Blood-Brain Barrier Breach Blamed For Brain-Fog

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Move Over, Leaky Gut. Now It’s A Leaky Brain.

…which is not a headline that promises good news, and indeed, the only good news about this currently is “now we know another thing that’s happening, and thus can work towards a treatment for it”.

Back in February (most popular media outlets did not rush to publish this, as it rather goes against the narrative of “remember when COVID was a thing?” as though the numbers haven’t risen since the state of emergency was declared over), a team of Irish researchers made a discovery:

❝For the first time, we have been able to show that leaky blood vessels in the human brain, in tandem with a hyperactive immune system may be the key drivers of brain fog associated with long covid❞

~ Dr. Matthew Campbell (one of the researchers)

Let’s break that down a little, borrowing some context from the paper itself:

  • the leaky blood vessels are breaching the blood-brain-barrier
    • that’s a big deal, because that barrier is our only filter between our brain and Things That Definitely Should Not Go In The Brain™
  • a hyperactive immune system can also be described as chronic inflammation
    • in this case, that includes chronic neuroinflammation which, yes, is also a major driver of dementia

You may be wondering what COVID has to do with this, and well:

  • these blood-brain-barrier breaches were very significantly associated (in lay terms: correlated, but correlated is only really used as an absolute in write-ups) with either acute COVID infection, or Long Covid.
  • checking this in vitro, exposure of brain endothelial cells to serum from patients with Long Covid induced the same expression of inflammatory markers.

How important is this?

As another researcher (not to mention: professor of neurology and head of the school of medicine at Trinity) put it:

❝The findings will now likely change the landscape of how we understand and treat post-viral neurological conditions.

It also confirms that the neurological symptoms of long covid are measurable with real and demonstrable metabolic and vascular changes in the brain.❞

~ Dr. Colin Doherty (see mini-bio above)

You can read a pop-science article about this here:

Irish researchers discover underlying cause of “brain fog” linked with long covid

…and you can read the paper in full here:

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Want to stay safe?

Beyond the obvious “get protected when offered boosters/updates” (see also: The Truth About Vaccines), other good practices include the same things most people were doing when the pandemic was big news, especially avoiding enclosed densely-populated places, washing hands frequently, and looking after your immune system. For that latter, see also:

Beyond Supplements: The Real Immune-Boosters!

Take care!

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  • Never Too Late To Start Over: Finding Purpose At Any Age

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dana Findwell’s late 50s were not an easy time, but upon now hitting 60 (this week, at time of writing), she’s enthusiastically throwing herself into the things that bring her purpose, and so can you.

    Start where you are

    Findwell was already no stranger to starting again, having been married and divorced twice, and having moved frequently, requiring constant “life resets”.

    Nevertheless, she always had her work to fall back on; she was a graphic designer and art director for 30 years… Until burnout struck.

    And when burnout struck, so did COVID, resulting in the loss of her job. Her job wasn’t the only thing she lost though, as her mother died around the same time. All in all, it was a lot, and not the fun kind of “a lot”.

    Struggling to find a new career direction, she ended up starting a small business for herself, so that she could direct the pace; pressing forwards as and when she had the energy. This became her new “ikigai“, the main thing that brings a sense of purpose to her life, but getting one part of her life back into order brought her attention to the rest; she realized she’d neglected her health, so she joined a gym. And a weightlifting class. And a hip-hop class. And she took up the practice of Japanese drumming (for the unfamiliar, this can be a rather athletic ability; it’s not a matter of sitting at a drum kit).

    And now? Her future is still not clear, but that’s ok, because she’s making it as she goes, and she’s doing it her way, trusting in her ability to handle what may come up, and doing the things now that future-her will be glad of having done (e.g. laying the groundwork of both financial security and good health).

    Change can sometimes be triggered by adverse circumstances, but there’s always the opportunity to find something better. For more on all of this, enjoy:

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    Want to learn more?

    You might also like to read:

    Our Resources About Ikigai

    Take care!

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  • Passion Fruit vs Pomegranate – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing passion fruit to pomegranate, we picked the passion fruit.

    Why?

    Both of these fruits have beaten a lot of other contenders, so it’s time to pit them against each other:

    In terms of macros, passion fruit has more protein, carbs, and fiber, the ratio of which meaning also that passion fruit has the lower glycemic index. So, we say passion fruit wins on macros.

    In the category of vitamins, things are more even; passion fruit has more of vitamins A, B2, B3, B6, and C, while pomegranate has more of vitamins B1, B5, B9, E, and K. In light of this 5:5 tie, and since passion fruit’s overall vitamin coverage is better (in terms of meeting RDA needs) but pomegranate’s vitamins are often in shorter supply in diet, we’re calling it a tie on vitamins.

    When it comes to minerals, passion fruit has more calcium, iron, magnesium, phosphorus, potassium, and selenium, while pomegranate has more copper, manganese, and zinc. That’s already an easy 6:3 win for passion fruit, before we even consider the fact that passion fruit’s minerals’ margin of difference is greater too.

    Adding it up makes for a clear win for passion fruit. As ever when it comes to plants, enjoy both if you can, though!

    Want to learn more?

    You might like to read:

    What’s Your Plant Diversity Score?

    Take care!

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  • Codependent No More – by Melody Beattie

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    This is a book review, not a book summary, but first let’s quickly cover a common misconception, because the word “codependent” gets misused a lot in popular parlance:

    • What codependence isn’t: “we depend on each other and must do everything together”
    • What codependence is:“person 1 has a dependency on a substance (or perhaps a behavior, such as gambling); person 2 is trying to look after person 1, and so has developed a secondary relationship with the substance/behavior. Person 2 is now said to be codependent, because it becomes all-consuming for them too, even if they’re not using the substance/behavior directly”

    Funny how often it happens that the reality is more complex than the perception, isn’t it?

    Melody Beattie unravels all this for us. We get a compassionate and insightful look at how we can look after ourselves, while looking after another. Perhaps most importantly: how and where to draw a line of what we can and cannot do/change for them.

    Because when we love someone, of course we want to fight their battles with them, if not for them. But if we want to be their rock of strength, we can’t get lost in it too, and of course that hurts.

    Beatty takes us through these ideas and more, for example:

    • How to examine our own feelings even when it’s scary
    • How to practice self-love and regain self-worth, while still caring for them
    • How to stop being reactionary, step back, and act with purpose

    If the book has any weak point, it’s that it repeatedly recommends 12-step programs, when in reality that’s just one option. But for those who wish to take another approach, this book does not require involvement in a 12-step program, so it’s not a barrier to usefulness.

    Click here to check out Codependent No More and take care of yourself, too

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  • Honey vs Maple Syrup – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing honey to maple syrup, we picked the honey.

    Why?

    It was very close, as both have small advantages:
    •⁠ ⁠Honey has some medicinal properties (and depending on type, may contain an antihistamine)
    •⁠ ⁠Maple syrup is a good source of manganese, as well as low-but-present amounts of other minerals

    However, you wouldn’t want to eat enough maple syrup to rely on it as a source of those minerals, and honey has the lower GI (average 46 vs 54; for comparison, refined sugar is 65), which works well as a tie-breaker.

    (If GI’s very important to you, though, the easy winner here would be agave syrup if we let it compete, with its GI of 15)

    Read more:
    •⁠ ⁠Can Honey Relieve Allergies?
    •⁠ ⁠From Apples to Bees, and High-Fructose C’s

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  • What Does “Balance Your Hormones” Even Mean?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Hormonal Health: Is It Really A Balancing Act?

    Have you ever wondered what “balancing your hormones” actually means?

    The popular view is that men’s hormones look like this:

    Testosterone (less) ⟷ Testosterone (more)

    …And that women’s hormones look more like this:

    ♀︎ Estrogen ↭ Progesterone ⤵︎

    ⇣⤷ FSH ⤦ ↴ ☾ ⤹⤷ Luteinizing Hormone ⤦

    DHEA ↪︎ Gonadotrophin ⤾

    ↪︎ Testosterone? ⥅⛢

    Clear as mud, right?

    But, don’t worry, Supplements McHerbal Inc will sell you something guaranteed to balance your hormones!

    How can a supplement (or dietary adjustment) “balance” all that hotly dynamic chaos, and make everything “balanced”?

    The truth is, “balanced” in such a nebulous term, and this is why you will not hear endocrinologists using it. It’s used in advertising to mean “in good order”, and “not causing problems”, and “healthy”.

    In reality, our hormone levels depend on everything from our diet to our age to our anatomy to our mood to the time of the day to the phase of the moon.

    Not that the moon has an influence on our physiology at all—that’s a myth—but you know, 28 day cycle and all. And, yes, half the hormones affect the levels of the others, either directly or indirectly.

    Trying to “balance” them would be quite a game of whack-a-mole, and not something that a “cure-all” single “hormone-balancing” supplement could do.

    So why aren’t we running this piece on Friday, for our “mythbusting” section? Well, we could have, but the more useful information is yet to come and will take up more of today’s newsletter than the myth-busting!

    What, then, can we do to untangle the confusion of these hormones?

    Well first, let’s understand what they do, in the most simple terms possible:

    • Estrogen—the most general feminizing hormone from puberty onwards, busiest in the beginning of the menstrual cycle, and starts getting things ready for ovulation.
    • Progesteronesecondary feminizing hormone, fluffs the pillows for the oncoming fertilized egg to be implanted, increases sex drive, and adjusts metabolism accordingly. Busiest in the second half of the menstrual cycle.
    • Testosterone—is also present, contributes to sex drive, is often higher in individuals with PCOS. If menopause is untreated, testosterone will also rise, because there will be less estrogen
      • (testosterone and estrogen “antagonize” each other, which is the colorfully scientific way of saying they work against each other)
      • DHEA—Dehydroepiandrosterone, supports production of testosterone (and estrogen!). Sounds self-balancing, but in practice, too much DHEA can thus cause elevated testosterone levels, and thus hirsutism.
    • Gonadotrophin—or more specifically human chorionic gonadotrophin, HcG, is “the pregnancy hormone“, present only during pregnancy, and has specific duties relating to such. This is what’s detected in (most) pregnancy test kits.
    • FSH—follicle stimulating hormone, is critical to ovulation, and is thus essential to female fertility. On the other hand, when the ovaries stop working, FSH levels will rise in a vain attempt to encourage the ovulation that isn’t going to happen anymore.
    • Luteinizing hormone—says “go” to the new egg and sends it on its merry way to go get fertilized. This is what’s detected by ovulation prediction kits.

    Sooooooo…

    What, for most women, most often is meant by a “hormonal imbalance” is:

    • Low levels of E and/or P
    • High levels of DHEA and/or T
    • Low or High levels of FSH

    In the case of low levels of E and/or P, the most reliable way to increase these is, drumroll please… To take E and/or P. That’s it, that’s the magic bullet.

    Bonus Tip: take your E in the morning (this is when your body will normally make more and use more) take your P in the evening (it won’t make you sleepy, but it will improve your sleep quality when you do sleep)

    In the case of high levels of DHEA and/or T, then that’s a bit more complex:

    • Taking E will antagonize (counteract) the unwanted T.
    • Taking T-blockers (such as spironolactone or bicalutamide) will do what it says on the tin, and block T from doing the jobs it’s trying to do, but the side-effects are considered sufficient to not prescribe them to most people.
    • Taking spearmint or saw palmetto will lower testosterone’s effects
      • Scientists aren’t sure how or why spearmint works for this
      • Saw palmetto blocks testosterone’s conversion into a more potent form, DHT, and so “detoothes” it a bit. It works similarly to drugs such as finasteride, often prescribed for androgenic alopecia, called “male pattern baldness”, but it affects plenty of women too.

    In the case of low levels of FSH, eating leafy greens will help.

    In the case of high levels of FSH, see a doctor. HRT (Hormone Replacement Therapy) may help. If you’re not of menopausal age, it could be a sign something else is amiss, so it could be worth getting that checked out too.

    What can I eat to boost my estrogen levels naturally?

    A common question. The simple answer is:

    • Flaxseeds and soy contain plant estrogens that the body can’t actually use as such (too incompatible). They’ve lots of high-quality nutrients though, and the polyphenols and isoflavones can help with some of the same jobs when it comes to sexual health.
    • Fruit, especially peaches, apricots, blueberries, and strawberries, contain a lot of lignans and also won’t increase your E levels as such, but will support the same functions and reduce your breast cancer risk.
    • Nuts, especially almonds (yay!), cashews, and pistachios, contain plant estrogens that again can’t be used as bioidentical estrogen (like you’d get from your ovaries or the pharmacy) but do support heart health.
    • Leafy greens and cruciferous vegetables support a lot of bodily functions including good hormonal health generally, in ways that are beyond the scope of this article, but in short: do eat your greens!

    Note: because none of these plant-estrogens or otherwise estrogenic nutrients can actually do the job of estradiol (the main form of estrogen in your body), this is why they’re still perfectly healthy for men to eat too, and—contrary to popular “soy boy” social myths—won’t have any feminizing effects whatsoever.

    On the contrary, most of the same foods support good testosterone-related health in men.

    The bottom line:

    • Our hormones are very special, and cannot be replaced with any amount of herbs or foods.
    • We can support our body’s natural hormonal functions with good diet, though.
    • Our hormones naturally fluctuate, and are broadly self-correcting.
    • If something gets seriously out of whack, you need an endocrinologist, not a homeopath or even a dietician.

    In case you missed it…

    We gave a more general overview of supporting hormonal health (including some hormones that aren’t sex hormones but are really important too), back in February.

    Check it out here: Healthy Hormones And How To Hack Them

    Want to read more?

    Anthea Levi, RD, takes much the same view:

    ❝For some ‘hormone-balancing’ products, the greatest risk might simply be lost dollars. Others could come at a higher cost.❞

    Read: Are Hormone-Balancing Products a Scam?

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  • Weight Vests Against Osteoporosis: Do They Really Build Bone?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Dr. Doug Lucas is a dual board-certified physician specializing in optimizing healthspan and bone health for women experiencing osteoporosis, perimenopause, and menopause. Here, he talks weight vests:

    Worth the weight?

    Dr. Lucas cites “Wolf’s Law”—bones respond to stress. A weighted vest adds stress, to help build bone density. That said, they may not be suitable for everyone (for example, in cases of severe osteoporosis or a recent vertebral fracture).

    He also cites some studies:

    • Erlanger Fitness Study (2004): participants with a weighted vest maintained or improved bone density compared to a control group, but there was no group with exercise alone, making it unclear if the vest itself had the biggest impact.
    • Newer studies (2016, 2017): showed improved outcomes for groups wearing a weighted vest, but again lacked an exercise-only group for comparison.
    • 2012 study: included three groups (control, weighted vest, exercise only). Results showed no significant bone density difference between vest and exercise-only groups, though the vest group showed better balance and motor control.

    Dr. Lucas concludes that weighted vests are a useful tool while nevertheless not being a magic bullet for bone health. In other words, they can complement exercise but you will also be fine without. If you do choose to level-up your exercise by using a weight vest, then starting with 5–10% of body weight in a vest is often recommended, but it depends on individual circumstances. If in doubt, start low and build up. Wearing the vest for daily activities can be effective, but improper use (awkward positions or improper impact training) can increase injury risk, so do be careful with that.

    For more on all of this, enjoy:

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    Want to learn more?

    You might also like to read:

    Take care!

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