same. They’re made by the same pharmaceutical company, Novo Nordisk.

    But there are two differences:

    1) They are approved for two different (but related) reasons.

    In Australia (and the United States), Ozempic is approved for use to improve blood glucose levels in adults with type 2 diabetes. By managing blood glucose levels effectively, the medication aims to reduce the risk of major complications, such as heart disease.

    Wegovy is approved for use alongside diet and exercise for people with a body mass index (BMI) of 30 or greater, or 27 or greater but with other conditions such as high blood pressure.

    Wegovy can also be used in people aged 12 years and older. Like Ozempic, Wegovy aims to reduce the risk of future health complications, including heart disease.

    2) They are both injected but come in different strengths.

    Ozempic is available in pre-loaded single-dose pens with varying dosages of 0.25 mg, 0.5 mg, 1 mg, or 2 mg per injection. The dose can be slowly increased, up to a maximum of 2 mg per week, if needed.

    Wegovy is available in prefilled single-dose pens with doses of 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, or 2.4 mg. The treatment starts with a dose of 0.25 mg once weekly for four weeks, after which the dose is gradually increased until reaching a maintenance dose of 2.4 mg weekly.

    While it’s unknown what the impact of Wegovy’s introduction will be on Ozempic’s availability, Ozempic is still anticipated to be in low supply for the remainder of 2024.

    Is Wegovy effective for weight loss?

    Given Wegovy is a semaglutide, there is very strong evidence it can help people lose weight and maintain this weight loss.

    A recent study found that over four years, participants taking Wevovy as indicated experienced an average weight loss of 10.2% body weight and a reduction in waist circumference of 7.7cm.

    For those who stop taking the medication, analyses have shown that about two-thirds of weight lost is regained.

    Man leans against a bridge rail
    Wegovy can help people lose weight and maintain their weight loss – while they take the drug. Mladen Mitrinovic/Shutterstock

    What are the side effects of Wegovy?

    The most common side effects are nausea and vomiting.

    However, other serious side effects are also possible because of the whole-of-body impact of the medication. Thyroid tumours and cancer have been detected as a risk in animal studies, yet are rarely seen in human scientific literature.

    In the four-year Wegovy trial, 16.6% of participants who received Wegovy (1,461 people) experienced an adverse event that led to them permanently discontinuing their use of the medication. This was higher than the 8.2% of participants (718 people) who received the placebo (with no active ingredient).

    Side effects included gastrointestinal disorders (including nausea and vomiting), which affected 10% of people who used Wegovy compared to 2% of people who used the placebo.

    Gallbladder-related disorders occurred in 2.8% of people who used Wegovy, and 2.3% of people who received the placebo.

    Recently, concerns about suicidal thoughts and behaviours have been raised, after a global analysis reviewed more than 36 million reports of adverse events from semaglutide (Ozempic or Wegovy) since 2000.

    There were 107 reports of suicidal thoughts and self-harm among people taking semaglutide, sadly including six actual deaths. When people stopped the medication, 62.5% found the thoughts went away. What we don’t know is whether dose, weight loss, or previous mental health status or use of antidepressants had a role to play.

    Finally, concerns are growing about the negative effect of semaglutides on our social and emotional connection with food. Anecdotal and scientific evidence suggests people who use semaglutides significantly reduce their daily dietary intake (as anticipated) by skipping meals and avoiding social occasions – not very enjoyable for people and their loved ones.

    How can people access Wegovy?

    Wegovy is available for purchase at pharmacists with a prescription from a doctor.

    But there is a hefty price tag. Wegovy is not currently subsidised through the Pharmaceutical Benefits Scheme, leaving patients to cover the cost. The current cost is estimated at around A$460 per month dose.

    If you’re considering Wegovy, make an appointment with your doctor for individual advice.

    Lauren Ball, Professor of Community Health and Wellbeing, The University of Queensland and Emily Burch, Accredited Practising Dietitian and Lecturer, Southern Cross University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • How Science News Outlets Can Lie To You (Yes, Even If They Cite Studies!)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Each Monday, we’re going to be bringing you cutting-edge research reviews to not only make your health and productivity crazy simple, but also, constantly up-to-date.

    But today, in this special edition, we want to lay out plain and simple how to see through a lot of the tricks used not just by popular news outlets, but even sometimes the research publications themselves.

    That way, when we give you health-related science news, you won’t have to take our word for it, because you’ll be able to see whether the studies we cite really support the claims we make.

    Of course, we’ll always give you the best, most honest information we have… But the point is that you shouldn’t have to trust us! So, buckle in for today’s special edition, and never have to blindly believe sci-hub (or Snopes!) again.

    The above now-famous Tumblr post that became a meme is a popular and obvious example of how statistics can be misleading, either by error or by deliberate spin.

    But what sort of mistakes and misrepresentations are we most likely to find in real research?

    Spin Bias

    Perhaps most common in popular media reporting of science, the Spin Bias hinges on the fact that most people perceive numbers in a very “fuzzy logic” sort of way. Do you?

    Try this:

    • A million seconds is 11.5 days
    • A billion seconds is not weeks, but 13.2 months!

    …just kidding, it’s actually nearly thirty-two years.

    Did the months figure seem reasonable to you, though? If so, this is the same kind of “human brains don’t do large numbers” problem that occurs when looking at statistics.

    Let’s have a look at reporting on statistically unlikely side effects for vaccines, as an example:

    • “966 people in the US died after receiving this vaccine!” (So many! So risky!)
    • “Fewer than 3 people per million died after receiving this vaccine!” (Hmm, I wonder if it is worth it?)
    • “Half of unvaccinated people with this disease die of it” (Oh)

    How to check for this: ask yourself “is what’s being described as very common really very common?”. To keep with the spiders theme, there are many (usually outright made-up) stats thrown around on social media about how near the nearest spider is at any given time. Apply this kind of thinking to medical conditions.. If something affects only 1% of the population (So few! What a tiny number!), how far would you have to go to find someone with that condition? The end of your street, perhaps?

    Selection/Sampling Bias

    Diabetes disproportionately affects black people, but diabetes research disproportionately focuses on white people with diabetes. There are many possible reasons for this, the most obvious being systemic/institutional racism. For example, advertisements for clinical trial volunteer opportunities might appear more frequently amongst a convenient, nearby, mostly-white student body. The selection bias, therefore, made the study much less reliable.

    Alternatively: a researcher is conducting a study on depression, and advertises for research subjects. He struggles to get a large enough sample size, because depressed people are less likely to respond, but eventually gets enough. Little does he know, even the most depressed of his subjects are relatively happy and healthy compared with the silent majority of depressed people who didn’t respond.

    See This And Many More Educational Cartoons At Sketchplanations.com!

    How to check for this: Does the “method” section of the scientific article describe how they took pains to make sure their sample was representative of the relevant population, and how did they decide what the relevant population was?

    Publication Bias

    Scientific publications will tend to prioritise statistical significance. Which seems great, right? We want statistically significant studies… don’t we?

    We do, but: usually, in science, we consider something “statistically significant” when it hits the magical marker of p=0.05 (in other words, the probability of getting that result is 1/20, and the results are reliably coming back on the right side of that marker).

    However, this can result in the clinic stopping testing once p=0.05 is reached, because they want to have their paper published. (“Yay, we’ve reached out magical marker and now our paper will be published”)

    So, you can think of publication bias as the tendency for researchers to publish ‘positive’ results.

    If it weren’t for publication bias, we would have a lot more studies that say “we tested this, and here are our results, which didn’t help answer our question at all”—which would be bad for the publication, but good for science, because data is data.

    To put it in non-numerical terms: this is the same misrepresentation as the technically true phrase “when I misplace something, it’s always in the last place I look for it”—obviously it is, because that’s when you stop looking.

    There’s not a good way to check for this, but be sure to check out sample sizes and see that they’re reassuringly large.

    Reporting/Detection/Survivorship Bias

    There’s a famous example of the rise in “popularity” of left-handedness. Whilst Americans born in ~1910 had a bit under a 3.5% chance of being left handed, those born in ~1950 had a bit under a 12% change.

    Why did left-handedness become so much more prevalent all of a sudden, and then plateau at 12%?

    Simple, that’s when schools stopped forcing left-handed children to use their right hands instead.

    In a similar fashion, countries have generally found that homosexuality became a lot more common once decriminalized. Of course the real incidence almost certainly did not change—it just became more visible to research.

    So, these biases are caused when the method of data collection and/or measurement leads to a systematic error in results.

    How to check for this: you’ll need to think this through logically, on a case by case basis. Is there a reason that we might not be seeing or hearing from a certain demographic?

    And perhaps most common of all…

    Confounding Bias

    This is the bias that relates to the well-known idea “correlation ≠ causation”.

    Everyone has heard the funny examples, such as “ice cream sales cause shark attacks” (in reality, both are more likely to happen in similar places and times; when many people are at the beach, for instance).

    How can any research paper possibly screw this one up?

    Often they don’t and it’s a case of Spin Bias (see above), but examples that are not so obviously wrong “by common sense” often fly under the radar:

    “Horse-riding found to be the sport that most extends longevity”

    Should we all take up horse-riding to increase our lifespans? Probably not; the reality is that people who can afford horses can probably afford better than average healthcare, and lead easier, less stressful lives overall. The fact that people with horses typically have wealthier lifestyles than those without, is the confounding variable here.

    See This And Many More Educational Cartoons on XKCD.com!

    In short, when you look at the scientific research papers cited in the articles you read (you do look at the studies, yes?), watch out for these biases that found their way into the research, and you’ll be able to draw your own conclusions, with well-informed confidence, about what the study actually tells us.

    Science shouldn’t be gatekept, and definitely shouldn’t be abused, so the more people who know about these things, the better!

    So…would one of your friends benefit from this knowledge? Forward it to them!

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  • The Couple’s Guide to Thriving with ADHD – by Melissa Orlov and Nancie Kohlenberger

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    ADHD (what a misleadingly-named condition) is most often undiagnosed in adults, especially older adults, and has far-reaching effects. This book explores those!

    Oftentimes ADHD is not a deficit of attention, it’s just a lack of choice about where one’s attention goes. And the H? It’s mostly not what people think it is. The diagnostic criteria have moved far beyond the original name.

    But in a marriage, ADHD symptoms such as wandering attention, forgetfulness, impulsiveness, and a focus on the “now” to the point of losing sight of the big picture (the forgotten past and the unplanned future), can cause conflict.

    The authors write in a way that is intended for the ADHD and/or non-ADHD partner to read, and ideally, for both to read.

    They shine light on why people with or without ADHD tend towards (or away from) certain behaviours, what miscommunications can arise, and how to smooth them over.

    Best of all, an integrated plan for getting you both on the same page, so that you can tackle anything that arises, as the diverse team (with quite different individual strengths) that you are.

    Bottom line: if you or a loved one has ADHD symptoms, this book can help you navigate and untangle what can otherwise sometimes get a little messy.

    Click here to check out The Couple’s Guide to Thriving with ADHD, and learn how to do just that!

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  • The End of Stress – by Don Joseph Goewey

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    So, we probably know to remember to take a deep breath once in a while, and adopt a “focus on what you can control, rather than what you can’t” attitude. In this book, Goewey covers a lot more.

    After an overview of how we have a brain wired for stress, what it does to us, and why we should rewire that, he dives straight into such topics as:

    • Letting go of fear—safely!
    • Number-crunching the real risks
    • Leading with good decisions, and trusting the process
    • Actively practicing a peaceful mindset (some very good tips here)
    • Transcending shame (and thus sidestepping the stress that it may otherwise bring)

    The book brings together a lot of ideas and factors, seamlessly. From scientific data to case studies, to “try this and see”, encouraging us to try certain exercises for ourselves and be surprised at the results.

    All in all, this is a great book on not just managing stress, but—as the title suggests—ending it in all and any cases it’s not useful to us. In other words, this book? It is useful to us.

    Click here to enjoy The End of Stress from Amazon today!

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