Aspirin vs Cancer Metastasis

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Aspirin is a bit of a mixed bag.

In the category of things in its favor, it’s a modest analgesic with few side effects from occasional use, so it’s a good option if you have a headache, for example.

Unless you’re already on blood thinners or having a bleeding disorder, in which case, aspirin is not the thing to reach for.

About aspirin and heart disease

This is actually a complicated one, and we covered it at length in a dedicated main feature. If you want a one-line summary, it’s “chronic low-dose aspirin use can lower overall CVD risk, but does not reduce CVD mortality or all-cause mortality, and you may pay for it with gastrointestinal bleeding, and increased risk of ulcers“.

For a more nuanced explanation, see: Aspirin, CVD Risk, & Potential Counter-Risks

On the other hand, if you are having a heart attack and are waiting for the ambulance that you already called, and have aspirin to hand that you don’t have to go looking for, then it can be good to take a dose then.

For more on that, see: How To Survive A Heart Attack When You’re Alone

There are more problems

In the case of chronic use of low-dose aspirin, not only does it increase the risks of bleeding, especially gastrointestinal bleeding, and ulcers, but also it increases the risk of anemia. Given that anemia also gives the symptom “dizziness”, this is also a significant threat for increasing the incidence of falls in the older population, too, which can of course lead to serious complications and ultimately death.

For the science about this, see: Low-Dose Aspirin & Anemia

Now, about aspirin and cancer metastasis

This one’s a point in aspirin’s favor.

Cancer is, in and of itself, obviously a big problem. In terms of when it’s most likely to kill someone, that is usually when the cancer becomes metastatic, that is to say, it has spread.

So, while preventing cancer and, failing that, killing cancer are very important goals, there is a third axis to cancer care, which is preventing metastasis in someone who has cancer.

And that’s what aspirin does. How, you ask?

Scientists found this one out by accident!

They were doing genetic research in mice, to find genes that had an effect on metastasis. In the process, they found a certain gene that instructs the creation of a certain protein, and mice that lacked that gene (and thus its associated protein) had less metastasis.

The protein in question suppresses T-cells, which are programmed to recognize and kill metastatic cancer cells (amongst having other great jobs; they are an important part of the immune system in general, and one that declines with aging; most people in their 60s or older are producing very few T-cells).

About that, see: Focusing On Health In Our Sixties

Tracing the cell signaling, the researchers found that the protein is activated when T-cells are exposed to thromboxane A2 (or TXA2 to its friends).

And TXA2? That’s produced by platelets, and aspirin works by inhibiting TXA2 production, effectively making platelets (and thus the blood as a whole) less sticky.

So, that’s quite a few steps in the process, but ultimately:

  1. Aspirin inhibits TXA2 production
  2. Lower TXA2 levels mean ARHGEF1 (that’s the protein) isn’t activated
  3. ARHGEF1 not being activated means T-cells are free to do their thing
  4. T-cells are now free to kill metastatic cancer cells

You can read the paper here:

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity

Take care!

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    When time doesn’t heal, ambiguous loss can freeze us in place. “Ambiguous Loss, Trauma, and Resilience” offers a roadmap for thriving in life despite the pain.

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  • Butter vs Ghee – Which is Healthier?

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    Our Verdict

    When comparing butter to ghee, we picked the butter.

    Why?

    Assuming a comparable source for each—e.g. butter from grass-fed cows, or ghee made from butter from grass-fed cows—both have a mostly comparable nutritional profile.

    Note: the above is not a safe assumption to make in the US, unless you’re paying attention. Grass-fed cows are not the norm in the US, so it’s something that has to be checked for. On the other hand, ghee is usually imported, and grass-fed cows are the norm in most of the rest of the world, including the countries that export ghee the most. So if “buying blind”, ghee will be the safer bet. However, checking labels can overcome this.

    Many of the Internet-popular health claims for ghee are exaggerated. For example, yes it contains butyrate… But at 1% or less. You’d be better off getting your butyrate from fibrous fruit and vegetables. Yes it contains medium-chain triglycerides (that’s also good), but in trace amounts. It even has conjugated linoleic acid, but you guessed it, the dose is insignificant.

    Meanwhile, both butter and ghee contain heart-unhealthy animal-based saturated fats (which are usually worse for the health than some, but not all, of their plant-based equivalents). However…

    • A tablespoon of butter contains about 7 grams of saturated fat
    • A tablespoon of ghee contains about 9 grams of saturated fat

    So, in this case, “ghee is basically butter, but purer” becomes a bad thing (and the deciding factor between the two).

    There is one reason to choose butter over ghee, but it’s not health-related—it simply has a higher smoke point, as is often the case for fats that have been more processed compared to fats that have been less processed.

    In short: either can be used in moderation, but even 2 tbsp of butter are taking an average person (because it depends on your metabolism, so we’ll say average) to the daily limit for saturated fats already, so we recommend to go easy even on that.

    Want to know more?

    Take care!

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  • Older Men’s Connections Often Wither When They’re on Their Own

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    At age 66, South Carolina physician Paul Rousseau decided to retire after tending for decades to the suffering of people who were seriously ill or dying. It was a difficult and emotionally fraught transition.

    “I didn’t know what I was going to do, where I was going to go,” he told me, describing a period of crisis that began in 2017.

    Seeking a change of venue, Rousseau moved to the mountains of North Carolina, the start of an extended period of wandering. Soon, a sense of emptiness enveloped him. He had no friends or hobbies — his work as a doctor had been all-consuming. Former colleagues didn’t get in touch, nor did he reach out.

    His wife had passed away after a painful illness a decade earlier. Rousseau was estranged from one adult daughter and in only occasional contact with another. His isolation mounted as his three dogs, his most reliable companions, died.

    Rousseau was completely alone — without friends, family, or a professional identity — and overcome by a sense of loss.

    “I was a somewhat distinguished physician with a 60-page resume,” Rousseau, now 73, wrote in the Journal of the American Geriatrics Society in May. “Now, I’m ‘no one,’ a retired, forgotten old man who dithers away the days.”

    In some ways, older men living alone are disadvantaged compared with older women in similar circumstances. Research shows that men tend to have fewer friends than women and be less inclined to make new friends. Often, they’re reluctant to ask for help.

    “Men have a harder time being connected and reaching out,” said Robert Waldinger, a psychiatrist who directs the Harvard Study of Adult Development, which has traced the arc of hundreds of men’s lives over a span of more than eight decades. The men in the study who fared the worst, Waldinger said, “didn’t have friendships and things they were interested in — and couldn’t find them.” He recommends that men invest in their “social fitness” in addition to their physical fitness to ensure they have satisfying social interactions.

    Slightly more than 1 in every 5 men ages 65 to 74 live alone, according to 2022 Census Bureau data. That rises to nearly 1 in 4 for those 75 or older. Nearly 40% of these men are divorced, 31% are widowed, and 21% never married.

    That’s a significant change from 2000, when only 1 in 6 older men lived by themselves. Longer life spans for men and rising divorce rates are contributing to the trend. It’s difficult to find information about this group — which is dwarfed by the number of women who live alone — because it hasn’t been studied in depth. But psychologists and psychiatrists say these older men can be quite vulnerable.

    When men are widowed, their health and well-being tend to decline more than women’s.

    “Older men have a tendency to ruminate, to get into our heads with worries and fears and to feel more lonely and isolated,” said Jed Diamond, 80, a therapist and the author of “Surviving Male Menopause” and “The Irritable Male Syndrome.”

    Add in the decline of civic institutions where men used to congregate — think of the Elks or the Shriners — and older men’s reduced ability to participate in athletic activities, and the result is a lack of stimulation and the loss of a sense of belonging.

    Depression can ensue, fueling excessive alcohol use, accidents, or, in the most extreme cases, suicide. Of all age groups in the United States, men over age 75 have the highest suicide rate, by far.

    For this column, I spoke at length to several older men who live alone. All but two (who’d been divorced) were widowed. Their experiences don’t represent all men who live alone. But still, they’re revealing.

    The first person I called was Art Koff, 88, of Chicago, a longtime marketing executive I’d known for several years. When I reached out in January, I learned that Koff’s wife, Norma, had died the year before, leaving him hobbled by grief. Uninterested in eating and beset by unremitting loneliness, Koff lost 45 pounds.

    “I’ve had a long and wonderful life, and I have lots of family and lots of friends who are terrific,” Koff told me. But now, he said, “nothing is of interest to me any longer.”

    “I’m not happy living this life,” he said.

    Nine days later, I learned that Koff had died. His nephew, Alexander Koff, said he had passed out and was gone within a day. The death certificate cited “end stage protein calorie malnutrition” as the cause.

    The transition from being coupled to being single can be profoundly disorienting for older men. Lodovico Balducci, 80, was married to his wife, Claudia, for 52 years before she died in October 2023. Balducci, a renowned physician known as the “patriarch of geriatric oncology,” wrote about his emotional reaction in the Journal of the American Geriatrics Society, likening Claudia’s death to an “amputation.”

    “I find myself talking to her all the time, most of the time in my head,” Balducci told me in a phone conversation. When I asked him whom he confides in, he admitted, “Maybe I don’t have any close friends.”

    Disoriented and disorganized since Claudia died, he said his “anxiety has exploded.”

    We spoke in late February. Two weeks later, Balducci moved from Tampa to New Orleans, to be near his son and daughter-in-law and their two teenagers.

    “I am planning to help as much as possible with my grandchildren,” he said. “Life has to go on.”

    Verne Ostrander, a carpenter in the small town of Willits, California, about 140 miles north of San Francisco, was reflective when I spoke with him, also in late February. His second wife, Cindy Morninglight, died four years ago after a long battle with cancer.

    “Here I am, almost 80 years old — alone,” Ostrander said. “Who would have guessed?”

    When Ostrander isn’t painting watercolors, composing music, or playing guitar, “I fall into this lonely state, and I cry quite a bit,” he told me. “I don’t ignore those feelings. I let myself feel them. It’s like therapy.”

    Ostrander has lived in Willits for nearly 50 years and belongs to a men’s group and a couples’ group that’s been meeting for 20 years. He’s in remarkably good health and in close touch with his three adult children, who live within easy driving distance.

    “The hard part of living alone is missing Cindy,” he told me. “The good part is the freedom to do whatever I want. My goal is to live another 20 to 30 years and become a better artist and get to know my kids when they get older.”

    The Rev. Johnny Walker, 76, lives in a low-income apartment building in a financially challenged neighborhood on Chicago’s West Side. Twice divorced, he’s been on his own for five years. He, too, has close family connections. At least one of his several children and grandchildren checks in on him every day.

    Walker says he had a life-changing religious conversion in 1993. Since then, he has depended on his faith and his church for a sense of meaning and community.

    “It’s not hard being alone,” Walker said when I asked whether he was lonely. “I accept Christ in my life, and he said that he would never leave us or forsake us. When I wake up in the morning, that’s a new blessing. I just thank God that he has brought me this far.”

    Waldinger recommended that men “make an effort every day to be in touch with people. Find what you love — golf, gardening, birdwatching, pickleball, working on a political campaign — and pursue it,” he said. “Put yourself in a situation where you’re going to see the same people over and over again. Because that’s the most natural way conversations get struck up and friendships start to develop.”

    Rousseau, the retired South Carolina doctor, said he doesn’t think about the future much. After feeling lost for several years, he moved across the country to Jackson, Wyoming, in the summer of 2023. He embraced solitude, choosing a remarkably isolated spot to live — a 150-square-foot cabin with no running water and no bathroom, surrounded by 25,000 undeveloped acres of public and privately owned land.

    “Yes, I’m still lonely, but the nature and the beauty here totally changed me and focused me on what’s really important,” he told me, describing a feeling of redemption in his solitude.

    Rousseau realizes that the death of his parents and a very close friend in his childhood left him with a sense of loss that he kept at bay for most of his life. Now, he said, rather than denying his vulnerability, he’s trying to live with it. “There’s only so long you can put off dealing with all the things you’re trying to escape from.”

    It’s not the life he envisioned, but it’s one that fits him, Rousseau said. He stays busy with volunteer activities — cleaning tanks and running tours at Jackson’s fish hatchery, serving as a part-time park ranger, and maintaining trails in nearby national forests. Those activities put him in touch with other people, mostly strangers, only intermittently.

    What will happen to him when this way of living is no longer possible?

    “I wish I had an answer, but I don’t,” Rousseau said. “I don’t see my daughters taking care of me. As far as someone else, I don’t think there’s anyone else who’s going to help me.”

    We’re eager to hear from readers about questions you’d like answered, problems you’ve been having with your care, and advice you need in dealing with the health care system. Visit http://kffhealthnews.org/columnists to submit your requests or tips.

    KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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  • Spiced Pear & Pecan Polyphenol Porridge

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Porridge doesn’t have to be boring; in fact, it can be a real treat. And while oats are healthy by default, this version has extra layers of benefits:

    You will need

    Per person:

    • 1 cup milk (your choice what kind; we recommend almond for this)
    • ½ cup oats
    • 1 pear, peeled, cored, and sliced
    • ¼ cup toasted pecans, chopped
    • 2 tbsp goji berries
    • 1 tsp sweet cinnamon

    Method

    (we suggest you read everything at least once before doing anything)

    1) Soak the goji berries in a small amount of hot water. If you have an espresso cup or something of a similar size, that’s a great “bowl” for this task. A ramekin will suffice, otherwise, but use only as much water as is absolutely necessary to cover the goji berries (excess water will just leech polyphenols from the berries, reducing their nutritional value).

    2) Combine the pear and cinnamon in a saucepan with a couple of tablespoons of water, and simmer for 5 minutes.

    3) Combine the oats and milk in a separate saucepan (we imagine you know how to make porridge, but we’d be remiss to not include the step), and simmer for 5 minutes, stirring as necessary.

    4) Drain the goji berries and the pear, if there is water remaining outside of the fruits.

    5) Assemble: we recommend the order: goji berries, porridge, pear, pecans.

    Alternative method: simply layer everything in a slow cooker, in the following order: goji berries (no need to pre-soak), oats, milk (stir it a little to ensure oats are all wet), pear-dusted-with-cinnamon (no need to pre-cook), pecans. Put it on the lowest heat with the lid on, and leave for a couple of hours.

    Alternative alternative method: layer everything as we just said, but this time in portions of 1 jar per person, and leave it overnight, per overnight oats. Then, in the morning, gently warm it (if you like) by putting it in the microwave (lid removed!) for 2 minutes on medium power.

    These latter methods are increasingly better nutritionally, as they won’t wash away some of the polyphenols from the goji berries and the lower temperatures keep the glycemic index of the oats lower, but we appreciate you won’t always have the time to do it this way.

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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Related Posts

  • Beat The Heat, With Fat
  • 7 Fruits Every Senior Should Eat Today (And Why)

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    What will you prioritize in the new year?

    Fruits to enjoy regularly

    The 7 fruits recommended for seniors in this video are:

    Apples

    • Rich in soluble fiber (pectin) for lowering LDL cholesterol.
    • Contains phytochemicals such as quercetin and other polyphenols that reduce inflammation and support heart health.
    • High in vitamin C for immunity, skin elasticity, and joint health.

    Bananas

    • Natural energy boost from carbohydrates.
    • High in potassium for regulating blood pressure, fluid balance, and preventing muscle cramps.
    • Supports cardiovascular health and muscle function.

    Avocados

    • Rich in monounsaturated fats to improve cholesterol levels.
    • High in potassium for blood pressure regulation.
    • Contains vitamins E and K for brain health and bone density.

    Grapes

    • Hydrating and rich in antioxidants like resveratrol, which supports circulation and reduces inflammation.
    • Contain vitamins C and K for immunity and bone health.

    Plums

    • Natural laxative with high fiber and sorbitol for digestive health.
    • Rich in potassium and vitamin K for bone density and reducing osteoporosis risk.
    • Contain polyphenols for reducing inflammation and supporting cognitive health.

    Pomegranates

    • Anti-inflammatory and antioxidant-rich (especially punicalagins and anthocyanins).
    • Supports heart health, improves cholesterol levels, and promotes brain health.
    • May help inhibit cancer cell growth in specific types.

    Kiwi

    • High in vitamin C to boost immunity.
    • Rich in fiber and enzymes for digestive health.
    • Low glycemic index, suitable for blood sugar management.

    10almonds note: a lot of those statements can go for a lot of fruits, but those are definitely high on the list for the qualities mentioned!

    For more on all the above, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    Top 8 Fruits That Prevent & Kill Cancer ← there are two fruits that appear on both lists!

    Take care!

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  • Vit D + Calcium: Too Much Of A Good Thing?

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    Vit D + Calcium: Too Much Of A Good Thing?

    • Myth: you can’t get too much calcium!
    • Myth: you must get as much vitamin D as possible!

    Let’s tackle calcium first:

    ❝Calcium is good for you! You need more calcium for your bones! Be careful you don’t get calcium-deficient!❞

    Contingently, those comments seem reasonable. Contingently on you not already having the right amount of calcium. Most people know what happens in the case of too little calcium: brittle bones, osteoporosis, and so forth.

    But what about too much?

    Hypercalcemia

    Having too much calcium—or “hypercalcemia”— can lead to problems with…

    • Groans: gastrointestinal pain, nausea, and vomiting. Peptic ulcer disease and pancreatitis.
    • Bones: bone-related pains. Osteoporosis, osteomalacia, arthritis and pathological fractures.
    • Stones: kidney stones causing pain.
    • Moans: refers to fatigue and malaise.
    • Thrones: polyuria, polydipsia, and constipation
    • Psychic overtones: lethargy, confusion, depression, and memory loss.

    (mnemonic courtesy of Sadiq et al, 2022)

    What causes this, and how do we avoid it? Is it just dietary?

    It’s mostly not dietary!

    Overconsumption of calcium is certainly possible, but not common unless one has an extreme diet and/or over-supplementation. However…

    Too much vitamin D

    Again with “too much of a good thing”! While keeping good levels of vitamin D is, obviously, good, overdoing it (including commonly prescribed super-therapeutic doses of vitamin D) can lead to hypercalcemia.

    This happens because vitamin D triggers calcium absorption into the gut, and acts as gatekeeper to the bloodstream.

    Normally, the body only absorbs 10–20% of the calcium we consume, and that’s all well and good. But with overly high vitamin D levels, the other 80–90% can be waved on through, and that is very much Not Good™.

    See for yourself:

    How much is too much?

    The United States’ Office of Dietary Supplements defines 4000 IU (100μg) as a high daily dose of vitamin D, and recommends 600 IU (15μg) as a daily dose, or 800 IU (20μg) if aged over 70.

    See for yourself: Vitamin D Fact Sheet for Health Professionals ← there’s quite a bit of extra info there too

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    Learn to Age Gracefully

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  • DBT Made Simple – by Sheri van Dijk

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    This book offers very clear explanations of DBT. In fact, a more fitting title might have been “DBT made clear”, because it does it without oversimplification.

    This is a way in which van Dijk’s work stands out from that of many writers on the subject! Many authors oversimplify, to the point that a reader may wonder “is that all it is?” when, in reality, there’s rather more to it.

    This work is, therefore, refreshingly comprehensive, without sacrificing clarity.

    Van Dijk also takes us through the four pillars of DBT:

    1. Mindfulness
    2. Distress tolerance
    3. Emotional regulation
    4. Interpersonal effectiveness

    Each of these can help an individual alone; together, they produce a composite effect with a synergy that makes each more effective. Hence, pillars.

    On the topic of “an individual”, you may be wondering “is this book for therapists or the general public?” and the answer is yes, yes it is.

    That is to say: it’s written with the assumption that the reader wants to learn DBT in order to practice it as a therapist… and/but is written in such a fashion that it’s very easy to apply the skills to oneself, too. As it’s an introductory guide—a comprehensive one, but without assuming prior knowledge—it’s a perfect resource for anyone to get a good grounding in the subject.

    Bottom line: if you’ve been hearing about DBT (possibly from us!) and wondering where you might start, this book is an excellent place to begin.

    Click here to check out DBT Made Simple, and start making many parts of life easier!

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    Learn to Age Gracefully

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