CBD Against Diabetes!

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It’s Q&A Day at 10almonds!

Have a question or a request? We love to hear from you!

In cases where we’ve already covered something, we might link to what we wrote before, but will always be happy to revisit any of our topics again in the future too—there’s always more to say!

As ever: if the question/request can be answered briefly, we’ll do it here in our Q&A Thursday edition. If not, we’ll make a main feature of it shortly afterwards!

So, no question/request too big or small

❝CBD for diabetes! I’ve taken CBD for body pain. Did no good. Didn’t pay attention as to diabetes. I’m type 1 for 62 years. Any ideas?❞

Thanks for asking! First up, for reference, here’s our previous main feature on the topic of CBD:

CBD Oil: What Does The Science Say?

There, we touched on CBD’s effects re diabetes:

in mice / in vitro / in humans

In summary, according to the above studies, it…

  • lowered incidence of diabetes in non-obese diabetic mice. By this they mean that pancreatic function improved (reduced insulitis and reduced inflammatory Th1-associated cytokine production). Obviously this has strong implications for Type 1 Diabetes in humans—but so far, just that, implications (because you are not a mouse).
  • attenuated high glucose-induced endothelial cell inflammatory response and barrier disruption. Again, this is promising, but it was an in vitro study in very controlled lab conditions, and sometimes “what happens in the Petri dish, stays in the Petri dish”—in order words, these results may or may not translate to actual living humans.
  • Improved insulin response ← is the main take-away that we got from reading through their numerical results, since there was no convenient conclusion given. Superficially, this may be of more interest to those with type 2 diabetes, but then again, if you have T1D and then acquire insulin resistance on top of that, you stand a good chance of dying on account of your exogenous insulin no longer working. In the case of T2D, “the pancreas will provide” (more or less), T1D, not so much.

So, what else is there out there?

The American Diabetes Association does not give a glowing review:

❝There’s a lot of hype surrounding CBD oil and diabetes. There is no noticeable effect on blood glucose (blood sugar) or insulin levels in people with type 2 diabetes. Researchers continue to study the effects of CBD on diabetes in animal studies. ❞

~ American Diabetes Association

Source: ADA | CBD & Diabetes

Of course, that’s type 2, but most research out there is for type 2, or else have been in vitro or rodent studies (and not many of those, at that).

Here’s a relatively more recent study that echoes the results of the previous mouse study we mentioned; it found:

❝CBD-treated non-obese diabetic mice developed T1D later and showed significantly reduced leukocyte activation and increased FCD in the pancreatic microcirculation.

Conclusions: Experimental CBD treatment reduced markers of inflammation in the microcirculation of the pancreas studied by intravital microscopy. ❞

~ Dr. Christian Lehmann et al.

Read more: Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes

…and here’s a 2020 study (so, more recent again) that was this time rats, and/but still more promising, insofar as it was with rats that had full-blown T1D already:

Read in full: Two-weeks treatment with cannabidiol improves biophysical and behavioral deficits associated with experimental type-1 diabetes

Finally, a paper in July 2023 (so, since our previous article about CBD), looked at the benefits of CBD against diabetes-related complications (so, applicable to most people with any kind of diabetes), and concluded:

❝CBDis of great value in the treatment of diabetes and its complications. CBD can improve pancreatic islet function, reduce pancreatic inflammation and improve insulin resistance. For diabetic complications, CBD not only has a preventive effect but also has a therapeutic value for existing diabetic complications and improves the function of target organs

~ Dr. Jin Zhang et al.

…before continuing:

❝However, the safety and effectiveness of CBD are still needed to prove. It should be acknowledged that the clinical application of CBD in the treatment of diabetes and its complications has a long way to go.

The dissecting of the pharmacology and therapeutic role of CBD in diabetes would guide the future development of CBD-based therapeutics for treating diabetes and diabetic complications❞

~ Ibid.

Now, the first part of that is standard ass-covering, and the second part of that is standard “please fund more studies please”. Nevertheless, we must also not fail to take heed—little is guaranteed, especially when it comes to an area of research where the science is still very young.

In summary…

It seems well worth a try, and with ostensibly nothing to lose except the financial cost of the CBD.

If you do, you might want to keep careful track of a) your usual diabetes metrics (blood sugar levels before and after meals, insulin taken), and b) when you took CBD, what dose, etc, so you can do some citizen science here.

Lastly: please remember our standard disclaimer; we are not doctors, let alone your doctors, so please do check with your endocrinologist before undertaking any such changes!

Want to read more?

You might like our previous main feature:

How To Prevent And Reverse Type 2 Diabetes ← obviously this will not prevent or reverse Type 1 Diabetes, but avoiding insulin resistance is good in any case!

If you’re not diabetic and you’ve perhaps been confused throughout this article, then firstly thank you for your patience, and secondly you might like this quick primer:

The Sweet Truth About Diabetes: Debunking Diabetes Myths! ← this gives a simplified but fair overview of types 1 & 2

(for space, we didn’t cover the much less common types 3 & 4; perhaps another time we will)

Meanwhile, take care!

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  • Escape Self-Sabotage

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Stop Making The Same Mistakes

    It’s easy to think that a self-destructive cycle is easy to avoid if you have no special will to self-destruction. However, the cycle is sneaky.

    It’s sneaky because it can be passive, and/or omissions rather than actions, procrastinations rather than obvious acts of impulse, and so forth.

    So, they’re often things that specifically aren’t there to see.

    How to catch them

    How often do you think “I wish I had [done xyz]” or “I wish I had [done yxz] sooner”?

    Now, how often have you thought that about the same thing more than once? For example, “I should have kept up my exercise”.

    For things like this, habit-trackers are a great way to, well, keep track of habits. If for example you planned to do a 10-minute exercise session daily but you’ve been postponing it since you got distracted on January the 2nd, then it’ll highlight that. See also:

    How To Really Pick Up (And Keep!) Those Habits

    Speaking of habits, this goes for other forms of procrastination, too. For example, if you are always slow to get medical check-ups, or renew your prescriptions, or get ready for some regularly-occurring thing in your schedule, then set a reminder in your preferred way (phone app, calendar on the wall, whatever) and when the appointed time arrives (to book the check-up, renew the prescription, do your taxes, whatever), do it on the day you set your reminder for, as a personal rule for you that you keep to, barring extreme calamity.

    By “extreme calamity” we mean less “running late today” and more “house burned down”.

    Digital traps

    Bad habits can be insidious in other ways too, like getting sucked into social media scrolling (it is literally designed to do that to you; you are not immune modern programming hijacking evolutionary dopamine responses).

    Setting a screentime limit (you can specify “just these apps” if you like) will help with this. On most devices, this feature includes a sticky notification in the notification bar, that’ll remind you “27 out of 30 minutes remaining” or whatever you set it for. That’ll remind you to do what you went there to do, instead of getting caught in the endless scroll (and if you went there to just browse, to do so briefly).

    Here’s how to set that:

    Instructions for iOS devices | Instructions for Android devices

    Oh, and on the topic of social media? If you find yourself getting caught up in unproductive arguments on the Internet, try the three-response rule:

    1. You reply; they reply (no progress made)
    2. You reply; they reply (still no progress made)
    3. You reply; they reply (still yet no progress made)

    You reply just one more time: “I have a personal rule that if I’m arguing on the Internet and no progress has been made after three replies, I don’t reply further—I find this is helpful to avoid a lot of time lost to pointless arguing that isn’t going anywhere. Best wishes.”

    (and then stick to it, no matter how they try to provoke you; best is to just not look until at least the next day)

    When “swept up in love” gets to one of those little whirlpools…

    The same works in personal relationships, by the way. If for example you are arguing with a loved one and not making progress, it can be good if you both have a pre-arranged agreement that either of you can, up to once on any given day, invoke a “time-out” (e.g. 30 minutes, but you agree the time between you when you first make this standing policy) during which you will both keep out of the other’s way, and come back with a more productive head on (remembering that things go best when it’s you both vs the problem, rather than vs each other).

    See also:

    Seriously Useful Communication Skills: Conflict Resolution

    What if the self-sabotaging cycle is active and apparent?

    Well, that is less sneaky, but certainly no less serious, and sometimes moreso. An obvious example is drinking too much; this is often cyclical in nature. We wrote about this one previously:

    How To Reduce Or Quit Alcohol

    That article’s alcohol-specific, but the same advices go for other harmful activities, including other substance abuse (which in turn includes binge-eating), as well psychological addictions (such as gambling, for example).

    Finally…

    If your destructive cycle is more of a rut you’ve got stuck in, a common advice is to change something, anything, to get out of the rut.

    That can be very bad advice! Because sometimes the change you go for is absolutely not the change that was needed, and is rather just cracking under pressure and doing something impulsive.

    Here’s one way to actively get out of a slump:

    Behavioral Activation Against Depression & Anxiety

    Note: you do not have to be depressed or anxious to do this. But the point is, it’s a tool you can use even if you are depressed and/or anxious, so it’s a good thing to try for getting out of most kinds of slumps.

    And really finally, here’s a resource for, well, the title speaks for itself:

    When You Know What You “Should” Do (But Knowing Isn’t The Problem)

    Take care!

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  • What To Eat, Take, And Do Before A Workout

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    What to eat, take, and do before a workout

    We’ve previously written about how to recover quickly after a workout:

    Overdone It? How To Speed Up Recovery After Exercise

    Today we’ll look at the flipside: how to prepare for exercise.

    Pre-workout nutrition

    As per what we wrote (and referenced) above, a good dictum is “protein whenever; carbs after”. See also:

    Pre- versus post-exercise protein intake has similar effects on muscular adaptations

    It’s recommended to have a light, balanced meal a few hours before exercising, though there are nuances:

    International society of sports nutrition position stand: nutrient timing

    Hydration

    You will not perform well unless you are well-hydrated:

    Influence of Dehydration on Intermittent Sprint Performance

    However, you also don’t want to just be sloshing around when exercising because you took care to get in your two litres before hitting the gym.

    For this reason, quality can be more important than quantity, and sodium and other electrolytes can be important and useful, but will not be so for everyone in all circumstances.

    Here’s what we wrote previously about that:

    Are Electrolyte Supplements Worth It?

    Pre-workout supplements

    We previously wrote about the use of creatine specifically:

    Creatine: Very Different For Young & Old People

    Caffeine is also a surprisingly effective pre-workout supplement:

    International society of sports nutrition position stand: caffeine and exercise performance

    Depending on the rate at which you metabolize caffeine (there are genes for this), the effects will come/go earlier/later, but as a general rule of thumb, caffeine should work within about 20 minutes, and will peak in effect 1–2 hours after consumption:

    Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity

    Branched Chain Amino Acids, or BCAAs, are commonly enjoyed as pre-workout supplement to help reduce creatine kinase and muscle soreness, but won’t accelerate recovery:

    The effect of branched-chain amino acid on muscle damage markers and performance following strenuous exercise: a systematic review and meta-analysis

    …but will help boost muscle-growth (or maintenance, depending on your exercise and diet) in the long run:

    Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein Synthesis following Resistance Exercise in Humans

    Where can I get those?

    We don’t sell them, but here’s an example product on Amazon, for your convenience 

    There are also many multi-nutrient pre-workout supplements on the market (like the secondary product offered with the BCAA above). We’d need a lot more room to go into all of those (maybe we’ll include some in our Monday Research Review editions), but meanwhile, here’s some further reading:

    The 11 Best Pre-Workout Supplements According to a Dietitian

    (it’s more of a “we ranked these commercial products” article than a science article, but it’s a good starting place for understanding about what’s on offer)

    Enjoy!

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  • The Problem With Active Listening

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    The problem with active listening

    Listening is an important skill to keep well-trained at any age. It’s important in romantic relationships, parent-child relationships, friendships, and more.

    First, for any unfamiliar or hazy-of-memory: active listening is the practice of listening, actively. The “active” side of this comes in several parts:

    1. Asking helpful questions
    2. Giving feedback to indicate that the answer has been understood
    3. Prompting further information-giving

    This can look like:

    • A: How did you feel when that happened?
    • B: My heart was racing and I felt panicked, it really shocked me
    • A: It really shocked you?
    • B: Yes, because it was so unexpected; I’d never imagined something like this happening
    • A: You’d never expect something like that
    • B: No, I mean, I had no reason to

    And… As a superficial listening technique, it’s not terrible, and it has its place

    But unfortunately, if it’s one’s only listening technique, one will very quickly start sounding like a Furby—that children’s toy from the 90s that allegedly randomly parroted fragments of things that had been said to it. In fact this was a trick of programming, but that’s beyond the scope of this article.

    The point is: the above technique, if used indiscriminately and/or too often, starts to feel like talking to a very basic simulacrum.

    Which is the opposite of feeling like being listened to!

    A better way to listen

    Start off similarly, but better.

    Ask open questions, or otherwise invite sharing of information.

    People can be resistant to stock phrases like “How did that make you feel?”, but this can be got around by simply changing it up, e.g.:

    • “What was your reaction?” ← oblique but often elicits the same information
    • “I’m not sure how I’d feel about that, in your shoes” ← not even a question, but shows active attention much better than the “mmhmm” noises of traditional active listening, and again prompts the same information

    Express understanding… But better

    People have been told “I understand” a lot, and often it’s code for “Stop talking”. So, avoid “I understand”. Instead, try:

    • “I can understand that”
    • “Understandable”
    • “That makes sense”

    Ask clarifying questions… Better

    Sometimes, a clarifying question doesn’t have to have its own point, beyond prompting more sharing, and sometimes, an “open question” can be truly wide open, meaning that vaguer is better, such as:

    • “Oh?”
    • “How so?” ← this is the heavy artillery that can open up a lot

    Know when to STFU

    Something that good therapists (and also military interrogators) know: when to STFU

    If someone is talking, don’t interrupt them. If you do, they might not start again, or might skip what they were going to say.

    Interruption says “I think you’ve said all that needs to be said there”, or else, if the interruption was to ask one of the above questions, it says “you’re not doing a good enough job of talking”, and neither of those sentiments encourage people to share, nor do they make someone feel listened-to!

    Instead, just listen. Passive listening has its place too! When there’s a break, then you can go to one of the above questions/prompts/expressions of understanding, as appropriate.

    Judge not, lest they feel judged

    Reserve judgement until the conversation is over, at the earliest. If asked for your judgement of some aspect, be as reassuring as you can. People feel listened-to when they don’t feel judged.

    If they feel judged, conversely, they can often feel you didn’t listen properly, or else you’d be in agreement with them. So instead, just sit on it for as long as you can.

    Note: that goes for positive judgements too! Sit on it. Expressing a positive judgement too soon can seem that you were simply eager to please, and can suggest insincerity.

    If this seems simple, that’s because it is. But, try it, and see the difference.

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  • Mung Beans vs Soy Beans – Which is Healthier?

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    Our Verdict

    When comparing mung beans to soy beans, we picked the soy.

    Why?

    Mung beans are great, but honestly, it’s not close:

    In terms of macronutrients, soy has more than 2x the protein (of which, it’s also a complete protein, containing significant amounts of all essential amino acids) while mung beans have more than 2x the carbs. In their defense, mung beans also have very slightly more fiber, but the carb:fiber ratio is such that soy beans have the lower GI by far.

    When it comes to vitamins, mung beans have more of vitamins A, B3, B5, and, B9, while soy beans have more of vitamins B2, B6, C, E, K, and choline, making for a moderate win for soy beans, especially as that vitamin K is more than 7x as much as mung beans have.

    In the category of minerals, soy wins even more convincingly; soy beans have more calcium, copper, iron, magnesium, manganese, phosphorus, potassium, selenium, and zinc. On the other hand, mung beans have more sodium.

    In short, while mung beans are a very respectable option, they don’t come close to meaningfully competing with soy.

    Want to learn more?

    You might like to read:

    How To Sprout Your Seeds, Grains, Beans, Etc

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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  • Chili Chestnut, Sweet Apricot, & Whipped Feta Toasts

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    This is a delightful breakfast or light lunch option, full of gut-healthy ingredients and a fair list of healthy polyphenols too.

    You will need

    • ½ baguette, sliced into ½” slices; if making your own, feel free to use our Delicious Quinoa Avocado Bread recipe. If buying shop-bought, a sourdough baguette will likely be the healthiest option, and tasty too.
    • 4 oz feta cheese; if you are vegan, a plant-based version will work in culinary terms, but will have a different (less gut-healthy) nutritional profile, as plant-based cheeses generally use a lot of coconut oil and potato starch, and are not actually fermented.
    • 1 tbsp yogurt; your preference what kind; live-cultured with minimal additives is of course best—and this time, plant-based is also just as good, healthwise, since they are fermented and contain more or less the same beneficial bacteria, and have a good macro profile too.
    • 4 oz precooked chestnuts, finely chopped
    • 6 dried apricots, finely chopped
    • ¼ bulb garlic, grated
    • 2 tsp harissa paste
    • 1 tsp black pepper, coarse ground
    • ¼ tsp MSG or ½ tsp low-sodium salt
    • Extra virgin olive oil, for frying
    • Optional garnish: finely chopped chives

    Method

    (we suggest you read everything at least once before doing anything)

    1) Combine the feta and yogurt in a small, high-speed blender and process into a smooth purée. If it isn’t working, add 1 tbsp kettle-hot water and try again.

    2) Heat the oil in a skillet over a medium heat; add the garlic and when it starts to turn golden, add the chestnuts and harissa, as well as the black pepper and MSG/salt. Stir for about 2 minutes, and then stir in the apricots and take it off the heat.

    3) Toast the baguette slices under the grill. If you’re feeling bold about the multitasking, you can start this while still doing the previous step, for optimal timing. If not, simply doing it in the order presented is fine.

    4) Assemble: spread the whipped feta over the toast; add the apricot-chestnut mixture, followed by the finely chopped chives if using, and serve immediately:

    Enjoy!

    Want to learn more?

    For those interested in some of the science of what we have going on today:

    Take care!

    Don’t Forget…

    Did you arrive here from our newsletter? Don’t forget to return to the email to continue learning!

    Learn to Age Gracefully

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  • Discipline is Destiny – by Ryan Holiday

    10almonds is reader-supported. We may, at no cost to you, receive a portion of sales if you purchase a product through a link in this article.

    We’ve previously reviewed another of Holiday’s books, The Daily Stoic, and here is another excellent work from the same author.

    We’re not a philosophy newsletter, but there are some things that make a big difference to physical and mental health, the habits we build, and the path we take in life for better or for worse.

    Self-discipline is one of those things. A lot of the time, we know what we need to do, but knowing isn’t the problem. We need to actually do it! This applies to diet, exercise, sleep, and more.

    Holiday gives us, in a casual easy-reading style, timeless principles to lock in strong discipline and good habits for life.

    The book’s many small chapters, by the way, are excellent for reading a chapter-per-day as a healthy dose of motivation each morning, if you’re so inclined.

    Bottom line: if you’ve noticed that one of the biggest barriers between you and your goals is actually doing the necessary things in a disciplined fashion, then this book will help you become more efficient, and actually get there.

    Click here to check out Discipline is Destiny, and upgrade yours!

    Don’t Forget…

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    Learn to Age Gracefully

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