Ageless – by Dr. Andrew Steele

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So, yet another book with “The new science of…” in the title; does this one deliver new science?

Actually, yes, this time! The author was originally a physicist before deciding that aging was the number one problem that needed solving, and switched tracks to computational biology, and pioneered a lot of research, some of the fruits of which can be found in this book, in amongst a more general history of the (very young!) field of biogerontology.

Downside: most of this is not very practical for the lay reader; most of it is explanations of how things happen on a cellular and/or genetic level, and how we learned that. A lot also pertains to what we can learn from animals that either age very slowly, or are biologically immortal (in other words, they can still be killed, but they don’t age and won’t die of anything age-related), or are immune to cancer—and how we might borrow those genes for gene therapy.

However, there are also chapters on such things as “running repairs”, “reprogramming aging”, and “how to live long enough to live even longer”.

The style is conversational pop science; in the prose, he simply states things without reference, but at the back, there are 40 pages of bibliography, indexed in the order in which they occurred and prefaced with the statement that he’s referencing in each case. It’s an odd way to do citations, but it works comfortably enough.

Bottom line: if you’d like to understand aging on the cellular level, and how we know what we know and what the likely future possibilities are, then this is a great book; it’s also simply very enjoyable to read, assuming you have an interest in the topic (as this reviewer does).

Click here to check out Ageless, and understand the science of getting older without getting old!

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    Feel winter’s chill deep in your bones? Studies reveal that weather may not be the culprit for your aches and pains after all.

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  • The Biological Mind – by Dr. Alan Jasanoff

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    How special is our brain? According to Dr. Alan Jasanoff, it’s not nearly as special as we think it is.

    In this work, he outlines the case for how we have collectively overstated the brain’s importance. That it’s just another organ like a heart or a kidney, and that who we are is as much a matter of other factors, as what goes on in our brain.

    In this reviewer’s opinion, he overcorrects a bit. The heart and kidneys are very simple organs, as organs go. The brain is not. And while everything from our gut microbiota to our environment to our hormones may indeed contribute to what is us, our brain is one thing that can’t just be swapped out.

    Nevertheless, this very well-written book can teach us a lot about everything else that makes us us, including many biological factors that many people don’t know about or consider.

    Towards the end of the book, he switches into futurist speculation, and his speculation can be summed up as “we cannot achieve anything worthwhile in the future”.

    Bottom line: if you’ve an interest in such things as how transplanting glial cells can give a 30% cognitive enhancement, and how a brain transplant wouldn’t result in the same us in a different body, this is the book for you.

    Click here to check out The Biological Mind, and learn about yours!

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  • ‘It’s okay to poo at work’: new health campaign highlights a common source of anxiety

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    For most people, the daily or near-daily ritual of having a bowel motion is not something we give a great deal of thought to. But for some people, the need to do a “number two” in a public toilet or at work can be beset with significant stress and anxiety.

    In recognition of the discomfort people may feel around passing a bowel motion at work, the Queensland Department of Health recently launched a social media campaign with the message “It’s okay to poo at work”.

    The campaign has gained significant traction on Instagram and Facebook. It has been praised by health and marketing experts for its humorous handling of a taboo topic.

    A colourful Instagram post is accompanied by a caption warning of the health risks of “holding it in”, including haemorrhoids and other gastrointestinal problems. The caption also notes:

    If you find it extremely difficult to poo around other people, you might have parcopresis.

    Queensland Health/Instagram

    What is parcopresis?

    Parcopresis, sometimes called “shy bowel”, occurs when people experience a difficulty or inability to poo in public toilets due to fear of perceived scrutiny by others.

    People with parcopresis may find it difficult to go to the toilet in public places such as shopping centres, restaurants, at work or at school, or even at home when friends or family are around.

    They may fear being judged by others about unpleasant smells or sounds when they have a bowel motion, or how long they take to go, for example.

    Living with a gastrointestinal condition (at least four in ten Australians do) may contribute to parcopresis due to anxiety about the need to use a toilet frequently, and perceived judgment from others when doing so. Other factors, such as past negative experiences or accessibility challenges, may also play a role.

    A man in office attire holding a roll of toilet paper.
    Some people may feel uncomfortable about using the toilet at work. Motortion Films/Shutterstock

    For sufferers, anxiety can present in the form of a faster heart rate, rapid breathing, sweating, muscle tension, blushing, nausea, trembling, or a combination of these symptoms. They may experience ongoing worry about situations where they may need to use a public toilet.

    Living with parcopresis can affect multiple domains of life and quality of life overall. For example, sufferers may have difficulties relating to employment, relationships and social life. They might avoid travelling or attending certain events because of their symptoms.

    How common is parcopresis?

    We don’t really know how common parcopresis is, partly due to the difficulty of evaluating this behaviour. It’s not necessarily easy or appropriate to follow people around to track whether they use or avoid public toilets (and their reasons if they do). Also, observing individual bathroom activities may alter the person’s behaviour.

    I conducted a study to try to better understand how common parcopresis is. The study involved 714 university students. I asked participants to respond to a series of vignettes, or scenarios.

    In each vignette participants were advised they were at a local shopping centre and they needed to have a bowel motion. In the vignettes, the bathrooms (which had been recently cleaned) had configurations of either two or three toilet stalls. Each vignette differed by the configuration of stalls available.

    The rate of avoidance was just over 14% overall. But participants were more likely to avoid using the toilet when the other stalls were occupied.

    Around 10% avoided going when all toilets were available. This rose to around 25% when only the middle of three toilets was available. Men were significantly less likely to avoid going than women across all vignettes.

    For those who avoided the toilet, many either said they would go home to poo, use an available disabled toilet, or come back when the bathroom was empty.

    Parcopresis at work

    In occupational settings, the rates of anxiety about using shared bathrooms may well be higher for a few reasons.

    For example, people may feel more self-conscious about their bodily functions being heard or noticed by colleagues, compared to strangers in a public toilet.

    People may also experience guilt, shame and fear about being judged by colleagues or supervisors if they need to make extended or frequent visits to the bathroom. This may particularly apply to people with a gastrointestinal condition.

    Reducing restroom anxiety

    Using a public toilet can understandably cause some anxiety or be unpleasant. But for a small minority of people it can be a real problem, causing severe distress and affecting their ability to engage in activities of daily living.

    If doing a poo in a toilet at work or another public setting causes you anxiety, be kind to yourself. A number of strategies might help:

    • identify and challenge negative thoughts about using public toilets and remind yourself that using the bathroom is normal, and that most people are not paying attention to others in the toilets
    • try to manage stress through relaxation techniques such as deep breathing and progressive muscle relaxation, which involves tensing and relaxing different muscles around the body
    • engaging in gradual exposure can be helpful, which means visiting public toilets at different times and locations, so you can develop greater confidence in using them
    • use grounding or distraction techniques while going to the toilet. These might include listening to music, watching something on your phone, or focusing on your breathing.

    If you feel parcopresis is having a significant impact on your life, talk to your GP or a psychologist who can help identify appropriate approaches to treatment. This might include cognitive behavioural therapy.

    Simon Robert Knowles, Associate Professor and Clinical Psychologist, Swinburne University of Technology

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

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  • Is It Possible To Lose Weight Quickly?

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    In Victorian England, weight-loss trends like the dangerous tapeworm diet were popular. While modern fad diets can seem less extreme, they often promise similarly fast results. However, these quick fixes can have similarly harmful consequences:

    Not so fast

    To illustrate the difference between gradual and extreme dieting, the video bids us consider two identical twins, Sam and Felix:

    • Sam adopts a gradual approach, slowly reducing calorie intake and exercising regularly. This causes his body to burn glycogen stores before transitioning to fat as an energy source. Regular exercise helps Sam maintain muscle mass, which boosts his metabolism and supports sustained weight loss.
    • Felix drastically cuts calories, forcing his body into starvation mode. He quickly depletes glycogen stores, loses muscle mass, and burns fewer calories, making long-term weight loss more difficult. Although Felix might initially lose water weight, this is temporary and unsustainable.


    You cannot “just lose it quickly now, and then worry about healthiness once the weight’s gone”, because you will lose health much more quickly than you will lose fat, and that will sabotage, rather than help, your fat loss journey.

    Healthy weight loss requires gradual, balanced changes in diet and exercise tailored to individual needs. Extreme diets, whether through calorie restriction or things like elimination of carbs or fats, are unsustainable and shock the body. It’s important to prioritize long-term health over societal pressures for quick weight loss and focus on developing a sustainable, healthy lifestyle.

    In short, the quickest way to lose weight and keep it off (without dying), is to lose it slowly.

    For more on all of this, enjoy:

    Click Here If The Embedded Video Doesn’t Load Automatically!

    Want to learn more?

    You might also like to read:

    How To Lose Weight (Healthily)

    Take care!

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Related Posts

  • Fast Exercise – by Dr. Michael Mosley & Peta Bee
  • How to Change – by Katy Milkman

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Sometimes it seems that we know everything we should be doing… We have systems and goals and principles, we know about the importance of habits, and we do our best to live them. Yet, somehow, life has other plans for us and things don’t quite come together they way they did in our genius masterplan.

    So, what happened? And more importantly, what are we supposed to do about this? Katy Milkman has answers, right from the start.

    Sometimes, it can be as simple as when we try to implement a change. It’s not that there’s a “wrong time” for a good change, so much that there are times that are much more likely to succeed than others… and those times can be identified and used.

    Sometimes we’re falling prey to vices—which she explains how to overcome—such as:

    • Impulsivity
    • Procrastination
    • Forgetfulness
    • Laziness

    We also learn some counterintuitive truths about what can boost or sabotage our confidence along the way!

    Milkman writes in a compelling, almost narrative style, that makes for very easy reading. The key ideas, built up to by little (ostensibly true) stories and then revealed, become both clear and memorable. Most importantly, applicable.

    Bottom line: this is a great troubleshooting guide for when you know how everything should be working, but somehow, it just doesn’t—and you’d like to fix that.

    Click here to check out “How To Change” on Amazon, and get those changes rolling!

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  • Lacking Motivation? Science Has The Answer

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    The Science Of Motivation (And How To Use It To Your Advantage)

    When we do something rewarding, our brain gets a little (or big!) spike of dopamine. Dopamine is popularly associated with pleasure—which is fair— but there’s more to it than this.

    Dopamine is also responsible for motivation itself, as a prime mover before we do the thing that we find rewarding. If we eat a banana, and enjoy it, perhaps because our body needed the nutrients from it, our brain gets a hit of dopamine.

    (and not because bananas contain dopamine; that dopamine is useful for the body, but can’t pass the blood-brain barrier to have an effect on the brain)

    So where does the dopamine in our brain come from? That dopamine is made in the brain itself.

    Key Important Fact: the brain produces dopamine when it expects an activity to be rewarding.

    If you take nothing else away from today’s newsletter, let it be this!

    It makes no difference if the activity is then not rewarding. And, it will keep on motivating you to do something it anticipated being rewarding, no matter how many times the activity disappoints, because it’ll remember the very dopamine that it created, as having been the reward.

    To put this into an example:

    • How often have you spent time aimlessly scrolling social media, flitting between the same three apps, or sifting through TV channels when “there’s nothing good on to watch”?
    • And how often did you think afterwards “that was a good and rewarding use of my time; I’m glad I did that”?

    In reality, whatever you felt like you were in search of, you were really in search of dopamine. And you didn’t find it, but your brain did make some, just enough to keep you going.

    Don’t try to “dopamine detox”, though.

    While taking a break from social media / doomscrolling the news / mindless TV-watching can be a great and healthful idea, you can’t actually “detox” from a substance your body makes inside itself.

    Which is fortunate, because if you could, you’d die, horribly and miserably.

    If you could “detox” completely from dopamine, you’d lose all motivation, and also other things that dopamine is responsible for, including motor control, language faculties, and critical task analysis (i.e. planning).

    This doesn’t just mean that you’d not be able to plan a wedding; it also means:

    • you wouldn’t be able to plan how to get a drink of water
    • you wouldn’t have any motivation to get water even if you were literally dying of thirst
    • you wouldn’t have the motor control to be able to physically drink it anyway

    Read: Dopamine and Reward: The Anhedonia Hypothesis 30 years on

    (this article is deep and covers a lot of ground, but is a fascinating read if you have time)

    Note: if you’re wondering why that article mentions schizophrenia so much, it’s because schizophrenia is in large part a disease of having too much dopamine.

    Consequently, antipsychotic drugs (and similar) used in the treatment of schizophrenia are generally dopamine antagonists, and scientists have been working on how to treat schizophrenia without also crippling the patient’s ability to function.

    Do be clever about how you get your dopamine fix

    Since we are hardwired to crave dopamine, and the only way to outright quash that craving is by inducing anhedonic depression, we have to leverage what we can’t change.

    The trick is: question how much your motivation aligns with your goals (or doesn’t).

    So if you feel like checking Facebook for the eleventieth time today, ask yourself: “am I really looking for new exciting events that surely happened in the past 60 seconds since I last checked, or am I just looking for dopamine?”

    You might then realize: “Hmm, I’m actually just looking for dopamine, and I’m not going to find it there”

    Then, pick something else to do that will actually be more rewarding. It helps if you make a sort of dopa-menu in advance, of things to pick from. You can keep this as a list on your phone, or printed and pinned up near your computer.

    Examples might be: Working on that passion project of yours, or engaging in your preferred hobby. Or spending quality time with a loved one. Or doing housework (surprisingly not something we’re commonly motivated-by-default to do, but actually is rewarding when done). Or exercising (same deal). Or learning that language on Duolingo (all those bells and whistles the app has are very much intentional dopamine-triggers to make it addictive, but it’s not a terrible outcome to be addicted to learning!).

    Basically… Let your brain’s tendency to get led astray work in your favor, by putting things in front of it that will lead you in good directions.

    Things for your health and/or education are almost always great things to allow yourself the “ooh, shiny” reaction and pick them up, try something new, etc.

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  • The Herbal Supplement That Rivals Prozac

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Flower Power: St. John’s Wort’s Drug-Level Effectiveness

    St. John’s wort is a small yellow flower, extract of which can be bought inexpensively off-the-shelf in pretty much any pharmacy in most places.

    It’s sold and used as a herbal mood-brightener.

    Does it work?

    Yes! It’s actually very effective. This is really uncontroversial, so we’ll keep it brief.

    The main findings of studies are that St. John’s wort not only gives significant benefits over placebo, but also works about as well as prescription anti-depressants:

    A systematic review of St. John’s wort for major depressive disorder

    They also found that fewer people stop taking it, compared to how many stop taking antidepressants. It’s not known how much of this is because of its inexpensive, freely-accessible nature, and how much might be because it gave them fewer adverse side effects:

    Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis

    How does it work?

    First and foremost, it’s an SSRI—a selective serotonin reuptake inhibitor. Basically, it doesn’t add serotonin, but it makes whatever serotonin you have, last longer. Same as most prescription antidepressants. It also affects adenosine and GABA pathways, which in lay terms, means it promotes feelings of relaxation, in a similar way to many prescription antianxiety medications.

    Mechanism of action of St John’s wort in depression: what is known?

    Any problems we should know about?

    Yes, definitely. To quote directly from the National Center for Complementary and Integrative Health:

    St. John’s wort can weaken the effects of many medicines, including crucially important medicines such as:

    • Antidepressants
    • Birth control pills
    • Cyclosporine, which prevents the body from rejecting transplanted organs
    • Some heart medications, including digoxin and ivabradine
    • Some HIV drugs, including indinavir and nevirapine
    • Some cancer medications, including irinotecan and imatinib
    • Warfarin, an anticoagulant (blood thinner)
    • Certain statins, including simvastatin

    Click here for a more comprehensive list of interactions, contraindications, and potential side effects

    I’ve read all that, and want to try it!

    As ever, we don’t sell it (or anything else), but here’s an example product on Amazon.

    Please be safe and do check with your doctor and/or pharmacist, though!

    Don’t Forget…

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    Learn to Age Gracefully

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