Does This New Machine Cure Depression?
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Let us first talk briefly about the slightly older tech that this may replace, transcranial magnetic stimulation (TMS).
TMS involves electromagnetic fields to stimulate the left half of the brain and inhibit the right half of the brain. It sounds like something from the late 19th century—“cure your melancholy with the mystical power of magnetism”—but the thing is, it works:
The main barriers to its use are that the machine itself is expensive, and it has to be done in a clinic by a trained clinician. Which, if it were treating one’s heart, say, would not be so much of an issue, but when treating depression, there is a problem that depressed people are not the most likely to commit to (and follow through with) going somewhere probably out-of-town regularly to get a treatment, when merely getting out of the door was already a challenge and motivation is thin on the ground to start with.
Thus, antidepressant medications are more often the go-to for cost-effectiveness and adherence. Of course, some will work better than others for different people, and some may not work at all in the case of what is generally called “treatment-resistant depression”:
Antidepressants: Personalization Is Key!
Transcranial stimulation… At home?
Move over transcranial magnetic stimulation; it’s time for transcranial direct-current stimulation (tDCS).
First, what it’s not: electroconvulsive therapy (ECT). Rather, it uses a very low current.
What it is: a small and portable headset (as opposed to the big machine to go sit in for TMS) that one can use at home. Here’s an example product on Amazon, though there are more stylish versions around, this is the same basic technology.
In a recent study, 45% of those who received treatment with this device experienced remission in 10 weeks, significantly beating placebo (bearing in mind that placebo effect is strongest when it comes to invisible ailments such as depression).
See also: How To Leverage Placebo Effect For Yourself ← this explains more about how the placebo effect works, to the extent that it can even be an adjuvant tool to augment “real” therapies
And as for the study, here it is:
…which rather cuts through the “depressed people don’t make it to the clinic consistently, if at all” problem. Of course, it still requires adherence to its use at home, for example three 30-minute sessions per week, but honestly, “lie/sit still” is likely within the abilities of the majority of depressed people. However…
Important note: you remember we said “in 10 weeks”? That may be critical, because shorter studies (e.g. 6 weeks) have previously returned without such glowing results:
Home-Use Transcranial Direct Current Stimulation for the Treatment of a Major Depressive Episode
This means that if you get this tech for yourself or a loved one, it’ll be necessary to persist for likely 10 weeks, certainly more than 6 weeks, and not abandon it after a few sessions when it hasn’t been life-changing yet. And that may be more of a challenge for a depressed person, so likely an “accountability buddy” of some kind is in order (partner, close friend, etc) to help ensure adherence and generally bug you/them into doing it consistently.
And then, of course, you/they might still be in the 55% of people for whom it didn’t work. And that does suck, but random antidepressant medications (i.e., not personalized) don’t fare much better, statistically.
Want something else against depression meanwhile?
Here are some strategies that not only can significantly help, but also are tailored to be actually doable while depressed:
The Mental Health First-Aid You’ll Hopefully Never Need ← written by your writer who has previously suffered extensively from depression and knows what it is like
Take care!
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Apple vs Pineapple – Which is Healthier?
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Our Verdict
When comparing apple to pineapple, we picked the pineapple.
Why?
An apple a day may keep the doctor away, but pineapples are heavier and armored and spiky and generally much more intimidating.
More seriously, apples are great but we say pineapples have the better nutritional and phytochemical properties overall:
In terms of macros, actually apples win this first round, albeit marginally; the two fruits are equal on carbs, while apple has a little more fiber and pineapple has a (very) little more protein. This makes the fiber content the deciding factor, so apples do win this one, even if by just 1g/100g difference.
When it comes to vitamins, however, apples have more of vitamins E and K, while pineapple has more of vitamins A, B1, B2, B3, B5, B6, B7, B9, C, and choline. The margins of difference are equally generous on both sides, so this is a clear and overwhelming win for pineapple (including 10x more vitamin C than apples, which are themselves considered a good source of vitamin C)
In the category of minerals, apples have slightly more phosphorus, and pineapple has a lot more calcium, copper, iron, magnesium, manganese, potassium, selenium, and zinc. Another easy win for pineapple.
Pineapples are not only also higher in polyphenols, but also contain bromelain, a powerful anti-inflammatory group of enzymes that are unique to pineapple—you can read about it in the link below!
Meanwhile, pineapple wins the day in our head-to-head here, but as ever when it comes to a plurality of healthy things, do enjoy either or both! Diversity is good.
Want to learn more?
You might like to read:
Bromelain vs Inflammation & Much More
Enjoy!
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Acorns vs Chestnuts – Which is Healthier?
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Our Verdict
When comparing acorns to chestnuts, we picked the acorns.
Why?
In terms of macros, chestnuts are mostly water, so it’s not surprising that acorns have a lot more carbs, fat, protein, and fiber. Thus, unless you have personal reasons for any of those to be a problem, acorns are the better choice, offering a lot more nutritional value.
In the category of vitamins, acorns lead with a lot more of vitamins A, B2, B3, B5, B6, and B9, while chestnuts have more of vitamins B1 and C. However, that vitamin C is useless to us, because it is destroyed in the cooking process (by boiling or roasting), and both of these nuts can be harmful if consumed raw, so that cooking does need to be done. That leaves acorns with a 6:1 lead.
When it comes to minerals, things are more even; acorns have more copper, magnesium, manganese, and zinc, while chestnuts have more calcium, iron, phosphorus, and potassium. Thus, a 4:4 tie (and yes, the margins of difference are approximately equal too).
We mentioned “both of these nuts can be harmful if consumed raw”, so a note on that: it’s because, while both contain an assortment of beneficial phytochemicals, they also both contain tannins that, if consumed raw, chelate with iron, essentially taking it out of our diet and potentially creating an iron deficiency. Cooking tannins stops this from being an issue, and the same cooking process renders the tannins actively beneficial to the health, for their antioxidant powers.
You may have heard that acorns are poisonous; that’s not strictly speaking true, except insofar as anything could be deemed poisonous in excess (including such things as water, and oxygen). Rather, it’s simply the above-described matter of the uncooked tannins and iron chelation. Even then, you’re unlikely to suffer ill effects unless you consume them raw in a fair quantity. While acorns have fallen from popular favor sufficient that one doesn’t see them in supermarkets, the fact is they’ve been enjoyed as an important traditional part of the diet by various indigenous peoples of N. America for centuries*, and provided they are cooked first, they are a good healthy food for most people.
*(going so far as to cultivate natural oak savannah areas, by burning out young oaks to leave the old ones to flourish without competition, to maximize acorn production, and then store dried acorns in bulk sufficient to cover the next year or so in case of a bad harvest later—so these was not just an incidental food, but very important “our life may depend on this” food. Much like grain in many places—and yes, acorns can be ground into flour and used to make bread etc too)
Do note: they are both still tree nuts though, so if you have a tree nut allergy, these ones aren’t for you.
Otherwise, enjoy both; just cook them first!
Want to learn more?
You might like to read:
Why You Should Diversify Your Nuts
Take care!
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More Things Dopamine Does For Us
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In this week’s news roundup, we have two dopamine items and one other for variety:
The real “dopamine switch”
Dopamine is well-known as “the reward chemical”, and indeed it is that, but it also plays a central role in many neurological processes, including:
- Linear task processing
- Motivation
- Learning and memory
- Motor functions
- Language faculties
Recent research has now shown its importance in cognitive flexibility, i.e. the ability to adapt to circumstances, and switch approaches appropriately to such, and generally not get stuck in a cognitive rut:
Read in full: Scientists confirm neurobiochemical link between dopamine and cognitive flexibility
Related: The Dopamine Myth
You may like the sound of this
It’s been known for a while that dopamine is involved in learning and memory (as mentioned above), but this has been established largely by associative studies, e.g. “people with lower dopamine levels learn less easily”. But scientists have now mapped out more of how it actually does that.
One more reason to ensure we have and maintain healthy dopamine levels!
Read in full: Songbirds highlight dopamine’s role in learning
Related: 10 Ways To Naturally Boost Dopamine
Resist Or Run!
When it comes to protecting against bone loss, resistance exercise remains key, but impact-laden activities such as running (but not lower-level everyday activity) can help too. There have been studies on the extent to which walking (a load-bearing activity) may be protective against bone loss, and the results of those studies have mostly been inconclusive.
This study looked into the incidence (or not, as the case may be) of bone-loading impacts in everyday movements, using accelerometers, and measured bone mineral density before and after testing periods. Those that had higher-intensity bone-loading movements (so, resistance training or running, for example) retained the best measures of bone density through menopause into postmenopause:
Read in full: Everyday physical activity does not slow bone loss during menopause, finds study
Related: The Bare-Bones Truth About Osteoporosis
Take care!
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Oranges vs Lemons – Which is Healthier?
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Our Verdict
When comparing oranges to lemons, we picked the oranges.
Why?
In the battle of these popular citrus fruits, there is a clear winner on the nutritional front.
Things were initially promising for lemons when looking at the macros—lemons have a little more fiber while oranges are slightly higher in carbs, but the differences are small and both are very healthy in this regard.
However, alas for this writer who prefers sour fruits to sweet ones (I’m sweet enough already), the micronutrient profiles tell a different story:
In terms of vitamins, oranges have more of vitamins A, B1, B2, B3, B5, B9, E, and choline. In contrast, lemons have a (very) little more vitamin B6. You might be wondering about vitamin C, since both fruits are famous for that—they’re equal on vitamin C. But, with that stack we listed above, oranges clearly win the vitamin category easily.
As for minerals, oranges boast more calcium, copper, magnesium, potassium, selenium, and zinc, while lemons have more iron, manganese, and phosphorus.
Technically lemons also have more sodium, but the numbers are truly miniscule (by coincidence, we discover upon grabbing a calculator, you’d need to eat approximately your own bodyweight in whole lemons to get to the RDA of sodium—and that’s to reach the RDA, not the upper healthy limit) so we’ll overlook the tiny sodium difference as irrelevant. Which means, while closer than the vitamins category, oranges win on minerals with a 6:3 lead over lemons.
Both fruits offer generous helpings of flavonoids and other polyphenols such as naringenin and hesperidin, which have anti-inflammatory properties and more specifically can also reduce allergy symptoms (unless, of course, you are allergic to citrus fruits, which is a relatively rare but extant allergy).
In short: as ever, enjoy both; diversity is great for the health. But if you want to maximize the nutrients you get, it’s oranges.
Want to learn more?
You might like to read:
Lemons vs Limes – Which is Healthier?
Take care!
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If Your Adult Kid Calls In Crisis…
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Parent(s) To The Rescue?
We’ve written before about the very common (yes, really, it is common) phenomenon of estrangement between parents and adult children:
Family Estrangement & How To Fix It
We’ve also written about the juggling act that can be…
Managing Sibling Relationships In Adult Life
…which includes dealing with such situations as supporting each other through difficult times, while still maintaining healthy boundaries.
But what about when one’s [adult] child is in crisis?
When a parent’s job never ends
Hopefully, we have not been estranged (or worse, bereaved) by our children.
In which case, when crisis hits, we are likely to be amongst the first to whom our children will reach out for support. Naturally, we will want to help. But how can we do that, and where (if applicable) to draw the line?
No “helicopter parenting”
If you’ve not heard the term “helicopter parenting”, it refers to the sort of parents who hover around, waiting to swoop in at a moment’s notice.
This is most often applied to parents of kids of university age and downwards, but it’s worth keeping it in mind at any age.
After all, we do want our kids to be able to solve their own problems if possible!
So, if you’ve ever advised your kid to “take a deep breath and count to 10” (or even if you haven’t), then, consider doing that too, and then…
Listen first!
If your first reaction isn’t to join them in panic, it might be to groan and “oh not again”. But for now, quietly shelve that, and listen to whatever it is.
See also: Active Listening (Without Sounding Like A Furby)
And certainly, do your best to maintain your own calm while listening. Your kid is in all likelihood looking to you to be the rock in the storm, so let’s be that.
Empower them, if you can
Maybe they just needed to vent. If so, the above will probably cover it.
More likely, they need help.
Perhaps they need guidance, from your greater life experience. Sometimes things that can seem like overwhelming challenges to one person, are a thing we dealt with 20 or more years ago (it probably felt overwhelming to us at the time, too, but here we are, the other side of it).
Tip: ask “are you looking for my guidance/advice/etc?” before offering it. Doing so will make it much more likely to be accepted rather than rejected as unsolicited advice.
Chances are, they will take the life-ring offered.
It could be that that’s not what they had in mind, and they’re looking for material support. If so…
When it’s about money or similar
Tip: it’s worth thinking about this sort of thing in advance (now is great, if you have adult kids), and ask yourself nowwhat you’d be prepared to give in that regard, e.g:
- if they need money, how much (if any) are you willing and able to provide?
- if they want/need to come stay with you, how prepared are you for that (including: if they want/need to actually move back in with you for a while, which is increasingly common these days)?
Having these answers in your head ready will make the conversation a lot less difficult in the moment, and will avoid you giving a knee-jerk response you might regret (in either direction).
Have a counteroffer up your sleeve if necessary
Maybe:
- you can’t solve their life problem for them, but you can help them find a therapist (if applicable, for example)
- you can’t solve their money problem for them, but you can help them find a free debt advice service (if applicable, for example)
- you can’t solve their residence problem for them, but you can help them find a service that can help with that (if applicable, for example)
You don’t need to brainstorm now for every option; you’re a parent, not Batman. But it’s a lot easier to think through such hypothetical thought-experiments now, than it will be with your fraught kid on the phone later.
Magic words to remember: “Let’s find a way through this for you”
Don’t forget to look after yourself
Many of us, as parents, will tend to not think twice before sacrificing something for our kid(s). That’s generally laudable, but we must avoid accidentally becoming “the giving tree” who has nothing left for ourself, and that includes our mental energy and our personal peace.
That doesn’t mean that when our kid comes in crisis we say “Shh, stop disturbing my personal peace”, but it does mean that we remember to keep at least some boundaries (also figure out now what they are, too!), and to take care of ourselves too.
The following article was written with a slightly different scenario in mind, but the advice remains just as valid here:
How To Avoid Carer Burnout (Without Dropping Care)
Take care!
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Why do I need to take some medicines with food?
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Have you ever been instructed to take your medicine with food and wondered why? Perhaps you’ve wondered if you really need to?
There are varied reasons, and sometimes complex science and chemistry, behind why you may be advised to take a medicine with food.
To complicate matters, some similar medicines need to be taken differently. The antibiotic amoxicillin with clavulanic acid (sold as Amoxil Duo Forte), for example, is recommended to be taken with food, while amoxicillin alone (sold as Amoxil), can be taken with or without food.
Different brands of the same medicine may also have different recommendations when it comes to taking it with food.
Ron Lach/Pexels Food impacts drug absorption
Food can affect how fast and how much a drug is absorbed into the body in up to 40% of medicines taken orally.
When you have food in your stomach, the makeup of the digestive juices change. This includes things like the fluid volume, thickness, pH (which becomes less acidic with food), surface tension, movement and how much salt is in your bile. These changes can impair or enhance drug absorption.
Eating a meal also delays how fast the contents of the stomach move into the small intestine – this is known as gastric emptying. The small intestine has a large surface area and rich blood supply – and this is the primary site of drug absorption.
Eating a meal with medicine will delay its onset. Farhad/Pexels Eating a larger meal, or one with lots of fibre, delays gastric emptying more than a smaller meal. Sometimes, health professionals will advise you to take a medicine with food, to help your body absorb the drug more slowly.
But if a drug can be taken with or without food – such as paracetamol – and you want it to work faster, take it on an empty stomach.
Food can make medicines more tolerable
Have you ever taken a medicine on an empty stomach and felt nauseated soon after? Some medicines can cause stomach upsets.
Metformin, for example, is a drug that reduces blood glucose and treats type 2 diabetes and polycystic ovary syndrome. It commonly causes gastrointestinal symptoms, with one in four users affected. To combat these side effects, it is generally recommended to be taken with food.
The same advice is given for corticosteroids (such as prednisolone/prednisone) and certain antibiotics (such as doxycycline).
Taking some medicines with food makes them more tolerable and improves the chance you’ll take it for the duration it’s prescribed.
Can food make medicines safer?
Ibuprofen is one of the most widely used over-the-counter medicines, with around one in five Australians reporting use within a two-week period.
While effective for pain and inflammation, ibuprofen can impact the stomach by inhibiting protective prostaglandins, increasing the risk of bleeding, ulceration and perforation with long-term use.
But there isn’t enough research to show taking ibuprofen with food reduces this risk.
Prolonged use may also affect kidney function, particularly in those with pre-existing conditions or dehydration.
The Australian Medicines Handbook, which guides prescribers about medicine usage and dosage, advises taking ibuprofen (sold as Nurofen and Advil) with a glass of water – or with a meal if it upsets your stomach.
If it doesn’t upset your stomach, ibuprofen can be taken with water. Tbel Abuseridze/Unsplash A systematic review published in 2015 found food delays the transit of ibuprofen to the small intestine and absorption, which delays therapeutic effect and the time before pain relief. It also found taking short courses of ibuprofen without food reduced the need for additional doses.
To reduce the risk of ibuprofen causing damage to your stomach or kidneys, use the lowest effective dose for the shortest duration, stay hydrated and avoid taking other non-steroidal anti-inflammatory medicines at the same time.
For people who use ibuprofen for prolonged periods and are at higher risk of gastrointestinal side effects (such as people with a history of ulcers or older adults), your prescriber may start you on a proton pump inhibitor, a medicine that reduces stomach acid and protects the stomach lining.
How much food do you need?
When you need to take a medicine with food, how much is enough?
Sometimes a full glass of milk or a couple of crackers may be enough, for medicines such as prednisone/prednisolone.
However, most head-to-head studies that compare the effects of a medicine “with food” and without, usually use a heavy meal to define “with food”. So, a cracker may not be enough, particularly for those with a sensitive stomach. A more substantial meal that includes a mix of fat, protein and carbohydrates is generally advised.
Your health professional can advise you on which of your medicines need to be taken with food and how they interact with your digestive system.
Mary Bushell, Clinical Associate Professor in Pharmacy, University of Canberra
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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