Viruses aren’t always harmful. 6 ways they’re used in health care and pest control

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We tend to just think of viruses in terms of their damaging impacts on human health and lives. The 1918 flu pandemic killed around 50 million people. Smallpox claimed 30% of those who caught it, and survivors were often scarred and blinded. More recently, we’re all too familiar with the health and economic impacts of COVID.

But viruses can also be used to benefit human health, agriculture and the environment.

Viruses are comparatively simple in structure, consisting of a piece of genetic material (RNA or DNA) enclosed in a protein coat (the capsid). Some also have an outer envelope.

Viruses get into your cells and use your cell machinery to copy themselves.
Here are six ways we’ve harnessed this for health care and pest control.

1. To correct genes

Viruses are used in some gene therapies to correct malfunctioning genes. Genes are DNA sequences that code for a particular protein required for cell function.

If we remove viral genetic material from the capsid (protein coat) we can use the space to transport a “cargo” into cells. These modified viruses are called “viral vectors”.

Viruses consist of a piece of RNA or DNA enclosed in a protein coat called the capsid.
DEXi

Viral vectors can deliver a functional gene into someone with a genetic disorder whose own gene is not working properly.

Some genetic diseases treated this way include haemophilia, sickle cell disease and beta thalassaemia.

2. Treat cancer

Viral vectors can be used to treat cancer.

Healthy people have p53, a tumour-suppressor gene. About half of cancers are associated with the loss of p53.

Replacing the damaged p53 gene using a viral vector stops the cancerous cell from replicating and tells it to suicide (apoptosis).

Viral vectors can also be used to deliver an inactive drug to a tumour, where it is then activated to kill the tumour cell.

This targeted therapy reduces the side effects otherwise seen with cytotoxic (cell-killing) drugs.

We can also use oncolytic (cancer cell-destroying) viruses to treat some types of cancer.

Tumour cells have often lost their antiviral defences. In the case of melanoma, a modified herpes simplex virus can kill rapidly dividing melanoma cells while largely leaving non-tumour cells alone.

3. Create immune responses

Viral vectors can create a protective immune response to a particular viral antigen.

One COVID vaccine uses a modified chimp adenovirus (adenoviruses cause the common cold in humans) to transport RNA coding for the SARS-CoV-2 spike protein into human cells.

The RNA is then used to make spike protein copies, which stimulate our immune cells to replicate and “remember” the spike protein.

Then, when you are exposed to SARS-CoV-2 for real, your immune system can churn out lots of antibodies and virus-killing cells very quickly to prevent or reduce the severity of infection.

4. Act as vaccines

Viruses can be modified to act directly as vaccines themselves in several ways.

We can weaken a virus (for an attenuated virus vaccine) so it doesn’t cause infection in a healthy host but can still replicate to stimulate the immune response. The chickenpox vaccine works like this.

The Salk vaccine for polio uses a whole virus that has been inactivated (so it can’t cause disease).

Others use a small part of the virus such as a capsid protein to stimulate an immune response (subunit vaccines).

An mRNA vaccine packages up viral RNA for a specific protein that will stimulate an immune response.

5. Kill bacteria

Viruses can – in limited situations in Australia – be used to treat antibiotic-resistant bacterial infections.

Bacteriophages are viruses that kill bacteria. Each type of phage usually infects a particular species of bacteria.

Unlike antibiotics – which often kill “good” bacteria along with the disease-causing ones – phage therapy leaves your normal flora (useful microbes) intact.

A phage
Bacteriophages (red) are viruses that kill bacteria (green).
Shutterstock

6. Target plant, fungal or animal pests

Viruses can be species-specific (infecting one species only) and even cell-specific (infecting one type of cell only).

This occurs because the proteins viruses use to attach to cells have a shape that binds to a specific type of cell receptor or molecule, like a specific key fits a lock.

The virus can enter the cells of all species with this receptor/molecule. For example, rabies virus can infect all mammals because we share the right receptor, and mammals have other characteristics that allow infection to occur whereas other non-mammal species don’t.

When the receptor is only found on one cell type, then the virus will infect that cell type, which may only be found in one or a limited number of species. Hepatitis B virus successfully infects liver cells primarily in humans and chimps.

We can use that property of specificity to target invasive plant species (reducing the need for chemical herbicides) and pest insects (reducing the need for chemical insecticides). Baculoviruses, for example, are used to control caterpillars.

Similarly, bacteriophages can be used to control bacterial tomato and grapevine diseases.

Other viruses reduce plant damage from fungal pests.

Myxoma virus and calicivirus reduce rabbit populations and their environmental impacts and improve agricultural production.

Just like humans can be protected against by vaccination, plants can be “immunised” against a disease-causing virus by being exposed to a milder version.The Conversation

Thea van de Mortel, Professor, Nursing, School of Nursing and Midwifery, Griffith University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Carrots vs Broccoli – Which is Healthier?

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    Our Verdict

    When comparing carrots to broccoli, we picked the broccoli.

    Why?

    These are both excellent candidates that should be in everyone’s diet, but there’s a clear winner:

    In terms of macros, carrots have 50% more carbs for the same fiber (giving carrots the relatively higher glycemic index, though really, nobody is getting metabolic disease from eating carrots, which are a low-GI food already), while broccoli has more protein. By the numbers, it’s a nominal win for broccoli here, but really, both are great.

    In the category of vitamins, carrots have more of vitamins A and B3, while broccoli has more of vitamins B1, B2, B5, B6, B7, B9, C, E, K, and choline. An easy win for broccoli. We’d like to emphasize, though, that this doesn’t mean carrots don’t have lots of vitamins—they do—it’s just that broccoli has even more!

    When it comes to minerals, carrots are genuinely great, and/but not higher in any minerals than broccoli, while broccoli has more calcium, copper, iron, magnesium, manganese, phosphorus, selenium, and zinc. So again, a clear win for broccoli, despite carrots’ fortitude.

    All in all, an overwhelming win for broccoli, though once again, enjoy either or both; diversity is good!

    Want to learn more?

    You might like to read:

    What Do The Different Kinds Of Fiber Do? 30 Foods That Rank Highest

    Enjoy!

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  • The Surprising Link Between Type 2 Diabetes & Alzheimer’s

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    The Surprising Link Between Type 2 Diabetes & Alzheimer’s

    This is Dr. Rhonda Patrick. She’s a biomedical scientist with expertise in the areas of aging, cancer, and nutrition. In the past five years she has expanded her research of aging to focus more on Alzheimer’s and Parkinson’s, as she has a genetic predisposition to both.

    What does that genetic predisposition look like? People who (like her) have the APOE-ε4 allele have a twofold increased risk of Alzheimer’s disease—and if you have two copies (i.e., one from each of two parents), the risk can be up to tenfold. Globally, 13.7% of people have at least one copy of this allele.

    So while getting Alzheimer’s or not is not, per se, hereditary… The predisposition to it can be passed on.

    What’s on her mind?

    Dr. Patrick has noted that, while we don’t know for sure the causes of Alzheimer’s disease, and can make educated guesses only from correlations, the majority of current science seems to be focusing on just one: amyloid plaques in the brain.

    This is a worthy area of research, but ignores the fact that there are many potential Alzheimer’s disease mechanisms to explore, including (to count only mainstream scientific ideas):

    • The amyloid hypothesis
    • The tau hypothesis
    • The inflammatory hypothesis
    • The cholinergic hypothesis
    • The cholesterol hypothesis
    • The Reelin hypothesis
    • The large gene instability hypothesis

    …as well as other strongly correlated factors such as glucose hypometabolism, insulin signalling, and oxidative stress.

    If you lost your keys and were looking for them, and knew at least half a dozen places they might be, how often would you check the same place without paying any attention to the others?

    To this end, she notes about those latter-mentioned correlated factors:

    ❝50–80% of people with Alzheimer’s disease have type 2 diabetes; there is definitely something going on❞

    There’s another “smoking gun” for this too, because dysfunction in the blood vessels and capillaries that line the blood-brain barrier seem to be a very early event that is common between all types of dementia (including Alzheimer’s) and between type 2 diabetes and APOE-ε4.

    Research is ongoing, and Dr. Patrick is at the forefront of that. However, there’s a practical take-away here meanwhile…

    What can we do about it?

    Dr. Patrick hypothesizes that if we can reduce the risk of type 2 diabetes, we may reduce the risk of Alzheimer’s with it.

    Obviously, avoiding diabetes if possible is a good thing to do anyway, but if we’re aware of an added risk factor for Alzheimer’s, it becomes yet more important.

    Of course, all the usual advices apply here, including a Mediterranean diet and regular moderate exercise.

    Three other things Dr. Patrick specifically recommends (to reduce both type 2 diabetes risk and to reduce Alzheimer’s risk) include:

    (links are to her blog, with lots of relevant science for each)

    You can also hear more from Dr. Patrick personally, as a guest on Dr. Peter Attia’s podcast recently. She discusses these topics in much greater detail than we have room for in our newsletter:

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  • The Origin of Everyday Moods – by Dr. Robert Thayer

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    First of all, what does this title mean by “everyday moods”? By this the author is referring to the kinds of moods we have just as a matter of the general wear-and-tear of everyday life—not the kind that come from major mood disorders and/or serious trauma.

    The latter kinds of mood take less explaining, in any case. Dr. Thayer, therefore, spends his time on the less obvious ones—which in turn are the ones that affect most of the most, every day.

    Critical to Dr. Thayer’s approach is the mapping of moods by four main quadrants:

    1. High energy, high tension
    2. High energy, low tension
    3. Low energy, high tension
    4. Low energy, low tension

    …though this can be further divided into 25 sectors, if we rate each variable on a scale of 0–4. But for the first treatment, it suffices to look at whether energy and tension are high or low, respectively, and which we’d like to have more or less of.

    Then (here be science) how to go about achieving that in the most efficient, evidence-based ways. So, it’s not just a theoretical book; it has great practical value too.

    The style of the book is accessible, and walks a fine line between pop-science and hard science, which makes it a great book for laypersons and academics alike.

    Bottom line: if you’d like the cheat codes to improve your moods and lessen the impact of bad ones, this is the book for you.

    Click here to check out The Origin of Everyday Moods, and manage yours!

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  • Curious Kids: what are the main factors in forming someone’s personality?

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    “What are the main factors in forming someone’s personality?” – Emma, age 10, from Shanghai

    Hello Emma, and thank you for this very interesting question!

    Let’s start by exploring what we mean by personality. Have you noticed no two people are completely alike? We all see, experience, and understand the world in different ways.

    For example, some people love spending time with friends and being the centre of attention, whereas other people are more shy and enjoy having time to themselves.

    Your unique personality is shaped by your genes as well as various influences in your environment. And your personality plays an important role in how you interact with the world.

    The big five

    Did you know there are scientists who spend time researching personality? Their research is concerned with describing the ways people differ from each other, and understanding how these differences could be important for other parts of life such as our health and how well we do in school or at work.

    There are many different perspectives on personality. A widely accepted viewpoint based on a lot of research is called the five factor model or the “big five”. According to this theory, a great deal of a person’s personality can be summarised in terms of where they sit on five dimensions, called traits:

    1. the introversion-extraversion trait refers to how much someone is outgoing and social (extroverted) or prefers being with smaller groups of friends or focusing on their own thoughts (introverted)
    2. agreeableness captures how much someone tends to be cooperative and helps others
    3. openness to experience refers to how much a person is creative and enjoys experiencing new things
    4. neuroticism describes a person’s tendency to experience negative feelings, like worrying about things that could go wrong
    5. conscientiousness encompasses how much a person is organised, responsible, and dedicated to things that are important to them, like schoolwork or training for a sports team.

    A person can have high, low, or moderate levels of each of these traits. And understanding whether someone has higher or lower levels of the big five can tell us a lot about how we might expect them to behave in different situations.

    So what shapes our personalities?

    A number of factors shape our personalities, including our genes and social environment.

    Our bodies are made up of many very small structures called cells. Within these cells are genes. We inherit genes from our parents, and they carry the information needed to make our bodies and personalities. So, your personality may be a bit like your parents’ personalities. For example, if you’re an outgoing sort of person who loves to meet new people, perhaps one or both of your parents are very social too.

    A mother getting her son ready, fastening his backpack.
    Our personalities are influenced by the genes we get from our parents.
    KieferPix/Shutterstock

    Personalities are also affected by our environment, such as our experiences and our relationships with family and friends. For example, some research has shown our relationships with our parents can influence our personality. If we have loving and warm relationships, we may be more agreeable and open. But if our relationships are hurtful or stressful, this may increase our neuroticism.

    Another study showed that, over time, young children who were more physically active were less introverted (less shy) and less likely to get very upset when things don’t go their way, compared to children who were less physically active. Although we don’t know why this is for sure, one possible explanation is that playing sport leads to reduced shyness because it introduces children to different people.

    While we’re learning more about personality development all the time, research in this area presents quite a few challenges. Many different biological, cultural and environmental influences shape our development, and these factors can interact with each other in complex ways.

    Is our personality fixed once we become adults?

    Although we develop most of our personality when we are young, and people’s personalities tend to become more stable as they get older, it is possible for aspects of a person’s personality to change, even when they are fully grown.

    A good example of this can be seen among people who seek treatment for conditions like anxiety or depression. People who respond well to working with a psychologist can show decreases in neuroticism, indicating they become less likely to worry a lot or feel strong negative feelings when something stressful happens.

    Hello, Curious Kids! Do you have a question you’d like an expert to answer? Ask an adult to send your question to mailto:curiouskids@theconversation.edu.auThe Conversation

    Tim Windsor, Professor, Director, Generations Research Initiative, College of Education, Psychology and Social Work, Flinders University and Natalie Goulter, Lecturer, College of Education, Psychology and Social Work, Flinders University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • 20 Easy Ways To Lose Belly Fat (Things To *Not* Do)

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    Waist circumference (and hip to waist ratio) has been found to be a much better indicator of metabolic health than BMI. So, while at 10almonds we generally advocate for not worrying too much about one’s BMI, there are good reasons why it can be good to trim up specifically the visceral belly fat. But how?

    What not to do…

    Autumn Bates is a nutritionist, and her tips include nutrition and other lifestyle factors; here are some that we agree with:

    For more, including to learn what she has against peanut butter, enjoy her video:

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    Want to know more?

    Check out our previous main feature:

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    Take care!

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  • Why the WHO has recommended switching to a healthier salt alternative

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    This week the World Health Organization (WHO) released new guidelines recommending people switch the regular salt they use at home for substitutes containing less sodium.

    But what exactly are these salt alternatives? And why is the WHO recommending this? Let’s take a look.

    goodbishop/Shutterstock

    A new solution to an old problem

    Advice to eat less salt (sodium chloride) is not new. It has been part of international and Australian guidelines for decades. This is because evidence clearly shows the sodium in salt can harm our health when we eat too much of it.

    Excess sodium increases the risk of high blood pressure, which affects millions of Australians (around one in three adults). High blood pressure (hypertension) in turn increases the risk of heart disease, stroke and kidney disease, among other conditions.

    The WHO estimates 1.9 million deaths globally each year can be attributed to eating too much salt.

    The WHO recommends consuming no more than 2g of sodium daily. However people eat on average more than double this, around 4.3g a day.

    In 2013, WHO member states committed to reducing population sodium intake by 30% by 2025. But cutting salt intake has proved very hard. Most countries, including Australia, will not meet the WHO’s goal for reducing sodium intake by 2025. The WHO has since set the same target for 2030.

    The difficulty is that eating less salt means accepting a less salty taste. It also requires changes to established ways of preparing food. This has proved too much to ask of people making food at home, and too much for the food industry.

    A salt shaker spilling onto a table.
    There’s been little progress on efforts to cut sodium intake. snezhana k/Shutterstock

    Enter potassium-enriched salt

    The main lower-sodium salt substitute is called potassium-enriched salt. This is salt where some of the sodium chloride has been replaced with potassium chloride.

    Potassium is an essential mineral, playing a key role in all the body’s functions. The high potassium content of fresh fruit and vegetables is one of the main reasons they’re so good for you. While people are eating more sodium than they should, many don’t get enough potassium.

    The WHO recommends a daily potassium intake of 3.5g, but on the whole, people in most countries consume significantly less than this.

    Potassium-enriched salt benefits our health by cutting the amount of sodium we consume, and increasing the amount of potassium in our diets. Both help to lower blood pressure.

    Switching regular salt for potassium-enriched salt has been shown to reduce the risk of heart disease, stroke and premature death in large trials around the world.

    Modelling studies have projected that population-wide switches to potassium-enriched salt use would prevent hundreds of thousands of deaths from cardiovascular disease (such as heart attack and stroke) each year in China and India alone.

    The key advantage of switching rather than cutting salt intake is that potassium-enriched salt can be used as a direct one-for-one swap for regular salt. It looks the same, works for seasoning and in recipes, and most people don’t notice any important difference in taste.

    In the largest trial of potassium-enriched salt to date, more than 90% of people were still using the product after five years.

    A female nurse taking a senior man's blood pressure.
    Excess sodium intake increases the risk of high blood pressure, which can cause a range of health problems. PeopleImages.com – Yuri A/Shutterstock

    Making the switch: some challenges

    If fully implemented, this could be one of the most consequential pieces of advice the WHO has ever provided.

    Millions of strokes and heart attacks could be prevented worldwide each year with a simple switch to the way we prepare foods. But there are some obstacles to overcome before we get to this point.

    First, it will be important to balance the benefits and the risks. For example, people with advanced kidney disease don’t handle potassium well and so these products are not suitable for them. This is only a small proportion of the population, but we need to ensure potassium-enriched salt products are labelled with appropriate warnings.

    A key challenge will be making potassium-enriched salt more affordable and accessible. Potassium chloride is more expensive to produce than sodium chloride, and at present, potassium-enriched salt is mostly sold as a niche health product at a premium price.

    If you’re looking for it, salt substitutes may also be called low-sodium salt, potassium salt, heart salt, mineral salt, or sodium-reduced salt.

    A review published in 2021 found low sodium salts were marketed in only 47 countries, mostly high-income ones. Prices ranged from the same as regular salt to almost 15 times higher.

    An expanded supply chain that produces much more food-grade potassium chloride will be needed to enable wider availability of the product. And we’ll need to see potassium-enriched salt on the shelves next to regular salt so it’s easy for people to find.

    In countries like Australia, about 80% of the salt we eat comes from processed foods. The WHO guideline falls short by not explicitly prioritising a switch for the salt used in food manufacturing.

    Stakeholders working with government to encourage food industry uptake will be essential for maximising the health benefits.

    Xiaoyue (Luna) Xu, Scientia Lecturer, School of Population Health, UNSW Sydney and Bruce Neal, Executive Director, George Institute Australia, George Institute for Global Health

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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