Creatine, Genomic Screening, & More

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In this week’s health news…

Creatine: no difference vs control at 5g/day

A study found, as the title suggests, no difference between creatine and placebo, at the usual dose of 5g/day, while doing a supervised resistance training program.

This was a 12-week trial, and in the first week, the creatine group put on an average of 0.5kg more lean (i.e. not fat) body mass than the control group, however, as this quickly equalized after the first week, it is assumed that the brief extra weight gain was water weight (creatine promotes water retention, especially in the initial phase).

However, it is still possible that it may promote weight gain at higher doses.

This study was done with adult participants under the age of 50; we’ve noted before that it is generally young people who use creatine for bodybuilding, so in principle, this should have been ideal for that, but it wasn’t.

Read in full: Sports supplement creatine makes no difference to muscle gains, trial finds

Related: Creatine’s Brain Benefits Increase With Age ← this, on the other hand, does work—but only for older adults.

Genomics & disease risk: what to know

In a recent study evaluation, 175,500 participants were screened, and 1 in 30 received medically important genetic results. More than 90% of those found to have a genetic risk were previously unaware of it.

This is important, because most current genetic risk assessment for patients is based on personal and family history, which often misses a lot of data due to barriers to care or lack of family history.

Genomic screening helps close these gaps:

Read in full: Genomic screening is important in identifying disease risk, study finds

Related: Do You Have A Personalized Health Plan? (Here’s How)

FDA-Approved Antivirals (Not Vaccines) Ineffective Against H5N1

The H5N1 avian influenza outbreak is now rife amongst dairy farms, with the virus found in cows’ milk and infecting farmworkers. Researchers studied potential treatments, revealing two FDA-approved antivirals (baloxavir and oseltamivir) were generally ineffective in treating severe H5N1 infections.

Oral infections per raw milk consumption, were the most severe and hardest to treat, and the virus spread quickly to the blood and brain (when the infection is respiratory, it is much slower to spread from the respiratory tract).

It wasn’t a complete loss, though:

  • Eye infections were better controlled with baloxavir, achieving a 100% survival rate compared to 25% with oseltamivir.
  • For nasal infections, baloxavir reduced viral levels better but still allowed the virus to reach the brain. Survival rates were 75% for baloxavir and 50% for oseltamivir.

The researchers in question are urging preventative measures as being of critical importance, given the difficulty of treatment:

Read in full: Current antivirals likely less effective against severe infection caused by bird flu virus in cows’ milk

Related: Bird Flu: Children At High Risk; Older Adults Not So Much

Take care!

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  • War in Ukraine affected wellbeing worldwide, but people’s speed of recovery depended on their personality

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    The war in Ukraine has had impacts around the world. Supply chains have been disrupted, the cost of living has soared and we’ve seen the fastest-growing refugee crisis since World War II. All of these are in addition to the devastating humanitarian and economic impacts within Ukraine.

    Our international team was conducting a global study on wellbeing in the lead up to and after the Russian invasion. This provided a unique opportunity to examine the psychological impact of the outbreak of war.

    As we explain in a new study published in Nature Communications, we learned the toll on people’s wellbeing was evident across nations, not just in Ukraine. These effects appear to have been temporary – at least for the average person.

    But people with certain psychological vulnerabilities struggled to recover from the shock of the war.

    Tracking wellbeing during the outbreak of war

    People who took part in our study completed a rigorous “experience-sampling” protocol. Specifically, we asked them to report their momentary wellbeing four times per day for a whole month.

    Data collection began in October 2021 and continued throughout 2022. So we had been tracking wellbeing around the world during the weeks surrounding the outbreak of war in February 2022.

    We also collected measures of personality, along with various sociodemographic variables (including age, gender, political views). This enabled us to assess whether different people responded differently to the crisis. We could also compare these effects across countries.

    Our analyses focused primarily on 1,341 participants living in 17 European countries, excluding Ukraine itself (44,894 experience-sampling reports in total). We also expanded these analyses to capture the experiences of 1,735 people living in 43 countries around the world (54,851 experience-sampling reports) – including in Australia.

    A global dip in wellbeing

    On February 24 2022, the day Russia invaded Ukraine, there was a sharp decline in wellbeing around the world. There was no decline in the month leading up to the outbreak of war, suggesting the change in wellbeing was not already occurring for some other reason.

    However, there was a gradual increase in wellbeing during the month after the Russian invasion, suggestive of a “return to baseline” effect. Such effects are commonly reported in psychological research: situations and events that impact our wellbeing often (though not always) do so temporarily.

    Unsurprisingly, people in Europe experienced a sharper dip in wellbeing compared to people living elsewhere around the world. Presumably the war was much more salient for those closest to the conflict, compared to those living on an entirely different continent.

    Interestingly, day-to-day fluctuations in wellbeing mirrored the salience of the war on social media as events unfolded. Specifically, wellbeing was lower on days when there were more tweets mentioning Ukraine on Twitter/X.

    Our results indicate that, on average, it took around two months for people to return to their baseline levels of wellbeing after the invasion.

    Different people, different recoveries

    There are strong links between our wellbeing and our individual personalities.

    However, the dip in wellbeing following the Russian invasion was fairly uniform across individuals. None of the individual factors assessed in our study, including personality and sociodemographic factors, predicted people’s response to the outbreak of war.

    On the other hand, personality did play a role in how quickly people recovered. Individual differences in people’s recovery were linked to a personality trait called “stability”. Stability is a broad dimension of personality that combines low neuroticism with high agreeableness and conscientiousness (three traits from the Big Five personality framework).

    Stability is so named because it reflects the stability of one’s overall psychological functioning. This can be illustrated by breaking stability down into its three components:

    1. low neuroticism describes emotional stability. People low in this trait experience less intense negative emotions such as anxiety, fear or anger, in response to negative events
    2. high agreeableness describes social stability. People high in this trait are generally more cooperative, kind, and motivated to maintain social harmony
    3. high conscientiousness describes motivational stability. People high in this trait show more effective patterns of goal-directed self-regulation.

    So, our data show that people with less stable personalities fared worse in terms of recovering from the impact the war in Ukraine had on wellbeing.

    In a supplementary analysis, we found the effect of stability was driven specifically by neuroticism and agreeableness. The fact that people higher in neuroticism recovered more slowly accords with a wealth of research linking this trait with coping difficulties and poor mental health.

    These effects of personality on recovery were stronger than those of sociodemographic factors, such as age, gender or political views, which were not statistically significant.

    Overall, our findings suggest that people with certain psychological vulnerabilities will often struggle to recover from the shock of global events such as the outbreak of war in Ukraine.The Conversation

    Luke Smillie, Professor in Personality Psychology, The University of Melbourne

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • White Potato vs Sweet Potato – Which is Healthier?

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    Our Verdict

    When comparing white potatoes to sweet potatoes, we picked the sweet potatoes.

    Why?

    In terms of macros, sweet potatoes are a little lighter on carbs and calories, though in the case of sugar and fiber, sweet potato has a few grams more of each, per potato. However, when an average sweet potato’s 7g of sugar are held against its 4g of fiber, this (much like with fruit!) not a sugar you need to avoid.

    See also: Which Sugars Are Healthier, And Which Are Just The Same?

    The glycemic index of a sweet potato is also lower than that of a white potato, so the sugars it does have are slower-release.

    Sweet potatoes famously are good sources of vitamin A and beta-carotene, which important nutrients white potatoes cannot boast.

    Both plants are equally good sources of potassium and vitamin C.

    Summary

    Both are good sources of many nutrients, and any nutritional health-hazards associated with them come with the preparation (for example, frying introduces unhealthy fats, and mashing makes the glycemic index skyrocket, and cooking with salt increases the salt content).

    Baking either is great (consider stuffing them with delicious well-seasoned beans and/or tomatoes; if you make it yourself, pesto can be a great option too, as can cheese if you’re so-inclined and judicious with choice and quantity) and preserves almost all of their nutrients. Remember that nearly 100% of the fiber is in the skin, so you do want to eat that.

    The deciding factor is: sweet potatoes are good sources of a couple more valuable nutrients that white potatoes aren’t, and come out as the overall healthiest for that reason.

    Enjoy!

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  • We created a VR tool to test brain function. It could one day help diagnose dementia

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    If you or a loved one have noticed changes in your memory or thinking as you’ve grown older, this could reflect typical changes that occur with ageing. In some cases though, it might suggest something more, such as the onset of dementia.

    The best thing to do if you have concerns is to make an appointment with your GP, who will probably run some tests. Assessment is important because if there is something more going on, early diagnosis can enable prompt access to the right interventions, supports and care.

    But current methods of dementia screening have limitations, and testing can be daunting for patients.

    Our research suggests virtual reality (VR) could be a useful cognitive screening tool, and mitigate some of the challenges associated with current testing methods, opening up the possibility it may one day play a role in dementia diagnosis.

    Where current testing is falling short

    If someone is worried about their memory and thinking, their GP might ask them to complete a series of quick tasks that check things like the ability to follow simple instructions, basic arithmetic, memory and orientation.

    These sorts of screening tools are really good at confirming cognitive problems that may already be very apparent. But commonly used screening tests are not always so good at detecting early and more subtle difficulties with memory and thinking, meaning such changes could be missed until they get worse.

    A clinical neuropsychological assessment is better equipped to detect early changes. This involves a comprehensive review of a patient’s personal and medical history, and detailed assessment of cognitive functions, including attention, language, memory, executive functioning, mood factors and more. However, this can be costly and the testing can take several hours.

    Testing is also somewhat removed from everyday experience, not directly tapping into activities of daily living.

    Enter virtual reality

    VR technology uses computer-generated environments to create immersive experiences that feel like real life. While VR is often used for entertainment, it has increasingly found applications in health care, including in rehabilitation and falls prevention.

    Using VR for cognitive screening is still a new area. VR-based cognitive tests generally create a scenario such as shopping at a supermarket or driving around a city to ascertain how a person would perform in these situations.

    Notably, they engage various senses and cognitive processes such as sight, sound and spatial awareness in immersive ways. All this may reveal subtle impairments which can be missed by standard methods.

    VR assessments are also often more engaging and enjoyable, potentially reducing anxiety for those who may feel uneasy in traditional testing environments, and improving compliance compared to standard assessments.

    A senior woman sitting on a bed with her hand to her face.
    Millions of people around the world have dementia.
    pikselstock/Shutterstock

    Most studies of VR-based cognitive tests have explored their capacity to pick up impairments in spatial memory (the ability to remember where something is located and how to get there), and the results have been promising.

    Given VR’s potential for assisting with diagnosis of cognitive impairment and dementia remains largely untapped, our team developed an online computerised game (referred to as semi-immersive VR) to see how well a person can remember, recall and complete everyday tasks. In our VR game, which lasts about 20 minutes, the user role plays a waiter in a cafe and receives a score on their performance.

    To assess its potential, we enlisted more than 140 people to play the game and provide feedback. The results of this research are published across three recent papers.

    Testing our VR tool

    In our most recently published study, we wanted to verify the accuracy and sensitivity of our VR game to assess cognitive abilities.

    We compared our test to an existing screening tool (called the TICS-M) in more than 130 adults. We found our VR task was able to capture meaningful aspects of cognitive function, including recalling food items and spatial memory.

    We also found younger adults performed better in the game than older adults, which echoes the pattern commonly seen in regular memory tests.

    A senior man sitting outdoors using a laptop.
    Adults of a range of ages tried our computerised game.
    pikselstock/Shutterstock

    In a separate study, we followed ten adults aged over 65 while they completed the game, and interviewed them afterwards. We wanted to understand how this group – who the tool would target – perceived the task.

    These seniors told us they found the game user-friendly and believed it was a promising tool for screening memory. They described the game as engaging and immersive, expressing enthusiasm to continue playing. They didn’t find the task created anxiety.

    For a third study, we spoke to seven health-care professionals about the tool. Overall they gave positive feedback, and noted its dynamic approach to age-old diagnostic challenges.

    However, they did flag some concerns and potential barriers to implementing this sort of tool. These included resource constraints in clinical practice (such as time and space to carry out the assessment) and whether it would be accessible for people with limited technological skills. There was also some scepticism about whether the tool would be an accurate method to assist with dementia diagnosis.

    While our initial research suggests this tool could be a promising way to assess cognitive performance, this is not the same as diagnosing dementia. To improve the test’s ability to accurately detect those who likely have dementia, we’ll need to make it more specific for that purpose, and carry out further research to validate its effectiveness.

    We’ll be conducting more testing of the game soon. Anyone interested in giving it a go to help with our research can register on our team’s website.The Conversation

    Joyce Siette, Research Theme Fellow in Health and Wellbeing, Western Sydney University and Paul Strutt, Senior Lecturer in Psychology, Western Sydney University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Red Potatoes vs Russet Potatoes – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing red potatoes to russet potatoes, we picked the russet.

    Why?

    In terms of macros, russet potatoes have more fiber, carbs, and protein; the ratio of fiber and carbs also gives them the lower glycemic index*, so really, a complete win for russets in the macros category.

    *Glycemic index of potatoes change a lot depending on what you do to them, but this statement (about russets having the lower GI) continues to hold true on a like-for-like basis, i.e. assuming we continue to compare the potatoes having been cooked the same way as each other. They’re poisonous raw, so please don’t eat them that way. We right now are looking at stats for potatoes “flesh and skin, baked“, which is generally considered the healthiest way to eat potatoes. Obviously, if you make them into mash then the glycemic index will be sky-high, and if you make them into fries they’ll now have lots of fat added, etc. So let’s just stick to the baked potatoes for now.

    In the category of vitamins, red potatoes have more vitamin C, while russet potatoes have more vitamin B6. All the other minerals are close enough between both potatoes to be within reasonable margins of variation/error (in particular, they are both fair sources of vitamins B1, B2, B3, B5, and B9), so it’s really just between those two vitamins, so we’ll call this round a tie.

    When it comes to minerals, red potatoes have more copper, phosphorus, and zinc, while russet potatoes have more calcium, iron, magnesium, manganese, and potassium. Thus, a win for russets here.

    Adding up the sections gives an overall win for russets, but by all means, enjoy either or both; diversity is good!

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    Enjoy!

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  • Random Acts of Medicine – by Dr. Anupam Jena & Dr. Christopher Worsham

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    We talked recently of small things that can change how productive your doctor’s appointment is, and this book is a more scientific version of that, and on a grander scale.

    The author use what they call “natural experiments”, essentially observational studies, to determine what factors beyond the obvious affect health outcomes. With this approach, they address such questions as why kids with summer birthdays are more likely to get the flu, and why heart attack outcomes improve when there’s a cardiologists’ convention elsewhere. And many more such things that can seem like non-causal correlation, until one examines the causative factors, and controls (in the statistical analysis; remember this is still entirely observational, so no interventions are made) for other potential confounding factors.

    They also look at what factors influence doctors’ decisions in ways they certainly shouldn’t, but they do, because doctors are as prone to biases as everyone else. And, for that matter, what factors influence patients’ decisions in ways they certainly shouldn’t—for the same reason. The authors acknowledge that they themselves are not immune, and you, dear reader, are not immune either.

    Nevertheless, the practical value in this book comes from trying to at least be more aware of such things, the better to either leverage them, or at least ensure you don’t fall foul of them.

    The style is conversational pop-science, making for quite light reading, albeit with many footnotes and a respectable bibliography.

    Bottom line: if you’d like to understand more about the machinations that decide who lives and who dies (especially when sometimes it will be you or a loved one who lives or dies), then this is a fascinating book that that delves deeply into that.

    Click here to check out Random Acts Of Medicine, and be aware!

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  • The Miracle of Flexibility – by Miranda Esmonde-White

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    We’ve reviewed books about stretching before, so what makes this one different?

    Mostly, it’s that this one takes a holistic approach, making the argument for looking after all parts of flexibility (even parts that might seem useless) because if one bit of us isn’t flexible, the others will start to suffer in compensation because of how that affects our posture, or movement, or in many cases our lack of movement.

    Esmonde-White’s “flexibility, from your toes to your shoulders” approach is very consistent with her background as a professional ballet dancer, and now she brings it into her profession as a coach.

    The book’s not just about stretching, though. It looks at problems and what can go wrong with posture and the body’s “musculoskeletal trifecta”, and also shares daily training routines that are tailored for specific sporting interests, and/or for those with specific chronic conditions and/or chronic pain. Working around what needs to be worked around, but also looking at strengthening what can be strengthened and fixing what can be fixed along the way.

    Bottom line: if your flexibility needs an overhaul, this book is a very good “one-stop shop” for that.

    Click here to check out The Miracle Of Flexibility, and discover what you can do!

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