
The Brain Circuit That Switches Off Chronic Pain
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
…and other items from this week’s health news:
Pain’s “off switch”
Chronic pain is chronic, that is to say, it is characterized by how it keeps on being there. However, in emergency situations, it’s common for the brain to override pain signals (acute or chronic) in order to function sufficiently to deal with the emergency.
In the case of chronic pain, even outside of emergencies it would be nice for the brain to override those pain signals, in order to function sufficiently to deal with everyday life, not to mention to simply enjoy some respite.
Scientists now understand how: there are special neurons in the brainstem’s lateral parabrachial nucleus that can suppress chronic pain signals when survival instincts—like hunger, thirst, or fear—take priority. These Y1R neurons (as they are called) act as a biological switchboard, helping the brain decide when to prioritize immediate needs over lingering pain. The key? They noticed that hunger seemed to reduce chronic pain more effectively than over-the-counter painkillers.
This means two things, in practical terms:
- states (like hunger) that the body recognizes as a threat can shut off pain signals—this is obviously not an ideal solution, since it requires creating states the body recognizes as a threat, and those states are usually not good/sustainable ones either
- new research can now look for ways to flip the switch on these Y1R neurons biochemically, hopefully creating a new class of painkillers that work more effectively and do not have the same drawbacks as, for example, opioids
Read in full: Scientists discover brain circuit that can switch off chronic pain
Related: How Nature Provides Us With A Surprisingly Powerful Painkiller ← this also interrupts the pain signals, albeit in a different way
Cannabis is extra risky for over-65s
Cannabis use is increasing in the US, including among those over 65, though research on long-term effects is still limited because of federal restrictions (the “war on drugs” may have done nothing to reduce drug availability, but has hobbled scientific research for decades).
However, there is still some research, and it’s clear that there are some extra risks for older users, including:
- older adults metabolize cannabis more slowly than younger ones, leading to longer-lasting highs, dizziness, confusion, and higher fall risk
- modern cannabis has far higher THC levels than in past decades (up to 35% in plant form and 90% in concentrates), which means that older adults (accustomed to how things used to be) are more likely to overconsume accidentally, with studies showing tripled emergency visits associated with this
- interactions with medications that are most commonly prescribed to older people—especially blood thinners—can cause further problems too
…in addition to the risks that are closer to the same for everyone, e.g. increased inflammation, cognitive decline, heart disease, heart attacks, and stroke.
Read in full: Regular cannabis use poses risks to those over 65, experts caution
Related: Cannabis Myths vs Reality
HRT: Immune-booster!
Immune function drops sharply after the age of about 60—in men and women, largely due to T-cell production slowing down and eventually all-but-stopping.
For women, there’s usually an additional problem: menopause significantly alters the immune system, leading to more inflammatory white blood cells (monocytes) that are less effective at clearing bacteria and associated with reduced levels of an immune protein essential for fighting infections (it’s called “complement C3”).
However, women have an extra resource at our disposal to give our aging immune systems a boost!
Researchers (Dr. Emma Chambers et al.) found that peri- and post-menopausal women using hormone replacement therapy (HRT) had healthier immune profiles, with fewer inflammatory monocytes, higher complement C3 levels, and infection-fighting capacity closer to that of younger women:
Read in full: Hormone replacement therapy may help restore immunity in menopausal women
Related: Your Brain On (And Off) Estrogen
Take care!
Don’t Forget…
Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!
Recommended
Learn to Age Gracefully
Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:
-
5 Hip Exercises To Strengthen Bones & Improve Balance (Osteoporosis-Friendly)
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Today’s video choice was inspired by: your writer here just got back from the radiology clinic where she had her hips and spine scanned for bone density (I get the results in a week; wish me luck!).
This is an important topic, because…
- Bad news: hip fractures are common in adults over 50 and can lead to long recovery and loss of independence (or indeed, loss of life; too many people go into hospital with a broken hip, get an infection in hospital, and don’t come home)
- Good news: consistent, targeted exercises can strengthen bones and joints to reduce fracture risk and maintain an active, confident lifestyle (and indeed, one conducive to healthy longevity)
Dr. Alyssa Kuhn explains:
Use it or lose it
Dr. Kuhn recommends the following exercises:
- Side stomp: this gentle impact exercise involves stepping to the side and stomping to stimulate bone strengthening, with adjustable intensity and optional upper body support, aiming for 10–15 stomps per side.
- Weighted squat: you can strengthen your leg muscles and bones by doing controlled squats with or without weights (held at shoulder level), keeping an upright posture, avoiding forward bending, and placing weights on a raised surface to prevent unsafe lifting; aim for 10–12 reps, 2–3 sets.
- Heel drops: raise up onto your toes and let your heels drop to create vertical impact for bone strength, starting gently and increasing intensity gradually on soft surfaces or barefoot if comfortable, with a goal of 10–20 reps, 2–3 sets.
- Tandem walking: walk heel-to-toe in a straight line to challenge balance and lower fall risk, using a wall or counter for support and adjusting foot spacing if needed, aiming for 1–2 minutes per round, 2–3 rounds, focusing on control over speed.
- Hop (jumping): begin with supported hops to test readiness, then progress to controlled free jumps that keep knees aligned and hips engaged on landing to safely build hip bone strength, starting with 10–20 reps, 2–3 sets, and increasing gradually.
Find a way to build them (or at least: one or more of them) into your daily routine. A good example, since these are quite “casual” exercises and not the kind for which one necessarily gets changed and/or goes to the gym, is to do some of these while waiting for water to boil, or for the microwave, or things like that.
For more on each of these plus visual demonstrations, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
21% Stronger Bones in a Year at 62? Yes, It’s Possible (No Calcium Supplements Needed!)
Take care!
Share This Post
-
What to say and how to help if someone close to you has attempted suicide
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
If someone close to you has attempted suicide, you may be feeling scared, confused or overwhelmed.
You’re not alone – the most recent data shows more than one in three Australians have been close to someone who has died by or attempted suicide.
Talking about suicide can be really hard. But your support can make a big difference. Here’s what you can do to support someone after a suicide attempt.
Adam Pretty/Getty It’s OK not to have all the answers
The days and weeks after a suicide attempt are often full of intense emotion — for the person who attempted and those who care about them.
Your loved one might feel guilt, shame, anger, confusion or relief. They might also be tired, both physically and emotionally. Meanwhile, you might feel worried, shocked, helpless, or unsure about what to say.
All of these feelings are normal. There’s no “right” way to feel in this situation. But staying connected and offering care (even in small ways) is one of the most powerful things you can do.
How you can help: emotional support
It’s OK to acknowledge the suicide attempt – avoiding it can add to feelings of stigma or isolation. But you don’t need to ask for details, and if you feel overwhelmed it’s also OK to set gentle boundaries.
If you’re unsure what to say, you can be honest about that.
Just be there. Let your loved one know you’re there to listen, without pressure or judgement.
Don’t rush the conversation. If they’re not ready to talk, that’s OK. Let them set the pace.
Avoid guilt or blame. Saying things like “how could you do this to us?” can make someone feel worse. Instead, say something like: “I’m really glad you’re still here. I care about you.”
Reassure them. Tell them they’re not alone and that it’s OK to ask for help.
How you can help: practical support
Offer help with everyday tasks, such as going to appointments, making meals or tidying up.
Encourage (but don’t force) activities they enjoy – maybe a walk, a movie, or just hanging out quietly.
If you’re not sure what would help, ask. Try: “What would make today a bit easier for you?”
Try not to take it personally if they seem withdrawn or say “nothing will help”. They may be feeling overwhelmed.
Stay with them, if they’re open to it, or check in later with a text message. Small acts that don’t require a response, such as dropping off a meal, can go a long way.
You don’t have to do this alone
Supporting someone after a suicide attempt can be both physically and emotionally draining. You might find yourself constantly alert, watching for signs they might be struggling again. This “hypervigilance” is normal, but remember – you don’t have to do this alone.
One person is not a support network. While your care and support make a real difference, professional help is essential too, whether from a psychologist, doctor or counsellor.
It can also help to bring in other trusted people, such as siblings, parents, friends or teachers. Ask your loved one who they’d like to involve, and how.
Support works best when shared.
If you’re worried it might happen again
Mental health professionals often help create a safety plan after a suicide attempt.
This is a step-by-step guide for what to do if suicidal thoughts come back. It usually includes information such as warning signs, how to reduce immediate risks, and strategies to use in the moment.
A plan can also involve personal motivations to keep going and a list of resources, trusted people and emergency contacts.
Lifeline has a free app called Beyond Now, where a plan can be written, saved, and shared with trusted people.
If you want to – and your loved one is open to it – ask if you can be part of the plan or at least know what to do if they’re in crisis again.
Don’t forget: your wellbeing matters too
This situation can take a toll on your own wellbeing. You might feel anxious, tired, sad, or even guilty, and struggle with sleep or appetite.
It’s OK to not be OK.
Make time to look after yourself – eat well, rest, move your body and talk to people you trust. You don’t need to share private details about your loved one to get the support you need.
If it feels overwhelming, speak to a doctor or therapist. Your GP can help set up a mental health treatment plan, which helps you access subsidised counselling.
And if you ever have thoughts of suicide yourself, or you’re deeply worried about someone, reach out – help is available 24/7.
Recovery is different for everyone
Recovery after a suicide attempt doesn’t follow a set path – it’s different for everyone. It may involve professional support, medication, changes in routine, or time off from work or school. Rebuilding takes time and often comes with ups and downs.
Patience and compassion – for your loved one and yourself – can make all the difference.
Remember, you’re not alone, and there is help available.
Beyond Blue:
- call: 1300 22 4636
- visit their website.
Suicide Call Back Service is a free nationwide service providing 24/7 phone and online counselling to people affected by suicide:
- call: 1300 659 467
- visit their website.
13YARN is a free and confidential 24/7 national crisis support line for Aboriginal and Torres Strait Islander people who are feeling overwhelmed or having difficulty coping. Call 13 92 76. WellMob also has a list of culturally safe mental health organisations for First Nations people.
Milena Heinsch, Professor and Head of Social Work, University of Tasmania and Campbell Tickner, Senior Fellow in Social Work, University of Tasmania
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Share This Post
-
Apple vs Kiwi Fruit – Which is Healthier?
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Our Verdict
When comparing apples to kiwi fruit, we picked the kiwi.
Why?
It wasn’t close!
In terms of macros, kiwi has more fiber and protein, scoring an easy first-round victory.
In the category of vitamins, apples are not higher in any vitamins, while kiwi is higher in vitamins A, B1, B3, B5, B6, B7, B9, C, E, and (appropriately enough) especially K, sweeping this round easily.
Looking at minerals, apples are not higher in any minerals, while kiwi has more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc, for another total win here.
In other considerations, kiwi also has some anticancer properties that apples can’t boast, so that’s another point in kiwi’s favor.
Adding up the sections makes for an overwhelmingly clear overall win for kiwi fruit, but by all means enjoy either or both, as diversity is best!
Want to learn more?
You might like:
Top 8 Fruits That Prevent & Kill Cancer ← kiwi is top of the list!
Enjoy!
Share This Post
Related Posts
-
Unbreakable: A Woman’s Guide to Aging with Power – by Dr. Vonda Wright
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
The author, an orthopedic surgeon and longevity specialist, puts the focus on a) women b) musculoskeletal health.
Because, while when thinking about hormones and health a lot of people focus on visible things like hair and nails and such, when it comes to the effects of untreated menopause, let’s face it: more people die from the consequences of a broken hip than from a broken nail.
So, she wants us to avoid the train of sarcopenia → osteopenia → osteoporosis → fractures → infections → death, by reducing our risk factors early, and staying more robust and biologically younger.
She advises doing this in four main ways:
- Exercise: because stronger muscles mean stronger bones, and the impact on metabolic health is important too
- Nutrition: nourishing our muscles and bones, looking after our gut microbiome, and eliminating inflammation
- Supplements: mostly things we can’t reasonably get from diet, such as senolytics that tackle aging on a cellular level
- Lifestyle: in ways not already covered by the above three methods, so now we’re adding such things as sleep, stress management, and so forth.
- This may sound like an optional add-on, but the reality is that our body can’t do the other things properly if we don’t also have this in hand.
With these things in order, she argues, we can reasonably expect to go from strength to strength, rather than the decline that most people experience in later years.
The style is light and personable easy-reading pop-science, with minimal jargon, and any necessary terms explained. After a respectable bibliography, there are also appendices with exercise protocols, recipes, and a how-to guide for managing pain and injury.
Bottom line: if you are a woman and/or care about a woman, the contents of this book are something you should know inside-out, because it’s that important.
Click here to check out Unbreakable, and make yourself as unbreakable as humanly possible!
Don’t Forget…
Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!
Learn to Age Gracefully
Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:
-
Undo It! – by Dr. Dean Ornish & Anne Ornish
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Of course, no lifestyle changes will magically undo Type 1 Diabetes or Cerebral Palsy. But for many chronic diseases, a lot can be done. The question is,how does one book cover them all?
As authors Dr. Dean Ornish and Anne Ornish explain, very many chronic diseases are exacerbated, or outright caused, by the same factors:
- Gene expression
- Inflammation
- Oxidative stress
This goes for chronic disease from heart disease to type 2 diabetes to cancer and many autoimmune diseases.
We cannot change our genes, but we can change our gene expression (the authors explain how). And certainly, we can control inflammation and oxidative stress.
Then first part of the book is given over to dietary considerations. If you’re a regular 10almonds reader, you won’t be too surprised at their recommendations, but you may enjoy the 70 recipes offered.
Attention is also given to exercising in ways optimized to beat chronic disease, and to other lifestyle factors.
Limiting stress is important, but the authors go further when it comes to psychological and sociological factors. Specifically, what matters most to health, when it comes to intimacy and community.
Bottom line: this is a very good guide to a comprehensive lifestyle overhaul, especially if something recently has given you cause to think “oh wow, I should really do more to avoid xyz disease”.
Click here to check out Undo It, and better yet, prevent it in advance!
Don’t Forget…
Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!
Learn to Age Gracefully
Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:
-
Correct An Upper Spine Hump (Simple Stretch & Exercise)
10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.
Generally called a neck hump in this video, it can be in the cervical (neck) vertebrae or it can be in the thoracic (upper back) vertebrae. It’s also known as a dowager’s hump, buffalo hump, or kyphosis.
However, it can be fixed:
What to do
First understand the cause: it generally comes from poor posture, especially from prolonged desk work or phone use.
With that in mind…
- Posture adjustments: lean back in a chair to counter gravity’s pull on your head. Avoid slumping; keep your head aligned with your spine.
- Stretching: lie flat on the floor without pillows to restore spinal alignment. Gradually reduce pillow height during sleep to decrease neck hyperflexion.
- Neck retraction: pull chin straight back while keeping your eyes looking forwards. Hold for 15 seconds, gradually increasing to 60 seconds. Perform 10 repetitions, resting between sets.
- Strengthening: lean forward and pull the chin back against gravity. Hold, or repeat for 10 repetitions. Over time, increase duration to a minute.
For more on all of this plus visual demonstrations, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like to read:
The Pains That Good Posture Now Can Help You Avoid Later
Take care!
Don’t Forget…
Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!
Learn to Age Gracefully
Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails:








