Olfactory Training, Better
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Anosmia, by any other name…
The loss of the sense of smell (anosmia) is these days well-associated with COVID and Long-COVID, but also can simply come with age:
National Institute of Aging | How Smell & Taste Change With Age
…although it can also be something else entirely:
❝Another possibility is a problem with part of the nervous system responsible for smell.
Some studies have suggested that loss of smell could be an early sign of a neurodegenerative disease, such as Alzheimer’s or Parkinson’s disease.
However, a recent study of 1,430 people (average age about 80) showed that 76% of people with anosmia had normal cognitive function at the study’s end.❞
Read more: Harvard Health | Is it normal to lose my sense of smell as I age?
We’d love to look at and cite the paper that they cite, but they didn’t actually provide a source. We did find some others, though:
❝Olfactory capacity declines with aging, but increasing evidence shows that smell dysfunction is one of the early signs of prodromal neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
The loss of smell is considered a clinical sign of early-stage disease and a marker of the disease’s progression and cognitive impairment.❞
Read more: Neurons, Nose, and Neurodegenerative Diseases: Olfactory Function and Cognitive Impairment
What’s clear is the association; what’s not clear is whether one worsens the other, and what causal role each might play. However, the researchers conclude that both ways are possible, including when there is another, third, underlying potential causal factor:
❝Ongoing studies on COVID-19 anosmia could reveal new molecular aspects unexplored in olfactory impairments due to neurodegenerative diseases, shedding a light on the validity of smell test predictivity of cognitive dementia.
The neuroepithelium might become a new translational research target (Neurons, Nose, and Neurodegenerative diseases) to investigate alternative approaches for intranasal therapy and the treatment of brain disorders. ❞
~ Ibid.
Another study explored the possible mechanisms of action, and found…
❝Olfactory impairment was significantly associated with increased likelihoods of MCI, amnestic MCI, and non-amnestic MCI.
In the subsamples, anosmia was significantly associated with higher plasma total tau and NfL concentrations, smaller hippocampal and entorhinal cortex volumes, and greater WMH volume, and marginally with lower AD-signature cortical thickness.
These results suggest that cerebral neurodegenerative and microvascular lesions are common neuropathologies linking anosmia with MCI in older adults❞
- MCI = Mild Cognitive Impairment
- NfL = Neurofilament Light [Chain]
- WMH = White Matter Hyperintensity
- AD =Alzheimer’s Disease
Read more: Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults
How to act on this information
You may be wondering, “this is fascinating and maybe even a little bit frightening, but how is this Saturday’s Life Hacks?”
We wanted to set up the “why” before getting to the “how”, because with a big enough “why”, it’s much easier to find the motivation to act on the “how”.
Test yourself
Or more conveniently, you and a partner/friend/relative can test each other.
Simply do like a “blind taste testing”, but for smell. Ideally these will be a range of simple and complex odors, and commercially available smell test kits will provide these, if you don’t want to make do with random items from your kitchen.
If you’d like to use a clinical diagnostic tool, you can check out:
Clinical assessment of patients with smell and taste disorders
…and especially, this really handy diagnostic flowchart:
Algorithm of evaluation of a patient who has olfactory loss
Train yourself
“Olfactory training” has been the got-to for helping people to regain their sense of smell after losing it due to COVID.
In simple terms, this means simply trying to smell things that “should” have a distinctive odor, and gradually working up one’s repertoire of what one can smell.
You can get some great tips here:
AbScent | Useful Insights Into Smell Training
Hack your training
An extra trick was researched deeply in a recent study which found that multisensory integration helped a) initially regain the ability to smell things and b) maintain that ability later without the cross-sensory input.
What that means: you will more likely be able to smell lemon while viewing the color yellow, and most likely of all to be able to smell lemon while actually holding and looking at a slice of lemon. Having done this, you’re more likely to be able to smell (and distinguish) the odor of lemon later in a blind smell test.
In other words: with this method, you may be able to cut out many months of frustration of trying and failing to smell something, and skip straight to the “re-adding specific smells to my brain’s olfactory database” bit.
Read the study: Olfactory training: effects of multisensory integration, attention towards odors and physical activity
Or if you prefer, here’s a pop-science article based on that:
One in twenty people has no sense of smell—here’s how they might get it back
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Miss Diagnosis: Anxiety, ADHD, & Women
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It’s Q&A Day at 10almonds!
Have a question or a request? We love to hear from you!
In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!
As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!
So, no question/request too big or small
❝Why is ADHD so often misdiagnosed as anxiety in women?❞
A great question! A short and slightly flippant answer could be “it’s the medical misogyny”:
Women and Minorities Bear the Brunt of Medical Misdiagnosis
…and if you’d like to learn more in-depth about this, we recommend this excellent book:
Unwell Women: Misdiagnosis and Myth in a Man-Made World – by Dr. Elinor Cleghorn ← you can read our review here
However, in this case there is more going on too!
Part of this is because ADHD is, like many psychiatric issues, a collection of symptoms that may or may not all always be present. Since clinical definitions are decided by clinicians, rather than some special natural law of the universe, sometimes this results in “several small conditions in a trenchcoat”, and if one symptom is or isn’t present, it can make things look quite different:
What’s The Difference Between ADD and ADHD?
There are two things at hand here: as in the above example, there’s the presence or absence of hyperactivity, but also, that “attention deficit”?
It’s often not really a deficit of attention, so much as the attention is going somewhere else—an example of naming psychiatric disorders for how they affect other people, rather than the person in question.
Sidenote: personality disorders really get the worst of this!
“You have a deep insecurity about never being good enough, and you constantly mess up in your attempt to overcompensate? You may have Evil Bastard Disorder!”
“You have a crippling fear of abandonment and that you are fundamentally unloveable, so you do all you can to try to keep people close? You must have Manipulative Bitch Disorder!”
etc
In the case of ADHD and anxiety and women, a lot of this comes down to how the redirection of focus is perceived:
❝For some time, it has been held that women with ADHD are more likely to internalize symptoms and become anxious and depressed and to suffer emotional dysregulation❞
This internalization of symptoms, vs the externalization more generally perceived in boys and men, is more likely to be seen as anxiety.
Double standards also abound for social reasons, e.g:
- He is someone who thinks ten steps ahead and covers all bases
- She is anxious and indecisive and unable to settle on one outcome
Here’s a very good overview of how this double-standard makes its way into diagnostic processes, along with other built-in biases:
Miss. Diagnosis: A Systematic Review of ADHD in Adult Women
Want to learn more?
We’ve reviewed quite a few books about ADHD, but if we had to pick one to spotlight, we’d recommend this one:
The Silent Struggle: Taking Charge of ADHD in Adults – by L. William Ross-Child, MLC
Enjoy! And while we have your attention… Would you like this section to be bigger? If so, send us more questions!
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Sticky Jackfruit Burgers
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All the taste and experience of pulled pork, without the increased risk of cancer and metabolic disease. On the contrary, jackfruit introduces lots of fiber, vitamins, carotenoids, and flavanones. We’ll have to do a main feature about jackfruit sometime; it’s an unusual fruit especially for its protein content, but for now, let’s get cooking!
You will need
- 1 can (14oz/400g) green jackfruit, drained (the flesh will not, in fact, be green—this is referring to the fruit being unripe and thus still firm in texture, which is what we want. The outside of the fruit, which will not be in the can, will have been green)
- 1/4 red cabbage, thinly sliced
- 1/2 carrot, grated
- 6 mangetout, thinly sliced
- 2 tbsp mayonnaise (your preference what kind, and yes, vegan is fine too)
- 1 tbsp extra virgin olive oil
- 1 tbsp gochujang paste (if you can’t find gochujang paste locally, you can either order it online (here it is on Amazon) or substitute with harissa paste, which is not the same—it uses different spices—but will do the same job here re texture, umami taste, and level of spiciness)
- 1 tbsp soy sauce
- 1 tbsp balsamic vinegar
- 1 tsp apple cider vinegar
- 1 tsp garlic paste
- 1 tsp tomato paste
- 1 tsp ginger paste
- 1 tsp chili flakes
- 3½ fl oz water
- 2 burger buns (unless you make them yourself, burger buns will probably not be healthy; you can, however, also look for small round wholemeal breads—the name of which varies far too much by region for us to try to get a catch-all name here—and use them in place of burger buns)
Method
(we suggest you read everything at least once before doing anything)
1) Combine the garlic paste, ginger paste, tomato paste, gochujang paste, soy sauce, balsamic vinegar, and chili flakes in a saucepan
2) Boil the 3½ fl oz water we mentioned; add it to the saucepan, mixing well, turn on the heat and let it simmer for 5 minutes or until it is thick and sticky (it will thicken more as it cools, too, so don’t worry if it doesn’t seem thick enough yet). Set it aside.
3) Dry the jackfruit (using strong kitchen paper should be fine), add the olive oil to a skillet and bring it to a high heat; add the jackfruit and fry on both sides for a few minutes, until it looks cooked (remember, while this may look like animal meat, it’s not, so there’s no danger of undercooking here).
4) When the jackfruit looks a nice golden-brown, add two thirds of the sauce from the saucepan, and break apart the jackfruit a bit (this can be done with a wooden/bamboo spatula, so as to not damage your pan), When it all looks how you’d expect pulled jackfruit (or pulled pork) to look, take it off the heat.
5) Combine the carrot, cabbage, and mangetout in a small bowl, adding the apple cider vinegar and mixing well; this will be the coleslaw element
6) Mix the remaining sauce with the mayonnaise
7) (optional) toast the burger buns
8) Assemble the burgers; we recommend the following order: bottom bun, pulled jackfruit, coleslaw, gochujang mayo, top bun
Enjoy!
Want to learn more?
For those interested in some of the science of what we have going on today:
- Level-Up Your Fiber Intake, The Fun Way!
- 10 Ways To Balance Blood Sugars
- Our Top 5 Spices: How Much Is Enough For Benefits?
Take care!
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How we can prepare for future public health emergencies
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The U.S. is experiencing an increasing number of disease outbreaks and extreme weather events. While state and national preparedness for public health emergencies has improved in some areas, dangerous gaps remain, says a recent report from Trust for America’s Health.
Titled, “Ready or Not 2024: Protecting the Public’s Health from Diseases, Disasters, and Bioterrorism,” the report identifies gaps in national and state preparedness for public health emergencies and provides recommendations for improvement.
Using nine key indicators, the report categorizes all U.S. states and the District of Columbia into three readiness levels: high, medium, and low. The writers hope the report will help policymakers in under-performing states improve public health infrastructure.
Read on to learn more about what the research found and how we can individually prepare for future public health emergencies.
There’s work to be done
The report highlights areas with strong performance as well as those that need improvement.
Some areas with strong performance:
- State public health funding: Most states and the District of Columbia either maintained or increased their public health funding during the 2023 fiscal year.
- Health care labor force preparedness: Most states have started expanding the health care labor force for improved emergency response. As of 2023, 39 states participated in the Nurse Licensure Compact, which allows nurses to work in multiple member states without the need for additional state licenses.
Some areas that need improvement:
- Hospital safety scores: Only 25 percent of acute care hospitals earned the highest patient safety grade in fall 2023. These scores measure health care-associated infection rates, intensive care unit capacity, and other metrics. More high-scoring hospitals would improve preparedness for future public health emergencies.
- Access to paid time off: From March 2018 to March 2023, only 55 percent of U.S. workers used paid time off. Access to paid time off is important for reducing the spread of infectious diseases.
We can all do our part by staying up to date on vaccines
While the report focuses on policy changes that would improve emergency preparedness, Trust for America’s Health’s research identifies one way that we can individually prepare for future public health emergencies: staying up to date on vaccines.
The report found that during the 2022-2023 flu season, only 49 percent of those eligible for the flu vaccine received it. Public health experts are concerned that false claims about COVID-19 vaccines have resulted in overall vaccine hesitancy.
A decline in vaccination rates has led to an uptick in life-threatening, vaccine-preventable diseases, such as measles. Increasing vaccine uptake would prevent the spread of vaccine-preventable diseases and reduce strain on hospital systems during public health crises.
Make sure that you and your children have received all recommended vaccines to prevent severe illness, hospitalization, and death. Learn more about recommended vaccines for adults and children from the CDC.
For more information, talk to your health care provider.
This article first appeared on Public Good News and is republished here under a Creative Commons license.
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Tomato vs Cucumber – Which is Healthier?
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Our Verdict
When comparing tomato to cucumber, we picked the tomato.
Why?
Both are certainly great, but there are some nutritional factors between them:
In terms of macros, everything is approximately equal except that tomato has more than 2x the fiber, so that’s a win for tomato.
When it comes to vitamins, tomatoes have more of vitamins A, B1, B3, B6, B9, C, E, and choline, while cucumber has more of vitamins B2, B5, and K. In short, an 8:3 victory for tomatoes.
In the category of minerals, tomatoes have more copper, potassium, and manganese, while cucumber has more calcium, iron, magnesium, selenium, and zinc. So, a win for cucumber this time.
Both have useful phytochemical properties, too; tomatoes are rich in lycopene which has many benefits, and cucumbers have powerful anti-inflammatory powers whose mechanism of action is not yet fully understood—see the links below for more details!
All in all, enjoy either or both (they make a great salad chopped roughly together with some olives, a little garlic, and a drizzle of olive oil and balsamic vinegar with a twist or three of black pepper), but if you have to pick just one (what a cruel world), we say the tomato has the most benefits, on balance.
Want to learn more?
You might like to read:
- Lycopene’s Benefits For The Gut, Heart, Brain, & More
- Cucumber Extract Beats Glucosamine & Chondroitin… At 1/135th Of The Dose?!
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Yoga Teacher: “If I wanted to get flexible in 2025, here’s what I’d do”
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Progress in flexibility isn’t about doing more but doing it smarter:
Step by step
First, we need a good foundation. Create three routines focusing on different areas of the body, namely:
- Hips & hamstrings
- Shoulders & spine
- Wrists, ankles, & neck
Alternate these on a daily basis (e.g. Mon = 1, Tue = 2, Wed = 3, Thu = 1, Fri = 2, Sat = 3, Sun = 1, Mon = 2, Tue = 3, and so on), doing just 10 minutes per day and focusing on consistency.
Next, we will want to identify problem areas (likely they will identify themselves, i.e. a particular stretch will be harder than others). Use “focus sessions” twice a week (20–30 minutes) to address these spots. While you’re at it, incorporate techniques like active stretches, weighted stretches, and resistance bands to improve strength and range of motion.
Because commitment is important, schedule flexibility sessions like important meetings and set calendar alerts. Focus on consistency rather than perfection.
To help keep you going, remember that flexibility improvements are less obvious than other fitness goals. Take photos every couple of weeks (e.g. forward fold, low lunge, shoulder stretch). Visual proof of progress can motivate you to keep going.
For more on all of this, plus suggested specific stretches for those routines, enjoy:
Click Here If The Embedded Video Doesn’t Load Automatically!
Want to learn more?
You might also like:
Getting Flexible, Starting As An Adult: How Long Does It Really Take?
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The Fruit That Can Specifically Reduce Belly Fat
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Gambooge: Game-Changer Or Gamble?
The gambooge, also called the gummi-gutta, whence its botanical name Garcinia gummi-gutta (formerly Gardinia cambogia), is also known as the Malabar tamarind, and it even got an English name, the brindle berry.
It’s a fruit that looks like a small pale yellow pumpkin in shape, but it grows on trees and has a taste so sour, that it’s usually used only in cooking, and not eaten raw
which makes this writer really want to try it raw now.Its active phytochemical compound hydroxycitric acid (HCA) rose to popularity as a supplement in the US based on a paid recommendation from Dr. Oz, and then became a controversy as supplements associated with it, were in turn associated with hepatotoxicity (more on this in the “Is it safe?” section below).
What do people use it for?
Simply put: it’s a weight loss supplement.
Less simply put: least interestingly, it’s a mild appetite suppressant:
Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX) ← this talks more about the biochemistry, but isn’t a human study. Human studies have been small and with mixed results. It seems likely that (as in the rat studies discussed above) the mechanism of action is largely about increasing serotonin, which itself is a well-established appetite suppressant. Therefore, the results will depend somewhat on a person’s brain’s serotonergic system.
We’ll revisit that later, but first let’s look at…
Even less simply put: its other mechanism of action is much more interesting; it actually blocks the production of fat (especially: visceral fat) in the body, by inhibiting citrate lyase, which enzyme plays a significant role in fat production:
Effects of (−)-hydroxycitrate on net fat synthesis as de novo lipogenesis
More illustratively, here’s another study, which found:
❝G cambogia reduced abdominal fat accumulation in subjects, regardless of sex, who had the visceral fat accumulation type of obesity. No rebound effect was observed.
It is therefore expected that G cambogia may be useful for the prevention and reduction of accumulation of visceral fat. ❞
~ Dr. Norihiro Shigematsu et al.
As to why this is particularly important, and far more important than mere fat loss in general, see our previous main feature:
Visceral Belly Fat (And How To Lose It)
Is it safe?
It has shown a good safety profile up to large doses (2.8g/day):
Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans
There have been some fears about hepatotoxicity, but they appear to be unfounded, and based on products that did not, in fact, contain HCA (and were merely sold by a company that used a similar name in their marketing):
No evidence demonstrating hepatotoxicity associated with hydroxycitric acid
However, as it has a serotoninergic effect, it could cause problems for anyone at risk of serotonin syndrome, which means caution is advisable if you are taking SSRIs (which reduce the rate at which the brain can scrub serotonin, with the usually laudable goal of having more serotonin in the brain—but it is possible to have too much of a good thing, and serotonin syndrome isn’t fun).
As ever, do check with your pharmacist and/or doctor, to be sure, since they can advise with regard to your specific situation and any medications you may be taking.
Want to try some?
We don’t sell it, but here for your convenience is an example product on Amazon
Enjoy!
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