Nanotechnology vs Alcohol Damage!

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One Thing That Does Pair Well With Alcohol…

Alcohol is not a healthy thing to consume. That shouldn’t be a controversial statement, but there is a popular belief that it can be good for the heart:

Red Wine & The Heart: Can We Drink To Good Health?

The above is an interesting and well-balanced article that examines the arguments for health benefits (including indirectly, e.g. social aspects).

Ultimately, though, as the World Health Organization puts it:

WHO: No level of alcohol consumption is safe for our health

There is some good news:

We can somewhat reduce the harm done by alcohol by altering our habits slightly:

How To Make Drinking Less Harmful

…and we can also, of course, reduce our alcohol consumption (ideally to zero, but any reduction is an improvement already):

How To Reduce Or Quit Alcohol

And, saving the best news (in this section, anyway) for last, it is almost always possible to undo the harm done specifically to one’s liver:

How To Unfatty A Fatty Liver

Nanotechnology to the rescue?

Remember when we had a main feature about how colloidal gold basically does nothing by itself (and that that’s precisely why gold is used in medicine, when it is used)?

Now it has an extra bit of nothing to do, for our benefit (if we drink alcohol, anyway), as part of a gel that detoxifies alcohol before it can get to our liver:

Gold is one of the “ingredients” in a gel containing a nanotechnology lattice of protein fibrils coated with iron (and the gold is there as an inert catalyst, which is chemistry’s way of saying it doesn’t react in any way but it does cheer the actual reagents on). There’s more chemistry going on than we have room to discuss in our little newsletter, so if you like the full details, you can read about that here:

Single-site iron-anchored amyloid hydrogels as catalytic platforms for alcohol detoxification

The short and oversimplified explanation is that instead of alcohol being absorbed from the gut and transported via the bloodstream to the liver, where it is metabolized (poisoning the liver as it goes, and poisoning the rest of the body too, including the brain), the alcohol is degraded while it is still in the gastrointestinal tract, converted by the gel’s lattice into acetic acid (which is at worst harmless, and actually in moderation a good thing to have).

Even shorter and even more oversimplified: the gel turns the alcohol into vinegar in the stomach and gut, before it can get absorbed into the blood.

But…

Of course there’s a “but”…

There are some limitations:

It doesn’t get it all (tests so far found it only gets about half of the alcohol), and so far it’s only been tested on mice, so it’s not on the market yet—while the researchers are sufficiently confident about it that a patent application has now been made, though, so it’ll probably show up on the market in the near future.

You can read a pop-science article about it (with diagrams!) here:

New gel breaks down alcohol in the body

Want to read more…

…about how to protect your organs (including your brain) from alcohol completely?

We’ve reviewed quite a number of books about quitting alcohol, so it’s hard to narrow it down to a single favorite, but after some deliberation, we’ll finish today with recommending:

Quit Drinking – by Rebecca Doltonyou can read our review here

Take care!

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  • Our ‘food environments’ affect what we eat. Here’s how you can change yours to support healthier eating

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    In January, many people are setting new year’s resolutions around healthy eating. Achieving these is often challenging – it can be difficult to change our eating habits. But healthy diets can enhance physical and mental health, so improving what we eat is a worthwhile goal.

    One reason it’s difficult to change our eating habits relates to our “food environments”. This term describes:

    The collective physical, economic, policy and sociocultural surroundings, opportunities and conditions that influence people’s food and beverage choices and nutritional status.

    Our current food environments are designed in ways that often make it easier to choose unhealthy foods than healthy ones. But it’s possible to change certain aspects of our personal food environments, making eating healthier a little easier.

    Unhealthy food environments

    It’s not difficult to find fast-food restaurants in Australian cities. Meanwhile, there are junk foods at supermarket checkouts, service stations and sporting venues. Takeaway and packaged foods and drinks routinely come in large portion sizes and are often considered tastier than healthy options.

    Our food environments also provide us with various prompts to eat unhealthy foods via the media and advertising, alongside health and nutrition claims and appealing marketing images on food packaging.

    At the supermarket, unhealthy foods are often promoted through prominent displays and price discounts.

    We’re also exposed to various situations in our everyday lives that can make healthy eating challenging. For example, social occasions or work functions might see large amounts of unhealthy food on offer.

    Not everyone is affected in the same way

    People differ in the degree to which their food consumption is influenced by their food environments.

    This can be due to biological factors (for example, genetics and hormones), psychological characteristics (such as decision making processes or personality traits) and prior experiences with food (for example, learned associations between foods and particular situations or emotions).

    People who are more susceptible will likely eat more and eat more unhealthy foods than those who are more immune to the effects of food environments and situations.

    Those who are more susceptible may pay greater attention to food cues such as advertisements and cooking smells, and feel a stronger desire to eat when exposed to these cues. Meanwhile, they may pay less attention to internal cues signalling hunger and fullness. These differences are due to a combination of biological and psychological characteristics.

    These people might also be more likely to experience physiological reactions to food cues including changes in heart rate and increased salivation.

    Two young women sitting on a couch eating chips.
    It’s common to eat junk food in front of the TV.
    PR Image Factory/Shutterstock

    Other situational cues can also prompt eating for some people, depending on what they’ve learned about eating. Some of us tend to eat when we’re tired or in a bad mood, having learned over time eating provides comfort in these situations.

    Other people will tend to eat in situations such as in the car during the commute home from work (possibly passing multiple fast-food outlets along the way), or at certain times of day such as after dinner, or when others around them are eating, having learned associations between these situations and eating.

    Being in front of a TV or other screen can also prompt people to eat, eat unhealthy foods, or eat more than intended.

    Making changes

    While it’s not possible to change wider food environments or individual characteristics that affect susceptibility to food cues, you can try to tune into how and when you’re affected by food cues. Then you can restructure some aspects of your personal food environments, which can help if you’re working towards healthier eating goals.

    Although both meals and snacks are important for overall diet quality, snacks are often unplanned, which means food environments and situations may have a greater impact on what we snack on.

    Foods consumed as snacks are often sugary drinks, confectionery, chips and cakes. However, snacks can also be healthy (for example, fruits, nuts and seeds).

    Try removing unhealthy foods, particularly packaged snacks, from the house, or not buying them in the first place. This means temptations are removed, which can be especially helpful for those who may be more susceptible to their food environment.

    Planning social events around non-food activities can help reduce social influences on eating. For example, why not catch up with friends for a walk instead of lunch at a fast-food restaurant.

    Creating certain rules and habits can reduce cues for eating. For example, not eating at your desk, in the car, or in front of the TV will, over time, lessen the effects of these situations as cues for eating.

    You could also try keeping a food diary to identify what moods and emotions trigger eating. Once you’ve identified these triggers, develop a plan to help break these habits. Strategies may include doing another activity you enjoy such as going for a short walk or listening to music – anything that can help manage the mood or emotion where you would have typically reached for the fridge.

    Write (and stick to) a grocery list and avoid shopping for food when hungry. Plan and prepare meals and snacks ahead of time so eating decisions are made in advance of situations where you might feel especially hungry or tired or be influenced by your food environment.The Conversation

    Georgie Russell, Senior Lecturer, Institute for Physical Activity and Nutrition (IPAN), Deakin University and Rebecca Leech, NHMRC Emerging Leadership Fellow, School of Exercise and Nutrition Sciences, Deakin University

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • L-Theanine: What’s The Tea?

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    L-Theanine: What’s The Tea?

    We’ve touched previously on l-theanine, when this newsletter was new, and we had only a few hundred subscribers and the carefully organized format wasn’t yet what it is today.

    So now it’s time to give this potent dietary compound / nutritional supplement the “Monday Research Review” treatment…

    What is it?

    L-theanine is an amino acid found in tea. The human body can’t produce it, and/but it’s not essential for humans. It does have a lot of benefits, though. See for example:

    L-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion

    How does it work?

    L-theanine works by moderating and modulating the brain’s neurotransmitters.

    This sounds fancy, but basically it means: it doesn’t actually add anything in the manner of a drug, but it changes how we use what we have naturally.

    What does it do? Read on…

    It increases mental focus

    It has been believed that l-theanine requires the presence of caffeine to achieve this (i.e., it’s a combination-only effect). For example:

    The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness

    But as it turns out, when a group of researchers actually checked… This isn’t true, as Foxe et al. write:

    ❝We asked whether either compound alone, or both in combination, would affect performance of the task in terms of reduced error rates over time, and whether changes in alpha-band activity would show a relationship to such changes in performance. When treated with placebo, participants showed a rise in error rates, a pattern that is commonly observed with increasing time-on-task, whereas after caffeine and theanine ingestion, error rates were significantly reduced. The combined treatment did not confer any additional benefits over either compound alone, suggesting that the individual compounds may confer maximal benefits at the dosages employed❞

    See: Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task

    It promotes a calmly wakeful feeling of serenity

    Those are not words typically found in biopharmaceutical literature, but they’re useful here to convey:

    • L-theanine promotes relaxation without causing drowsiness
    • L-theanine promotes mental alertness without being a stimulant

    Here is where l-theanine really stands out from caffeine. If both substances promote mental focus, but one of them does it by making us “wired” and the other does it while simultaneously promoting calm, it makes the choice between them clearer!

    Read more: L-theanine, a natural constituent in tea, and its effect on mental state

    It relieves stress and anxiety

    Building on from the above, but there’s more: l-theanine relieves stress and anxiety in people experiencing stressful situations, without any known harmful side effects… This is something that sets it apart from a lot of anxiolytic (antianxiety) drugs!

    Here’s what a big systematic review of clinical trials had to say:

    Theanine consumption, stress and anxiety in human clinical trials: A systematic review

    L-theanine has other benefits too

    We’ve talked about some of the most popular benefits of l-theanine, and we can’t make this newsletter too long, but research also suggests that it…

    If you’re interested in this topic, we recommend also reading our previous article on l-theanine—pardon that we hadn’t really nailed down our style yet—but there’s a bunch of useful information about how l-theanine makes caffeine “better” in terms of benefits. We also talk dosage, and reference some other studies we didn’t have room to include today!

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  • Forever Strong – by Dr. Gabrielle Lyon

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    Obesity kills a lot of people (as does medical neglect and malpractice when it comes to obese patients, but that is another matter), but often the biggest problem is not “too much fat” but rather “too little muscle”. This gets disguised a bit, because these factors often appear in the same people, but it’s a distinction that’s worthy of note.

    Dr. Lyon lays out a lot of good hard science in this work, generally in the field of protein metabolism, but also with a keen eye on all manner of blood metrics (triglycerides, LDL/HDL, fasting blood sugars, assorted other biomarkers of metabolic health).

    The style of this book is two books in one. It’s a very accessible pop-science book in its primary tone, with an extra layer of precise science and lots of references, for those who wish to dive into that.

    In the category of criticism, the diet plan section of the book is rather meat-centric, but the goal of this is protein content, not meat per se, so substitutions can easily be made. That’s just one small section of the book, though, and it’s little enough a downside that even Dr. Mark Hyman (a popular proponent of plant-based nutrition) highly recommends the book.

    Bottom line: if you’d like to be less merely fighting decline and more actually becoming healthier as you age, then this book will help you do just that.

    Click here to check out Forever Strong, and level up your wellness as you age!

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  • Breakfasting For Health?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Breakfast Time!

    In yesterday’s newsletter, we asked you for your health-related opinions on the timings of meals.

    But what does the science say?

    Quick recap on intermittent fasting first:

    Today’s article will rely somewhat on at least a basic knowledge of intermittent fasting, what it is, and how and why it works.

    Armed with that knowledge, we can look at when it is good to break the fast (i.e. breakfast) and when it is good to begin the fast (i.e. eat the last meal of the day).

    So, if you’d like a quick refresher on intermittent fasting, here it is:

    Intermittent Fasting: We Sort The Science From The Hype

    And now, onwards!

    One should eat breakfast first thing: True or False?

    True! Give or take one’s definition of “first thing”. We did a main feature about this previously, and you can read a lot about the science of it, and see links to studies:

    The Circadian Rhythm: Far More Than Most People Know

    In case you don’t have time to read that now, we’ll summarize the most relevant-to-today’s-article conclusion:

    The optimal time to breakfast is around 10am (this is based on getting sunlight around 8:30am, so adjust if this is different for you)

    It doesn’t matter when we eat; calories are calories & nutrients are nutrients: True or False?

    Broadly False, for practical purposes. Because, indeed calories are calories and nutrients are nutrients at any hour, but the body will do different things with them depending on where we are in the circadian cycle.

    For example, this study in the Journal of Nutrition found…

    ❝Our results suggest that in relatively healthy adults, eating less frequently, no snacking, consuming breakfast, and eating the largest meal in the morning may be effective methods for preventing long-term weight gain.

    Eating breakfast and lunch 5-6 h apart and making the overnight fast last 18-19 h may be a useful practical strategy.❞

    ~ Dr. Hana Kahleova et al.

    Read in full: Meal Frequency and Timing Are Associated with Changes in Body Mass Index

    We should avoid eating too late at night: True or False?

    False per se, True in the context of the above. Allow us to clarify:

    There is nothing inherently bad about eating late at night; there is no “bonus calorie happy hour” before bed.

    However…

    If we are eating late at night, that makes it difficult to breakfast in the morning (as is ideal) and still maintain a >16hr fasting window as is optimal, per:

    ❝the effects of the main forms of fasting, activating the metabolic switch from glucose to fat and ketones (G-to-K), starting 12-16 h after cessation or strong reduction of food intake

    ~ Dr. Françoise Wilhelmi de Toledo et al.

    Read in full: Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition

    So in other words: since the benefits of intermittent fasting start at 12 hours into the fast, you’re not going to get them if you’re breakfasting at 10am and also eating in the evening.

    Summary:

    • It is best to eat breakfast around 10am, generally (ideally after some sunlight and exercise)
    • While there’s nothing wrong with eating in the evening per se, doing so means that a 10am breakfast will eliminate any fasting benefits you might otherwise get
    • If a “one meal a day, and that meal is breakfast” lifestyle doesn’t suit you, then one possible good compromise is to have a large breakfast, and then a smaller meal in the late afternoon / early evening.

    One last tip: the above is good, science-based information. Use it (or don’t), as you see fit. We’re not the boss of you:

    • Maybe you care most about getting the best circadian rhythm benefits, in which case, prioritizing breakfast being a) in the morning and b) the largest meal of the day, is key
    • Maybe you care most about getting the best intermittent fasting benefits, in which case, for many people’s lifestyle, a fine option is skipping eating in the morning, and having one meal in the late afternoon / early evening.

    Take care!

    Don’t Forget…

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  • Stop Walking on Eggshells – by Randi Kreger & Paul Mason

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    As you may gather from the title, the angle here is not “Borderline Personality Disorder is fine and dandy”, but nor is it something anyone chooses to have, and as such, importantly, this book’s advice is also not “and so you should immediately disown, divorce, defenestrate your partner”, either.

    Rather, it has a balanced and compassionate approach that examines both the pitfalls and the possibilities, and provides the tools to make your relationship feel (and hopefully, actually be) safe for all concerned.

    And yes, ending a relationship is always an option too, even if it can sometimes feel like it’s not, on account of how the relationships of people with BPD often have a lot of “near miss” situations, nearly ending but not quite, or (in the case of a partner who’s amenable to such), off-and-on relationships—either of which can make it seem like it’ll never truly be over.

    First, though, the authors do look at a variety of ways of avoiding that outcome; making changes within oneself, setting boundaries and honing related skills, asserting your needs with confidence and clarity, and dealing with the lies, rumor-mongering, and accusations that often come with BPD. For that matter, the authors do also note that not all conflict is abuse (something that many forget), but on the flipside, how to tell when it actually is, too.

    The style is very pop-science, light in tone albeit sometimes heavy in content.

    Bottom line: if you or a loved one has BPD, or even just has a lot of the same symptoms as such, this book can be very helpful.

    Click here to check out Stop Walking On Eggshells, and stop walking on eggshells!

    Don’t Forget…

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  • Altered Traits – by Dr. Daniel Goleman & Dr. Richard Davidson

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We know that meditation helps people to relax, but what more than that?This book explores the available science.

    We say “explore the available science”, but it’d be remiss of us not to note that the authors have also expanded the available science, conducting research in their own lab.

    From stress tests and EEGs to attention tests and fMRIs, this book looks at the hard science of what different kinds of meditation do to the brain. Not just in terms of brain state, either, but gradual cumulative anatomical changes, too. Powerful stuff!

    The style is very pop-science in presentation, easily comprehensible to all. Be aware though that this is an “if this, then that” book of science, not a how-to manual. If you want to learn to meditate, this isn’t the book for that.

    Bottom line: if you’d like to understand more about how different kinds of meditation affect the brain differently, this is the book for you.

    Click here to check out Altered Traits, and alter yours!

    Don’t Forget…

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