Viruses aren’t always harmful. 6 ways they’re used in health care and pest control
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We tend to just think of viruses in terms of their damaging impacts on human health and lives. The 1918 flu pandemic killed around 50 million people. Smallpox claimed 30% of those who caught it, and survivors were often scarred and blinded. More recently, we’re all too familiar with the health and economic impacts of COVID.
But viruses can also be used to benefit human health, agriculture and the environment.
Viruses are comparatively simple in structure, consisting of a piece of genetic material (RNA or DNA) enclosed in a protein coat (the capsid). Some also have an outer envelope.
Viruses get into your cells and use your cell machinery to copy themselves.
Here are six ways we’ve harnessed this for health care and pest control.
1. To correct genes
Viruses are used in some gene therapies to correct malfunctioning genes. Genes are DNA sequences that code for a particular protein required for cell function.
If we remove viral genetic material from the capsid (protein coat) we can use the space to transport a “cargo” into cells. These modified viruses are called “viral vectors”.
DEXi
Viral vectors can deliver a functional gene into someone with a genetic disorder whose own gene is not working properly.
Some genetic diseases treated this way include haemophilia, sickle cell disease and beta thalassaemia.
2. Treat cancer
Viral vectors can be used to treat cancer.
Healthy people have p53, a tumour-suppressor gene. About half of cancers are associated with the loss of p53.
Replacing the damaged p53 gene using a viral vector stops the cancerous cell from replicating and tells it to suicide (apoptosis).
Viral vectors can also be used to deliver an inactive drug to a tumour, where it is then activated to kill the tumour cell.
This targeted therapy reduces the side effects otherwise seen with cytotoxic (cell-killing) drugs.
We can also use oncolytic (cancer cell-destroying) viruses to treat some types of cancer.
Tumour cells have often lost their antiviral defences. In the case of melanoma, a modified herpes simplex virus can kill rapidly dividing melanoma cells while largely leaving non-tumour cells alone.
3. Create immune responses
Viral vectors can create a protective immune response to a particular viral antigen.
One COVID vaccine uses a modified chimp adenovirus (adenoviruses cause the common cold in humans) to transport RNA coding for the SARS-CoV-2 spike protein into human cells.
The RNA is then used to make spike protein copies, which stimulate our immune cells to replicate and “remember” the spike protein.
Then, when you are exposed to SARS-CoV-2 for real, your immune system can churn out lots of antibodies and virus-killing cells very quickly to prevent or reduce the severity of infection.
4. Act as vaccines
Viruses can be modified to act directly as vaccines themselves in several ways.
We can weaken a virus (for an attenuated virus vaccine) so it doesn’t cause infection in a healthy host but can still replicate to stimulate the immune response. The chickenpox vaccine works like this.
The Salk vaccine for polio uses a whole virus that has been inactivated (so it can’t cause disease).
Others use a small part of the virus such as a capsid protein to stimulate an immune response (subunit vaccines).
An mRNA vaccine packages up viral RNA for a specific protein that will stimulate an immune response.
5. Kill bacteria
Viruses can – in limited situations in Australia – be used to treat antibiotic-resistant bacterial infections.
Bacteriophages are viruses that kill bacteria. Each type of phage usually infects a particular species of bacteria.
Unlike antibiotics – which often kill “good” bacteria along with the disease-causing ones – phage therapy leaves your normal flora (useful microbes) intact.
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6. Target plant, fungal or animal pests
Viruses can be species-specific (infecting one species only) and even cell-specific (infecting one type of cell only).
This occurs because the proteins viruses use to attach to cells have a shape that binds to a specific type of cell receptor or molecule, like a specific key fits a lock.
The virus can enter the cells of all species with this receptor/molecule. For example, rabies virus can infect all mammals because we share the right receptor, and mammals have other characteristics that allow infection to occur whereas other non-mammal species don’t.
When the receptor is only found on one cell type, then the virus will infect that cell type, which may only be found in one or a limited number of species. Hepatitis B virus successfully infects liver cells primarily in humans and chimps.
We can use that property of specificity to target invasive plant species (reducing the need for chemical herbicides) and pest insects (reducing the need for chemical insecticides). Baculoviruses, for example, are used to control caterpillars.
Similarly, bacteriophages can be used to control bacterial tomato and grapevine diseases.
Other viruses reduce plant damage from fungal pests.
Myxoma virus and calicivirus reduce rabbit populations and their environmental impacts and improve agricultural production.
Just like humans can be protected against by vaccination, plants can be “immunised” against a disease-causing virus by being exposed to a milder version.
Thea van de Mortel, Professor, Nursing, School of Nursing and Midwifery, Griffith University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Metabolism Made Simple – by Sam Miller
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The author, a nutritionist, sets out to present exactly what the title promises: metabolism made simple.
On this, he delivers. Explaining things from the most basic elements upwards, he gives a well-rounded introduction to the science of metabolism and what it means for us when it comes to our dietary habits.
The book is in large part a how-to, but with a lot of flexibility left to the reader. He doesn’t advocate for any particular dietary plan, but he does give the reader the tools necessary to make an informed choice and go from there—including the pros and cons of some popular dietary approaches.
He talks a lot about getting the most out of whatever we do choose to—managing appetite, mitigating adaptation, maximizing adherence, optimizing absorption of nutrients, and so forth.
The book does also touch on things like exercise and stress management, but diet is always center-stage and is the main topic of the book.
The style is—as promised by the title—simple. However, this simply means that he avoids unnecessary jargon and explains any necessary terms along the way. As for backing up claims with science, there are 22 pages of references, which is always a good sign.
Bottom line: if you’d like a simple, practical guide to eating for metabolic health, this book will start you off on a good footing.
Click here to check out Metabolism Made Simple, and give your metabolic health a boost!
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Gut-Positive Pot Noodles
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Everything we consume either improves our health a little or worsens it. Pot noodles aren’t generally the healthiest foods, but these ones sure are! There’s quite a range of fiber in this, including the soluble fiber of the noodles themselves (which are, in fact, mostly fiber and water). As a bonus, the glucomannan in the noodles promotes feelings of fullness, notwithstanding its negligible carb count. Of course, the protein in the edamame beans also counts for satiety!
You will need
- ½ cup konjac noodles (also called shirataki), tossed in 1 tsp avocado oil (or sesame oil, if you don’t have avocado)
- 2 oz mangetout, thinly sliced
- 1 oz edamame beans
- ¼ carrot, grated
- 2 baby sweetcorn, cut in half lengthways
- 1 scallion, finely diced
- 1 heaped tsp crunchy peanut butter (omit if allergic)
- 1 tsp miso paste
- 1 tsp chili oil
- 1 tsp black pepper, coarse ground
- 1 tsp peeled-and-grated ginger
Method
(we suggest you read everything at least once before doing anything)
1) Layer a heat-resistant jar (mason jars are usually quite resistant to temperature changes) with the noodles and vegetables.
2) Combine the peanut butter, miso paste, and chili oil, black pepper, and ginger in a small bowl. Pour this dressing over the layered vegetables and noodles, and screw the lid on. Refrigerate until needed.
3) Add hot water to the jar and stir, to serve. If you prefer the vegetables to be more cooked, you can microwave (without the lid!) for a minute or two.
Enjoy!
Want to learn more?
For those interested in some of the science of what we have going on today:
- Making Friends With Your Gut (You Can Thank Us Later)
- Why You’re Probably Not Getting Enough Fiber (And How To Fix It)
- 10 Ways To Balance Blood Sugars ← today’s recipe makes a perfect high-fiber, low-carb starter, per the hacks here
- Capsaicin For Weight Loss And Against Inflammation
- Black Pepper’s Impressive Anti-Cancer Arsenal (And More)
- Ginger Does A Lot More Than You Think
Take care!
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The Circadian Code – by Dr. Satchin Panda
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There’s a lot more to circadian rhythm than “sleep during these hours”. And there’s a lot more to bear in mind than “don’t have blue/white light at night”.
In fact, Dr. Satchin Panda explains, there’s a whole daily symphony of movements in our body as different biochemical processes wax and wane according to what time of day it is.
There are several important things he wants us to know about this:
- Our body needs to know what time it is, for those processes to work correctly
- Because of these daily peaks and troughs of various physiological functions, we get “correct” times for things we do every day. Not just sleeping/waking, but also:
- The best time to eat
- The best time to exercise
- The best time to do mental work
- The best times to take different kinds of supplements/medications
Dr. Panda also looks at what things empower, or disempower, our body to keep track of what time it is.
Bottom line: if you’d like to optimize your days and your health, this book has a lot of very valuable practicable tips.
Click here to check out The Circadian Code, and make the most of yours!
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Eat This Daily For No Wrinkles (& How It Works)
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Dr. Andrea Suarez explains:
Go nuts for…
Almonds! They’re rich in vitamin E (alpha-tocopherol), beta-sitosterol, squalane, protein, and fiber:
- Vitamin E acts as an antioxidant, protecting skin lipids.
- Lipids in almonds support the skin barrier and hydration.
- Protein is necessary for collagen synthesis.
- Fiber promotes gut health, indirectly benefiting skin.
- Polyphenolic compounds in almond skins (not the shells, the skins, the fibrous brown part that slides off if you blanch them) provide additional skin protection.
The science (yes, there have been almond intervention studies!):
- 2019 Study:
- Participants: 28 post-menopausal women with fair skin (Fitzpatrick phototype 1-2).
- Design: 20% of daily calories from almonds vs. a calorie-matched snack.
- Results: 9% decrease in facial wrinkles in the almond group, no change in oil production or barrier function.
- 2021 Study:
- Extended Duration: 24 weeks with a similar design as the 2019 study.
- Findings: further wrinkle reduction and improvement in skin pigmentation.
- Mechanism: vitamin E may reduce hyperpigmentation and support antioxidant defense.
- UV Protection Study (2021):
- Participants: healthy Asian women (18–45 years, Fitzpatrick phototype 2-4).
- Method: daily almond snack vs pretzel snack for 12 weeks.
- Outcome: increased skin resistance to UV damage in the almond group.
Obviously, a limitation is there is not really an option to make a RCT with a blinded control; “…and group B will only think they are eating almonds” doesn’t really work. Hence, interventional RCTs with a non-blinded control (the calorie-matched snack).
Almonds may not be the cure to all things, but they certainly are potent nuts. Best enjoyed, of course, as part of a healthy overall diet (Mediterranean diet is great), and it’s certainly advisable to take care of your skin from the outside too (sunscreen as a must; other things optional).
For more on all of this, enjoy:
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Want to learn more?
You might also like to read:
Why You Should Diversify Your Nuts
Take care!
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Feel Better In 5 – by Dr. Rangan Chatterjee
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We’ve featured Dr. Rangan Chatterjee before, and here’s a great book of his.
The premise is a realistic twist on a classic, the classic being “such-and-such, in just 5 minutes per day!”
In this case, Dr. Chatterjee offers many lifestyle interventions that each take just 5 minutes, with the idea that you implement 3 of them per day (your choice which and when), and thus gradually build up healthy habits. Of course, once things take as habits, you’ll start adding in more, and before you know it, half your lifestyle has changed for the better.
Which, you may be thinking “my lifestyle’s not that bad”, but if you improve the health outcomes of, say, 20 areas of your life by just a few percent each, you know much better health that adds up to? We’ll give you a clue: it doesn’t add up, it compounds, because each improves the other too, for no part of the body works entirely in isolation.
And Dr. Chatterjee does tackle the body systematically, by the way; interventions for the gut, heart, brain, and so on.
As for what these interventions look like; it is very varied. One might be a physical exercise; another, a mental exercise; another, a “make this health 5-minute thing in the kitchen”, etc, etc.
Bottom line: this is the most supremely easy of easy-ins to healthier living, whatever your starting point—because even if you’re doing half of these interventions, chances are you aren’t doing the other half, and the idea is to pick and choose how and when you adopt them in any case, just picking three 5-minute interventions each day with no restrictions. In short, a lot of value to had here when it comes to real changes to one’s serious measurable health.
Click here to check out Feel Better In 5, and indeed feel better in 5!
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Continuous Glucose Monitors Without Diabetes: Pros & Cons
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The “Glucose Goddess”, biochemist Jessie Inchauspé, gives us the low-down:
Knowledge is power (but watch out)
A continuous glucose monitor (CGM) is a device that continually monitors glucose levels, without the need to stab one’s finger every few hours to test blood.
It was designed for diabetics, especially for those with Type 1 Diabetes, where around-the-clock monitoring is necessary for appropriate insulin dosing.
For non-diabetics, they can be a good way of learning what our body’s response to various foods and activities is like, the better to be able to tweak our habits to avoid undue glucose spikes (which are harmful for our pancreas, liver, heart, brain, kidneys, and more).
How it works: there’s a sensor that sits on the arm (or elsewhere, but the arm is a popular placement) with a little probe that goes under the skin. It’s applied using a device that inserts it automatically using a needle (you only need to press a button, you don’t need to guide the needle yourself); the needle then retracts, leaving the soft, flexible probe in place. Having been attached, that sensor can now stay in place for 2 weeks (usually; depends on brand, but for example FreeStyle Libre, the most popular brand, the sensors last 2 weeks), and yes, it’s fine to bathe/shower/etc with it. When you want an update from your CGM, you scan it with your phone (or you can buy a dedicated reader, but that is more expensive and unnecessary), and it uploads the data since your last scan.
Pros: it’s convenient and gives a lot of data, so even if you only use it for a short period of time (for example, a month) you can get a very good idea of what affects your blood sugar levels and how. Also, because of the constant nature of the monitoring, it helps avoid accidental sample bias of the kind that can occur with manual testing, by testing a little too soon or too late, and missing a spike/dip.
Cons: it can be expensive, depending on where you live and what options are available for you locally, so you might not want to do it long-term (since that would require buying two sensors per month). It’s also, for all its wealth of data, slightly less accurate than fingerprick testing—that’s because it takes an interstitial reading instead of directly from the blood. For this reason, if you test both ways, you may find a discrepancy of about 3mg/dL. Given that the healthy range is about 70–140mg/dL, a discrepancy of 3mg/dL is probably not going to be important, but it is a thing to mention can (and probably will) happen.
Patterns to bear in mind (with any kind of blood sugar monitoring):
- Dawn phenomenon: a natural glucose rise upon waking.
- Exercise-induced spikes (normal due to energy demands).
- Fat in meals slowing glucose absorption.
- Different foods can sometimes cause a double-wave after dinner (because glucose from different foods is absorbed differently, and/or different foods affect insulin response independent of glucose)
- Steep, rapid spikes that are more harmful than gradual, sustained increases.
- Vitamin C spikes: temporary chemical interference with the sensor, not actual glucose rises.
- Nighttime glucose dips (often false readings caused by sleeping position).
For more on all of this, enjoy:
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Want to learn more?
You might also like to read:
10 Ways To Balance Blood Sugars
Take care!
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