Things Many People Forget When It Comes To Hydration

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Good hydration is about more than just “drink lots of water”, and in fact it’s quite possible for a person to drink too much water, and at the same time, be dehydrated. Here’s how and why and what to do about it:

Water, water, everywhere

Factors that people forget:

  • Electrolyte balance: without it, we can technically have lots of water while either retaining it (in the case of too high salt levels) or peeing it out (in the case of too low salt levels), neither of which are as helpful as getting it right and actually being able to use the water.
  • Gastrointestinal health: conditions like IBS, Crohn’s, or celiac disease can impair water and nutrient absorption, affecting hydration
  • Genetic factors: some people simply have a predisposition to need more or less water for proper hydration
  • Dietary factors: high salt, caffeine, and alcohol intake (amongst other diuretics) can increase water loss, while water-rich foods (assuming they aren’t also diuretics) increase hydration.

Strategies to do better:

  • Drink small amounts of water consistently throughout the day rather than large quantities at once—healthy kidneys can process about 1 liter (about 1 quart) of water per hour, so drinking more than that will not help, no matter how dehydrated you are when you start. If your kidneys aren’t in peak health, the amount processable per hour will be lower for you.
  • Increase fiber intake (e.g., fruit and vegetables) to retain water in the intestines and improve hydration
  • Consume water-rich foods (e.g., watermelon, cucumbers, grapes) to enhance overall hydration and support cellular function (the body can use this a lot more efficiently than if you just drink water).
  • Counteract the diuretic effects of caffeine and alcohol by drinking an additional 12 oz of water for every 8 oz of these beverages. Best yet, don’t drink alcohol and keep caffeine to a low level (or quit entirely, if you prefer, but for most people that’s not necessary).
  • If you are sweating (be it because of weather, exercise, or any other reasons), include electrolyte fluids to improve cellular hydration, as they contain essential minerals like magnesium, potassium, and in moderation yes even sodium which you will have lost in your sweat too, supporting fluid regulation.

For more details on all of these, enjoy:

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  • Keeping Your Kidneys Healthy (Especially After 60)

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    Keeping your kidneys happy: it’s more than just hydration!

    Your kidneys are very busy organs. They filter waste products, balance hydration, pH, salt, and potassium. They also make some of our hormones, and are responsible for regulating red blood cell production too. They also handle vitamin D in a way our bodies would not work without, making them essential for calcium absorption and the health of our bones, and even muscular function.

    So, how to keep them in good working order?

    Yes, hydrate

    This is obvious and may go without saying, but we try to not leave important things without saying. So yes, get plenty of water, spread out over the day (you can only usefully absorb so much at once!). If you feel thirsty, you’re probably already dehydrated, so have a little (hydrating!) drink.

    Don’t smoke

    It’s bad for everything, including your kidneys.

    Look after your blood

    Not just “try to keep it inside your body”, but also:

    Basically, your kidneys’ primary job of filtering blood will go much more smoothly if that blood is less problematic on the way in.

    Watch your over-the-counter pill intake

    A lot of PRN OTC NSAIDs (PRN = pro re nata, i.e. you take them as and when symptoms arise) (NSAIDs = Non-Steroidal Anti-Inflammatory Drugs, such as ibuprofen for example) can cause kidney damage if taken regularly.

    Many people take ibuprofen (for example) constantly for chronic pain, especially the kind cause by chronic inflammation, including many autoimmune diseases.

    It is recommended to not take them for more than 10 days, nor more than 8 per day. Taking more than that, or taking them for longer, could damage your kidneys temporarily or permanently.

    Read more: National Kidney Foundation: Advice About Pain Medicines

    See also: Which Drugs Are Harmful To Your Kidneys?

    Get a regular kidney function checkup if you’re in a high risk group

    Who’s in a high risk group?

    • If you’re over 60
    • If you have diabetes
    • If you have cardiovascular disease
    • If you have high blood pressure
    • If you believe, or know, you have existing kidney damage

    The tests are very noninvasive, and will be a urine and/or blood test.

    For more information, see:

    Kidney Testing: Everything You Need to Know

    Take care!

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  • SMOL Bowl With Sautéed Greens

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    Whole grains are good, and gluten is bad for some people. Today’s dish has four whole grains, and no gluten (assuming no cross-contamination, so look for the gluten-free label if that’s important to you). Breafast? Brunch? Lunch? Supper, even? This is good at any time of day, packed with nutrients and full of flavor!

    You will need (per person)

    • 1 cup mixed cooked grains of equal parts sorghum, millet, oats, lentils (SMOL)—these can be cooked in bulk in advance and frozen in portions, as it’s often good to used mixed grains, and these four are a great combination for many purposes.
    • ½ cup low sodium vegetable stock (ideally you made this yourself from vegetable offcuts you kept in the freezer until you had enough for this purpose, but failing that, low-sodium stock cubes can be bought at most large supermarkets).
    • ½ cup finely chopped red onion
    • 6 oz cavolo nero, finely chopped
    • 1 small carrot, finely chopped
    • 3 cloves garlic, finely chopped
    • 1 tbsp nutritional yeast
    • 1 tsp black pepper, coarse ground
    • 1 tsp white miso paste
    • To serve: 1 lemon wedge

    Method

    (we suggest you read everything at least once before doing anything)

    1) Add the stock to a sauté pan over a medium heat, and add the onion, garlic, and carrot. Stir frequently for about 7 minutes.

    2) Add the cavolo nero and miso paste, stirring for another 4 minutes. If there is any liquid remaining, drain it off now.

    3) Warm the SMOL mixture (microwave is fine) and spoon it into a bowl, topping with the nutritional yeast and black pepper. Finally, add the hot cavolo nero mixture.

    4) Serve with the lemon wedge on the side, to add a dash of lemon at will.

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

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  • The Not-So-Sweet Science Of Sugar Addiction

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    One Lump Mechanism Of Addiction Or Two?

    In Tuesday’s newsletter, we asked you to what extent, if any, you believe sugar is addictive; we got the above-depicted, below-described, set of responses:

    • About 47% said “Sugar is chemically addictive, comparable to alcohol”
    • About 34% said “Sugar is chemically addictive, comparable to cocaine”
    • About 11% said “Sugar is not addictive; that’s just excuse-finding hyperbole”
    • About 9% said “Sugar is a behavioral addiction, comparable to video gaming”

    So what does the science say?

    Sugar is not addictive; that’s just excuse-finding hyperbole: True or False?

    False, by broad scientific consensus. As ever, the devil’s in the details definitions, but while there is still discussion about how best to categorize the addiction, the scientific consensus as a whole is generally: sugar is addictive.

    That doesn’t mean scientists* are a hive mind, and so there will be some who disagree, but most papers these days are looking into the “hows” and “whys” and “whats” of sugar addiction, not the “whether”.

    *who are also, let us remember, a diverse group including chemists, neurobiologists, psychologists, social psychologists, and others, often collaborating in multidisciplinary teams, each with their own focus of research.

    Here’s what the Center of Alcohol and Substance Use Studies has to say, for example:

    Sugar Addiction: More Serious Than You Think

    Sugar is a chemical addiction, comparable to alcohol: True or False?

    True, broadly, with caveats—for this one, the crux lies in “comparable to”, because the neurology of the addiction is similar, even if many aspects of it chemically are not.

    In both cases, sugar triggers the release of dopamine while also (albeit for different chemical reasons) having a “downer” effect (sugar triggers the release of opioids as well as dopamine).

    Notably, the sociology and psychology of alcohol and sugar addictions are also similar (both addictions are common throughout different socioeconomic strata as a coping mechanism seeking an escape from emotional pain).

    See for example in the Journal of Psychoactive Drugs:

    Sweet Preference, Sugar Addiction and the Familial History of Alcohol Dependence: Shared Neural Pathways and Genes

    On the other hand, withdrawal symptoms from heavy long-term alcohol abuse can kill, while withdrawal symptoms from sugar are very much milder. So there’s also room to argue that they’re not comparable on those grounds.

    Sugar is a chemical addiction, comparable to cocaine: True or False?

    False, broadly. There are overlaps! For example, sugar drives impulsivity to seek more of the substance, and leads to changes in neurobiological brain function which alter emotional states and subsequent behaviours:

    The impact of sugar consumption on stress driven, emotional and addictive behaviors

    However!

    Cocaine triggers a release of dopamine (as does sugar), but cocaine also acts directly on our brain’s ability to remove dopamine, serotonin, and norepinephrine:

    The Neurobiology of Cocaine Addiction

    …meaning that in terms of comparability, they (to use a metaphor now, not meaning this literally) both give you a warm feeling, but sugar does it by turning up the heating a bit whereas cocaine does it by locking the doors and burning down the house. That’s quite a difference!

    Sugar is a behavioral addiction, comparable to video gaming: True or False?

    True, with the caveat that this a “yes and” situation.

    There are behavioral aspects of sugar addiction that can reasonably be compared to those of video gaming, e.g. compulsion loops, always the promise of more (without limiting factors such as overdosing), anxiety when the addictive element is not accessible for some reason, reduction of dopaminergic sensitivity leading to a craving for more, etc. Note that the last is mentioning a chemical but the mechanism itself is still behavioral, not chemical per se.

    So, yes, it’s a behavioral addiction [and also arguably chemical in the manners we’ve described earlier in this article].

    For science for this, we refer you back to:

    The impact of sugar consumption on stress driven, emotional and addictive behaviors

    Want more?

    You might want to check out:

    Beating Food Addictions: When It’s More Than “Just” Cravings

    Take care!

    Share This Post

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    Most of us know the theory when it comes to building new habits and/or replacing old ones, and maybe we even implement those ideas. So why is our success rate still not as high as we think it should be?

    Dr. Sean Young is here to do science to it!

    This book comes with advice and explanations that rely a lot less on “that sounds reasonable” and a lot more on “in this recent high-quality study, researchers found…”

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    Dr. Young is big on using that science to find ways to trick our brains and get them working the way we want.

    Each chapter has lots of science, lots of explanations, and lots of actionable step-by-step advice.

    Bottom line: if you’re all over “Atomic Habits”, this one’s the science-based heavy-artillery for your practical neurohacking.

    Click here to check out “Stick With It” on Amazon today, and start enjoying the much easier (and more lasting) rewards!

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  • The Real Benefit Of Genetic Testing

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    Genetic Testing: Health Benefits & Methods

    Genetic testing is an oft-derided American pastime, but there’s a lot more to it than finding out about your ancestry!

    Note: because there are relatively few companies offering health-related genetic testing services, and we are talking about the benefits of those services, some of this main feature may seem like an advert.

    It’s not; none of those companies are sponsoring us, and if any of them become a sponsor at some point, we’ll make it clear and put it in the clearly-marked sponsor segment.

    As ever, our only goal here is to provide science-backed information, to enable you to make your own, well-informed, decisions.

    Health genomics & genetic testing

    The basic goal of health genomics and genetic testing is to learn:

    • What genetic conditions you have
      • Clearcut genetic conditions, such as Fragile X syndrome, or Huntington’s disease
    • What genetic predispositions you have
      • Such as an increased/decreased risk for various kinds of cancer, diabetes, heart conditions, and so forth
    • What genetic traits you have
      • These may range from “blue eyes” to “superathlete muscle type”
    • More specifically, pharmacogenomic information
      • For example, “fast caffeine metabolizer” or “clopidogrel (Plavix) non-responder” (i.e., that drug simply will not work for you)

    Wait, what’s the difference between health genomics and genetic testing?

    • Health genomics is the science of how our genes affect our health.
    • Genetic testing can be broadly defined as the means of finding out which genes we have.

    A quick snippet…

    More specifically, a lot of these services look at which single nucleotide polymorphisms (SNPs, pronounced “snips”) we have. While we share almost all of our DNA with each other (and indeed, with most vertebrates), our polymorphisms are the bits that differ, and are the bits that, genetically speaking, make us different.

    So, by looking just at the SNPs, it means we “only” need to look at about 3,000,000 DNA positions, and not our entire genome. For perspective, those 3,000,000 DNA positions make up about 0.1% of our whole genome, so without focusing on SNPs, the task would be 1000x harder.

    For example, the kind of information that this sort of testing may give you, includes (to look at some “popular” SNPs):

    • rs53576 in the oxytocin receptor influences social behavior and personality
    • rs7412 and rs429358 can raise the risk of Alzheimer’s disease by more than 10x
    • rs6152 can influence baldness
    • rs333 resistance to HIV
    • rs1800497 in a dopamine receptor may influence the sense of pleasure
    • rs1805007 determines red hair and sensitivity to anesthetics
    • rs9939609 triggers obesity and type-2 diabetes
    • rs662799 prevents weight gain from high fat diets
    • rs12255372 linked to type-2 diabetes and breast cancer
    • rs1799971 makes alcohol cravings stronger
    • rs17822931 determines earwax, sweating and body odor
    • rs1333049 coronary heart disease
    • rs1051730 and rs3750344 nicotine dependence
    • rs4988235 lactose intolerance

    (You can learn about these and more than 100,000 other SNPs at SNPedia.com)

    I don’t know what SNPs I have, and am disinclined to look them up one by one!

    The first step to knowing, is to get your DNA out of your body and into a genetic testing service. This is usually done by saliva or blood sample. This writer got hers done many years ago by 23andMe and was very happy with that service, but there are plenty of other options.

    Healthline did an independent review of the most popular companies, so you might like to check out:

    Healthline: Best DNA Testing Kits of 2023

    Those companies will give you some basic information, such as “6x higher breast cancer risk” or “3x lower age-related macular degeneration risk” etc.

    However, to really get bang-for-buck, what you want to do next is:

    1. Get your raw genetic data (the companies above should provide it); this will probably look like a big text file full of As, Cs, Gs, and Ts, but it make take another form.
    2. Upload it to Promethease. When this writer got hers done , the cost was $2; that price has now gone up to a whopping $12.
    3. You will then get a report that will cross-reference your data with everything known about SNPs, and give a supremely comprehensive, readable-to-the-human-eye, explanation of what it all means for you—from much more specific health risk prognostics, to more trivial things like whether you can roll your tongue or smell decomposed asparagus metabolites in urine.

    A note on privacy: anything you upload to Promethease will be anonymized, and/but in doing so, you consent to it going into the grand scientific open-source bank of “things we know about the human genome”, and thus contribute to the overall sample size of genetic data.

    In our opinion, it means you’re doing your bit for science, without personal risk. But your opinion may differ, and that’s your decision to make.

    Lastly, on the pros and cons of pharmacogenetic testing specifically:

    Don’t Forget…

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  • Stress Resets – by Dr. Jennifer Taitz

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    You may be thinking: “that’s a bold claim in the subtitle; does the book deliver?”

    And yes, yes it does.

    The “resets” themselves are divided into categories:

    1. Mind resets, which are mostly CBT,
    2. Body resets, which include assorted somatic therapies such as vagus nerve resets, the judicious use of ice-water, what 1-minute sprints of exercise can do for your mental state, and why not to use the wrong somatic therapy for the wrong situation!
    3. Behavior resets, which are more about the big picture, and not falling into common traps.

    What common traps, you ask? This is about how we often have maladaptive responses to stress, e.g. we’re short of money so we overspend, we have an important deadline so we over-research and procrastinate, we’re anxious so we hyperfixate on the problem, we’re grieving so we look to substances to try to cope, we’re exhausted so we stay up late to try to claw back some lost time. Things where our attempt to cope actually makes things worse for us.

    Instead, Dr. Taitz advises us of how to get ourselves from “knowing we shouldn’t do that” to actually not doing that, and how to respond more healthily to stress, how to turn general stress into eustress, or as she puts it, how to “turn your knots into bows”.

    The style is… “Academic light”, perhaps we could say. It’s a step above pop-science, but a step below pure academic literature, which does make it a very pleasant read as well as informative. There are often footnotes at the bottom of each page to bridge any knowledge-gap, and for those who want to know the evidence of these evidence-based approaches, she does provide 35 pages of hard science sources to back up her claims.

    Bottom line: if you’d like to learn how better to manage stress from an evidence-based perspective that’s not just “do minfdulness meditation”, then this book gives a lot of ways.

    Click here to check out Stress Resets, and indeed soothe your body and mind in minutes!

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