Does PRP Work For Hair Loss?

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Dr. Ankit Gupta takes us through the details of this hair loss remedy for androgenic alopecia.

The bald truth

Platelet-Rich Plasma (PRP) is a controversial treatment for androgenic hair loss.

What it involves: blood is drawn and separated using a centrifuge. PRP—including growth proteins and hormones—is extracted from the blood; about 30 ml of blood is needed to produce 5 ml of PRP. This is then injected directly into the scalp. As this can be painful, local anaesthetic is sometimes used first. This usually involves monthly sessions for the first 3 months, then booster sessions every 3–6 months thereafter.

Does it work? Research is young; so far 60% of trials have found it worked; 40% found it didn’t. When it works, effectiveness (in terms of hair restoration) is considered to be between 25–43%. Results are inconsistent and seem to vary from person to person.

In short, this doctor’s recommendation is to consider it after already having tried standard treatments such as finasteride and/or minoxidil, as they are more likely to work and don’t involve such exciting procedures as injecting your own blood extracts back into your head.

For more on all of this, plus links to the 13 papers cited, enjoy:

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  • The Abs-Brain Axis

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    You’ve heard of the gut-brain axis, but now there’s also this!

    Quick note: if you in fact haven’t heard of the gut-brain axis, then here you go:

    Whence such considerations as: Heal Your Gut, Save Your Brain – by Dr. Partha Nandi

    So, what’s the new news?

    Abs-olute brain benefits

    This time, it has more to do with brain-cleaning, and how even small body movements—especially abdominal muscle contractions—can gently shift your brain inside your skull, helping cerebrospinal fluid circulate and clear waste.

    You might remember the brain-centric part of this general idea from such things as:

    So, why are abdominal muscles special in this regard?

    Per recent research by Dr. Beatrice Ghitti et al., tightening your core increases abdominal pressure, which pushes blood through the vertebral venous plexus—a vein network linking your abdomen, spine, and brain—creating a subtle hydraulic effect that moves your brain slightly. Sounds bad, doesn’t it? Well, it isn’t!

    This tiny brain motion was observed to help “rinse” the brain by moving cerebrospinal fluid across brain tissue, to support waste removal and reduce buildup associated with neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and so forth.

    We talk often about how “what’s good for your heart is good for your brain”, because of how the circulation is so important for that, and it goes not just for reducing risk factors (see: What’s Your Vascular Dementia Risk?), but also for improving cognitive function, e.g: How Your Exercise Today Gives A Brain Boost Tomorrow

    In this case, it’s not just about circulation, however, because brain motion was linked more strongly to movement and abdominal contractions than to breathing or heartbeat, showing how physical activity itself may directly support brain-cleaning processes, in addition to circulatory benefits.

    You can read the paper in full, here: Brain motion is driven by mechanical coupling with the abdomen

    Want to learn more?

    Check out:

    Breathing For Pain Relief & Core Strength (How To Reconnect Your Breath & Body) ← this has to do with abdominal control also for, incidentally, brain benefits

    Take care!

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  • The Plant Power Doctor

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    A Prescription For GLOVES

    Dr. Genma Newman is a Doctor with expertise in Plant Power.

    This is Dr. Gemma Newman. She’s a GP (General Practitioner, British equivalent to what is called a family doctor in America), and she realized that she was treating a lot of patients while nobody was actually getting better.

    So, she set out to help people actually get better… But how?

    The biggest thing

    The single biggest thing she recommends is a whole foods plant-based diet, as that’s a starting point for a lot of other things.

    Click here for an assortment of short videos by her and other health professionals on this topic!

    Specifically, she advocates to “love foods that love you back”, and make critical choices when deciding between ingredients.

    Click here to see her recipes and tips (this writer is going to try out some of these!)

    What’s this about GLOVES?

    We recently reviewed her book “Get Well, Stay Well: The Six Healing Health Habits You Need To Know”, and now we’re going to talk about those six things in more words than we had room for previously.

    They are six things that she says we should all try to get every day. It’s a lot simpler than a lot of checklists, and very worthwhile:

    Gratitude

    May seem like a wishy-washy one to start with, but there’s a lot of evidence for this making a big difference to health, largely on account of how it lowers stress and anxiety. See also:

    How To Get Your Brain On A More Positive Track (Without Toxic Positivity)

    Love

    This is about social connections, mostly. We are evolved to be a social species, and while some of us want/need more or less social interaction than others, generally speaking we thrive best in a community, with all the social support that comes with that. See also:

    How To Beat Loneliness & Isolation

    Outside

    This is about fresh air and it’s about moving and it’s about seeing some green plants (and if available, blue sky), marvelling at the wonder of nature and benefiting in many ways. See also:

    Walking… Better.

    Vegetables

    We spoke earlier about the whole foods plant-based diet for which she advocates, so this is that. While reducing/skipping meat etc is absolutely a thing, the focus here is on diversity of vegetables; it is best to make a game of seeing how many different ones you can include in a week (not just the same three!). See also:

    Three Critical Kitchen Prescriptions

    Exercise

    At least 150 minutes moderate exercise per week, and some kind of resistance work. It can be calisthenics or something; it doesn’t have to be lifting weights if that’s not your thing! See also:

    Resistance Is Useful! (Especially As We Get Older)

    Sleep

    Quality and quantity. Yes, 7–9 hours, yes, regardless of age. Unless you’re a child or a bodybuilder, in which case make it nearer 12. But for most of us, 7–9. See also:

    Why You Probably Need More Sleep

    Want to know more?

    As well as the book we mentioned earlier, you might also like:

    The Plant Power Doctor – by Dr. Gemma Newman

    While the other book we mentioned is available for pre-order for Americans (it’s already released for the rest of the world), this one is available to all right now, so that’s a bonus too.

    If books aren’t your thing (or even if they are), you might like her award-winning podcast:

    The Wellness Edit

    Take care!

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  • How To Actually Access Early Dementia Screening

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    It’s Q&A Day at 10almonds!

    Have a question or a request? We love to hear from you!

    In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

    As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

    So, no question/request too big or small 😎

    ❝Hi, do you know where you can get early dementia testing done in the UK? Great job on the newletter.❞

    Thank you for the kind words!

    With regard to early dementia testing in the UK, we have good and bad news:

    The bad news

    The NHS does not love to offer dementia testing:

    • they will first try to dismiss any concerns ← not official policy, but we imagine you know how it is
    • they will offer cognitive assessment tests, to test your mental abilities. If these give any cause for concern, then…
    • they will offer an array of unrelated blood tests “to rule out other causes of symptoms that can be confused with dementia”
    • if you have dementia symptoms and the unrelated blood tests didn’t bring anything else up, then they may do an MRI:

    An MRI scan is recommended to:

    • help confirm a diagnosis of dementia and the type of disease causing the dementia
    • provide detailed information about the blood vessel damage that happens in vascular dementia
    • show shrinkage in specific areas of the brain – for example, the frontal and temporal lobes are mainly affected by shrinkage in frontotemporal dementia, while usually just the temporal lobes are affected in the early stages of Alzheimer’s disease

    Source: NHS: Tests for diagnosing dementia

    Those cognitive assessment tests, by the way, you can get a head start if you like; here’s the industry’s gold standard test (it’s free):

    SAGE: A Test to Detect Signs of Alzheimer’s and Dementia

    (The Self-Administered Gerocognitive Exam (SAGE) is designed to detect early signs of cognitive, memory or thinking impairments)

    See also: Is It Dementia? Spot The Signs (Because None Of Us Are Immune)

    The good news

    For actual early dementia screening based on blood, there’s a clinical trial that’s right now accepting volunteers to sign up for it:

    ❝Two expert research teams, one from University College London and the other from Dementias Platform UK at the University of Oxford, will conduct UK-wide clinical trials to identify blood tests to boost dementia diagnosis. The two studies will take complementary approaches:

    The READ-OUT study will be led by Dr Vanessa Raymont, Associate Director of Dementias Platform UK and a clinical researcher based at the University of Oxford.  Her team will test multiple existing and novel blood tests for a range of types of dementia, including Alzheimer’s disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. The researchers will also look at whether these blood tests can help detect these diseases at various stages.

    The second study will be led by Prof Jonathan Schott and Dr Ashvini Keshavan, who are both based at University College London. Their study, ADAPT, will focus on the most promising test for Alzheimer’s disease, which measures levels of a protein called p-tau217. This increases in the blood as other proteins build up in the brain during the development of Alzheimer’s disease. The researchers will carry out a clinical trial to see whether measuring p-tau217 in the blood increases the rate of diagnosis for Alzheimer’s disease both in people with early dementia. It will also involve those with mild, progressive problems with memory.❞

    Source: Two revolutionary studies set to bring blood tests for dementia a step closer to NHS ← published literally today, at time of writing; you timed your question well!

    Here’s the sign-up form for that: Blood Biomarker Challenge Registration Form

    Not from the UK?

    We appreciate that most of our readers are from N. America, so normally we cater particularly to what’s most relevant for most of our readers. Of course, if someone asks a specific question that pertains to somewhere else, we’ll do our best to answer it, as we did today.

    However! If you are, for example, in the US or Canada, then the above-mentioned tests are still the ones you want to ask your doctor about,

    You can also refer to the tests we discussed in the article that surely prompted today’s question, here:

    Early Dementia Screening From Your Blood & More

    Take care!

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  • Do We Need Supplements, And Do They Work?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Does our diet need a little help?

    We asked you for your take on supplements, and got the above-illustrated, below-described set of results.

    • The largest minority of respondents (a little over a third) voted for “I just take something very specific”
    • The next most respondents voted for “I take so many supplements; every little helps!”
    • Almost as many voted for “I just take a vitamin or two / a multivitamin”
    • Fewest, about 8%, voted for “I get everything I need from my diet”

    But what does the science say?

    Food is less nutritious now than it used to be: True or False?

    True or False depending on how you measure it.

    An apple today and an apple from a hundred years ago are likely to contain the same amounts of micronutrients per apple, but a lower percentage of micronutrients per 100g of apple.

    The reason for this is that apples (and many other food products; apples are just an arbitrary example) have been selectively bred (and in some cases, modified) for size, and because the soil mineral density has remained the same, the micronutrients per apple have not increased commensurate to the increase in carbohydrate weight and/or water weight. Thus, the resultant percentage will be lower, despite the quantity remaining the same.

    We’re going to share some science on this, and/but would like to forewarn readers that the language of this paper is a bit biased, as it looks to “debunk” claims of nutritional values dropping while skimming over “yes, they really have dropped percentage-wise” in favor of “but look, the discrete mass values are still the same, so that’s just a mathematical illusion”.

    The reality is, it’s no more a mathematical illusion than is the converse standpoint of saying the nutritional value is the same, despite the per-100g values dropping. After all, sometimes we eat an apple as-is; sometimes we buy a bag of frozen chopped fruit. That 500g bag of chopped fruit is going to contain less copper (for example) than one from decades past.

    Here’s the paper, and you’ll see what we mean:

    Mineral nutrient composition of vegetables, fruits and grains: The context of reports of apparent historical declines

    Supplements aren’t absorbed properly and thus are a waste of money: True or False?

    True or False depending on the supplement (and your body, and the rest of your diet)

    Many people are suffering from dietary deficiencies of vitamins and minerals, that could be easily correctable by supplementation:

    However, as this study by Dr. Fang Fang Zhang shows, a lot of vitamin and mineral supplementation does not appear to have much of an effect on actual health outcomes, vis-à-vis specific diseases. She looks at:

    • Cardiovascular disease
    • Cancer
    • Type 2 diabetes
    • Osteoporosis

    Her key take-aways from this study were:

    • Randomised trial evidence does not support use of vitamin, mineral, and fish oil supplements to reduce the risk of non-communicable diseases
    • People using supplements tend to be older, female, and have higher education, income, and healthier lifestyles than people who do not use them
    • Use of supplements appreciably reduces the prevalence of inadequate intake for most nutrients but also increases the prevalence of excess intake for some nutrients
    • Further research is needed to assess the long term effects of supplements on the health of the general population and in individuals with specific nutritional needs, including those from low and middle income countries

    Read her damning report: Health effects of vitamin and mineral supplements

    On the other hand…

    This is almost entirely about blanket vitamin-and-mineral supplementation. With regard to fish oil supplementation, many commercial fish oil supplements break down in the stomach rather than the intestines, and don’t get absorbed well. Additionally, many people take them in forms that aren’t pleasant, and thus result in low adherence (i.e., they nominally take them, but in fact they just sit on the kitchen counter for a year).

    One thing we can conclude from this is that it’s good to check the science for any given supplement before taking it, and know what it will and won’t help for. Our “Monday Research Review” editions of 10almonds do this a lot, although we tend to focus on herbal supplements rather than vitamins and minerals.

    We can get everything we need from our diet: True or False?

    Contingently True (but here be caveats)

    In principle, if we eat the recommended guideline amounts of various macro- and micro-nutrients, we will indeed get all that we are generally considered to need. Obviously.

    However, this may come with:

    • Make sure to get enough protein… Without too much meat, and also without too much carbohydrate, such as from most plant sources of protein
    • Make sure to get enough carbohydrates… But only the right kinds, and not too much, nor at the wrong time, and without eating things in the wrong order
    • Make sure to get enough healthy fats… Without too much of the unhealthy fats that often exist in the same foods
    • Make sure to get the right amount of vitamins and minerals… We hope you have your calculators out to get the delicate balance of calcium, magnesium, potassium, phosphorus, and vitamin D right.

    That last one’s a real pain, by the way. Too much or too little of one or another and the whole set start causing problems, and several of them interact with several others, and/or compete for resources, and/or are needed for the others to do their job.

    And, that’s hard enough to balance when you’re taking supplements with the mg/µg amount written on them, never mind when you’re juggling cabbages and sardines.

    On the topic of those sardines, don’t forget to carefully balance your omega-3, -6, and -9, and even within omega-3, balancing ALA, EPA, and DHA, and we hope you’re juggling those HDL and LDL levels too.

    So, when it comes to getting everything we need from our diet, for most of us (who aren’t living in food deserts and/or experiencing food poverty, or having a medical condition that restricts our diet), the biggest task is not “getting enough”, it’s “getting enough of the right things without simultaneously overdoing it on the others”.

    With supplements, it’s a lot easier to control what we’re putting in our bodies.

    And of course, unless our diet includes things that usually can’t be bought in supermarkets, we’re not going to get the benefits of taking, as a supplement, such things as:

    Etc.

    So, there definitely are supplements with strong science-backed benefits, that probably can’t be found on your plate!

    Don’t Forget…

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  • Change Your Brain, Change Your Life – by Dr. Daniel G. Amen

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    To what extent can we change our brains, and to what extent are we stuck with what we have?

    Dr. Amen tells us that being mindful of both ends of this is critical:

    • Neuroplasticity means we can, indeed, change our brains
    • We do, however, have fundamental “brain types” based on our neurochemistry and physical brain structure

    He argues for the use of brain imaging technology to learn more about the latter… In order to better go about doing what we can with the former.

    The book looks at how these different brain types can lead to situations where what works as a treatment for one person can often not work for another. It’s also prescriptive, about what sorts of treatments (and lifestyle adjustments) are more likely to do better for each.

    Where the book excels is in giving ideas and pointers for exploration… Things to take to one’s doctor, and—for example—request certain tests, and then what to do with those.

    Where the book is a little light is on including hard science in the explanations. The hard science is referred to, but is considered beyond the scope of the book, or perhaps beyond the interest of the reader. That’s unfortunate, as we’d have liked to have seen more of it, rather than taking claims at face value without evidence.

    Bottom line: this is distinctly “pop science” in presentation, but can give a lot of great ideas for learning more about our own brains and brain health… And then optimizing such.

    Click here to check out “Change Your Brain; Change Your Life” on Amazon today!

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  • How Stress Affects Your Body

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    Dr. Sharon Bergquist gives us a tour:

    Stress, from the inside out

    Stress is a natural physical and emotional response to challenges or being overwhelmed. It can be beneficial in short-term situations (e.g. escape from a tiger) but is harmful when prolonged or frequent (e.g. escape the rat-race).

    Immediate physiological response: cortisol, adrenaline (epinephrine), and norepinephrine are released by the adrenal glands.

    The effects this has (non-exhaustive list; we’re just citing what’s in the video here):

    • Cortisol impairs blood vessel function, promoting atherosclerosis.
    • Adrenaline increases heart rate and blood pressure, leading to hypertension.
    • Stress disrupts the brain-gut connection, causing:
      • Digestive issues like irritable bowel syndrome and heartburn.
      • Changes in gut bacteria composition, potentially affecting overall health.
    • Cortisol increases appetite and cravings for energy-dense “comfort foods”.
      • This in turn promotes visceral fat storage, which raises the risk of heart disease and insulin resistance.
    • Immune-specific effects:
      • Stress hormones initially aid in healing and immune defense.
      • Chronic stress weakens immune function (by over-working it constantly), increasing susceptibility to infections and slowing recovery.
    • Other systemic effects:
      • Chronic stress shortens telomeres, which protect chromosomes. Shortened telomeres accelerate cellular aging.
      • Chronic stress can also cause acne, hair loss, sexual dysfunction, headaches, muscle tension, fatigue, irritability, and difficulty concentrating.

    So, how to manage this? The video says that viewing stressful situations as controllable challenges, rather than insurmountable threats, leads to better short-term performance and long-term health.

    Which would be wonderful, except that usually things are stressful precisely because they are not entirely within the field of our control, and the usual advice is to tend to what we can control, and accept what we can’t.

    However… That paradigm still leaves out the very big set of “this might be somewhat within our control or it might not; we really don’t know yet; we can probably impact it but what if we don’t do enough, or take the wrong approach and do the wrong thing? And also we have 17 competing stressors, which ones should we prioritize tending to first, and…” and so on.

    To that end, we suggest checking out the “Want to learn more?” link we drop below the video today, as it is about managing stress realistically, in a world that, if we’re honest about it, can sometimes be frankly unmanageable.

    Meanwhile, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Heart Health vs Systemic Stress ← this is good in and of itself, and also links to other stress-related resources of ours

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

    Join the 98k+ American women taking control of their health & aging with our 100% free (and fun!) daily emails: